{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T02:40:38Z","timestamp":1773196838380,"version":"3.50.1"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.humpath.2025.105961","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T01:34:17Z","timestamp":1761788057000},"page":"105961","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["HPV-related multiphenotypic sinonasal carcinoma: Clinicopathologic and immunohistochemical characterization of 3 cases with comprehensive literature review and emphasis on differential diagnosis"],"prefix":"10.1016","volume":"170","author":[{"given":"Gabriella C.","family":"Speakman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Paul E.","family":"Wakely","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5965-6181","authenticated-orcid":false,"given":"Prokopios P.","family":"Argyris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2025.105961_bib1","unstructured":"WHO Classification of Tumours Editorial Board. Head and neck tumours [Internet]. Lyon (France): International Agency for Research on Cancer; 2023 [cited on 07\/20\/25]. (WHO classification of tumours series, 5th ed.; vol. 9). Available from: https:\/\/tumourclassification.iarc.who.int\/chapters\/52."},{"issue":"5","key":"10.1016\/j.humpath.2025.105961_bib2","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/s41571-022-00603-7","article-title":"HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management","volume":"19","author":"Lechner","year":"2022","journal-title":"Nat Rev Clin Oncol"},{"issue":"4","key":"10.1016\/j.humpath.2025.105961_bib3","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s12105-023-01589-z","article-title":"Human papillomavirus-associated oral epithelial dysplasia: report of 5 illustrative cases from Latin America","volume":"17","author":"Aloc","year":"2023","journal-title":"Head Neck Pathol"},{"key":"10.1016\/j.humpath.2025.105961_bib4","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.virusres.2016.12.017","article-title":"The low-risk papillomaviruses","volume":"231","author":"Egawa","year":"2017","journal-title":"Virus Res"},{"issue":"3","key":"10.1016\/j.humpath.2025.105961_bib5","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1007\/s12105-022-01426-9","article-title":"Changing trends in benign human papillomavirus (HPV) related epithelial neoplasms of the oral cavity: 1995-2015","volume":"16","author":"Alramadhan","year":"2022","journal-title":"Head Neck Pathol"},{"issue":"3","key":"10.1016\/j.humpath.2025.105961_bib6","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1177\/1066896913509013","article-title":"Oral fibroma with HPV-associated epithelial dysplasia: even in fibromas you should look for the unexpected","volume":"22","author":"Argyris","year":"2014","journal-title":"Int J Surg Pathol"},{"issue":"1","key":"10.1016\/j.humpath.2025.105961_bib7","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.oooo.2013.06.005","article-title":"Histopathologic features of high risk HPV-associated oral epithelial dysplasia","volume":"117","author":"McCord","year":"2014","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"issue":"1","key":"10.1016\/j.humpath.2025.105961_bib8","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s12105-024-01707-5","article-title":"Uncommon and challenging phenotypes of high-risk human papillomavirus-associated head and neck carcinomas revealed by high-throughput studies","volume":"18","author":"Tannenbaum","year":"2024","journal-title":"Head Neck Pathol"},{"issue":"12","key":"10.1016\/j.humpath.2025.105961_bib9","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1038\/modpathol.2017.71","article-title":"HPV-16 in a distinct subset of oral epithelial dysplasia","volume":"30","author":"Lerman","year":"2017","journal-title":"Mod Pathol"},{"issue":"10","key":"10.1016\/j.humpath.2025.105961_bib10","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1038\/modpathol.2013.70","article-title":"Human papillomavirus-associated oral intraepithelial neoplasia","volume":"26","author":"Woo","year":"2013","journal-title":"Mod Pathol"},{"issue":"2","key":"10.1016\/j.humpath.2025.105961_bib11","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s40136-020-00279-6","article-title":"Sinonasal squamous cell carcinoma: etiology, pathogenesis, and the role of human papilloma virus","volume":"8","author":"Elgart","year":"2020","journal-title":"Curr Otorhinolaryngol Rep"},{"issue":"Suppl 1","key":"10.1016\/j.humpath.2025.105961_bib12","doi-asserted-by":"crossref","first-page":"S104","DOI":"10.1007\/s12105-012-0368-1","article-title":"Human papillomavirus in non-oropharyngeal head and neck cancers: a systematic literature review","volume":"6","author":"Isayeva","year":"2012","journal-title":"Head Neck Pathol"},{"issue":"1","key":"10.1016\/j.humpath.2025.105961_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.oraloncology.2012.07.002","article-title":"Low etiologic fraction for high-risk human papillomavirus in oral cavity squamous cell carcinomas","volume":"49","author":"Lingen","year":"2013","journal-title":"Oral Oncol"},{"issue":"4","key":"10.1016\/j.humpath.2025.105961_bib14","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s00428-024-03837-1","article-title":"Histologic spectrum and outcome of Human papillomavirus (HPV)-associated oral cavity squamous cell carcinoma: a single center experience and a survey of The Cancer Genome Atlas (TGCA) cohort","volume":"485","author":"Ghossein","year":"2024","journal-title":"Virchows Arch"},{"issue":"4","key":"10.1016\/j.humpath.2025.105961_bib15","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1007\/s12105-022-01467-0","article-title":"Human papillomavirus-associated oral cavity squamous cell carcinoma: an entity with distinct morphologic and clinical features","volume":"16","author":"Lewis","year":"2022","journal-title":"Head Neck Pathol"},{"issue":"10","key":"10.1016\/j.humpath.2025.105961_bib16","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1016\/j.joms.2013.04.004","article-title":"Comparison between p16 INK4A immunohistochemistry and human papillomavirus polymerase chain reaction assay in oral papillary squamous cell carcinoma","volume":"71","author":"Argyris","year":"2013","journal-title":"J Oral Maxillofac Surg"},{"issue":"3","key":"10.1016\/j.humpath.2025.105961_bib17","article-title":"Updates on treatments and management of nasopharyngeal carcinoma","volume":"45","author":"Chua","year":"2025","journal-title":"Am Soc Clin Oncol Educ Book"},{"key":"10.1016\/j.humpath.2025.105961_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.oraloncology.2024.107057","article-title":"Human papillomavirus-associated nasopharyngeal carcinoma: a systematic review and meta-analysis","volume":"159","author":"Zhao","year":"2024","journal-title":"Oral Oncol"},{"issue":"13","key":"10.1016\/j.humpath.2025.105961_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12134264","article-title":"The clinical characteristics and outcomes of human papillomavirus-positive nasopharyngeal carcinoma in a single-institution cohort","volume":"12","author":"Awawda","year":"2023","journal-title":"J Clin Med"},{"issue":"2","key":"10.1016\/j.humpath.2025.105961_bib20","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s12105-023-01538-w","article-title":"Sinonasal adenosquamous Carcinoma - Morphology and genetic drivers including Low- and high-risk human papillomavirus mRNA, DEK::AFF2 fusion, and MAML2 rearrangement","volume":"17","author":"Holliday","year":"2023","journal-title":"Head Neck Pathol"},{"issue":"3","key":"10.1016\/j.humpath.2025.105961_bib21","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s12105-013-0514-4","article-title":"The sinonasal tract: another potential \"hot spot\" for carcinomas with transcriptionally-active human papillomavirus","volume":"8","author":"Lewis","year":"2014","journal-title":"Head Neck Pathol"},{"key":"10.1016\/j.humpath.2025.105961_bib22","series-title":"Human papillomavirus","author":"Luria","year":"2025"},{"issue":"2","key":"10.1016\/j.humpath.2025.105961_bib23","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1007\/s12105-021-01381-x","article-title":"Detection of human papillomavirus and p16","volume":"16","author":"Rungraungrayabkul","year":"2022","journal-title":"Head Neck Pathol"},{"issue":"3","key":"10.1016\/j.humpath.2025.105961_bib24","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/s41588-019-0558-9","article-title":"The landscape of viral associations in human cancers","volume":"52","author":"Zapatka","year":"2020","journal-title":"Nat Genet"},{"issue":"3","key":"10.1016\/j.humpath.2025.105961_bib25","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.oooo.2024.10.082","article-title":"Human oncogenic viruses: a focus on head and neck carcinogenesis: a systematic review and meta-analysis","volume":"139","author":"de Moraes","year":"2025","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"issue":"6","key":"10.1016\/j.humpath.2025.105961_bib26","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1097\/PAS.0b013e31827b1cd6","article-title":"Human papillomavirus-related carcinoma with adenoid cystic-like features: a peculiar variant of head and neck cancer restricted to the sinonasal tract","volume":"37","author":"Bishop","year":"2013","journal-title":"Am J Surg Pathol"},{"issue":"12","key":"10.1016\/j.humpath.2025.105961_bib27","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1097\/PAS.0000000000000944","article-title":"HPV-related multiphenotypic sinonasal carcinoma: an expanded series of 49 cases of the tumor formerly known as HPV-related carcinoma with adenoid cystic carcinoma-like features","volume":"41","author":"Bishop","year":"2017","journal-title":"Am J Surg Pathol"},{"issue":"7","key":"10.1016\/j.humpath.2025.105961_bib28","first-page":"191","article-title":"HPV-related sinonasal carcinoma with adenoid cystic-like features with intracranial invasion","volume":"97","author":"Hung","year":"2018","journal-title":"Ear Nose Throat J"},{"key":"10.1016\/j.humpath.2025.105961_bib29","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ehpc.2018.05.008","article-title":"Human papillomavirus-related multiphenotypic sinonasal carcinoma: first case report associated with an intermediate-risk HPV type and literatures review","volume":"14","author":"Ruangritchankul","year":"2018","journal-title":"Hum Pathol Case Rep"},{"issue":"4","key":"10.1016\/j.humpath.2025.105961_bib30","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s12105-018-0895-5","article-title":"Human papillomavirus-related multiphenotypic sinonasal carcinoma: a case report documenting the potential for very late tumor recurrence","volume":"12","author":"Shah","year":"2018","journal-title":"Head Neck Pathol"},{"issue":"3","key":"10.1016\/j.humpath.2025.105961_bib31","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s12105-018-0969-4","article-title":"Human papillomavirus-related multiphenotypic sinonasal carcinoma with unique HPV type 52 Association: a case report with review of literature","volume":"13","author":"Adamane","year":"2019","journal-title":"Head Neck Pathol"},{"issue":"5","key":"10.1016\/j.humpath.2025.105961_bib32","doi-asserted-by":"crossref","first-page":"337","DOI":"10.4132\/jptm.2019.04.02","article-title":"Human papillomavirus-related multiphenotypic sinonasal carcinoma with late recurrence","volume":"53","author":"Ahn","year":"2019","journal-title":"J Pathol Transl Med"},{"issue":"8","key":"10.1016\/j.humpath.2025.105961_bib33","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1177\/1066896919866508","article-title":"HPV-related multiphenotypic sinonasal carcinoma: a unique case","volume":"27","author":"Ching","year":"2019","journal-title":"Int J Surg Pathol"},{"issue":"4","key":"10.1016\/j.humpath.2025.105961_bib34","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1055\/s-0039-3399571","article-title":"Human papillomavirus related multiphenotypic sinonasal carcinoma: report of a case with early and progressive metastatic disease","volume":"80","author":"Rodarte","year":"2019","journal-title":"J Neurol Surg Rep"},{"issue":"2","key":"10.1016\/j.humpath.2025.105961_bib35","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.otorri.2018.02.005","article-title":"Recurrence of human papillomavirus-related carcinoma with adenoid cystic-like features","volume":"70","author":"S\u00e1enz Gonz\u00e1lez","year":"2019","journal-title":"Acta Otorrinolaringol Esp"},{"issue":"2","key":"10.1016\/j.humpath.2025.105961_bib36","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s12105-019-01069-3","article-title":"Human papillomavirus-related multiphenotypic sinonasal carcinoma: a recent discovery. A case report and literature review","volume":"14","author":"Brzezinska","year":"2020","journal-title":"Head Neck Pathol"},{"issue":"2","key":"10.1016\/j.humpath.2025.105961_bib37","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1177\/0145561319884199","article-title":"Endoscopic view of HPV-related multiphenotypic sinonasal carcinoma","volume":"99","author":"Liao","year":"2020","journal-title":"Ear Nose Throat J"},{"issue":"1","key":"10.1016\/j.humpath.2025.105961_bib38","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/lary.28598","article-title":"HPV-related multiphenotypic sinonasal carcinoma: a case report and literature review","volume":"131","author":"Ward","year":"2021","journal-title":"Laryngoscope"},{"key":"10.1016\/j.humpath.2025.105961_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijscr.2022.107462","article-title":"Human papillomavirus-related carcinoma with adenoid cystic-like features of the sinonasal tract: case report and literature review","volume":"97","author":"Abraham","year":"2022","journal-title":"Int J Surg Case Rep"},{"issue":"1","key":"10.1016\/j.humpath.2025.105961_bib40","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/neup.12762","article-title":"Effectiveness of radiation therapy on brain invasion by human papillomavirus-related multiphenotypic sinonasal carcinoma: a case report","volume":"42","author":"Kuroda","year":"2022","journal-title":"Neuropathology"},{"issue":"1","key":"10.1016\/j.humpath.2025.105961_bib41","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.anl.2021.10.008","article-title":"Human papillomavirus-related multiphenotypic sinonasal carcinoma","volume":"50","author":"Morishita","year":"2023","journal-title":"Auris Nasus Larynx"},{"key":"10.1016\/j.humpath.2025.105961_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.oraloncology.2023.106555","article-title":"Induction chemotherapy response of HPV-related multiphenotypic sinonasal carcinoma: First-ever reported therapeutic outcome and a brief literature review","volume":"146","author":"Vieira","year":"2023","journal-title":"Oral Oncol"},{"issue":"1","key":"10.1016\/j.humpath.2025.105961_bib43","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s12105-024-01670-1","article-title":"Morphologic spectrum of HPV-associated sinonasal carcinomas","volume":"18","author":"Abi-Saab","year":"2024","journal-title":"Head Neck Pathol"},{"key":"10.1016\/j.humpath.2025.105961_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2024.1448213","article-title":"Whole exome sequencing of human papillomavirus-related multiphenotypic sinonasal carcinoma: a case report","volume":"14","author":"Cubides-C\u00f3rdoba","year":"2024","journal-title":"Front Oncol"},{"issue":"9","key":"10.1016\/j.humpath.2025.105961_bib45","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1177\/01455613221112334","article-title":"A case of human papillomavirus-related multiphenotypic sinonasal carcinoma","volume":"103","author":"Jung","year":"2024","journal-title":"Ear Nose Throat J"},{"issue":"9","key":"10.1016\/j.humpath.2025.105961_bib46","article-title":"Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma with intracranial extension and rapid recurrence: a case report","volume":"16","author":"Reinders","year":"2024","journal-title":"Cureus"},{"issue":"6","key":"10.1016\/j.humpath.2025.105961_bib47","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/his.13301","article-title":"Human papillomavirus-related carcinoma with adenoid cystic-like features: a series of five cases expanding the pathological spectrum","volume":"71","author":"Hang","year":"2017","journal-title":"Histopathology"},{"issue":"7","key":"10.1016\/j.humpath.2025.105961_bib48","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1002\/lary.26957","article-title":"Case report: HPV-related carcinoma with adenoid cystic-like features of the sinonasal tract","volume":"128","author":"Chouake","year":"2018","journal-title":"Laryngoscope"},{"issue":"3","key":"10.1016\/j.humpath.2025.105961_bib49","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s12105-019-01079-1","article-title":"HPV-related multiphenotypic sinonasal carcinoma: four cases that expand the morpho-molecular spectrum and include occupational data","volume":"14","author":"Rupp","year":"2020","journal-title":"Head Neck Pathol"},{"issue":"10","key":"10.1016\/j.humpath.2025.105961_bib50","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1007\/s00234-022-03009-5","article-title":"Radiological features of human papillomavirus-related multiphenotypic sinonasal carcinoma: systematic review and case series","volume":"64","author":"Baba","year":"2022","journal-title":"Neuroradiology"},{"issue":"3","key":"10.1016\/j.humpath.2025.105961_bib51","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.anl.2022.03.019","article-title":"Human papillomavirus-related multiphenotypic sinonasal carcinoma: a report of two patients and review of the literature","volume":"50","author":"Miyamaru","year":"2023","journal-title":"Auris Nasus Larynx"},{"key":"10.1016\/j.humpath.2025.105961_bib52","doi-asserted-by":"crossref","DOI":"10.1177\/01455613241247729","article-title":"HPV-related multiphenotypic sinonasal carcinoma: a clinicoradiological series of 3 cases with full endoscopic surgical outcome","author":"Beaumont","year":"2024","journal-title":"Ear Nose Throat J"},{"issue":"3","key":"10.1016\/j.humpath.2025.105961_bib53","first-page":"156","article-title":"Evaluation of some prognostic biomarkers in human papillomavirus-related multiphenotypic sinonasal carcinoma","volume":"49","author":"Alabiad","year":"2024","journal-title":"Iran J Med Sci"},{"key":"10.1016\/j.humpath.2025.105961_bib54","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.oraloncology.2018.10.011","article-title":"Human papillomavirus-related multiphenotypic sinonasal carcinoma: an emerging tumor type with a unique microscopic appearance and a paradoxical clinical behaviour","volume":"87","author":"Bishop","year":"2018","journal-title":"Oral Oncol"},{"issue":"1","key":"10.1016\/j.humpath.2025.105961_bib55","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s12105-022-01508-8","article-title":"Top 10 basaloid neoplasms of the sinonasal tract","volume":"17","author":"Ban\u011b\u010dkov\u00e1","year":"2023","journal-title":"Head Neck Pathol"},{"issue":"2","key":"10.1016\/j.humpath.2025.105961_bib56","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/s12105-018-0951-1","article-title":"Consistent LEF-1 and MYB immunohistochemical expression in human papillomavirus-related multiphenotypic sinonasal carcinoma: a potential diagnostic pitfall","volume":"13","author":"Shah","year":"2019","journal-title":"Head Neck Pathol"},{"issue":"1","key":"10.1016\/j.humpath.2025.105961_bib57","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s12105-014-0554-4","article-title":"Polymorphous low grade adenocarcinoma has a consistent p63+\/p40- immunophenotype that helps distinguish it from adenoid cystic carcinoma and cellular pleomorphic adenoma","volume":"9","author":"Rooper","year":"2015","journal-title":"Head Neck Pathol"},{"issue":"3","key":"10.1016\/j.humpath.2025.105961_bib58","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.oooo.2015.10.016","article-title":"Clinical utility of myb rearrangement detection and p63\/p40 immunophenotyping in the diagnosis of adenoid cystic carcinoma of minor salivary glands: a pilot study","volume":"121","author":"Argyris","year":"2016","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"issue":"1","key":"10.1016\/j.humpath.2025.105961_bib59","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s12105-012-0383-2","article-title":"Lacrimal gland adenoid cystic carcinoma with high-grade transformation to myoepithelial carcinoma: report of a case and review of literature","volume":"7","author":"Argyris","year":"2013","journal-title":"Head Neck Pathol"},{"key":"10.1016\/j.humpath.2025.105961_bib60","first-page":"143","article-title":"Assessment of p16 expression and HPV infection in adenoid cystic carcinoma of the lacrimal gland","volume":"24","author":"Wang","year":"2018","journal-title":"Mol Vis"},{"issue":"7","key":"10.1016\/j.humpath.2025.105961_bib61","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1002\/hed.24778","article-title":"Sinonasal adenoid cystic carcinoma: treatment outcomes and association with human papillomavirus","volume":"39","author":"Miller","year":"2017","journal-title":"Head Neck"},{"issue":"4","key":"10.1016\/j.humpath.2025.105961_bib62","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/modpathol.2011.186","article-title":"Detection of human papilloma virus and p16 expression in high-grade adenoid cystic carcinoma of the head and neck","volume":"25","author":"Boland","year":"2012","journal-title":"Mod Pathol"},{"issue":"6","key":"10.1016\/j.humpath.2025.105961_bib63","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1111\/his.14212","article-title":"p16 immunoexpression in sinonasal and nasopharyngeal adenoid cystic carcinomas: a potential pitfall in ruling out HPV-related multiphenotypic sinonasal carcinoma","volume":"77","author":"Antony","year":"2020","journal-title":"Histopathology"},{"issue":"1","key":"10.1016\/j.humpath.2025.105961_bib64","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.path.2020.09.005","article-title":"Basal cell adenoma and basal cell adenocarcinoma","volume":"14","author":"Robinson","year":"2021","journal-title":"Surg Pathol Clin"},{"issue":"8","key":"10.1016\/j.humpath.2025.105961_bib65","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1097\/PAS.0000000000000669","article-title":"Distinctive patterns of CTNNB1 (\u03b2-Catenin) alterations in salivary gland basal cell adenoma and basal cell adenocarcinoma","volume":"40","author":"Jo","year":"2016","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"10.1016\/j.humpath.2025.105961_bib66","doi-asserted-by":"crossref","first-page":"4657","DOI":"10.1038\/s41467-025-59871-3","article-title":"Wnt\/\u03b2-catenin activation by mutually exclusive FBXW11 and CTNNB1 hotspot mutations drives salivary basal cell adenoma","volume":"16","author":"Wong","year":"2025","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.humpath.2025.105961_bib67","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00428-025-04120-7","article-title":"Correlation between basal cell adenoma and basal cell adenocarcinoma of the salivary gland: a histomorphological and molecular review of 129 cases","volume":"487","author":"Yagi","year":"2025","journal-title":"Virchows Arch"},{"issue":"11","key":"10.1016\/j.humpath.2025.105961_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.modpat.2023.100305","article-title":"Comprehensive molecular characterization of polymorphous adenocarcinoma, cribriform subtype: identifying novel fusions and fusion partners","volume":"36","author":"Hahn","year":"2023","journal-title":"Mod Pathol"},{"issue":"9","key":"10.1016\/j.humpath.2025.105961_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.modpat.2025.100803","article-title":"Comprehensive clinicopathologic, morphologic, and molecular evaluation and outcomes in polymorphous adenocarcinoma tumors with applicability of a 2-Tiered grading system","volume":"38","author":"Viswanathan","year":"2025","journal-title":"Mod Pathol"},{"issue":"1","key":"10.1016\/j.humpath.2025.105961_bib70","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/s41379-019-0351-4","article-title":"Histologic spectrum of polymorphous adenocarcinoma of the salivary gland harbor genetic alterations affecting PRKD genes","volume":"33","author":"Sebastiao","year":"2020","journal-title":"Mod Pathol"},{"issue":"1","key":"10.1016\/j.humpath.2025.105961_bib71","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/s41467-017-01178-z","article-title":"Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions","volume":"8","author":"Dalin","year":"2017","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.humpath.2025.105961_bib72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/PAS.0000000000001591","article-title":"Molecular profiling of clear cell myoepithelial carcinoma of salivary glands with EWSR1 rearrangement identifies frequent PLAG1 gene fusions but no EWSR1 fusion transcripts","volume":"45","author":"Sk\u00e1lov\u00e1","year":"2021","journal-title":"Am J Surg Pathol"},{"issue":"7","key":"10.1016\/j.humpath.2025.105961_bib73","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1097\/PAS.0b013e31816380ec","article-title":"Basaloid squamous cell carcinoma of the head and neck is a mixed variant that can be further resolved by HPV status","volume":"32","author":"Begum","year":"2008","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"10.1016\/j.humpath.2025.105961_bib74","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s12105-017-0825-y","article-title":"Squamous and neuroendocrine specific immunohistochemical markers in head and neck squamous cell carcinoma: a tissue microarray study","volume":"12","author":"Lewis","year":"2018","journal-title":"Head Neck Pathol"},{"issue":"2","key":"10.1016\/j.humpath.2025.105961_bib75","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/PAS.0b013e3182698673","article-title":"Human papillomavirus-related carcinomas of the sinonasal tract","volume":"37","author":"Bishop","year":"2013","journal-title":"Am J Surg Pathol"},{"issue":"4","key":"10.1016\/j.humpath.2025.105961_bib76","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00428-015-1812-x","article-title":"The presence of high-risk human papillomavirus (HPV) E6\/E7 mRNA transcripts in a subset of sinonasal carcinomas is evidence of involvement of HPV in its etiopathogenesis","volume":"467","author":"Laco","year":"2015","journal-title":"Virchows Arch"},{"key":"10.1016\/j.humpath.2025.105961_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.oraloncology.2020.105109","article-title":"Human papillomavirus genotype distribution in head and neck cancer: informing developing strategies for cancer prevention, diagnosis, treatment and surveillance","volume":"113","author":"Mashiana","year":"2021","journal-title":"Oral Oncol"},{"issue":"21","key":"10.1016\/j.humpath.2025.105961_bib78","doi-asserted-by":"crossref","first-page":"6861","DOI":"10.3390\/jcm12216861","article-title":"p16 overexpression in sinonasal squamous cell carcinoma: association with human papillomavirus and prediction of survival outcomes","volume":"12","author":"Hirakawa","year":"2023","journal-title":"J Clin Med"},{"key":"10.1016\/j.humpath.2025.105961_bib79","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s40136-022-00404-7","article-title":"Human papillomavirus-related carcinomas of the sinonasal tract","volume":"10","author":"Lopez","year":"2022","journal-title":"Curr Otorhinolaryngol Rep"},{"issue":"12","key":"10.1016\/j.humpath.2025.105961_bib80","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.oraloncology.2015.10.002","article-title":"Salivary adenoid cystic carcinoma in Denmark 1990-2005: outcome and independent prognostic factors including the benefit of radiotherapy. Results of the Danish Head and Neck Cancer Group (DAHANCA)","volume":"51","author":"Bj\u00f8rndal","year":"2015","journal-title":"Oral Oncol"},{"issue":"1","key":"10.1016\/j.humpath.2025.105961_bib81","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1056\/NEJMoa0912217","article-title":"Human papillomavirus and survival of patients with oropharyngeal cancer","volume":"363","author":"Ang","year":"2010","journal-title":"N Engl J Med"},{"issue":"15","key":"10.1016\/j.humpath.2025.105961_bib82","doi-asserted-by":"crossref","first-page":"3677","DOI":"10.3390\/cancers13153677","article-title":"Human papillomavirus and survival of sinonasal squamous cell carcinoma patients: a systematic review and meta-analysis","volume":"13","author":"Sharma","year":"2021","journal-title":"Cancers (Basel)"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817725002485?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817725002485?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T05:52:00Z","timestamp":1773121920000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817725002485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":82,"alternative-id":["S0046817725002485"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2025.105961","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HPV-related multiphenotypic sinonasal carcinoma: Clinicopathologic and immunohistochemical characterization of 3 cases with comprehensive literature review and emphasis on differential diagnosis","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2025.105961","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105961"}}