{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T09:10:25Z","timestamp":1758705025326,"version":"3.44.0"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.humpath.2022.05.007","type":"journal-article","created":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T23:25:38Z","timestamp":1652138738000},"page":"55-62","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Mast cell neoplasm: a challenging pathological diagnosis"],"prefix":"10.1016","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7843-3314","authenticated-orcid":false,"given":"Rodrigo de Andrade","family":"Natal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Humberto Carvalho","family":"Carneiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1via Fonseca","family":"de Carvalho Barra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u00e1tia Borgia Barbosa","family":"Pagnano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando Augusto","family":"Soares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Vassallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2022.05.007_bib1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1159\/000504099","article-title":"The spectrum of aggressive mastocytosis: a workshop report and literature review","volume":"87","author":"Leguit","year":"2016","journal-title":"Rev Artic Pathobiol"},{"key":"10.1016\/j.humpath.2022.05.007_bib2","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/S0140-6736(96)07056-0","article-title":"Mastocytosis","volume":"349","author":"L","year":"1997","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.humpath.2022.05.007_bib3","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0145-2126(01)00038-8","article-title":"Diagnostic criteria and classification of mastocytosis: a consensus proposal","volume":"25","author":"Valent","year":"2001","journal-title":"Leuk Res"},{"key":"10.1016\/j.humpath.2022.05.007_bib4","first-page":"283","article-title":"Epidemiology, prognosis, and risk factors in mastocytosis","volume":"34","author":"K","year":"2014","journal-title":"Immunol Allergy Clin"},{"key":"10.1016\/j.humpath.2022.05.007_bib5","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/bjh.12916","article-title":"Epidemiology of systemic mastocytosis in Denmark","volume":"166","author":"Cohen","year":"2014","journal-title":"Br J Haematol"},{"key":"10.1016\/j.humpath.2022.05.007_bib6","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/bjd.13567","article-title":"Paediatric mastocytosis: a systematic review of 1747 cases","volume":"172","author":"M\u00e9ni","year":"2015","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.humpath.2022.05.007_bib7","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/ajh.25371","article-title":"Systemic mastocytosis in adults: 2019 update on diagnosis, risk stratification and management","volume":"94","author":"Pardanani","year":"2019","journal-title":"Am J Hematol"},{"year":"2017","author":"Swerdlow","series-title":"WHO classification of tumors of hematopoietic and lymphoid tissues","key":"10.1016\/j.humpath.2022.05.007_bib8"},{"key":"10.1016\/j.humpath.2022.05.007_bib9","doi-asserted-by":"crossref","first-page":"5727","DOI":"10.1182\/blood-2009-02-205237","article-title":"Systemic mastocytosis in 342 consecutive adults: survival studies and prognostic factors","volume":"113","author":"Lim","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2022.05.007_bib10","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/MOH.0b013e3283366c59","article-title":"Systemic mastocytosis in adults: a review on prognosis and treatment based on 342 Mayo Clinic patients and current literature","volume":"17","author":"Pardanani","year":"2010","journal-title":"Curr Opin Hematol"},{"key":"10.1016\/j.humpath.2022.05.007_bib11","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.leukres.2014.07.010","article-title":"Familial systemic mastocytosis with germline KIT K509I mutation is sensitive to treatment with imatinib, dasatinib and PKC412","volume":"38","author":"de Melo Campos","year":"2014","journal-title":"Leuk Res"},{"key":"10.1016\/j.humpath.2022.05.007_bib12","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/bjh.16288","article-title":"The clinical and pathological panoply of systemic mastocytosis","volume":"188","author":"Radia","year":"2020","journal-title":"Br J Haematol"},{"key":"10.1016\/j.humpath.2022.05.007_bib13","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.humpath.2012.06.012","article-title":"Benign lymphoid aggregates in the bone marrow: distribution patterns of B and T lymphocytes","volume":"44","author":"Naemi","year":"2013","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2022.05.007_bib14","doi-asserted-by":"crossref","first-page":"233","DOI":"10.5858\/arpa.2013-0678-OA","article-title":"Differentiating benign from malignant bone marrow B-cell lymphoid aggregates: a statistical analysis of distinguishing features","volume":"139","author":"Johnston","year":"2015","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.humpath.2022.05.007_bib15","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/modpathol.2012.199","article-title":"Mast cell sarcoma: a rare and potentially under-recognized diagnostic entity with specific therapeutic implications","volume":"26","author":"Ryan","year":"2013","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2022.05.007_bib16","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1097\/PAS.0000000000000190","article-title":"A clinicopathologic study of 24 cases of systemic mastocytosis involving the gastrointestinal tract and assessment of mucosal mast cell density in irritable bowel syndrome and asymptomatic patients","volume":"38","author":"Doyle","year":"2014","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2022.05.007_bib17","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1111\/his.13033","article-title":"Clinicopathological characteristics of systemic mastocytosis in the intestine","volume":"69","author":"AR","year":"2016","journal-title":"Histopathology"},{"key":"10.1016\/j.humpath.2022.05.007_bib18","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1038\/modpathol.2008.158","article-title":"Systemic mastocytosis involving the gastrointestinal tract: clinicopathologic and molecular study of five cases","volume":"21","author":"Kirsch","year":"2008","journal-title":"Mod Pathol"},{"year":"2008","author":"Campiotti","series-title":"Acute myeloid leukemia with associated translocation t(15;17) and 11q23\/MLL abnormality","key":"10.1016\/j.humpath.2022.05.007_bib19"},{"key":"10.1016\/j.humpath.2022.05.007_bib20","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00277-019-03806-8","article-title":"Systemic mastocytosis associated with acute myeloid leukemia","volume":"99","author":"Nogueira","year":"2019","journal-title":"Ann Hematol"},{"key":"10.1016\/j.humpath.2022.05.007_bib21","doi-asserted-by":"crossref","DOI":"10.1182\/blood.2021010957","article-title":"Systemic mastocytosis with an associated t(8;21)(q22;q22) acute myeloid leukemia","volume":"137","author":"Wimmer","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2022.05.007_bib22","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/ajh.23380","article-title":"Systemic mastocytosis with associated clonal hematological non-mast cell lineage disease: clinical significance and comparison of chomosomal abnormalities in SM and AHNMD components","volume":"88","author":"Wang","year":"2013","journal-title":"Am J Hematol"},{"key":"10.1016\/j.humpath.2022.05.007_bib23","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/bjh.17567","article-title":"Clinical and histopathological features of myeloid neoplasms with concurrent Janus kinase 2 (JAK2) V617F and KIT proto-oncogene, receptor tyrosine kinase (KIT) D816V mutations","volume":"194","author":"Naumann","year":"2021","journal-title":"Br J Haematol"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817722001216?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817722001216?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T16:39:58Z","timestamp":1758645598000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817722001216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":23,"alternative-id":["S0046817722001216"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2022.05.007","relation":{},"ISSN":["0046-8177"],"issn-type":[{"type":"print","value":"0046-8177"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mast cell neoplasm: a challenging pathological diagnosis","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2022.05.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}