{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:13:35Z","timestamp":1793643215951,"version":"4.5.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.humpath.2025.106018","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T16:08:20Z","timestamp":1765901300000},"page":"106018","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Updates in bladder and prostate pathology: Diagnostic consensus and clinical relevance"],"prefix":"10.1016","volume":"169","author":[{"given":"Katrina","family":"Collins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sounak","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6049-5293","authenticated-orcid":false,"given":"Liang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.humpath.2025.106018_bib1","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1097\/PAS.0000000000002077","volume":"48","author":"Paner","year":"2024","journal-title":"Am J Surg Pathol"},{"issue":"10","key":"10.1016\/j.humpath.2025.106018_bib2","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1200\/JCO.1999.17.10.3182","article-title":"Predicting cancer progression in patients with stage T1 bladder carcinoma","volume":"17","author":"Cheng","year":"1999","journal-title":"J Clin Oncol"},{"issue":"1","key":"10.1016\/j.humpath.2025.106018_bib3","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41585-018-0105-y","article-title":"T1 bladder cancer: current considerations for diagnosis and management","volume":"16","author":"Jordan","year":"2019","journal-title":"Nat Rev Urol"},{"key":"10.1016\/j.humpath.2025.106018_bib4","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.euros.2023.03.019","article-title":"International opinions on grading of urothelial carcinoma: a Survey among European association of urology and international society of urological pathology members","volume":"52","author":"Beijert","year":"2023","journal-title":"Eur Urol Open Sci"},{"issue":"2","key":"10.1016\/j.humpath.2025.106018_bib5","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.euo.2020.12.002","article-title":"Prognostic value of the WHO1973 and WHO2004\/2016 classification systems for grade in primary Ta\/T1 non-muscle-invasive bladder cancer: a multicenter European association of urology non-muscle-Invasive bladder cancer guidelines panel study","volume":"4","author":"van Rhijn","year":"2021","journal-title":"Eur Urol Oncol"},{"issue":"1","key":"10.1016\/j.humpath.2025.106018_bib6","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.pathol.2020.09.014","article-title":"Stage T1 bladder cancer: diagnostic criteria and pitfalls","volume":"53","author":"Lopez-Beltran","year":"2021","journal-title":"Pathology"},{"issue":"4","key":"10.1016\/j.humpath.2025.106018_bib7","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.pathol.2021.10.005","article-title":"The impact of grading scheme on non-muscle invasive bladder cancer progression: potential utility of hybrid grading schemes","volume":"54","author":"Downes","year":"2022","journal-title":"Pathology"},{"issue":"2","key":"10.1016\/j.humpath.2025.106018_bib8","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.euf.2021.03.017","article-title":"International society of urological pathology expert opinion on grading of urothelial carcinoma","volume":"8","author":"van der Kwast","year":"2022","journal-title":"Eur Urol Focus"},{"issue":"5","key":"10.1016\/j.humpath.2025.106018_bib9","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.eururo.2024.08.013","article-title":"The importance of being grade 3: a plea for a three-tier hybrid classification system for grade in primary non-muscle-invasive bladder cancer","volume":"86","author":"Beijert","year":"2024","journal-title":"Eur Urol"},{"issue":"1","key":"10.1016\/j.humpath.2025.106018_bib10","doi-asserted-by":"crossref","first-page":"e24","DOI":"10.1097\/PAS.0000000000002121","article-title":"International society of urological pathology (ISUP) consensus conference on current issues in Bladder Cancer: Working group 3: subcategorization of T1 bladder cancer","volume":"48","author":"Lopez-Beltran","year":"2024","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"10.1016\/j.humpath.2025.106018_bib11","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1097\/PAS.0000000000002059","article-title":"International society of urological pathology (ISUP) consensus conference on current issues in bladder cancer. Working group 1: comparison of bladder cancer grading system performance","volume":"48","author":"Downes","year":"2024","journal-title":"Am J Surg Pathol"},{"issue":"5","key":"10.1016\/j.humpath.2025.106018_bib12","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/his.15438","article-title":"Interobserver reproducibility of a hybrid three-tier grading system of papillary nonmuscle invasive urothelial carcinoma: an international uropathology study","volume":"87","author":"Downes","year":"2025","journal-title":"Histopathology"},{"issue":"2","key":"10.1016\/j.humpath.2025.106018_bib13","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/PAP.0000000000000110","article-title":"Updates in the pathologic diagnosis and classification of epithelial neoplasms of urachal origin","volume":"23","author":"Paner","year":"2016","journal-title":"Adv Anat Pathol"},{"key":"10.1016\/j.humpath.2025.106018_bib14","article-title":"The Dublin international society of urological pathology (ISUP) consensus conference on best practice recommendations on the pathology of glandular lesions of the urinary bladder","author":"Paner","year":"2025","journal-title":"Adv Anat Pathol"},{"issue":"11","key":"10.1016\/j.humpath.2025.106018_bib15","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1097\/PAS.0000000000002416","article-title":"The Dublin international society of urological pathology (ISUP) consensus conference on best practice recommendations on the pathology of urachal neoplasms","volume":"49","author":"Reis","year":"2025","journal-title":"Am J Surg Pathol"},{"issue":"2","key":"10.1016\/j.humpath.2025.106018_bib16","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.eururo.2024.03.027","article-title":"EAU-EANM-ESTRO-ESUR-ISUP-SIOG guidelines on prostate Cancer-2024 update. Part I: screening, diagnosis, and local treatment with curative intent","volume":"86","author":"Cornford","year":"2024","journal-title":"Eur Urol"},{"issue":"5","key":"10.1016\/j.humpath.2025.106018_bib17","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/pros.24664","article-title":"Diagnosis and management of neuroendocrine prostate cancer","volume":"84","author":"de Kouchkovsky","year":"2024","journal-title":"Prostate"},{"issue":"5","key":"10.1016\/j.humpath.2025.106018_bib18","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/his.13273","article-title":"Atypical intraductal proliferation and intraductal carcinoma of the prostate on core needle biopsy: a comparative clinicopathological and molecular study with a proposal to expand the morphological spectrum of intraductal carcinoma","volume":"71","author":"Shah","year":"2017","journal-title":"Histopathology"},{"key":"10.1016\/j.humpath.2025.106018_bib19","series-title":"Histological typing of urinary bladder tumours","author":"Mostofi","year":"1999"},{"issue":"6","key":"10.1016\/j.humpath.2025.106018_bib20","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1007\/s00428-003-0905-0","article-title":"Reproducibility of the 1998 world health organization\/international society of urologic pathology classification of papillary urothelial neoplasms of the urinary bladder","volume":"443","author":"Yorukoglu","year":"2003","journal-title":"Virchows Arch"},{"issue":"6","key":"10.1016\/j.humpath.2025.106018_bib21","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.eururo.2009.09.022","article-title":"The pathologist's mean grade is constant and individualizes the prognostic value of bladder cancer grading","volume":"57","author":"van Rhijn","year":"2010","journal-title":"Eur Urol"},{"key":"10.1016\/j.humpath.2025.106018_bib22","series-title":"World health organization classification of tumours: pathology and genetics of tumours of the urinary system and male genital organs","author":"Jn","year":"2004"},{"issue":"3","key":"10.1016\/j.humpath.2025.106018_bib23","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3109\/00365598709180320","article-title":"Recurrence, progression and survival in bladder cancer. A retrospective analysis of 232 patients with greater than or equal to 5-year follow-up","volume":"21","author":"Malmstr\u00f6m","year":"1987","journal-title":"Scand J Urol Nephrol"},{"issue":"1","key":"10.1016\/j.humpath.2025.106018_bib24","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/his.15559","article-title":"Grading of bladder cancer: updates, controversies and practic solutions","volume":"88","author":"Downes","year":"2026","journal-title":"Histopathology"},{"key":"10.1016\/j.humpath.2025.106018_bib25","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.humpath.2022.06.005","article-title":"Biological and clinical perspectives of TERT promoter mutation detection on bladder cancer diagnosis and management","volume":"133","author":"Cheng","year":"2023","journal-title":"Hum Pathol"},{"issue":"2","key":"10.1016\/j.humpath.2025.106018_bib26","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jmoldx.2020.11.003","article-title":"A pan-cancer study of somatic TERT promoter mutations and amplification in 30,773 tumors profiled by clinical genomic sequencing","volume":"23","author":"Gupta","year":"2021","journal-title":"J Mol Diagn"},{"issue":"12","key":"10.1016\/j.humpath.2025.106018_bib27","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.1097\/PAS.0000000000002430","article-title":"International Society of Urological Pathology Consensus on Cancer Precursor Lesions. Working Group 1: The Prostate","volume":"49","author":"Iczkowski","year":"2025","journal-title":"Am J Surg Pathol."},{"issue":"5","key":"10.1016\/j.humpath.2025.106018_bib28","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00428-019-02544-6","article-title":"Intraductal carcinoma of the prostate: a critical re-appraisal","volume":"474","author":"Varma","year":"2019","journal-title":"Virchows Arch"},{"issue":"5","key":"10.1016\/j.humpath.2025.106018_bib29","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.euf.2020.10.007","article-title":"Intraductal carcinoma of the prostate: pathogenesis and molecular perspectives","volume":"7","author":"Zong","year":"2021","journal-title":"Eur Urol Focus"},{"key":"10.1016\/j.humpath.2025.106018_bib30","article-title":"Intraductal carcinoma of the prostate: a comprehensive literature review focused on grading challenges and controversies","author":"Grypari","year":"2025","journal-title":"Histol Histopathol"},{"issue":"2","key":"10.1016\/j.humpath.2025.106018_bib31","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/PAS.0000000000000348","article-title":"Utility of PTEN and ERG immunostaining for distinguishing high-grade PIN from intraductal carcinoma of the prostate on needle biopsy","volume":"39","author":"Morais","year":"2015","journal-title":"Am J Surg Pathol"},{"issue":"3","key":"10.1016\/j.humpath.2025.106018_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14030820","article-title":"Intraductal carcinoma of the prostate as a cause of prostate cancer metastasis: a molecular portrait","volume":"14","author":"Pantazopoulos","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"4","key":"10.1016\/j.humpath.2025.106018_bib33","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/modpathol.2012.201","article-title":"Cytoplasmic PTEN protein loss distinguishes intraductal carcinoma of the prostate from high-grade prostatic intraepithelial neoplasia","volume":"26","author":"Lotan","year":"2013","journal-title":"Mod Pathol"},{"issue":"5","key":"10.1016\/j.humpath.2025.106018_bib34","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1097\/PAS.0000000000002376","article-title":"Atypical intraductal proliferation in prostate needle core biopsy: validation as a marker of unsampled adverse pathology in a clinicopathologic series of 142 new patients","volume":"49","author":"Bhattarai","year":"2025","journal-title":"Am J Surg Pathol"},{"issue":"12","key":"10.1016\/j.humpath.2025.106018_bib35","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.1097\/PAS.0000000000002425","article-title":"Genitourinary pathology society of urological pathology white paper on defining indolent prostate cancer","volume":"49","author":"Shah","year":"2025","journal-title":"Am J Surg Pathol"},{"issue":"4","key":"10.1016\/j.humpath.2025.106018_bib36","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1111\/his.15231","article-title":"Proposal for an optimised definition of adverse pathology (unfavourable histology) that predicts metastatic risk in prostatic adenocarcinoma independent of grade group and pathological stage","volume":"85","author":"Nguyen","year":"2024","journal-title":"Histopathology"},{"issue":"2","key":"10.1016\/j.humpath.2025.106018_bib37","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s12022-016-9421-z","article-title":"Neuroendocrine tumors of the prostate: emerging insights from molecular data and updates to the 2016 world health organization classification","volume":"27","author":"Priemer","year":"2016","journal-title":"Endocr Pathol"},{"issue":"3","key":"10.1016\/j.humpath.2025.106018_bib38","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1158\/1078-0432.CCR-24-2061","article-title":"Framework for the pathology workup of metastatic castration-resistant prostate cancer biopsies","volume":"31","author":"Haffner","year":"2025","journal-title":"Clin Cancer Res"},{"issue":"1","key":"10.1016\/j.humpath.2025.106018_bib39","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s12022-025-09871-2","article-title":"Reappraisal of neuroendocrine tumor classification of the prostate gland: translating molecular insights into clinical practice","volume":"36","author":"Lobo","year":"2025","journal-title":"Endocr Pathol"},{"key":"10.1016\/j.humpath.2025.106018_bib40","article-title":"Current and future directions in theranostics for neuroendocrine prostate cancer","volume":"136","author":"Belge","year":"2025","journal-title":"Cancer Treat Rev"},{"issue":"4","key":"10.1016\/j.humpath.2025.106018_bib41","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.euo.2023.10.005","article-title":"Outcomes of biopsy grade group 1 prostate cancer diagnosis in the Danish population","volume":"7","author":"Stroomberg","year":"2024","journal-title":"Eur Urol Oncol"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817725003053?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817725003053?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T15:37:50Z","timestamp":1772725070000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817725003053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":41,"alternative-id":["S0046817725003053"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2025.106018","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Updates in bladder and prostate pathology: Diagnostic consensus and clinical relevance","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2025.106018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106018"}}