{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T22:11:47Z","timestamp":1794003107988,"version":"4.8.0"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T00:00:00Z","timestamp":1679875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.humpath.2023.03.007","type":"journal-article","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T03:45:45Z","timestamp":1680061545000},"page":"56-62","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Urothelial carcinoma in situ with \u201coverriding\u201d features can evade detection by mimicking umbrella cells"],"prefix":"10.1016","volume":"136","author":[{"given":"Dorukhan","family":"Bahceci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane K.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankur R.","family":"Sangoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley A.","family":"Stohr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7290-4004","authenticated-orcid":false,"given":"Emily","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2023.03.007_bib1","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.juro.2016.06.049","article-title":"Diagnosis and treatment of non-muscle invasive bladder cancer: AUA\/SUO guideline","volume":"196","author":"Chang","year":"2016","journal-title":"J Urol"},{"key":"10.1016\/j.humpath.2023.03.007_bib2","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1053\/hupa.2001.27109","article-title":"An objective morphologic parameter to aid in the diagnosis of flat urothelial carcinoma in situ","volume":"32","author":"Milord","year":"2001","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2023.03.007_bib3","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1097\/00000478-200103000-00010","article-title":"Morphologic expressions of urothelial carcinoma in situ: a detailed evaluation of its histologic patterns with emphasis on carcinoma in situ with microinvasion","volume":"25","author":"McKenney","year":"2001","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2023.03.007_bib4","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.pathol.2020.10.001","article-title":"Urothelial carcinoma in situ: diagnostic update","volume":"53","author":"McKenney","year":"2021","journal-title":"Pathology"},{"key":"10.1016\/j.humpath.2023.03.007_bib5","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s00428-013-1378-4","article-title":"Different subtypes of carcinoma in situ of the bladder do not have a different prognosis","volume":"462","author":"Comp\u00e9rat","year":"2013","journal-title":"Virchows Arch"},{"key":"10.1016\/j.humpath.2023.03.007_bib6","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1097\/PAS.0000000000001318","article-title":"Carcinoma in situ with plasmacytoid features: a clinicopathologic study of 23 cases","volume":"43","author":"Sangoi","year":"2019","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2023.03.007_bib7","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1097\/00000478-200108000-00013","article-title":"Discriminatory immunohistochemical staining of urothelial carcinoma in situ and non-neoplastic urothelium: an analysis of cytokeratin 20, p53, and CD44 antigens","volume":"25","author":"McKenney","year":"2001","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2023.03.007_bib8","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1097\/PAS.0000000000000240","volume":"38","author":"Amin","year":"2014","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2023.03.007_bib9","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/01.MP.0000056628.38714.5D","article-title":"Immunohistochemical expression of CK20, p53, and Ki-67 as objective markers of urothelial dysplasia","volume":"16","author":"Mallofr\u00e9","year":"2003","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2023.03.007_bib10","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.humpath.2020.02.008","article-title":"Immunohistochemical staining patterns of Ki-67 and p53 in florid reactive urothelial atypia and urothelial carcinoma in situ demonstrate significant overlap","volume":"98","author":"Nguyen","year":"2020","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2023.03.007_bib11","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1440-1827.2005.01821.x","article-title":"Utility of cytokeratin 20 and Ki-67 as markers of urothelial dysplasia","volume":"55","author":"Kunju","year":"2005","journal-title":"Pathol Int"},{"key":"10.1016\/j.humpath.2023.03.007_bib12","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.cell.2018.07.036","article-title":"Comprehensive molecular characterization of muscle-invasive bladder cancer","volume":"174","author":"Robertson","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.humpath.2023.03.007_bib13","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/s41585-018-0001-5","article-title":"Implications of TERT promoter mutations and telomerase activity in urothelial carcinogenesis","volume":"15","author":"G\u00fcnes","year":"2018","journal-title":"Nat Rev Urol"},{"key":"10.1016\/j.humpath.2023.03.007_bib14","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1469-185X.1975.tb01057.x","article-title":"The mammalian urinary bladder: an accommodating organ","volume":"50","author":"Hicks","year":"1975","journal-title":"Biol Rev Camb Phil Soc"},{"key":"10.1016\/j.humpath.2023.03.007_bib15","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.humpath.2009.07.002","article-title":"Urothelial dysplasia and other flat lesions of the urinary bladder: clinicopathologic and molecular features","volume":"41","author":"Hodges","year":"2010","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2023.03.007_bib16","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1097\/00000478-199904000-00009","article-title":"Natural history of urothelial dysplasia of the bladder","volume":"23","author":"Cheng","year":"1999","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2023.03.007_bib17","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1097\/00000478-200412000-00010","article-title":"Urothelial papilloma of the bladder: a review of 34 de novo cases","volume":"28","author":"Magi-Galluzzi","year":"2004","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2023.03.007_bib18","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.humpath.2012.08.011","article-title":"Immunohistochemistry as an adjunct in the differential diagnosis of radiation-induced atypia versus urothelial carcinoma in situ of the bladder: a study of 45 cases","volume":"44","author":"Oliva","year":"2013","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2023.03.007_bib19","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1126\/science.aba8347","article-title":"Extensive heterogeneity in somatic mutation and selection in the human bladder","volume":"370","author":"Lawson","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.humpath.2023.03.007_bib20","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1126\/science.aba7300","article-title":"Macroscopic somatic clonal expansion in morphologically normal human urothelium","volume":"370","author":"Li","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.humpath.2023.03.007_bib21","first-page":"2","article-title":"TERT promoter mutation analysis of whole-organ mapping bladder cancers","volume":"12","author":"Weyerer","year":"2021","journal-title":"Genesvol."}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817723000679?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817723000679?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T16:41:24Z","timestamp":1758645684000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817723000679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":21,"alternative-id":["S0046817723000679"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2023.03.007","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Urothelial carcinoma in situ with \u201coverriding\u201d features can evade detection by mimicking umbrella cells","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2023.03.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}