{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T08:12:12Z","timestamp":1777018332204,"version":"3.51.4"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000043","name":"American Association for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000043","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.humpath.2022.06.028","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T19:32:37Z","timestamp":1657135957000},"page":"31-47","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["A diagnostic approach to paratesticular lesions with tubulopapillary architecture: a series of 16 serous borderline tumors\/low-grade serous carcinoma and 14 well-differentiated papillary mesothelial tumors and mesothelioma"],"prefix":"10.1016","volume":"128","author":[{"given":"Rabia","family":"Zafar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lacey J.","family":"Schrader","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Cheville","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Kenneth","family":"Schoolmeester","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja C.","family":"Roden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Christine","family":"Aubry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunhee S.","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditya","family":"Raghunathan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loren","family":"Herrera-Hernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Houston","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen A.","family":"Boorjian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley C.","family":"Leibovich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary L.","family":"Keeney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael E.","family":"Jimenez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5163-6955","authenticated-orcid":false,"given":"Sounak","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2022.06.028_bib1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1093\/ajcp\/86.2.146","article-title":"Testicular and paratesticular tumors and tumor-like lesions of ovarian common epithelial and mullerian types. A report of four cases and review of the literature","volume":"86","author":"Young","year":"1986","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.humpath.2022.06.028_bib2","doi-asserted-by":"crossref","first-page":"S131","DOI":"10.1016\/S0893-3952(22)04463-5","article-title":"Selected other problematic testicular and paratesticular lesions: rete testis neoplasms and pseudotumors, mesothelial lesions and secondary tumors","volume":"18","author":"Amin","year":"2005","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2022.06.028_bib3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.humpath.2020.06.006","article-title":"Appendageal tumors and tumor-like lesions of the testis and paratestis: a 32-year experience at a single institution","volume":"103","author":"Al-Obaidy","year":"2020","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2022.06.028_bib4","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1038\/modpathol.2010.113","article-title":"Mesothelioma of the tunica vaginalis: a series of eight cases with uncertain malignant potential","volume":"23","author":"Brimo","year":"2010","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2022.06.028_bib5","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1097\/00000478-200103000-00012","article-title":"Serous borderline tumor of the paratestis: a report of seven cases","volume":"25","author":"McClure","year":"2001","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2022.06.028_bib6","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","article-title":"The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data","volume":"2","author":"Cerami","year":"2012","journal-title":"Cancer Discov"},{"key":"10.1016\/j.humpath.2022.06.028_bib7","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1158\/2159-8290.CD-17-0151","article-title":"AACR Project GENIE: powering precision medicine through an international consortium","volume":"7","author":"Consortium","year":"2017","journal-title":"Cancer Discov"},{"key":"10.1016\/j.humpath.2022.06.028_bib8","doi-asserted-by":"crossref","first-page":"pl1","DOI":"10.1126\/scisignal.2004088","article-title":"Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal","volume":"6","author":"Gao","year":"2013","journal-title":"Sci Signal"},{"key":"10.1016\/j.humpath.2022.06.028_bib9","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/s41379-019-0310-0","article-title":"MTAP immunohistochemistry is an accurate and reproducible surrogate for CDKN2A fluorescence in situ hybridization in diagnosis of malignant pleural mesothelioma","volume":"33","author":"Chapel","year":"2020","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2022.06.028_bib10","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.humpath.2018.05.001","article-title":"BAP1 loss is unusual in well-differentiated papillary mesothelioma and may predict development of malignant mesothelioma","volume":"79","author":"Lee","year":"2018","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2022.06.028_bib11","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.jtho.2021.09.012","article-title":"Molecular characterization of peritoneal mesotheliomas","volume":"17","author":"Offin","year":"2022","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.humpath.2022.06.028_bib12","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s00429-004-0445-7","article-title":"Contribution to the origin and development of the appendices of the testis and epididymis in humans","volume":"209","author":"Jacob","year":"2005","journal-title":"Anat Embryol"},{"key":"10.1016\/j.humpath.2022.06.028_bib13","article-title":"KRAS mutation in serous borderline tumor of the testis: report of a case and review of the literature","volume":"2020","author":"Bouri","year":"2020","journal-title":"Case Rep Urol"},{"key":"10.1016\/j.humpath.2022.06.028_bib14","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s13000-015-0342-9","article-title":"Ovarian-type epithelial tumours of the testis: immunohistochemical and molecular analysis of two serous borderline tumours of the testis","volume":"10","author":"Burger","year":"2015","journal-title":"Diagn Pathol"},{"key":"10.1016\/j.humpath.2022.06.028_bib15","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1111\/his.13261","article-title":"The mutational frequency of BRAF and KRAS in low-grade serous testicular neoplasms-a case series","volume":"71","author":"Gwiti","year":"2017","journal-title":"Histopathology"},{"key":"10.1016\/j.humpath.2022.06.028_bib16","doi-asserted-by":"crossref","first-page":"e50","DOI":"10.1097\/PAI.0000000000000326","article-title":"Comprehensive immunophenotypic characterization of adult and fetal testes, the excretory duct system, and testicular and epididymal appendages","volume":"24","author":"Magers","year":"2016","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"10.1016\/j.humpath.2022.06.028_bib17","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1097\/00000478-199512000-00003","article-title":"Paratesticular serous papillary carcinoma. A report of six cases","volume":"19","author":"Jones","year":"1995","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2022.06.028_bib18","first-page":"ED13","article-title":"High grade serous cystadenocarcinoma of testis-case report of a rare ovarian epithelial type tumour","volume":"11","author":"Aravind","year":"2017","journal-title":"J Clin Diagn Res"},{"key":"10.1016\/j.humpath.2022.06.028_bib19","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/his.12630","article-title":"The V600E BRAF mutation in a borderline serous tumour of the testis is genotypic evidence of similarity with its phenotypic ovarian counterpart","volume":"67","author":"Cundell","year":"2015","journal-title":"Histopathology"},{"key":"10.1016\/j.humpath.2022.06.028_bib20","doi-asserted-by":"crossref","first-page":"225","DOI":"10.4132\/KoreanJPathol.2014.48.3.225","article-title":"Well-differentiated papillary mesothelioma of the tunica vaginalis: a case study and review of the literature","volume":"48","author":"Erdogan","year":"2014","journal-title":"Korean J Pathol"},{"key":"10.1016\/j.humpath.2022.06.028_bib21","doi-asserted-by":"crossref","first-page":"113","DOI":"10.5858\/arpa.2010-0550-RS","article-title":"Malignant mesothelioma of the tunica vaginalis testis: diagnostic studies and differential diagnosis","volume":"136","author":"Chekol","year":"2012","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.humpath.2022.06.028_bib22","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s12885-020-6648-3","article-title":"Malignant mesothelioma of the tunica vaginalis testis: a rare case and review of literature","volume":"20","author":"Drevinskaite","year":"2020","journal-title":"BMC Cancer"},{"key":"10.1016\/j.humpath.2022.06.028_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/s41379-022-01082-y","article-title":"Well differentiated papillary mesothelial tumor: a new name and new problems","author":"Churg","year":"2022","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2022.06.028_bib24","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/1746-1596-6-78","article-title":"Mesothelioma of tunica vaginalis of \"uncertain malignant potential\" - an evolving concept: case report and review of the literature","volume":"6","author":"Trpkov","year":"2011","journal-title":"Diagn Pathol"},{"key":"10.1016\/j.humpath.2022.06.028_bib25","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41379-018-0127-2","article-title":"Well-differentiated papillary mesothelioma of the peritoneum is genetically defined by mutually exclusive mutations in TRAF7 and CDC42","volume":"32","author":"Stevers","year":"2019","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2022.06.028_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12061568","article-title":"Well-differentiated papillary mesothelioma of the peritoneum is genetically distinct from malignant mesothelioma","volume":"12","author":"Shrestha","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.humpath.2022.06.028_bib27","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/his.14669","article-title":"Molecular and immunohistochemical characterization of mesothelioma of the tunica vaginalis","volume":"81","author":"Anderson","year":"2022","journal-title":"Histopathology"},{"key":"10.1016\/j.humpath.2022.06.028_bib28","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/modpathol.2017.153","article-title":"Adenomatoid tumors of the male and female genital tract are defined by TRAF7 mutations that drive aberrant NF-kB pathway activation","volume":"31","author":"Goode","year":"2018","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2022.06.028_bib29","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/modpathol.2015.121","article-title":"The prognostic significance of BAP1, NF2, and CDKN2A in malignant peritoneal mesothelioma","volume":"29","author":"Singhi","year":"2016","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2022.06.028_bib30","doi-asserted-by":"crossref","DOI":"10.1038\/s41379-022-01081-z","article-title":"Clinical and molecular validation of BAP1, MTAP, P53, and Merlin immunohistochemistry in diagnosis of pleural mesothelioma","author":"Chapel","year":"2022","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2022.06.028_bib31","doi-asserted-by":"crossref","first-page":"89","DOI":"10.5858\/arpa.2017-0124-RA","article-title":"Guidelines for pathologic diagnosis of malignant mesothelioma 2017 update of the consensus statement from the international mesothelioma interest group","volume":"142","author":"Husain","year":"2018","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.humpath.2022.06.028_bib32","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1097\/PAS.0000000000000935","article-title":"PAX8 expression in a subset of malignant peritoneal mesotheliomas and benign mesothelium has diagnostic implications in the differential diagnosis of ovarian serous carcinoma","volume":"41","author":"Chapel","year":"2017","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2022.06.028_bib33","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.humpath.2017.10.036","article-title":"Aberrant Pax-8 expression in well-differentiated papillary mesothelioma and malignant mesothelioma of the peritoneum: a clinicopathologic study","volume":"72","author":"Xing","year":"2018","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2022.06.028_bib34","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1097\/PAS.0000000000001771","article-title":"Adenocarcinoma of the rete testis: seven additional cases, including exclusively and predominantly intrarete tumors","volume":"45","author":"Al-Obaidy","year":"2021","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2022.06.028_bib35","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.anndiagpath.2018.10.012","article-title":"Well-differentiated papillary mesothelioma: a 17-year single institution experience with a series of 75 cases","volume":"38","author":"Sun","year":"2019","journal-title":"Ann Diagn Pathol"},{"key":"10.1016\/j.humpath.2022.06.028_bib36","doi-asserted-by":"crossref","first-page":"e167","DOI":"10.1016\/j.mayocp.2016.06.019","article-title":"Paratesticular adenomatoid tumor","volume":"91","author":"Gupta","year":"2016","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.humpath.2022.06.028_bib37","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.mayocp.2020.12.031","article-title":"Paratesticular papillary cystadenoma of the epididymis in the setting of von Hippel-lindau","volume":"96","author":"Gupta","year":"2021","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.humpath.2022.06.028_bib38","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.humpath.2022.02.009","article-title":"Immunohistochemical expression of carbonic anhydrase 9, glucose transporter 1, and paired box 8 in von Hippel-Lindau disease-related lesions","volume":"123","author":"Chatzopoulos","year":"2022","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2022.06.028_bib39","doi-asserted-by":"crossref","first-page":"630","DOI":"10.5858\/134.4.630","article-title":"Papillary cystadenoma of the epididymis","volume":"134","author":"Odrzywolski","year":"2010","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.humpath.2022.06.028_bib40","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1097\/PAS.0000000000000152","article-title":"Papillary cystadenoma of the epididymis and broad ligament: morphologic and immunohistochemical overlap with clear cell papillary renal cell carcinoma","volume":"38","author":"Cox","year":"2014","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2022.06.028_bib41","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1177\/106689690000800308","article-title":"Allelic deletion of VHL gene detected in papillary tumors of the broad ligament, epididymis, and retroperitoneum in von Hippel-lindau disease patients","volume":"8","author":"Shen","year":"2000","journal-title":"Int J Surg Pathol"},{"key":"10.1016\/j.humpath.2022.06.028_bib42","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/his.14661","article-title":"Molecular analysis of adenocarcinomas of the rete testis demonstrates frequent alterations in genes involved in cell cycle regulation","volume":"81","author":"Acosta","year":"2022","journal-title":"Histopathology"},{"key":"10.1016\/j.humpath.2022.06.028_bib43","article-title":"Papillary adenocarcinoma of rete testis mimics inflammatory lump: a case report","volume":"2011","author":"Wu","year":"2011","journal-title":"Case Rep Urol"},{"key":"10.1016\/j.humpath.2022.06.028_bib44","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.humpath.2021.03.008","article-title":"Assessment of isochromosome 12p and 12p abnormalities in germ cell tumors using fluorescence in situ hybridization, single-nucleotide polymorphism arrays, and next-generation sequencing\/mate-pair sequencing","volume":"112","author":"Freitag","year":"2021","journal-title":"Hum Pathol"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817722001721?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817722001721?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T16:40:04Z","timestamp":1758645604000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817722001721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":44,"alternative-id":["S0046817722001721"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2022.06.028","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A diagnostic approach to paratesticular lesions with tubulopapillary architecture: a series of 16 serous borderline tumors\/low-grade serous carcinoma and 14 well-differentiated papillary mesothelial tumors and mesothelioma","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2022.06.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}