{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T09:07:30Z","timestamp":1780045650617,"version":"3.53.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.humpath.2026.106117","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T15:31:08Z","timestamp":1775057468000},"page":"106117","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Mullerian adenosarcoma of the uterus, ovary and peritoneum: Whole transcriptomic digital spatial profiling (DSP) in a cohort of 42 tumors"],"prefix":"10.1016","volume":"173","author":[{"given":"Emanuela","family":"D'Angelo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandra G.","family":"Kingsley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u00f1igo","family":"Espinosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Cipriani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Marotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"Nasr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Zdravkovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke E.","family":"Howitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Prat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2026.106117_bib1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/0046-8177(90)90198-E","article-title":"Mullerian adenosarcoma of the uterus: a clinicopathologic analysis of 100 cases with a review of the literature","volume":"21","author":"Clement","year":"1990","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2026.106117_bib2","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1002\/1097-0142(197904)43:4<1439::AID-CNCR2820430434>3.0.CO;2-A","article-title":"Adenosarcoma of uterus and ovary: a clinicopathologic study of two cases","volume":"43","author":"Valdez","year":"1979","journal-title":"Cancer"},{"key":"10.1016\/j.humpath.2026.106117_bib3","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1097\/PAP.0b013e3181cfe732","article-title":"Mullerian adenosarcoma of the female genital tract","volume":"17","author":"McCluggage","year":"2010","journal-title":"Adv Anat Pathol"},{"key":"10.1016\/j.humpath.2026.106117_bib4","series-title":"Female genital tumours","first-page":"305","year":"2020"},{"key":"10.1016\/j.humpath.2026.106117_bib5","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/path.4675","article-title":"Uterine adenosarcomas are mesenchymal neoplasms","volume":"238","author":"Piscuoglio","year":"2016","journal-title":"J Pathol"},{"key":"10.1016\/j.humpath.2026.106117_bib6","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s13000-019-0909-y","article-title":"Uterine lesions with sex cord-like architectures: a systematic review","volume":"14","author":"Jia","year":"2019","journal-title":"Diagn Pathol"},{"key":"10.1016\/j.humpath.2026.106117_bib7","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1097\/PAS.0b013e318181a80d","article-title":"Mullerian adenosarcoma: a clinicopathologic and immunohistochemical study of 55 cases challenging the existence of adenofibroma","volume":"33","author":"Gallardo","year":"2009","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2026.106117_bib8","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s11912-016-0552-7","article-title":"Uterine adenosarcoma: a review","volume":"18","author":"Nathenson","year":"2016","journal-title":"Curr Oncol Rep"},{"key":"10.1016\/j.humpath.2026.106117_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2024.1393707","article-title":"Prognostic factors in uterine adenosarcoma: subanalysis of the SARCUT study","volume":"14","author":"Mancari","year":"2024","journal-title":"Front Oncol"},{"key":"10.1016\/j.humpath.2026.106117_bib10","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1097\/PAS.0000000000000907","article-title":"High-grade m\u00fcllerian adenosarcoma: genomic and clinicopathologic characterization of a distinct neoplasm with prevalent TP53 pathway alterations and aggressive behavior","volume":"41","author":"Hodgson","year":"2017","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2026.106117_bib11","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1097\/PGP.0000000000000287","article-title":"Involvement of chromosome 8 in M\u00fcllerian adenosarcoma","volume":"36","author":"Howitt","year":"2017","journal-title":"Int J Gynecol Pathol"},{"key":"10.1016\/j.humpath.2026.106117_bib12","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/path.4442","article-title":"Targeted genomic analysis of M\u00fcllerian adenosarcoma","volume":"235","author":"Howitt","year":"2015","journal-title":"J Pathol"},{"key":"10.1016\/j.humpath.2026.106117_bib13","doi-asserted-by":"crossref","first-page":"538","DOI":"10.3389\/fonc.2020.00538","article-title":"Whole-genome sequencing and target validation analysis of m\u00fcllerian adenosarcoma: a tumor with complex but specific genetic alterations","volume":"10","author":"Ban","year":"2020","journal-title":"Front Oncol"},{"key":"10.1016\/j.humpath.2026.106117_bib14","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1038\/s41379-022-01160-1","article-title":"Mullerian adenosarcoma: clinicopathologic and molecular characterization highlighting recurrent BAP1 loss and distinctive features of high-grade tumors","volume":"35","author":"Momeni Boroujeni","year":"2022","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2026.106117_bib15","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41586-021-03634-9","article-title":"Exploring tissue architecture using spatial transcriptomics","volume":"596","author":"Rao","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.humpath.2026.106117_bib16","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/00000478-198901000-00004","article-title":"M\u00fcllerian adenosarcomas of the uterus with sarcomatous overgrowth. A clinicopathological analysis of 10 cases","volume":"13","author":"Clement","year":"1989","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2026.106117_bib17","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ijgo.2008.12.008","article-title":"FIGO staging for uterine sarcomas","volume":"104","author":"Prat","year":"2009","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.humpath.2026.106117_bib18","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1097\/00000478-200210000-00001","article-title":"Mesodermal (m\u00fcllerian) adenosarcoma of the ovary: a clinicopathologic analysis of 40 cases and a review of the literature","volume":"26","author":"Eichhorn","year":"2002","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2026.106117_bib19","doi-asserted-by":"crossref","DOI":"10.1126\/science.abq4964","article-title":"The dawn of spatial omics","volume":"381","author":"Bressan","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.humpath.2026.106117_bib20","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s41379-021-00946-z","article-title":"Atypical uterine polyps show morphologic and molecular overlap with mullerian adenosarcoma but follow a benign clinical course","volume":"35","author":"Chapel","year":"2022","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2026.106117_bib21","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1097\/PAS.0000000000000303","article-title":"Uterine polyps with features overlapping with those of M\u00fcllerian adenosarcoma: a clinicopathologic analysis of 29 cases emphasizing their likely benign nature","volume":"39","author":"Howitt","year":"2015","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2026.106117_bib22","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3389\/fonc.2015.00215","article-title":"Association between CLN3 (Neuronal ceroid lipofuscinosis, CLN3 type) gene expression and clinical characteristics of breast cancer patients","volume":"5","author":"Makoukji","year":"2015","journal-title":"Front Oncol"},{"key":"10.1016\/j.humpath.2026.106117_bib23","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1186\/s12885-024-12213-w","article-title":"ESCO2's oncogenic role in human tumors: a pan-cancer analysis and experimental validation","volume":"24","author":"Huang","year":"2024","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.humpath.2026.106117_bib24","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1158\/0008-5472.CAN-18-1310","article-title":"Histone demethylase KDM4B promotes DNA damage by activating long interspersed nuclear Element-1","volume":"79","author":"Xiang","year":"2019","journal-title":"Cancer Res"},{"key":"10.1016\/j.humpath.2026.106117_bib25","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s10238-023-01281-0","article-title":"RUNX transcription factors: biological functions and implications in cancer","volume":"24","author":"Chen","year":"2024","journal-title":"Clin Exp Med"},{"key":"10.1016\/j.humpath.2026.106117_bib26","doi-asserted-by":"crossref","first-page":"5212","DOI":"10.1038\/ncomms6212","article-title":"Lin28\/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1","volume":"5","author":"Ma","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.humpath.2026.106117_bib27","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1755-148X.2010.00781.x","article-title":"Quantitative expression profiling of G-protein-coupled receptors (GPCRs) in metastatic melanoma: the constitutively active orphan GPCR GPR18 as novel drug target","volume":"24","author":"Qin","year":"2011","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.humpath.2026.106117_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2023.216225","article-title":"Regulatory network and targeted interventions for CCDC family in tumor pathogenesis","volume":"565","author":"Liu","year":"2023","journal-title":"Cancer Lett"},{"key":"10.1016\/j.humpath.2026.106117_bib29","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1093\/carcin\/bgu065","article-title":"Inhibition of KIF22 suppresses cancer cell proliferation by delaying mitotic exit through upregulating CDC25C expression","volume":"35","author":"Yu","year":"2014","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.humpath.2026.106117_bib30","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.canlet.2011.12.038","article-title":"Base excision repair and cancer","volume":"327","author":"Wallace","year":"2012","journal-title":"Cancer Lett"},{"key":"10.1016\/j.humpath.2026.106117_bib31","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.1021\/bi100593a","article-title":"Detection of damaged DNA bases by DNA glycosylase enzymes","volume":"49","author":"Friedman","year":"2010","journal-title":"Biochemistry"},{"key":"10.1016\/j.humpath.2026.106117_bib32","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1089\/ars.2012.4938","article-title":"New insights into the link between DNA damage and apoptosis","volume":"19","author":"De Zio","year":"2013","journal-title":"Antioxidants Redox Signal"},{"key":"10.1016\/j.humpath.2026.106117_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11030287","article-title":"Implication of voltage-gated potassium channels in neoplastic cell proliferation","volume":"11","author":"Serrano-Novillo","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.humpath.2026.106117_bib34","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/d41586-024-00240-3","article-title":"How cancer hijacks the nervous system to grow and spread","volume":"626","author":"Prillaman","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.humpath.2026.106117_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/cells12151996","article-title":"Unveiling the neural environment in cancer: exploring the role of neural circuit players and potential therapeutic strategies","volume":"12","author":"Nguyen","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.humpath.2026.106117_bib36","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1515\/mr-2021-0028","article-title":"Extracellular matrix in cancer progression and therapy","volume":"2","author":"He","year":"2022","journal-title":"Mediev Rev"},{"key":"10.1016\/j.humpath.2026.106117_bib37","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41379-018-0132-5","article-title":"DICER1 mutations are frequent in m\u00fcllerian adenosarcomas and are independent of rhabdomyosarcomatous differentiation","volume":"32","author":"Bean","year":"2019","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2026.106117_bib38","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1038\/modpathol.2016.99","article-title":"Genomewide copy number analysis of M\u00fcllerian adenosarcoma identified chromosomal instability in the aggressive subgroup","volume":"29","author":"Lee","year":"2016","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humpath.2026.106117_bib39","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.semcancer.2021.07.003","article-title":"Clinical interpretation of whole-genome and whole-transcriptome sequencing for precision oncology","volume":"84","author":"Jobanputra","year":"2022","journal-title":"Semin Cancer Biol"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817726000869?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817726000869?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T08:23:08Z","timestamp":1780042988000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817726000869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":39,"alternative-id":["S0046817726000869"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2026.106117","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mullerian adenosarcoma of the uterus, ovary and peritoneum: Whole transcriptomic digital spatial profiling (DSP) in a cohort of 42 tumors","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2026.106117","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106117"}}