{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:07:30Z","timestamp":1792714050257,"version":"4.5.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.humpath.2021.04.013","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T11:35:03Z","timestamp":1620128103000},"page":"9-18","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":61,"special_numbering":"C","title":["Low-Grade Oncocytic Tumor of Kidney (CK7-Positive, CD117-Negative): Incidence in a single institutional experience with clinicopathological and molecular characteristics"],"prefix":"10.1016","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0997-1933","authenticated-orcid":false,"given":"Oleksandr","family":"Kravtsov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5163-6955","authenticated-orcid":false,"given":"Sounak","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Cheville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Sukov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross","family":"Rowsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loren P.","family":"Herrera-Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M.","family":"Lohse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Knudson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley C.","family":"Leibovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael E.","family":"Jimenez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2021.04.013_bib1","first-page":"153","article-title":"Oncocytoma versus chromophobe renal cell carcinoma: is there something in between?","volume":"37","author":"Luders","year":"2016","journal-title":"Pathologe"},{"key":"10.1016\/j.humpath.2021.04.013_bib2","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/his.13865","article-title":"Low-grade oncocytic tumour of kidney (CD117-negative, cytokeratin 7-positive): a distinct entity?","volume":"75","author":"Trpkov","year":"2019","journal-title":"Histopathology"},{"key":"10.1016\/j.humpath.2021.04.013_bib3","article-title":"Novel, emerging and provisional renal entities: the Genitourinary Pathology Society (GUPS) update on renal neoplasia","author":"Trpkov","year":"2021","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2021.04.013_bib4","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.ccr.2014.07.014","article-title":"The somatic genomic landscape of chromophobe renal cell carcinoma","volume":"26","author":"Davis","year":"2014","journal-title":"Canc Cell"},{"key":"10.1016\/j.humpath.2021.04.013_bib5","article-title":"Contemporary characterization and recategorization of adult unclassified renal cell carcinoma","author":"Kwon","year":"2020","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2021.04.013_bib6","article-title":"FOXI1 expression in chromophobe renal cell carcinoma and renal oncocytoma: a study of the Cancer Genome Atlas transcriptome-based outlier mining and immunohistochemistry","author":"Tong","year":"2020","journal-title":"Virchows Arch"},{"key":"10.1016\/j.humpath.2021.04.013_bib7","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.humpath.2009.01.016","article-title":"CCND1 rearrangements and cyclin D1 overexpression in renal oncocytomas: frequency, clinicopathologic features, and utility in differentiation from chromophobe renal cell carcinoma","volume":"40","author":"Sukov","year":"2009","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2021.04.013_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.mayocp.2020.11.004","article-title":"Renal neoplasia in tuberous sclerosis: a study of 41 patients","author":"Gupta","year":"2021","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.humpath.2021.04.013_bib9","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1097\/PAS.0b013e318299f0fb","article-title":"The International Society of Urological Pathology (ISUP) grading system for renal cell carcinoma and other prognostic parameters","volume":"37","author":"Delahunt","year":"2013","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2021.04.013_bib10","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.cancergen.2012.06.005","article-title":"Molecular inversion probes: a novel microarray technology and its application in cancer research","volume":"205","author":"Wang","year":"2012","journal-title":"Canc Genet"},{"key":"10.1016\/j.humpath.2021.04.013_bib11","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1097\/PAS.0000000000000508","article-title":"Eosinophilic, solid, and cystic renal cell carcinoma: clinicopathologic study of 16 unique, sporadic neoplasms occurring in women","volume":"40","author":"Trpkov","year":"2016","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2021.04.013_bib12","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1097\/PAS.0000000000001307","article-title":"TFEB expression profiling in renal cell carcinomas: clinicopathologic correlations","volume":"43","author":"Gupta","year":"2019","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2021.04.013_bib13","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1097\/PAS.0000000000000292","article-title":"Succinate dehydrogenase (SDH)-deficient renal carcinoma: a morphologically distinct entity: a clinicopathologic series of 36 tumors from 27 patients","volume":"38","author":"Gill","year":"2014","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2021.04.013_bib14","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/his.13183","article-title":"A distinctive, low-grade oncocytic fumarate hydratase-deficient renal cell carcinoma, morphologically reminiscent of succinate dehydrogenase-deficient renal cell carcinoma","volume":"71","author":"Smith","year":"2017","journal-title":"Histopathology"},{"key":"10.1016\/j.humpath.2021.04.013_bib15","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.5858\/arpa.2013-0653-RA","article-title":"Diagnostic approach to eosinophilic renal neoplasms","volume":"138","author":"Kryvenko","year":"2014","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.humpath.2021.04.013_bib16","doi-asserted-by":"crossref","first-page":"S123","DOI":"10.21037\/tau.2018.11.02","article-title":"Utility of cytokeratin 7, S100A1 and caveolin-1 as immunohistochemical biomarkers to differentiate chromophobe renal cell carcinoma from renal oncocytoma","volume":"8","author":"Ng","year":"2019","journal-title":"Transl Androl Urol"},{"key":"10.1016\/j.humpath.2021.04.013_bib17","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1093\/ajcp\/111.6.796","article-title":"Renal oncocytoma and chromophobe renal cell carcinoma. A comparison of colloidal iron staining and electron microscopy","volume":"111","author":"Skinnider","year":"1999","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.humpath.2021.04.013_bib18","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.humpath.2017.03.004","article-title":"Diagnostic criteria for oncocytic renal neoplasms: a survey of urologic pathologists","volume":"63","author":"Williamson","year":"2017","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2021.04.013_bib19","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1159\/000020172","article-title":"Utility of cytokeratin 7 for distinguishing chromophobe renal cell carcinoma from renal oncocytoma","volume":"37","author":"Leroy","year":"2000","journal-title":"Eur Urol"},{"key":"10.1016\/j.humpath.2021.04.013_bib20","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1097\/PAS.0000000000000248","article-title":"Tuberous sclerosis-associated renal cell carcinoma: a clinicopathologic study of 57 separate carcinomas in 18 patients","volume":"38","author":"Guo","year":"2014","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2021.04.013_bib21","article-title":"Characterization of a distinct low-grade oncocytic renal tumor (CD117-negative and cytokeratin 7-positive) based on a tertiary oncology center experience: the new evidence from China","author":"Guo","year":"2020","journal-title":"Virchows Arch"},{"key":"10.1016\/j.humpath.2021.04.013_bib22","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.euros.2020.11.001","article-title":"In situ metabolomics expands the spectrum of renal tumours positive on 99mTc-sestamibi single photon emission computed tomography\/computed tomography examination","volume":"22","author":"Papathomas","year":"2020","journal-title":"Eur Urol Open Sci"},{"key":"10.1016\/j.humpath.2021.04.013_bib23","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/j.1442-2042.2010.02574.x","article-title":"Molecular pathology of renal oncocytoma: a review","volume":"17","author":"Yusenko","year":"2010","journal-title":"Int J Urol"},{"key":"10.1016\/j.humpath.2021.04.013_bib24","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.eururo.2020.03.003","article-title":"Next-generation RNA sequencing-based biomarker characterization of chromophobe renal cell carcinoma and related oncocytic neoplasms","volume":"78","author":"Skala","year":"2020","journal-title":"Eur Urol"},{"key":"10.1016\/j.humpath.2021.04.013_bib25","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1097\/PAS.0000000000001457","article-title":"Eosinophilic renal cell tumors with a TSC and MTOR gene mutations are morphologically and immunohistochemically heterogenous: clinicopathologic and molecular study","volume":"44","author":"Tjota","year":"2020","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2021.04.013_bib26","article-title":"TSC\/MTOR mutated eosinophilic renal tumors are a distinct entity that are CK7+\/CK20-\/vimentin-: a validation study","author":"Tjota","year":"2020","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2021.04.013_bib27","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.eururo.2020.10.007","article-title":"Grading chromophobe renal cell carcinoma: evidence for a four-tiered classification incorporating coagulative tumor necrosis","volume":"79","author":"Avulova","year":"2021","journal-title":"Eur Urol"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004681772100071X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004681772100071X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T16:38:11Z","timestamp":1758645491000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004681772100071X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":27,"alternative-id":["S004681772100071X"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2021.04.013","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Low-Grade Oncocytic Tumor of Kidney (CK7-Positive, CD117-Negative): Incidence in a single institutional experience with clinicopathological and molecular characteristics","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2021.04.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}