{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T10:06:35Z","timestamp":1773050795191,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.humpath.2022.01.004","type":"journal-article","created":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T10:57:13Z","timestamp":1643021833000},"page":"1-10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Global assessment of IRF8 as a novel cancer biomarker"],"prefix":"10.1016","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2880-3062","authenticated-orcid":false,"given":"Daniel C.","family":"McQuaid","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5762-3490","authenticated-orcid":false,"given":"Gauri","family":"Panse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Lien","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geraldine S.","family":"Pinkus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1744-8568","authenticated-orcid":false,"given":"Samuel G.","family":"Katz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9513-245X","authenticated-orcid":false,"given":"Mina L.","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2022.01.004_bib1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S1074-7613(00)00016-9","article-title":"ICSBP directs bipotential myeloid progenitor cells to differentiate into mature macrophages","volume":"13","author":"Tamura","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.humpath.2022.01.004_bib2","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1182\/blood-2012-06-437863","article-title":"Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation","volume":"121","author":"Kurotaki","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2022.01.004_bib3","doi-asserted-by":"crossref","first-page":"4978","DOI":"10.1038\/ncomms5978","article-title":"IRF8 inhibits C\/EBP\u03b1 activity to restrain mononuclear phagocyte progenitors from differentiating into neutrophils","volume":"5","author":"Kurotaki","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.humpath.2022.01.004_bib4","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.4049\/jimmunol.170.3.1131","article-title":"Cutting edge: IFN consensus sequence binding protein\/IFN regulatory factor 8 drives the development of type I IFN-producing plasmacytoid dendritic cells","volume":"170","author":"Tsujimura","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.humpath.2022.01.004_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0025812","article-title":"Shared and distinct functions of the transcription factors IRF4 and IRF8 in myeloid cell development","volume":"6","author":"Yamamoto","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.humpath.2022.01.004_bib6","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1056\/NEJMoa1100066","article-title":"IRF8 mutations and human dendritic-cell immunodeficiency","volume":"365","author":"Hambleton","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.humpath.2022.01.004_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13040764","article-title":"IRF8 is an AML-specific susceptibility factor that regulates signaling pathways and proliferation of AML cells","volume":"13","author":"Liss","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.humpath.2022.01.004_bib8","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1097\/PAS.0000000000001765","article-title":"IRF8 is a reliable monoblast marker for acute monocytic leukemias","volume":"45","author":"Katz","year":"2021","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2022.01.004_bib9","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1746-1596-2-42","article-title":"Myeloid sarcomas: a histologic, immunohistochemical, and cytogenetic study","volume":"2","author":"Alexiev","year":"2007","journal-title":"Diagn Pathol"},{"key":"10.1016\/j.humpath.2022.01.004_bib10","series-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","first-page":"167","article-title":"AML and related precursor neoplasms","author":"Swerdlow","year":"2017"},{"key":"10.1016\/j.humpath.2022.01.004_bib11","doi-asserted-by":"crossref","first-page":"100773","DOI":"10.1016\/j.blre.2020.100773","article-title":"Myeloid sarcoma, chloroma, or extramedullary acute myeloid leukemia tumor: a tale of misnomers, controversy and the unresolved","volume":"47","author":"Shallis","year":"2021","journal-title":"Blood Rev"},{"key":"10.1016\/j.humpath.2022.01.004_bib12","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.clml.2017.02.027","article-title":"Myeloid sarcoma: presentation, diagnosis, and treatment","volume":"17","author":"Almond","year":"2017","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"10.1016\/j.humpath.2022.01.004_bib13","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.biopha.2012.10.014","article-title":"Is there a \"gold\" standard treatment for patients with isolated myeloid sarcoma?","volume":"67","author":"Antic","year":"2013","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.humpath.2022.01.004_bib14","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1002\/cncr.10399","article-title":"Comparison in treatments of nonleukemic granulocytic sarcoma: report of two cases and a review of 72 cases in the literature","volume":"94","author":"Yamauchi","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.humpath.2022.01.004_bib15","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1159\/000497210","article-title":"Myeloid sarcoma","volume":"42","author":"Magdy","year":"2019","journal-title":"Oncol Res Treat"},{"key":"10.1016\/j.humpath.2022.01.004_bib16","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/sj.leu.2404491","article-title":"Myeloid sarcoma: clinico-pathologic, phenotypic and cytogenetic analysis of 92 adult patients","volume":"21","author":"Pileri","year":"2007","journal-title":"Leukemia"},{"key":"10.1016\/j.humpath.2022.01.004_bib17","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1038\/leu.2014.64","article-title":"Molecular profiling of blastic plasmacytoid dendritic cell neoplasm reveals a unique pattern and suggests selective sensitivity to NF-kB pathway inhibition","volume":"28","author":"Sapienza","year":"2014","journal-title":"Leukemia"},{"key":"10.1016\/j.humpath.2022.01.004_bib18","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3324\/haematol.2012.072645","article-title":"Blastic plasmacytoid dendritic cell neoplasm with leukemic presentation: an Italian multicenter study","volume":"98","author":"Pagano","year":"2013","journal-title":"Haematologica"},{"key":"10.1016\/j.humpath.2022.01.004_bib19","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/PAS.0b013e3181c5e26b","article-title":"Cutaneous manifestations of blastic plasmacytoid dendritic cell neoplasm-morphologic and phenotypic variability in a series of 33 patients","volume":"34","author":"Cota","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2022.01.004_bib20","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/bjd.12412","article-title":"Blastic plasmacytoid dendritic cell neoplasm: clinical features in 90 patients","volume":"169","author":"Julia","year":"2013","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.humpath.2022.01.004_bib21","doi-asserted-by":"crossref","first-page":"564","DOI":"10.5858\/arpa.2013-0101-RS","article-title":"Blastic plasmacytoid dendritic cell neoplasm: a clinicopathologic review","volume":"138","author":"Shi","year":"2014","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.humpath.2022.01.004_bib22","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1182\/asheducation-2016.1.16","article-title":"Treatment of blastic plasmacytoid dendritic cell neoplasm","volume":"2016","author":"Sullivan","year":"2016","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1016\/j.humpath.2022.01.004_bib23","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/ajh.24258","article-title":"Blastic plasmacytoid dendritic cell neoplasm with leukemic presentation: 10-Color flow cytometry diagnosis and HyperCVAD therapy","volume":"91","author":"Deotare","year":"2016","journal-title":"Am J Hematol"},{"key":"10.1016\/j.humpath.2022.01.004_bib24","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1111\/j.1365-2141.2009.07679.x","article-title":"Extended diagnostic criteria for plasmacytoid dendritic cell leukaemia","volume":"145","author":"Garnache-Ottou","year":"2009","journal-title":"Br J Haematol"},{"key":"10.1016\/j.humpath.2022.01.004_bib25","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1186\/1471-2407-14-324","article-title":"Clinical relevance of breast cancer-related genes as potential biomarkers for oral squamous cell carcinoma","volume":"14","author":"Parris","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1016\/j.humpath.2022.01.004_bib26","doi-asserted-by":"crossref","first-page":"4238","DOI":"10.1182\/bloodadvances.2019000647","article-title":"How should we diagnose and treat blastic plasmacytoid dendritic cell neoplasm patients?","volume":"3","author":"Garnache-Ottou","year":"2019","journal-title":"Blood Adv"},{"key":"10.1016\/j.humpath.2022.01.004_bib27","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ijscr.2019.03.027","article-title":"Isolated myeloid sarcoma of the temporal bone: as the first clinical manifestation of acute myeloid leukemia in a patient of down's syndrome","volume":"58","author":"Marwah","year":"2019","journal-title":"Int J Surg Case Rep"},{"key":"10.1016\/j.humpath.2022.01.004_bib28","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1016\/j.bbmt.2016.03.022","article-title":"Blastic plasmacytoid dendritic cell neoplasm: from origin of the cell to targeted therapies","volume":"22","author":"Laribi","year":"2016","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.humpath.2022.01.004_bib29","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1097\/PAS.0000000000001316","article-title":"Dual expression of TCF4 and CD123 is highly sensitive and specific for blastic plasmacytoid dendritic cell neoplasm","volume":"43","author":"Sukswai","year":"2019","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2022.01.004_bib30","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13058-021-01418-7","article-title":"High IRF8 expression correlates with CD8 T cell infiltration and is a predictive biomarker of therapy response in ER-negative breast cancer","volume":"23","author":"Gatti","year":"2021","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.humpath.2022.01.004_bib31","article-title":"IRF8 deficiency in colonic epithelial cells promotes inflammation-mediated colon tumorigenesis and myeloid-derived suppressor cell differentiation","volume":"198","author":"Ibrahim Mll","year":"2017","journal-title":"J Immunol"},{"key":"10.1016\/j.humpath.2022.01.004_bib32","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1111\/j.1349-7006.2010.01581.x","article-title":"DNA methylation of interferon regulatory factors in gastric cancer and noncancerous gastric mucosae","volume":"101","author":"Yamashita","year":"2010","journal-title":"Cancer Sci"},{"key":"10.1016\/j.humpath.2022.01.004_bib33","doi-asserted-by":"crossref","first-page":"4028","DOI":"10.1182\/blood-2008-01-129049","article-title":"IRF8 regulates B-cell lineage specification, commitment, and differentiation","volume":"112","author":"Wang","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2022.01.004_bib34","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1177\/2040620711410774","article-title":"Myeloid sarcoma: current approach and therapeutic options","volume":"2","author":"Avni","year":"2011","journal-title":"Ther Adv Hematol"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817722000144?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817722000144?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T16:39:21Z","timestamp":1758645561000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817722000144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":34,"alternative-id":["S0046817722000144"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2022.01.004","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.12.06.21267361","asserted-by":"object"}]},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Global assessment of IRF8 as a novel cancer biomarker","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2022.01.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}