{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:20:38Z","timestamp":1790252438757,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.humpath.2022.07.024","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T22:52:04Z","timestamp":1660776724000},"page":"32-39","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["EBV-positive nodular lymphocyte predominant Hodgkin lymphoma: a single institution experience"],"prefix":"10.1016","volume":"129","author":[{"given":"Fei","family":"Fei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kala Gnanasekaran","family":"Kiruthiga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheren","family":"Younes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9816-1018","authenticated-orcid":false,"given":"Yasodha","family":"Natkunam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2022.07.024_bib1","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1200\/JCO.1999.17.3.776","article-title":"Clinical presentation, course, and prognostic factors in lymphocyte-predominant Hodgkin's disease and lymphocyte-rich classical Hodgkin's disease: report from the European task force on lymphoma project on lymphocyte-predominant Hodgkin's disease","volume":"17","author":"Diehl","year":"1999","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.humpath.2022.07.024_bib2","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1200\/JCO.2009.24.9516","article-title":"Transformation to aggressive lymphoma in nodular lymphocyte predominant Hodgkin's lymphoma","volume":"28","author":"Al-Mansour","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.humpath.2022.07.024_bib3","doi-asserted-by":"crossref","first-page":"E103","DOI":"10.1002\/ajh.23989","article-title":"Incidence, management, and outcome of high-grade transformation of nodular lymphocyte predominant Hodgkin lymphoma: long-term outcomes from a 30-year experience","volume":"90","author":"Eyre","year":"2015","journal-title":"Am J Hematol"},{"key":"10.1016\/j.humpath.2022.07.024_bib4","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1182\/blood-2015-08-665505","article-title":"Large B-cell transformation in nodular lymphocyte predominant Hodgkin lymphoma: 40-year experience from a single institution","volume":"127","author":"Kenderian","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2022.07.024_bib5","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1309\/YCH8DWUFFQBKGPVB","article-title":"The B-cell transcription factors BSAP, Oct-2, and BOB.1 and the pan-B-cell markers CD20, CD22, and CD79a are useful in the differential diagnosis of classic Hodgkin lymphoma","volume":"120","author":"Browne","year":"2003","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.humpath.2022.07.024_bib6","first-page":"2080","article-title":"Oct-2 and Bob-1 deficiency in Hodgkin and reed sternberg cells","volume":"61","author":"Re","year":"2001","journal-title":"Cancer Res"},{"key":"10.1016\/j.humpath.2022.07.024_bib7","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1182\/blood.V87.2.465.bloodjournal872465","article-title":"Distinctive expression pattern of the BCL-6 protein in nodular lymphocyte predominance Hodgkin's disease","volume":"87","author":"Falini","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2022.07.024_bib8","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.anndiagpath.2014.03.007","article-title":"Epstein-Barr virus-positive nodular lymphocyte predominant Hodgkin lymphoma","volume":"18","author":"Wang","year":"2014","journal-title":"Ann Diagn Pathol"},{"key":"10.1016\/j.humpath.2022.07.024_bib9","first-page":"1889","article-title":"European Task Force on Lymphoma project on lymphocyte predominance Hodgkin disease: histologic and immunohistologic analysis of submitted cases reveals 2 types of Hodgkin disease with a nodular growth pattern and abundant lymphocytes","volume":"96","author":"Anagnostopoulos","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2022.07.024_bib10","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/annonc\/mdj037","article-title":"Lymphocyte-rich classical Hodgkin lymphoma (LRCHL): clinico-pathological characteristics and outcome of a rare entity","volume":"17","author":"de Jong","year":"2006","journal-title":"Ann Oncol"},{"key":"10.1016\/j.humpath.2022.07.024_bib11","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/bjh.15614","article-title":"Diagnosis of Hodgkin lymphoma in the modern era","volume":"184","author":"Wang","year":"2019","journal-title":"Br J Haematol"},{"key":"10.1016\/j.humpath.2022.07.024_bib12","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1097\/PAS.0000000000000107","article-title":"EBV may be expressed in the LP cells of nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) in both children and adults","volume":"38","author":"Huppmann","year":"2014","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2022.07.024_bib13","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/bjh.15616","article-title":"Modern principles in the management of nodular lymphocyte predominant Hodgkin lymphoma","volume":"184","author":"Spinner","year":"2019","journal-title":"Br J Haematol"},{"key":"10.1016\/j.humpath.2022.07.024_bib14","doi-asserted-by":"crossref","DOI":"10.1093\/ajcp\/aqac045","article-title":"Diagnostic impact of next-generation sequencing panels for lymphoproliferative neoplasms on small-volume biopsies","author":"Fei","year":"2022","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.humpath.2022.07.024_bib15","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1038\/sj.onc.1205337","article-title":"Ligand-independent signaling by overexpressed CD30 drives NF-kappaB activation in Hodgkin-Reed-Sternberg cells","volume":"21","author":"Horie","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.humpath.2022.07.024_bib16","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1111\/his.14652","article-title":"Epstein-Barr virus infection patterns in nodular lymphocyte predominant Hodgkin lymphoma","volume":"80","author":"Gerhard-Hartmann","year":"2022","journal-title":"Histopathology"},{"key":"10.1016\/j.humpath.2022.07.024_bib17","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/s41375-021-01204-6","article-title":"Molecular biology of Hodgkin lymphoma","volume":"35","author":"Weniger","year":"2021","journal-title":"Leukemia"},{"key":"10.1016\/j.humpath.2022.07.024_bib18","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1182\/blood-2002-05-1592","article-title":"Frequent occurrence of BCL6 rearrangements in nodular lymphocyte predominance Hodgkin lymphoma but not in classical Hodgkin lymphoma","volume":"101","author":"Wlodarska","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2022.07.024_bib19","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/bjh.13310","article-title":"Array comparative genomic hybridization reveals similarities between nodular lymphocyte predominant Hodgkin lymphoma and T cell\/histiocyte rich large B cell lymphoma","volume":"169","author":"Hartmann","year":"2015","journal-title":"Br J Haematol"},{"key":"10.1016\/j.humpath.2022.07.024_bib20","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1182\/blood-2007-03-082511","article-title":"Somatic hypermutation of SOCS1 in lymphocyte-predominant Hodgkin lymphoma is accompanied by high JAK2 expression and activation of STAT6","volume":"110","author":"Mottok","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2022.07.024_bib21","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/leu.2015.328","article-title":"Highly recurrent mutations of SGK1, DUSP2 and JUNB in nodular lymphocyte predominant Hodgkin lymphoma","volume":"30","author":"Hartmann","year":"2016","journal-title":"Leukemia"},{"key":"10.1016\/j.humpath.2022.07.024_bib22","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1182\/bloodadvances.2017014118","article-title":"B-cell tumor development in Tet2-deficient mice","volume":"2","author":"Mouly","year":"2018","journal-title":"Blood Adv"},{"key":"10.1016\/j.humpath.2022.07.024_bib23","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1097\/00000478-200310000-00007","article-title":"Characterization of variant patterns of nodular lymphocyte predominant Hodgkin lymphoma with immunohistologic and clinical correlation","volume":"27","author":"Fan","year":"2003","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2022.07.024_bib24","doi-asserted-by":"crossref","first-page":"4246","DOI":"10.1182\/blood-2013-07-515825","article-title":"The prognostic impact of variant histology in nodular lymphocyte predominant Hodgkin lymphoma: a report from the German Hodgkin Study Group (GHSG)","volume":"122","author":"Hartmann","year":"2013","journal-title":"Blood"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004681772200209X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004681772200209X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T16:40:10Z","timestamp":1758645610000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004681772200209X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":24,"alternative-id":["S004681772200209X"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2022.07.024","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"EBV-positive nodular lymphocyte predominant Hodgkin lymphoma: a single institution experience","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2022.07.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}