{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:00:45Z","timestamp":1791234045646,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T00:00:00Z","timestamp":1718236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.humpath.2024.06.001","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T05:48:25Z","timestamp":1718171305000},"page":"21-28","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Comparison of genomic profiling of patient-matched primary colorectal and surgical resected distant metastatic (stage IV) colorectal carcinoma for drug actionability"],"prefix":"10.1016","volume":"149","author":[{"given":"Yi-Hua","family":"Jan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cu tai","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2771-564X","authenticated-orcid":false,"given":"Alfred King-yin","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.humpath.2024.06.001_bib1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s12094-013-1154-6","article-title":"Tissue-based biomarkers predicting outcomes in metastatic colorectal cancer: a review","volume":"16","author":"Ung","year":"2014","journal-title":"Clin Transl Oncol"},{"issue":"4","key":"10.1016\/j.humpath.2024.06.001_bib2","first-page":"302","article-title":"Does a localized intra-abdominal abscess produce a positive peritoneal lavage?","volume":"45","author":"Levine","year":"1988","journal-title":"Curr Surg"},{"issue":"6","key":"10.1016\/j.humpath.2024.06.001_bib3","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.tranon.2018.08.005","article-title":"Chemotherapeutic treatments increase PD-L1 expression in esophageal squamous cell carcinoma through EGFR\/ERK activation","volume":"11","author":"Ng","year":"2018","journal-title":"Transl Oncol"},{"issue":"3","key":"10.1016\/j.humpath.2024.06.001_bib4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s11912-021-01019-9","article-title":"Anaplastic thyroid carcinoma: current issues in genomics and therapeutics","volume":"23","author":"Abe","year":"2021","journal-title":"Curr Oncol Rep"},{"issue":"10","key":"10.1016\/j.humpath.2024.06.001_bib5","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1007\/s00384-012-1474-y","article-title":"Metachronous carcinomas in colorectum and its clinicopathological significance","volume":"27","author":"Lam","year":"2012","journal-title":"Int J Colorectal Dis"},{"issue":"2","key":"10.1016\/j.humpath.2024.06.001_bib6","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.yexcr.2015.10.004","article-title":"Deregulation of miR-126 expression in colorectal cancer pathogenesis and its clinical significance","volume":"339","author":"Ebrahimi","year":"2015","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.humpath.2024.06.001_bib7","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/978-1-0716-2505-7_14","article-title":"Whole-slide imaging: updates and applications in papillary thyroid carcinoma","volume":"2534","author":"Lam","year":"2022","journal-title":"Methods Mol Biol"},{"issue":"1","key":"10.1016\/j.humpath.2024.06.001_bib8","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/s12859-018-2234-y","article-title":"Mutational Signatures in Cancer (MuSiCa): a web application to implement mutational signatures analysis in cancer samples","volume":"19","author":"D\u00edaz-Gay","year":"2018","journal-title":"BMC Bioinf"},{"issue":"D1","key":"10.1016\/j.humpath.2024.06.001_bib9","doi-asserted-by":"crossref","first-page":"D777","DOI":"10.1093\/nar\/gkw1121","article-title":"COSMIC: somatic cancer genetics at high resolution","volume":"45","author":"Forbes","year":"2017","journal-title":"Nucleic Acids Res"},{"issue":"7","key":"10.1016\/j.humpath.2024.06.001_bib10","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1200\/JCO.2004.10.182","article-title":"Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor","volume":"22","author":"Saltz","year":"2004","journal-title":"J Clin Oncol"},{"issue":"4","key":"10.1016\/j.humpath.2024.06.001_bib11","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1056\/NEJMoa033025","article-title":"Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer","volume":"351","author":"Cunningham","year":"2004","journal-title":"N Engl J Med"},{"issue":"13","key":"10.1016\/j.humpath.2024.06.001_bib12","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1200\/JCO.2006.08.1620","article-title":"Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer","volume":"25","author":"Van Cutsem","year":"2007","journal-title":"J Clin Oncol"},{"issue":"3","key":"10.1016\/j.humpath.2024.06.001_bib13","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1200\/JCO.19.00818","article-title":"Nivolumab is effective in mismatch repair-deficient noncolorectal cancers: results from arm Z1D-A subprotocol of the NCI-match (EAY131) study","volume":"38","author":"Azad","year":"2020","journal-title":"J Clin Oncol"},{"issue":"9","key":"10.1016\/j.humpath.2024.06.001_bib14","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/S1470-2045(17)30422-9","article-title":"Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study","volume":"18","author":"Overman","year":"2017","journal-title":"Lancet Oncol"},{"issue":"8","key":"10.1016\/j.humpath.2024.06.001_bib15","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1200\/JCO.2017.76.9901","article-title":"Durable clinical benefit with nivolumab plus ipilimumab in DNA mismatch repair-deficient\/microsatellite instability-high metastatic colorectal cancer","volume":"36","author":"Overman","year":"2018","journal-title":"J Clin Oncol"},{"issue":"10","key":"10.1016\/j.humpath.2024.06.001_bib16","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/S1470-2045(20)30445-9","article-title":"Association of tumour mutational burden with outcomes in patients with advanced solid tumours treated with pembrolizumab: prospective biomarker analysis of the multicohort, open-label, phase 2 KEYNOTE-158 study","volume":"21","author":"Marabelle","year":"2020","journal-title":"Lancet Oncol"},{"issue":"7","key":"10.1016\/j.humpath.2024.06.001_bib17","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41588-020-0628-z","article-title":"Multi-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastases","volume":"52","author":"Hu","year":"2020","journal-title":"Nat Genet"},{"issue":"14","key":"10.1016\/j.humpath.2024.06.001_bib18","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1200\/JCO.21.02583","article-title":"Temozolomide followed by combination with low-dose ipilimumab and nivolumab in patients with microsatellite-stable, O6-methylguanine-DNA methyltransferase-silenced metastatic colorectal cancer: the MAYA trial","volume":"40","author":"Morano","year":"2022","journal-title":"J Clin Oncol"},{"issue":"7","key":"10.1016\/j.humpath.2024.06.001_bib19","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1158\/2159-8290.CD-21-1434","article-title":"Temozolomide treatment alters mismatch repair and boosts mutational burden in tumor and blood of colorectal cancer patients","volume":"12","author":"Crisafulli","year":"2022","journal-title":"Cancer Discov"},{"key":"10.1016\/j.humpath.2024.06.001_bib20","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/978-1-0716-0377-2_15","article-title":"Liquid biopsy: detection of circulating tumor cells in esophageal squamous cell carcinoma","volume":"2129","author":"Lam","year":"2020","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.humpath.2024.06.001_bib21","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/978-1-4939-7734-5_16","article-title":"Circulatory tumor cells in esophageal adenocarcinoma","volume":"1756","author":"Gopalan","year":"2018","journal-title":"Methods Mol Biol"},{"issue":"3","key":"10.1016\/j.humpath.2024.06.001_bib22","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/jop.13240","article-title":"A comparison of two methods for the detection of circulating tumour cells in patients with oral cavity cancer","volume":"51","author":"Curtin","year":"2022","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.humpath.2024.06.001_bib23","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.cancergen.2021.02.002","article-title":"Enumeration, characterisation and clinicopathological significance of circulating tumour cells in patients with colorectal carcinoma","volume":"254\u2013255","author":"Hamid","year":"2021","journal-title":"Cancer Genet"},{"issue":"20","key":"10.1016\/j.humpath.2024.06.001_bib24","doi-asserted-by":"crossref","first-page":"7766","DOI":"10.3390\/ijms21207766","article-title":"Genetic heterogeneity of single circulating tumour cells in colorectal carcinoma","volume":"21","author":"Hamid","year":"2020","journal-title":"Int J Mol Sci"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817724001023?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817724001023?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T22:03:57Z","timestamp":1720994637000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817724001023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":24,"alternative-id":["S0046817724001023"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2024.06.001","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of genomic profiling of patient-matched primary colorectal and surgical resected distant metastatic (stage IV) colorectal carcinoma for drug actionability","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2024.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}