{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T17:14:57Z","timestamp":1783358097083,"version":"3.54.6"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.humpath.2022.05.006","type":"journal-article","created":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T01:56:10Z","timestamp":1652061370000},"page":"121-128","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["The association between tumour sub-site and local nodal and\/or distant metastasis at the time of resection of colorectal cancer: a prospective study of 3,360 consecutive cases"],"prefix":"10.1016","volume":"126","author":[{"given":"Ronald","family":"Newland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kheng-Seong","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Chapuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen","family":"Dent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2022.05.006_bib1","doi-asserted-by":"crossref","first-page":"779","DOI":"10.7326\/0003-4819-113-10-779","article-title":"Colorectal cancer: evidence for distinct genetic categories based on proximal or distal tumor location","volume":"113","author":"Bufill","year":"1990","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.humpath.2022.05.006_bib2","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/ijc.10635","article-title":"Are there two sides to colorectal cancer?","volume":"101","author":"Iacopetta","year":"2002","journal-title":"Int J Cancer"},{"key":"10.1016\/j.humpath.2022.05.006_bib3","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1080\/14737140.2018.1442217","article-title":"Difference between right-sided and left-sided colorectal cancers: from embryology to molecular subtype","volume":"18","author":"Yang","year":"2018","journal-title":"Expert Rev Anticancer Ther"},{"key":"10.1016\/j.humpath.2022.05.006_bib4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/DCR.0b013e3181c703a4","article-title":"Colon\/Rectum Carcinomas Study G. Comparison of 17,641 patients with right- and left-sided colon cancer: differences in epidemiology, perioperative course, histology, and survival","volume":"53","author":"Benedix","year":"2010","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.humpath.2022.05.006_bib5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1177\/1724600818807164","article-title":"Clinicopathological and molecular differences in colorectal cancer according to location","volume":"34","author":"Hsu","year":"2019","journal-title":"Int J Biol Markers"},{"key":"10.1016\/j.humpath.2022.05.006_bib6","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1007\/s12094-019-02083-1","article-title":"Clinical characteristics and prognosis of different primary tumor location in colorectal cancer: a population-based cohort study","volume":"21","author":"Zheng","year":"2019","journal-title":"Clin Transl Oncol"},{"key":"10.1016\/j.humpath.2022.05.006_bib7","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/jso.2930440109","article-title":"Evidence for the existence of different types of large bowel tumor: suggestions from the clinical data of a population-based registry","volume":"44","author":"Ponz de Leon","year":"1990","journal-title":"J Surg Oncol"},{"key":"10.1016\/j.humpath.2022.05.006_bib8","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1093\/annonc\/mdu275","article-title":"Distal and proximal colon cancers differ in terms of molecular, pathological, and clinical features","volume":"25","author":"Missiaglia","year":"2014","journal-title":"Ann Oncol"},{"key":"10.1016\/j.humpath.2022.05.006_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0167540","article-title":"Characteristics of differently located colorectal cancers support proximal and distal classification: a population-based study of 57,847 patients","volume":"11","author":"Yang","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.humpath.2022.05.006_bib10","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1111\/codi.15137","article-title":"Factors predictive of an advanced stage of colorectal cancer at presentation - a bi-national study","volume":"22","author":"Vather","year":"2020","journal-title":"Colorectal Dis"},{"key":"10.1016\/j.humpath.2022.05.006_bib11","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/ans.13758","article-title":"Trends in pathology and long-term outcomes after resection of colorectal cancer: 1971-2013","volume":"87","author":"Dent","year":"2017","journal-title":"ANZ J Surg"},{"key":"10.1016\/j.humpath.2022.05.006_bib12","doi-asserted-by":"crossref","first-page":"17","DOI":"10.5694\/j.1326-5377.1976.tb76694.x","article-title":"Colorectal carcinoma: a prospect clinicopathological study","volume":"1","author":"Pheils","year":"1976","journal-title":"Med J Aust"},{"key":"10.1016\/j.humpath.2022.05.006_bib13","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1007\/s10350-004-6673-3","article-title":"Surgical technique and survival in patients having a curative resection for colon cancer","volume":"46","author":"Bokey","year":"2003","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.humpath.2022.05.006_bib14","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1046\/j.1365-2168.1999.01216.x","article-title":"Local recurrence after curative excision of the rectum for cancer without adjuvant therapy: role of total anatomical dissection","volume":"86","author":"Bokey","year":"1999","journal-title":"Br J Surg"},{"key":"10.1016\/j.humpath.2022.05.006_bib15","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1445-2197.1983.tb02430.x","article-title":"Terminology and classification of colorectal adenocarcinoma: the Australian clinico-pathological staging system","volume":"53","author":"Davis","year":"1983","journal-title":"Aust N Z J Surg"},{"key":"10.1016\/j.humpath.2022.05.006_bib16","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1002\/1097-0142(19810315)47:6<1424::AID-CNCR2820470630>3.0.CO;2-O","article-title":"The relationship of survival to staging and grading of colorectal carcinoma: a prospective study of 503 cases","volume":"47","author":"Newland","year":"1981","journal-title":"Cancer"},{"key":"10.1016\/j.humpath.2022.05.006_bib17","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1097\/SLA.0b013e318163d264","article-title":"Correlates and outcomes of tumor adherence in resected colonic and rectal cancers","volume":"247","author":"Darakhshan","year":"2008","journal-title":"Ann Surg"},{"key":"10.1016\/j.humpath.2022.05.006_bib18","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1463-1318.2006.01136.x","article-title":"The significance of involvement of a free serosal surface for recurrence and survival following resection of clinicopathological stage B and C rectal cancer","volume":"9","author":"Keshava","year":"2007","journal-title":"Colorectal Dis"},{"key":"10.1016\/j.humpath.2022.05.006_bib19","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1097\/DCR.0000000000000162","article-title":"Mural and extramural venous invasion and prognosis in colorectal cancer","volume":"57","author":"Gibson","year":"2014","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.humpath.2022.05.006_bib20","series-title":"AJCC cancer staging manual","author":"Edge","year":"2010"},{"key":"10.1016\/j.humpath.2022.05.006_bib21","series-title":"Coding systems for categorical variables in regression analysis","year":"2021"},{"key":"10.1016\/j.humpath.2022.05.006_bib22","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1002\/bjs.11517","article-title":"Colorectal cancer treated by resection and extended lymphadenectomy: patterns of spread in left- and right-sided tumours","volume":"107","author":"Kataoka","year":"2020","journal-title":"Br J Surg"},{"key":"10.1016\/j.humpath.2022.05.006_bib23","doi-asserted-by":"crossref","first-page":"86356","DOI":"10.18632\/oncotarget.21169","article-title":"Comparative molecular analyses of left-sided colon, right-sided colon, and rectal cancers","volume":"8","author":"Salem","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.humpath.2022.05.006_bib24","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ejca.2017.07.016","article-title":"Understanding the role of primary tumour localisation in colorectal cancer treatment and outcomes","volume":"84","author":"Stintzing","year":"2017","journal-title":"Eur J Cancer"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817722001204?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817722001204?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T16:40:23Z","timestamp":1758645623000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817722001204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":24,"alternative-id":["S0046817722001204"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2022.05.006","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The association between tumour sub-site and local nodal and\/or distant metastasis at the time of resection of colorectal cancer: a prospective study of 3,360 consecutive cases","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2022.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}