{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T09:55:40Z","timestamp":1787738140098,"version":"build-2784847793"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100024583","name":"Medizinische Fakult\u00e4t, Universit\u00e4t zu K\u00f6ln","doi-asserted-by":"publisher","award":["98\/2023"],"award-info":[{"award-number":["98\/2023"]}],"id":[{"id":"10.13039\/501100024583","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008001","name":"Universit\u00e4t zu K\u00f6ln","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.humpath.2025.105934","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T06:54:10Z","timestamp":1757660050000},"page":"105934","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["GNAQ-\/GNA14-mutated hepatic vascular malformation with capillary proliferation in adults and children"],"prefix":"10.1016","volume":"165","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0665-9693","authenticated-orcid":false,"given":"Anne Kristin","family":"Fischer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Heydt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janna","family":"Siemanowski-Hrach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vedat","family":"Alibegovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Hauptmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Vokuhl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8806-4786","authenticated-orcid":false,"given":"Reinhard","family":"B\u00fcttner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2584-4958","authenticated-orcid":false,"given":"Hans-Peter","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.humpath.2025.105934_bib1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.humpath.2003.09.017","article-title":"GLUT1 endothelial reactivity distinguishes hepatic infantile hemangioma from congenital hepatic vascular malformation with associated capillary proliferation","volume":"35","author":"Mo","year":"2004","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2025.105934_bib2","series-title":"Digestive system tumours, 5th edition WHO classification of tumours series","article-title":"WHO classification of tumours editorial board","year":"2019"},{"key":"10.1016\/j.humpath.2025.105934_bib3","series-title":"Paediatric tumours, 5th edition WHO classification of tumours series","article-title":"WHO classification of tumours editorial board","year":"2022"},{"key":"10.1016\/j.humpath.2025.105934_bib4","series-title":"ISSVA Classification & Glossary for Vascular anomalies by international Society for the Study of Vascular anomalies","year":"2025"},{"key":"10.1016\/j.humpath.2025.105934_bib5","series-title":"MacSween's Pathology of the liver","first-page":"902","year":"2024"},{"key":"10.1016\/j.humpath.2025.105934_bib6","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1016\/j.jpedsurg.2020.02.008","article-title":"Congenital hepatic hemangiomas: clinical, histologic, and genetic correlation","volume":"55","author":"Triana","year":"2020","journal-title":"J Pediatr Surg"},{"issue":"4","key":"10.1016\/j.humpath.2025.105934_bib7","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.ajhg.2016.03.009","article-title":"Somatic activating mutations in GNAQ and GNA11 are associated with congenital hemangioma","volume":"98","author":"Ayturk","year":"2016","journal-title":"Am J Hum Genet"},{"issue":"6","key":"10.1016\/j.humpath.2025.105934_bib8","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s10024-003-2134-6","article-title":"Rapidly involuting congenital hemangioma: clinical and histopathologic features","volume":"6","author":"Berenguer","year":"2003","journal-title":"Pediatr Dev Pathol"},{"issue":"2","key":"10.1016\/j.humpath.2025.105934_bib9","article-title":"Cutaneous and hepatic vascular lesions due to a recurrent somatic GJA4 mutation reveal a pathway for vascular malformation","volume":"2","author":"Ugwu","year":"2021","journal-title":"HGG Adv"},{"issue":"9","key":"10.1016\/j.humpath.2025.105934_bib10","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1001\/jamadermatol.2016.2365","article-title":"Symptomatic congenital hemangioma and congenital hemangiomatosis associated with a somatic activating mutation in GNA11","volume":"152","author":"Funk","year":"2016","journal-title":"JAMA Dermatol"},{"issue":"1","key":"10.1016\/j.humpath.2025.105934_bib11","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0046-8177(00)80192-6","article-title":"GLUT1: a newly discovered immunohistochemical marker for juvenile hemangiomas","volume":"31","author":"North","year":"2000","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2025.105934_bib12","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0140-6736(16)00645-0","article-title":"Infantile haemangioma","volume":"390","author":"L\u00e9aut\u00e9-Labr\u00e8ze","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.humpath.2025.105934_bib13","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/nm.1877","article-title":"Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma","volume":"14","author":"Jinnin","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.humpath.2025.105934_bib14","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.humpath.2016.03.018","article-title":"Hepatic small vessel neoplasm, a rare infiltrative vascular neoplasm of uncertain malignant potential","volume":"54","author":"Gill","year":"2016","journal-title":"Hum Pathol"},{"issue":"9","key":"10.1016\/j.humpath.2025.105934_bib15","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1097\/PAS.0000000000001110","article-title":"Frequent GNAQ and GNA14 mutations in hepatic small vessel neoplasm","volume":"42","author":"Joseph","year":"2018","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2025.105934_bib16a","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijscr.2021.105742","article-title":"Hepatic small vessel neoplasm case report: a surveillance conundrum","volume":"81","author":"Mulholland","year":"2021","journal-title":"Int J Surg Case Rep"},{"issue":"4","key":"10.1016\/j.humpath.2025.105934_bib16b","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/ng1294-345","article-title":"Endoglin, a TGF-\u03b2 binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1","volume":"8","author":"McAllister","year":"1994","journal-title":"Nat Genetics"},{"key":"10.1016\/j.humpath.2025.105934_bib17","article-title":"Malignant hepatic vascular neoplasm with novel RAF1 and GNA11 mutations: risk stratification considerations for hepatic small vessel neoplasm (HSVN)","volume":"29","author":"Akanuma","year":"2022","journal-title":"Hum Pathol Rep"},{"issue":"1","key":"10.1016\/j.humpath.2025.105934_bib18","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1086\/513903","article-title":"The activin receptor-like kinase 1 gene: genomic structure and mutations in hereditary hemorrhagic telangiectasia type 2","volume":"61","author":"Berg","year":"1997","journal-title":"Am J Hum Genet"},{"issue":"9412","key":"10.1016\/j.humpath.2025.105934_bib19","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/S0140-6736(04)15732-2","article-title":"A combined syndrome of juvenile polyposis and hereditary haemorrhagic telangiectasia associated with mutations in MADH4 (SMAD4)","volume":"363","author":"Gallione","year":"2004","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.humpath.2025.105934_bib20","first-page":"189","article-title":"Mutations in the activin receptor\u2013like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2","volume":"3","author":"Johnson","year":"1996","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.humpath.2025.105934_bib21","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1093\/hmg\/4.10.1983","article-title":"Six novel mutations in the endoglin gene in hereditary hemorrhagic telangiectasia type 1 suggest a dominant-negative effect of receptor function","volume":"4","author":"McAllister","year":"1995","journal-title":"Hum Mol Genet"},{"issue":"5","key":"10.1016\/j.humpath.2025.105934_bib22","doi-asserted-by":"crossref","first-page":"707","DOI":"10.4254\/wjh.v15.i5.707","article-title":"Giant cavernous hemangioma of the liver with satellite nodules: aspects on tumour\/tissue interface: a case report","volume":"15","author":"Fischer","year":"2023","journal-title":"World J Hepatol"},{"issue":"23","key":"10.1016\/j.humpath.2025.105934_bib23","doi-asserted-by":"crossref","first-page":"5878","DOI":"10.1002\/cncr.27614","article-title":"Alterations of the p53 and PIK3CA\/AKT\/mTOR pathways in angiosarcomas: a pattern distinct from other sarcomas with complex genomics","volume":"118","author":"Italiano","year":"2012","journal-title":"Cancer"},{"key":"10.1016\/j.humpath.2025.105934_bib24","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.cellsig.2005.08.004","article-title":"Cell signalling diversity of the Gq-alpha family of heterotrimeric G proteins","volume":"18","author":"Hubbard","year":"2006","journal-title":"Cell Signal"},{"key":"10.1016\/j.humpath.2025.105934_bib25","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1038\/s41467-023-37516-7","article-title":"MEK inhibition reduced vascular tumour growth and coagulopathy in a mouse model with hyperactive GNAQ","volume":"14","author":"Schrenk","year":"2023","journal-title":"Nat Commun"},{"issue":"2","key":"10.1016\/j.humpath.2025.105934_bib26","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1093\/hmg\/ddac169","article-title":"Trametinib as a promising therapeutic option in alleviating vascular defects in an endothelial KRAS-induced mouse model","volume":"32","author":"Nguyen","year":"2022","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.humpath.2025.105934_bib27","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.ajhg.2016.06.010","article-title":"GNA14 Somatic mutation causes congenital and sporadic vascular tumours by MAPK activation","volume":"99","author":"Lim","year":"2016","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.humpath.2025.105934_bib28","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1056\/NEJMoa1213507","article-title":"Sturge-Weber syndrome and port-wine stains caused by somatic mutation in GNAQ","volume":"368","author":"Shirley","year":"2013","journal-title":"N Engl J Med"},{"issue":"7","key":"10.1016\/j.humpath.2025.105934_bib29","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1053\/j.gastro.2010.12.042","article-title":"A large liver tumour in a 3-month-old girl. Diagnosis: GLUT1-negative hepatic vascular malformation with capillary proliferation","volume":"140","author":"Menke","year":"2011","journal-title":"Gastroenterology"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817725002217?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817725002217?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T05:51:43Z","timestamp":1773121903000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817725002217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":30,"alternative-id":["S0046817725002217"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2025.105934","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"GNAQ-\/GNA14-mutated hepatic vascular malformation with capillary proliferation in adults and children","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2025.105934","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"105934"}}