{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:05:30Z","timestamp":1787069130839,"version":"build-2736575974"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.humpath.2021.11.007","type":"journal-article","created":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T08:53:41Z","timestamp":1637312021000},"page":"105-113","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Clinicopathological features of syncytial variant nodular sclerosis Hodgkin lymphoma"],"prefix":"10.1016","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5287-264X","authenticated-orcid":false,"given":"Qingling","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3389-2618","authenticated-orcid":false,"given":"Do Hwan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangwei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6577-8006","authenticated-orcid":false,"given":"L. Jeffrey","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2021.11.007_bib1","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1084\/jem.184.4.1495","article-title":"Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells","volume":"184","author":"Kanzler","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/j.humpath.2021.11.007_bib2","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.pathol.2019.09.005","article-title":"Hodgkin lymphoma: a review of pathological features and recent advances in pathogenesis","volume":"52","author":"Piris","year":"2020","journal-title":"Pathology"},{"key":"10.1016\/j.humpath.2021.11.007_bib3","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/s12254-017-0367-8","article-title":"Aggressive lymphoma 2016: revision of the WHO classification","volume":"10","author":"Beham-Schmid","year":"2017","journal-title":"Memo"},{"key":"10.1016\/j.humpath.2021.11.007_bib4","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/1097-0142(19950101)75:1+<357::AID-CNCR2820751318>3.0.CO;2-A","article-title":"Hodgkin's disease","volume":"75","author":"Medeiros","year":"1995","journal-title":"Cancer"},{"key":"10.1016\/j.humpath.2021.11.007_bib5","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1097\/00000478-198607000-00004","article-title":"The \"syncytial variant\" of nodular sclerosing Hodgkin's disease","volume":"10","author":"Strickler","year":"1986","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2021.11.007_bib6","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1002\/1097-0142(19900301)65:5<1167::AID-CNCR2820650523>3.0.CO;2-V","article-title":"Syncytial variant of nodular sclerosing Hodgkin's disease. A new clinicopathologic entity","volume":"65","author":"Ben-Yehuda-Salz","year":"1990","journal-title":"Cancer"},{"key":"10.1016\/j.humpath.2021.11.007_bib7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1177\/2040620716676256","article-title":"Differences in outcome of patients with syncytial variant Hodgkin lymphoma compared with typical nodular sclerosis Hodgkin lymphoma","volume":"8","author":"Sethi","year":"2017","journal-title":"Ther Adv Hematol"},{"key":"10.1016\/j.humpath.2021.11.007_bib8","doi-asserted-by":"crossref","unstructured":"Wang W, Zhang Q, Medeiros LJ. Syncytial variant of nodular sclerosis Hodgkin lymphoma: an under-emphasized variant. Hum Pathol. Accepted manuscript. Published online May 28, 2021. https:\/\/doi.org\/10.1016\/j.humpath.2021.05.008.","DOI":"10.1016\/j.humpath.2021.05.008"},{"key":"10.1016\/j.humpath.2021.11.007_bib9","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1158\/1078-0432.CCR-17-1597","article-title":"Validation of immunohistochemical assays for integral biomarkers in the NCI-MATCH EAY131 clinical trial","volume":"24","author":"Khoury","year":"2018","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.humpath.2021.11.007_bib10","doi-asserted-by":"crossref","unstructured":"Medeiros LJ, Marques-Piubelli ML, Sangiorgio VFI, Ruiz-Cordero R, Vega F, Feldman AL, et\u00a0al. Epstein-Barr-virus-positive large B-cell lymphoma associated with breast implants: an analysis of eight patients suggesting a possible pathogenetic relationship. Mod Pathol. Accpeted Manuscript. Published online July 5, 2021. https:\/\/doi.org\/10.1038\/s41379-021-00863-1.","DOI":"10.1038\/s41379-021-00863-1"},{"key":"10.1016\/j.humpath.2021.11.007_bib11","first-page":"1864","article-title":"Report of the committee on histopathological criteria contributing to staging of hodgkin's disease","volume":"31","author":"Rappaport","year":"1971","journal-title":"Cancer Res"},{"key":"10.1016\/j.humpath.2021.11.007_bib12","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1002\/1097-0142(19891015)64:8<1686::AID-CNCR2820640822>3.0.CO;2-I","article-title":"Relationship of histopathologic features to survival and relapse in nodular sclerosing Hodgkin's disease. A study of 1659 patients","volume":"64","author":"MacLennan","year":"1989","journal-title":"Cancer"},{"key":"10.1016\/j.humpath.2021.11.007_bib13","doi-asserted-by":"crossref","first-page":"4063","DOI":"10.1182\/blood-2002-05-1548","article-title":"Nodular sclerosing Hodgkin disease: new grading predicts prognosis in intermediate and advanced stages","volume":"101","author":"von Wasielewski","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2021.11.007_bib14","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1023\/A:1008337100424","article-title":"Epstein-Barr virus association in classical Hodgkin's disease provides survival advantage to patients and correlates with higher expression of proliferation markers in Reed-Sternberg cells","volume":"11","author":"Naresh","year":"2000","journal-title":"Ann Oncol"},{"key":"10.1016\/j.humpath.2021.11.007_bib15","first-page":"2429","article-title":"Adverse clinical outcome in Hodgkin's disease is associated with loss of retinoblastoma protein expression, high Ki67 proliferation index, and absence of Epstein-Barr virus-latent membrane protein 1 expression","volume":"90","author":"Morente","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2021.11.007_bib16","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1182\/blood.V92.7.2477","article-title":"Analysis of major histocompatibility complex class I, TAP expression, and LMP2 epitope sequence in Epstein-Barr virus-positive Hodgkin's disease","volume":"92","author":"Murray","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2021.11.007_bib17","doi-asserted-by":"crossref","first-page":"4048","DOI":"10.1200\/JCO.2005.01.701","article-title":"Impact of latent Epstein-Barr virus infection on outcome in children and adolescents with Hodgkin's lymphoma","volume":"23","author":"Claviez","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.humpath.2021.11.007_bib18","doi-asserted-by":"crossref","first-page":"7604","DOI":"10.1200\/JCO.2005.02.6310","article-title":"Epstein-Barr virus as a marker of survival after Hodgkin's lymphoma: a population-based study","volume":"23","author":"Keegan","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.humpath.2021.11.007_bib19","doi-asserted-by":"crossref","first-page":"3935","DOI":"10.1182\/blood.V100.12.3935","article-title":"BCL-2 expression in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease predicts a poorer prognosis in patients treated with ABVD or equivalent regimens","volume":"100","author":"Rassidakis","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2021.11.007_bib20","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1309\/PNVQ0PQGXHVY6L7G","article-title":"HIV-associated Hodgkin lymphoma: a clinicopathologic and immunophenotypic study of 45 cases","volume":"121","author":"Thompson","year":"2004","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.humpath.2021.11.007_bib21","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1097\/00129039-200309000-00002","article-title":"Apoptosis and cell cycle-related genes and proteins in classical Hodgkin lymphoma: application of tissue microarray technique","volume":"11","author":"Wang","year":"2003","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"10.1016\/j.humpath.2021.11.007_bib22","first-page":"1278","article-title":"CD20 expression in Hodgkin and Reed-Sternberg cells of classical Hodgkin's disease: associations with presenting features and clinical outcome","volume":"20","author":"Rassidakis","year":"2002","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.humpath.2021.11.007_bib23","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1097\/01.MP.0000093627.51090.3F","article-title":"Expression of B-cell markers in classical hodgkin lymphoma: a tissue microarray analysis of 330 cases","volume":"16","author":"Tzankov","year":"2003","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2021.11.007_bib24","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1600-0609.2005.00453.x","article-title":"Non-mediastinal grey zone lymphomas and report from the workshop","author":"Stein","year":"2005","journal-title":"Eur J Haematol Suppl"},{"key":"10.1016\/j.humpath.2021.11.007_bib25","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3324\/haematol.2016.152256","article-title":"Mediastinal gray zone lymphoma: clinico-pathological characteristics and outcomes of 99 patients from the Lymphoma Study Association","volume":"102","author":"Sarkozy","year":"2017","journal-title":"Haematologica"},{"key":"10.1016\/j.humpath.2021.11.007_bib26","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1182\/bloodadvances.2017009472","article-title":"Clinicopathologic consensus study of gray zone lymphoma with features intermediate between DLBCL and classical HL","volume":"1","author":"Pilichowska","year":"2017","journal-title":"Blood Adv"},{"key":"10.1016\/j.humpath.2021.11.007_bib27","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/his.13100","article-title":"Grey zone lymphoma with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma: a clinicopathological study of 14 Epstein-Barr virus-positive cases","volume":"70","author":"Elsayed","year":"2017","journal-title":"Histopathology"},{"key":"10.1016\/j.humpath.2021.11.007_bib28","doi-asserted-by":"crossref","first-page":"533","DOI":"10.4103\/IJPM.IJPM_778_15","article-title":"Story of survival in anaplastic large cell lymphoma - sometimes more than the anaplastic lymphoma kinase status: an evaluation of pathologic prognostic factors in 102 cases","volume":"60","author":"Agrawal","year":"2017","journal-title":"Indian J Pathol Microbiol"},{"key":"10.1016\/j.humpath.2021.11.007_bib29","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/01.pas.0000179123.66748.c2","article-title":"ALK-positive anaplastic large cell lymphoma mimicking nodular sclerosis Hodgkin's lymphoma: report of 10 cases","volume":"30","author":"Vassallo","year":"2006","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2021.11.007_bib30","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0002-9440(10)61724-5","article-title":"Differential expression of BCL-2 family proteins in ALK-positive and ALK-negative anaplastic large cell lymphoma of T\/null-cell lineage","volume":"159","author":"Rassidakis","year":"2001","journal-title":"Am J Pathol"},{"key":"10.1016\/j.humpath.2021.11.007_bib31","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1177\/1066896916683447","article-title":"PAX-5 positivity in anaplastic lymphoma kinase-negative anaplastic large cell lymphoma: a case report and review of literature","volume":"25","author":"Arun","year":"2017","journal-title":"Int J Surg Pathol"},{"key":"10.1016\/j.humpath.2021.11.007_bib32","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/modpathol.2010.4","article-title":"PAX5-positive T-cell anaplastic large cell lymphomas associated with extra copies of the PAX5 gene locus","volume":"23","author":"Feldman","year":"2010","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2021.11.007_bib33","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1080\/10428190701342000","article-title":"Hodgkin-like anaplastic large cell lymphoma (previously designated in the REAL classification) has same immunophenotypic features to classical Hodgkin lymphoma","volume":"48","author":"Tamaru","year":"2007","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.humpath.2021.11.007_bib34","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.humpath.2018.10.003","article-title":"The histologic, immunohistochemical, and genetic features of classical Hodgkin lymphoma and anaplastic large cell lymphoma with aberrant T-cell\/B-cell antigen expression","volume":"84","author":"Liang","year":"2019","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2021.11.007_bib35","doi-asserted-by":"crossref","first-page":"4626","DOI":"10.1200\/JCO.2006.06.5342","article-title":"Prognostic significance of T-cell or cytotoxic molecules phenotype in classical Hodgkin's lymphoma: a clinicopathologic study","volume":"24","author":"Asano","year":"2006","journal-title":"J Clin Oncol"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817721001957?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817721001957?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T16:39:43Z","timestamp":1758645583000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817721001957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":35,"alternative-id":["S0046817721001957"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2021.11.007","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinicopathological features of syncytial variant nodular sclerosis Hodgkin lymphoma","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2021.11.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}