{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T07:56:14Z","timestamp":1792828574656,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T00:00:00Z","timestamp":1620604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.humpath.2021.05.002","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T02:05:25Z","timestamp":1620785125000},"page":"1-8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Follicular cells in pituitary neuroendocrine tumors"],"prefix":"10.1016","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8008-6128","authenticated-orcid":false,"given":"Luvy","family":"Delfin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0469-2801","authenticated-orcid":false,"given":"Ozgur","family":"Mete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8418-5054","authenticated-orcid":false,"given":"Sylvia L.","family":"Asa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2021.05.002_bib1","series-title":"Tumors of the pituitary gland. AFIP atlas of tumor and non-tumor pathology, series 5, fascicle 1","author":"Asa","year":"2020"},{"key":"10.1016\/j.humpath.2021.05.002_bib2","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1111\/j.1365-2826.2008.01716.x","article-title":"An insight to pituitary folliculo-stellate cells","volume":"20","author":"Devnath","year":"2008","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.humpath.2021.05.002_bib3","first-page":"199","article-title":"Possible function and fate of 'follicular cells' in the anterior lobe of the human pituitary","volume":"77","author":"Horvath","year":"1974","journal-title":"Am J Pathol"},{"key":"10.1016\/j.humpath.2021.05.002_bib4","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/BF02915456","article-title":"Immunohistochemical study of folliculostellate cells in pituitary lesions","volume":"2","author":"Nishioka","year":"1991","journal-title":"Endocr Pathol"},{"key":"10.1016\/j.humpath.2021.05.002_bib5","first-page":"713","article-title":"Folliculo-stellate cells in normal human adenohypophyses and in pituitary adenomas","volume":"16","author":"Miyazaki","year":"1988","journal-title":"Noshinkeigeka"},{"key":"10.1016\/j.humpath.2021.05.002_bib6","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/s41379-018-0016-8","article-title":"Epidemiology and biomarker profile of pituitary adenohypophysial tumors","volume":"31","author":"Mete","year":"2018","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2021.05.002_bib7","article-title":"'Corticotroph' of the rat adenohypophysis as revealed by electron microscopy","volume":"127","author":"Farquhar","year":"1957","journal-title":"Anat Rec"},{"key":"10.1016\/j.humpath.2021.05.002_bib8","first-page":"E304","article-title":"Transport epithelial characteristics of cultured bovine pituitary follicular cells","volume":"252","author":"Ferrara","year":"1987","journal-title":"Am J Physiol"},{"key":"10.1016\/j.humpath.2021.05.002_bib9","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/303711a0","article-title":"Novel clonal strains from adult rat anterior pituitary producing S-100 protein","volume":"303","author":"Ishikawa","year":"1983","journal-title":"Nature"},{"key":"10.1016\/j.humpath.2021.05.002_bib10","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1440-1827.2005.01820.x","article-title":"Immunohistochemical study on so-called follicular cells and folliculostellate cells in the human adenohypophysis","volume":"55","author":"Yamashita","year":"2005","journal-title":"Pathol Int"},{"key":"10.1016\/j.humpath.2021.05.002_bib11","doi-asserted-by":"crossref","first-page":"8891","DOI":"10.1073\/pnas.151339598","article-title":"Folliculostellate cell network: a route for long-distance communication in the anterior pituitary","volume":"98","author":"Fauquier","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.humpath.2021.05.002_bib12","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/(SICI)1097-0029(19971015)39:2<138::AID-JEMT5>3.0.CO;2-H","article-title":"Folliculo-stellate cells and intercellular communication within the rat anterior pituitary gland","volume":"39","author":"Soji","year":"1997","journal-title":"Microsc Res Tech"},{"key":"10.1016\/j.humpath.2021.05.002_bib13","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/S1043-2760(01)00476-3","article-title":"A novel view of the function of pituitary folliculo-stellate cell network","volume":"12","author":"Stojilkovic","year":"2001","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.humpath.2021.05.002_bib14","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.1210\/endo.137.8.8754762","article-title":"Cell-to-cell communication in the anterior pituitary: evidence for gap junction-mediated exchanges between endocrine cells and folliculostellate cells","volume":"137","author":"Morand","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.humpath.2021.05.002_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0182495","article-title":"Distinctive actions of connexin 46 and connexin 50 in anterior pituitary folliculostellate cells","volume":"12","author":"Vitale","year":"2017","journal-title":"PloS One"},{"key":"10.1016\/j.humpath.2021.05.002_bib16","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1055\/s-2001-18995","article-title":"The intrapituitary stimulatory effect of lipopolysaccharide on ACTH secretion is mediated by paracrine-acting IL-6","volume":"109","author":"Gloddek","year":"2001","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"10.1016\/j.humpath.2021.05.002_bib17","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0739-7240(98)00027-7","article-title":"Regulation and role of intrapituitary IL-6 production by folliculostellate cells","volume":"15","author":"Renner","year":"1998","journal-title":"Domest Anim Endocrinol"},{"key":"10.1016\/j.humpath.2021.05.002_bib18","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1365-2826.2005.01286.x","article-title":"Bacterial endotoxin (lipopolysaccharide) stimulates interleukin-6 production and inhibits growth of pituitary tumour cells expressing the toll-like receptor 4","volume":"17","author":"Tichomirowa","year":"2005","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.humpath.2021.05.002_bib19","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1076\/apab.110.1.50.911","article-title":"Are folliculo-stellate cells in the anterior pituitary gland supportive cells or organ-specific stem cells?","volume":"110","author":"Inoue","year":"2002","journal-title":"Arch Physiol Biochem"},{"key":"10.1016\/j.humpath.2021.05.002_bib20","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/jne.12117","article-title":"Vascular endothelial growth factor secretion from pituitary folliculostellate cells: role of KATP channels","volume":"26","author":"Budzik","year":"2014","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.humpath.2021.05.002_bib21","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0076-6879(91)98040-D","article-title":"Purification and cloning of vascular endothelial growth factor secreted by pituitary folliculostellate cells","volume":"198","author":"Ferrara","year":"1991","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.humpath.2021.05.002_bib22","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1210\/en.2002-220283","article-title":"Transforming growth factor-beta stimulates vascular endothelial growth factor production by folliculostellate pituitary cells","volume":"143","author":"Renner","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.humpath.2021.05.002_bib23","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1210\/endo.137.5.8612495","article-title":"Gonadotropin-releasing hormone regulation of pituitary follistatin gene expression during the primary follicle-stimulating hormone surge","volume":"137","author":"Bauer-Dantoin","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.humpath.2021.05.002_bib24","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1055\/s-2007-984744","article-title":"Paracrine control of gonadotrophs","volume":"25","author":"Winters","year":"2007","journal-title":"Semin Reprod Med"},{"key":"10.1016\/j.humpath.2021.05.002_bib25","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1095\/biolreprod.110.087593","article-title":"PACAP, an autocrine\/paracrine regulator of gonadotrophs","volume":"84","author":"Winters","year":"2011","journal-title":"Biol Reprod"},{"key":"10.1016\/j.humpath.2021.05.002_bib26","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/0006-8993(80)91300-1","article-title":"S100 protein in folliculostellate cells of the rat pituitary anterior lobe","volume":"191","author":"Nakajima","year":"1980","journal-title":"Brain Res"},{"key":"10.1016\/j.humpath.2021.05.002_bib27","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1080\/01913120290104476","article-title":"Folliculo-stellate cells of the human pituitary: a type of adult stem cell?","volume":"26","author":"Horvath","year":"2002","journal-title":"Ultrastruct Pathol"},{"key":"10.1016\/j.humpath.2021.05.002_bib28","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/BF02890089","article-title":"Intermediate filament expression in non-neoplastic pituitary cells","volume":"58","author":"Ogawa","year":"1990","journal-title":"Virchows Arch B Cell Pathol Incl Mol Pathol"},{"key":"10.1016\/j.humpath.2021.05.002_bib29","first-page":"16","article-title":"Development of folliculo-stellate cells in the human pituitary","volume":"119","author":"Coates","year":"1988","journal-title":"Acta Endocrinol (Copenh)"},{"key":"10.1016\/j.humpath.2021.05.002_bib30","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s12022-008-9015-5","article-title":"Clusterin expression in non-neoplastic adenohypophyses and pituitary adenomas: cytoplasmic clusterin localization in adenohypophysis is related to aging","volume":"19","author":"Ekici","year":"2008","journal-title":"Endocr Pathol"},{"key":"10.1016\/j.humpath.2021.05.002_bib31","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/jemt.1070290605","article-title":"Sulfated glycoprotein-2 synthesized by nonciliated cells of the efferent ducts is targeted to the lysosomal compartment","volume":"29","author":"Igdoura","year":"1994","journal-title":"Microsc Res Tech"},{"key":"10.1016\/j.humpath.2021.05.002_bib32","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1158\/0008-5472.CAN-08-2912","article-title":"Advances and challenges in basic and translational research on clusterin","volume":"69","author":"Trougakos","year":"2009","journal-title":"Canc Res"},{"key":"10.1016\/j.humpath.2021.05.002_bib33","doi-asserted-by":"crossref","first-page":"7412","DOI":"10.1158\/0008-5472.CAN-04-2077","article-title":"Clusterin-mediated apoptosis is regulated by adenomatous polyposis coli and is p21 dependent but p53 independent","volume":"64","author":"Chen","year":"2004","journal-title":"Canc Res"},{"key":"10.1016\/j.humpath.2021.05.002_bib34","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1677\/ERC-09-0140","article-title":"The clusterin paradigm in prostate and breast carcinogenesis","volume":"17","author":"Rizzi","year":"2010","journal-title":"Endocr Relat Canc"},{"key":"10.1016\/j.humpath.2021.05.002_bib35","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.acthis.2006.01.006","article-title":"Phagocytotic removal of apoptotic endocrine cells by folliculostellate cells and its functional implications in clusterin accumulation in pituitary colloids in helmeted Guinea fowl (Numida meleagris)","volume":"108","author":"Claudius","year":"2006","journal-title":"Acta Histochem"},{"key":"10.1016\/j.humpath.2021.05.002_bib36","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/BF02915206","article-title":"Folliculostellate cells of the pituitary","volume":"2","author":"Marin","year":"1991","journal-title":"Endocr Pathol"},{"key":"10.1016\/j.humpath.2021.05.002_bib37","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S0344-0338(11)80090-7","article-title":"Folliculo-stellate cells in the human anterior pituitary express cytokeratin","volume":"189","author":"Tsuchida","year":"1993","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.humpath.2021.05.002_bib38","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s12022-020-09634-1","volume":"31","author":"Soukup","year":"2020","journal-title":"Endocr Pathol"},{"key":"10.1016\/j.humpath.2021.05.002_bib39","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/s12022-020-09632-3","article-title":"Images in endocrine pathology: progressive loss of sustentacular cells in a case of recurrent jugulotympanic paraganglioma over a span of 5 years","volume":"31","author":"Zhou","year":"2020","journal-title":"Endocr Pathol"},{"key":"10.1016\/j.humpath.2021.05.002_bib40","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s12022-020-09633-2","article-title":"Immunohistochemical staining for SOX10 and SDHB in SDH-deficient paragangliomas indicates that sustentacular cells are not neoplastic","volume":"31","author":"Powers","year":"2020","journal-title":"Endocr Pathol"},{"key":"10.1016\/j.humpath.2021.05.002_bib41","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/s11102-019-01015-0","article-title":"Pituitary neuroendocrine tumors (PitNETs): nomenclature evolution, not clinical revolution","volume":"23","author":"Asa","year":"2020","journal-title":"Pituitary"},{"key":"10.1016\/j.humpath.2021.05.002_bib42","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.humpath.2020.10.004","article-title":"Cytokeratin profiles in pituitary neuroendocrine tumors","volume":"107","author":"Asa","year":"2021","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2021.05.002_bib43","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s12022-019-09598-x","article-title":"A novel expression profile of cell cycle and DNA repair proteins in nonfunctioning pituitary adenomas","volume":"31","author":"Metin-Armagan","year":"2020","journal-title":"Endocr Pathol"},{"key":"10.1016\/j.humpath.2021.05.002_bib44","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.mce.2010.02.012","article-title":"Pituitary senescence: the evolving role of Pttg","volume":"326","author":"Chesnokova","year":"2010","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.humpath.2021.05.002_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0017924","article-title":"Lineage-specific restraint of pituitary gonadotroph cell adenoma growth","volume":"6","author":"Chesnokova","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.humpath.2021.05.002_bib46","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1210\/me.2012-1158","article-title":"Clusterin and FOXL2 act concordantly to regulate pituitary gonadotroph adenoma growth","volume":"26","author":"Chesnokova","year":"2012","journal-title":"Mol Endocrinol"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817721000757?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817721000757?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T16:38:28Z","timestamp":1758645508000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817721000757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":46,"alternative-id":["S0046817721000757"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2021.05.002","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Follicular cells in pituitary neuroendocrine tumors","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2021.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}