{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T03:27:36Z","timestamp":1771471656970,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.humpath.2021.04.015","type":"journal-article","created":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T11:31:31Z","timestamp":1620387091000},"page":"28-35","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Papillary thyroid microcarcinomas: does subtyping predict aggressive clinical behavior?"],"prefix":"10.1016","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2246-7958","authenticated-orcid":false,"given":"Maria A.","family":"Gubbiotti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Livolsi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5794-3371","authenticated-orcid":false,"given":"Kathleen","family":"Montone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zubair","family":"Baloch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2021.04.015_bib1","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1210\/jc.2015-2917","article-title":"Differential clinicopathological risk and prognosis of major papillary thyroid cancer variants","volume":"101","author":"Shi","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.humpath.2021.04.015_bib2","series-title":"Atlas of tumor pathology: tumors in the thyroid gland","author":"Rosai","year":"1992"},{"key":"10.1016\/j.humpath.2021.04.015_bib3","series-title":"Asa. Endocrine pathology","author":"Livolsi","year":"2002"},{"key":"10.1016\/j.humpath.2021.04.015_bib4","first-page":"224","article-title":"Radiation induced thyroid diseases","volume":"14","author":"Hunt","year":"2009","journal-title":"AJSP: Rev Rep"},{"key":"10.1016\/j.humpath.2021.04.015_bib5","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1001\/jama.1973.03220320021007","article-title":"Thyroid carcinoma and radiation. A Chicago endemic","volume":"225","author":"DeGroot","year":"1973","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.humpath.2021.04.015_bib6","first-page":"317","article-title":"Neoplasms in persons treated with x rays in infancy for thymic enlargement. A report of the third follow-up survey","volume":"38","author":"Hempelmann","year":"1967","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.humpath.2021.04.015_bib7","doi-asserted-by":"crossref","first-page":"R577","DOI":"10.1530\/ERC-16-0067","article-title":"Familial non-medullary thyroid cancer: unraveling the genetic maze","volume":"23","author":"Peiling Yang","year":"2016","journal-title":"Endocr Relat Canc"},{"key":"10.1016\/j.humpath.2021.04.015_bib8","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.mpdhp.2016.02.005","article-title":"Familial non-medullary thyroid cancer: an update on the genetic and pathologic features","volume":"22","author":"Griffith","year":"2016","journal-title":"Diagn Histopathol"},{"key":"10.1016\/j.humpath.2021.04.015_bib9","doi-asserted-by":"crossref","first-page":"394","DOI":"10.5144\/0256-4947.2005.394","article-title":"Prevalence of differentiated thyroid cancer in 810 cases of surgically treated goiter in Yemen","volume":"25","author":"Al-Jaradi","year":"2005","journal-title":"Ann Saudi Med"},{"key":"10.1016\/j.humpath.2021.04.015_bib10","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12902-019-0351-x","article-title":"Association between Hashimoto's thyroiditis and papillary thyroid carcinoma: a retrospective analysis of 305 patients","volume":"19","author":"Graceffa","year":"2019","journal-title":"BMC Endocr Disord"},{"key":"10.1016\/j.humpath.2021.04.015_bib11","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3949\/ccjm.43.4.207","article-title":"The many appearances of papillary carcinoma of the thyroid","volume":"43","author":"Hawk","year":"1976","journal-title":"Cleve Clin Q"},{"key":"10.1016\/j.humpath.2021.04.015_bib12","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/dc.20830","article-title":"Diagnostic terminology and morphologic criteria for cytologic diagnosis of thyroid lesions: a synopsis of the national cancer institute thyroid fine-needle aspiration state of the science conference","volume":"36","author":"Baloch","year":"2008","journal-title":"Diagn Cytopathol"},{"key":"10.1016\/j.humpath.2021.04.015_bib13","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1001\/jamaoncol.2016.0386","article-title":"Nomenclature revision for encapsulated follicular variant of papillary thyroid carcinoma: a paradigm shift to reduce overtreatment of indolent tumors","volume":"2","author":"Nikiforov","year":"2016","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.humpath.2021.04.015_bib14","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s12022-010-9106-y","article-title":"Papillary carcinoma tall cell variant (TCV): a review","volume":"21","author":"LiVolsi","year":"2010","journal-title":"Endocr Pathol"},{"key":"10.1016\/j.humpath.2021.04.015_bib15","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.5858\/2000-124-1192-WLPCOT","article-title":"Warthin-like papillary carcinoma of the thyroid","volume":"124","author":"Baloch","year":"2000","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.humpath.2021.04.015_bib16","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1007\/s12325-020-01391-1","article-title":"Papillary thyroid cancer-aggressive variants and impact on management: a narrative review","volume":"37","author":"Coca-Pelaz","year":"2020","journal-title":"Adv Ther"},{"key":"10.1016\/j.humpath.2021.04.015_bib17","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/01.pap.0000213006.10362.17","article-title":"Microcarcinoma of the thyroid","volume":"13","author":"Baloch","year":"2006","journal-title":"Adv Anat Pathol"},{"key":"10.1016\/j.humpath.2021.04.015_bib18","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ejso.2017.03.004","article-title":"Low-risk papillary microcarcinoma of the thyroid: a review of active surveillance trials","volume":"44","author":"Ito","year":"2018","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.humpath.2021.04.015_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/CCO.0000000000000595","article-title":"Papillary thyroid microcarcinoma: optimal management versus overtreatment","volume":"32","author":"Walgama","year":"2020","journal-title":"Curr Opin Oncol"},{"key":"10.1016\/j.humpath.2021.04.015_bib20","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ecl.2018.10.006","article-title":"Management of papillary thyroid microcarcinoma","volume":"48","author":"Brito","year":"2019","journal-title":"Endocrinol Metab Clin N Am"},{"key":"10.1016\/j.humpath.2021.04.015_bib21","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.surg.2019.03.030","article-title":"Aggressive variants of papillary thyroid microcarcinoma are associated with high-risk features, but not decreased survival","volume":"167","author":"Holoubek","year":"2020","journal-title":"Surgery"},{"key":"10.1016\/j.humpath.2021.04.015_bib22","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s10147-017-1170-6","article-title":"Impact of major different variants of papillary thyroid microcarcinoma on the clinicopathological characteristics: the study of 1041 cases","volume":"23","author":"Zhi","year":"2018","journal-title":"Int J Clin Oncol"},{"key":"10.1016\/j.humpath.2021.04.015_bib23","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1089\/thy.2013.0154","article-title":"Tall cell variant of papillary thyroid microcarcinoma: clinicopathologic features with BRAF(V600E) mutational analysis","volume":"23","author":"Bernstein","year":"2013","journal-title":"Thyroid"},{"key":"10.1016\/j.humpath.2021.04.015_bib24","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jss.2014.03.032","article-title":"Distinguishing classical papillary thyroid microcancers from follicular-variant microcancers","volume":"190","author":"Singhal","year":"2014","journal-title":"J Surg Res"},{"key":"10.1016\/j.humpath.2021.04.015_bib25","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/(SICI)1097-0339(199707)17:1<25::AID-DC5>3.0.CO;2-O","article-title":"Tall cell variant of papillary thyroid carcinoma: cytologic features and differential diagnostic considerations","volume":"17","author":"Bocklage","year":"1997","journal-title":"Diagn Cytopathol"},{"key":"10.1016\/j.humpath.2021.04.015_bib26","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/dc.10156","article-title":"Distinguishing tall cell variant of papillary thyroid carcinoma from usual variant of papillary thyroid carcinoma in cytologic specimens","volume":"27","author":"Solomon","year":"2002","journal-title":"Diagn Cytopathol"},{"key":"10.1016\/j.humpath.2021.04.015_bib27","doi-asserted-by":"crossref","DOI":"10.2967\/jnumed.121.261898","article-title":"Minimal extrathyroid extension in papillary micro carcinoma of the thyroid is an independent risk factor for relapse through lymph node and distant metastases","author":"Seifert","year":"2021","journal-title":"J Nucl Med"},{"key":"10.1016\/j.humpath.2021.04.015_bib28","doi-asserted-by":"crossref","first-page":"640565","DOI":"10.3389\/fendo.2021.640565","article-title":"Risk factors for central and lateral lymph node metastases in patients with papillary thyroid micro-carcinoma: retrospective analysis on 484 cases","volume":"12","author":"Huang","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.humpath.2021.04.015_bib29","first-page":"2359","article-title":"Prognostic factors for incomplete response in thyroid microcarcinoma: an analysis of initial response to therapy in 517 patients","author":"Faro","year":"2021","journal-title":"Arch Endocrinol Metab"},{"key":"10.1016\/j.humpath.2021.04.015_bib30","series-title":"World Health Organization classification of tumors of endocrine organs","author":"Lloyd","year":"2017"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817721000733?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817721000733?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T16:38:33Z","timestamp":1758645513000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817721000733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":30,"alternative-id":["S0046817721000733"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2021.04.015","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Papillary thyroid microcarcinomas: does subtyping predict aggressive clinical behavior?","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2021.04.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}