{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T12:26:52Z","timestamp":1770121612045,"version":"3.49.0"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100012287","name":"Andrew Sabin Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012287","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007313","name":"The University of Texas MD Anderson Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007313","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.humpath.2025.106026","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T23:51:23Z","timestamp":1766447483000},"page":"106026","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["B72.3 serves as a new diagnostic marker for testicular Leydig cell tumor"],"prefix":"10.1016","volume":"168","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1855-3039","authenticated-orcid":false,"given":"Jianping","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Mi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varsha","family":"Nair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barrett C.","family":"Lawson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles C.","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth M.","family":"Jacobi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingqing","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2025.106026_bib1","series-title":"WHO classification of tumours: urinary and Male genital tumours","year":"2022"},{"key":"10.1016\/j.humpath.2025.106026_bib2","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1016\/j.juro.2009.02.051","article-title":"Leydig cell tumor of the testis","volume":"181","author":"Jou","year":"2009","journal-title":"J Urol"},{"key":"10.1016\/j.humpath.2025.106026_bib3","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/00000478-198503000-00002","article-title":"Leydig cell tumors of the testis. A clinicopathological analysis of 40 cases and review of the literature","volume":"9","author":"Kim","year":"1985","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2025.106026_bib4","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1097\/JU.0000000000000705","article-title":"Risk factors and treatment outcomes of 1,375 patients with testicular Leydig cell tumors: analysis of published case series data","volume":"203","author":"Fankhauser","year":"2020","journal-title":"J Urol"},{"key":"10.1016\/j.humpath.2025.106026_bib5","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1007\/s00345-020-03079-1","article-title":"Leydig-cell tumour of the testis: retrospective analysis of clinical and therapeutic features in 204 cases","volume":"38","author":"Ruf","year":"2020","journal-title":"World J Urol"},{"key":"10.1016\/j.humpath.2025.106026_bib6","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1097\/PAS.0000000000001704","article-title":"Immunohistochemical characterization of 120 testicular sex cord-stromal tumors with an emphasis on the diagnostic utility of SOX9, FOXL2, and SF-1","volume":"45","author":"Lau","year":"2021","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2025.106026_bib7","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/PAS.0b013e31829cdbc6","article-title":"Frequent mutation and nuclear localization of beta-catenin in sertoli cell tumors of the testis","volume":"38","author":"Perrone","year":"2014","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2025.106026_bib8","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1097\/PAS.0000000000000455","article-title":"Nuclear localization of beta-Catenin in sertoli cell tumors and other sex cord-stromal tumors of the testis: an immunohistochemical study of 87 cases","volume":"39","author":"Zhang","year":"2015","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2025.106026_bib9","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/his.15175","article-title":"beta-Catenin alterations in testicular Leydig cell tumour: a immunohistochemical and molecular analysis","volume":"85","author":"Kitagawa","year":"2024","journal-title":"Histopathology"},{"key":"10.1016\/j.humpath.2025.106026_bib10","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1038\/s41379-021-00845-3","article-title":"Comparative molecular analysis of testicular Leydig cell tumors demonstrates distinct subsets of neoplasms with aggressive histopathologic features","volume":"34","author":"Rizzo","year":"2021","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2025.106026_bib11","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/PAP.0000000000000423","article-title":"Contemporary updates on sex cord-stromal tumors of the testis","volume":"31","author":"Acosta","year":"2024","journal-title":"Adv Anat Pathol"},{"key":"10.1016\/j.humpath.2025.106026_bib12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.path.2024.08.009","article-title":"Sex cord stromal tumors of the testis: a review with molecular updates","volume":"18","author":"Colecchia","year":"2025","journal-title":"Surg Pathol Clin"},{"key":"10.1016\/j.humpath.2025.106026_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.modpat.2023.100152","article-title":"Molecular correlates of aggressive behavior and biological progression in testicular sertoli cell tumors","volume":"36","author":"Rizzo","year":"2023","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2025.106026_bib14","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/cyt.13493","article-title":"Performance of the monoclonal antibody B72.3 in diagnosis of malignant carcinomatous serous Effusions-A systematic review and meta-analysis of diagnostic performance","volume":"36","author":"Lin","year":"2025","journal-title":"Cytopathology"},{"key":"10.1016\/j.humpath.2025.106026_bib15","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1089\/hyb.1997.16.53","article-title":"Anti-TAG-72 antibody B72.3--immunological and clinical effects in ovarian carcinoma","volume":"16","author":"Schmolling","year":"1997","journal-title":"Hybridoma"},{"key":"10.1016\/j.humpath.2025.106026_bib16","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3109\/07357908809080650","article-title":"Reactivity of the monoclonal antibody B72.3 with fetal antigen: correlation with expression of TAG-72 in human carcinomas","volume":"6","author":"Stanick","year":"1988","journal-title":"Cancer Invest"},{"key":"10.1016\/j.humpath.2025.106026_bib17","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.prp.2018.10.024","article-title":"The prognostic role of tumor associated glycoprotein 72 (TAG-72) in stage II and III colorectal adenocarcinoma","volume":"215","author":"Cho","year":"2019","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.humpath.2025.106026_bib18","first-page":"1123","article-title":"Expression of tumor-associated glycoprotein-72 (TAG-72) antigen in human prostatic adenocarcinomas","volume":"8","author":"Karan","year":"2001","journal-title":"Oncol Rep"},{"key":"10.1016\/j.humpath.2025.106026_bib19","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.canlet.2006.11.025","article-title":"Expression of TAG-72 in ovarian cancer and its correlation with tumor stage and patient prognosis","volume":"251","author":"Ponnusamy","year":"2007","journal-title":"Cancer Lett"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817725003132?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817725003132?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T01:46:25Z","timestamp":1770083185000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817725003132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":19,"alternative-id":["S0046817725003132"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2025.106026","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"B72.3 serves as a new diagnostic marker for testicular Leydig cell tumor","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2025.106026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106026"}}