{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:34:35Z","timestamp":1790422475971,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.humpath.2026.106192","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:24:37Z","timestamp":1781105077000},"page":"106192","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["GPNMB immunohistochemistry distinguishes diagnostically challenging cases of lymphangioleiomyomatosis from other mesenchymal neoplasms presenting with cystic lung metastases"],"prefix":"10.1016","volume":"176","author":[{"given":"Selina F.","family":"Ji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E.","family":"Law","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian C.","family":"Dawley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Manchen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmeen M.","family":"Butt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxwell L.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry D.","family":"Tazelaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0472-6947","authenticated-orcid":false,"given":"Brandon T.","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2026.106192_bib1","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1097\/PAS.0b013e318235edbd","article-title":"Prevalence of uterine and adnexal involvement in pulmonary lymphangioleiomyomatosis: a clinicopathologic study of 10 patients","volume":"35","author":"Hayashi","year":"2011","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2026.106192_bib2","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1164\/rccm.201709-1965ST","article-title":"Lymphangioleiomyomatosis diagnosis and management: high-resolution chest computed tomography, transbronchial lung biopsy, and pleural disease management. An official American thoracic society\/Japanese Respiratory Society Clinical Practice Guideline","volume":"196","author":"Gupta","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.humpath.2026.106192_bib3","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1186\/1477-7819-11-279","article-title":"Benign metastasizing leiomyoma of the lung","volume":"11","author":"Ki","year":"2013","journal-title":"World J Surg Oncol"},{"key":"10.1016\/j.humpath.2026.106192_bib4","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1259\/bjr\/33935946","article-title":"Pulmonary benign metastasising leiomyomas presenting as fluid-containing masses on CT in a patient with two unrelated malignancies","volume":"78","author":"Osadchy","year":"2005","journal-title":"Br J Radiol"},{"key":"10.1016\/j.humpath.2026.106192_bib5","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1055\/s-0033-1345266","article-title":"Benign metastasizing leiomyoma of the lung with spontaneous pneumothorax","volume":"2","author":"Okabe","year":"2013","journal-title":"Thorac Cardiovasc Surg Rep"},{"key":"10.1016\/j.humpath.2026.106192_bib6","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3109\/10520295.2011.591834","article-title":"Metastatic endometrial stromal sarcoma of the lung: importance of immunohistochemical staining, clinical history and imaging studies","volume":"87","author":"Mentrikoski","year":"2012","journal-title":"Biotech Histochem"},{"key":"10.1016\/j.humpath.2026.106192_bib7","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/00000478-200204000-00005","article-title":"Endometrial stromal sarcoma metastatic to the lung: a detailed analysis of 16 patients","volume":"26","author":"Aubry","year":"2002","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2026.106192_bib8","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/00000478-198902000-00006","article-title":"Pulmonary metastases in patients with low-grade endometrial stromal sarcoma. Clinicopathologic findings with immunohistochemical characterization","volume":"13","author":"Abrams","year":"1989","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2026.106192_bib9","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1016\/j.humpath.2013.07.022","article-title":"Association of D2-40 and MMP-1 expression with cyst formation in lung metastatic lesions of cutaneous angiosarcoma on the scalp: immunohistochemical analysis of 23 autopsy cases","volume":"44","author":"Masuzawa","year":"2013","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2026.106192_bib10","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.2214\/ajr.180.6.1801671","article-title":"Metastatic angiosarcoma of the lung: spectrum of CT findings","volume":"180","author":"Tateishi","year":"2003","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.humpath.2026.106192_bib11","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1177\/0284185115571789","article-title":"Pulmonary metastases from angiosarcoma: a spectrum of CT findings","volume":"57","author":"Yogi","year":"2016","journal-title":"Acta Radiol"},{"key":"10.1016\/j.humpath.2026.106192_bib12","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1097\/00000478-199708000-00015","article-title":"Metastasizing dermatofibroma","volume":"21","author":"Colby","year":"1997","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2026.106192_bib13","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.anndiagpath.2005.12.001","article-title":"Metastasizing dermatofibroma in lung","volume":"11","author":"Gu","year":"2007","journal-title":"Ann Diagn Pathol"},{"key":"10.1016\/j.humpath.2026.106192_bib14","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1097\/00000478-199611000-00007","article-title":"Metastasizing cellular dermatofibroma. A report of two cases","volume":"20","author":"Colome-Grimmer","year":"1996","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2026.106192_bib15","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S0025-6196(12)65014-9","article-title":"Multiple cystic fibrohistiocytic tumors of the lung: report of two cases","volume":"65","author":"Joseph","year":"1990","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.humpath.2026.106192_bib16","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1097\/PAS.0b013e31827070d4","article-title":"Metastasizing \"benign\" cutaneous fibrous histiocytoma: a clinicopathologic analysis of 16 cases","volume":"37","author":"Doyle","year":"2013","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2026.106192_bib17","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1097\/PAI.0000000000000968","article-title":"Cathepsin K is superior to HMB45 for the diagnosis of pulmonary lymphangioleiomyomatosis","volume":"30","author":"Rolim","year":"2022","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"10.1016\/j.humpath.2026.106192_bib18","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1097\/00000478-199311000-00002","article-title":"Transbronchial biopsy in lymphangiomyomatosis of the lung. HMB45 for diagnosis","volume":"17","author":"Bonetti","year":"1993","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.humpath.2026.106192_bib19","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1053\/hupa.2000.18500","article-title":"Extrapulmonary lymphangioleiomyomatosis (LAM): clinicopathologic features in 22 cases","volume":"31","author":"Matsui","year":"2000","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2026.106192_bib20","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1309\/AJCPDTRTO2Z4UEXD","article-title":"A broad survey of cathepsin K immunoreactivity in human neoplasms","volume":"139","author":"Zheng","year":"2013","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.humpath.2026.106192_bib21","doi-asserted-by":"crossref","first-page":"109","DOI":"10.4103\/0973-1482.63548","article-title":"PEComa of the lung","volume":"6","author":"Vijayabhaskar","year":"2010","journal-title":"J Cancer Res Therapeut"},{"key":"10.1016\/j.humpath.2026.106192_bib22","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00428-018-2325-1","article-title":"Cathepsin K expression in clear cell \"sugar\" tumor (PEComa) of the lung","volume":"473","author":"Calio","year":"2018","journal-title":"Virchows Arch"},{"key":"10.1016\/j.humpath.2026.106192_bib23","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.steroids.2017.10.013","article-title":"Glycoprotein non-metastatic melanoma protein B (GPNMB) and cancer: a novel potential therapeutic target","volume":"133","author":"Taya","year":"2018","journal-title":"Steroids"},{"key":"10.1016\/j.humpath.2026.106192_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.humpath.2025.105799","article-title":"Unlocking diagnostic potential: a retrospective analysis of GPNMB immunohistochemistry in nearly 1000 surgical pathology specimens","volume":"159","author":"Li","year":"2025","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humpath.2026.106192_bib25","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1111\/his.70026","article-title":"GPNMB immunohistochemistry is a useful ancillary tool for the diagnosis of pulmonary lymphangioleiomyomatosis","volume":"88","author":"Szalai","year":"2026","journal-title":"Histopathology"},{"key":"10.1016\/j.humpath.2026.106192_bib26","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1016\/j.ajpath.2017.04.014","article-title":"Cathepsin K in lymphangioleiomyomatosis: LAM cell-fibroblast interactions enhance protease activity by extracellular acidification","volume":"187","author":"Dongre","year":"2017","journal-title":"Am J Pathol"},{"key":"10.1016\/j.humpath.2026.106192_bib27","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1002\/cncr.31892","article-title":"A phase 2 study of glembatumumab vedotin, an antibody-drug conjugate targeting glycoprotein NMB, in patients with advanced melanoma","volume":"125","author":"Ott","year":"2019","journal-title":"Cancer"},{"key":"10.1016\/j.humpath.2026.106192_bib28","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.pharmthera.2017.05.010","article-title":"Targeting GPNMB with glembatumumab vedotin: current developments and future opportunities for the treatment of cancer","volume":"179","author":"Rose","year":"2017","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.humpath.2026.106192_bib29","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1200\/JCO.2014.56.2959","article-title":"EMERGE: a randomized phase II study of the antibody-drug conjugate Glembatumumab Vedotin in advanced glycoprotein NMB-expressing breast cancer","volume":"33","author":"Yardley","year":"2015","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.humpath.2026.106192_bib30","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1530\/ERC-15-0505","article-title":"Estrogen maintains myometrial tumors in a lymphangioleiomyomatosis model","volume":"23","author":"Prizant","year":"2016","journal-title":"Endocr Relat Cancer"},{"key":"10.1016\/j.humpath.2026.106192_bib31","doi-asserted-by":"crossref","DOI":"10.1530\/ERC-23-0312","article-title":"Glycoprotein non-metastatic melanoma protein B promotes tumor growth and is a biomarker for lymphangioleiomyomatosis","volume":"31","author":"Gibbons","year":"2024","journal-title":"Endocr Relat Cancer"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817726001619?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817726001619?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T08:39:31Z","timestamp":1788770371000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817726001619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":31,"alternative-id":["S0046817726001619"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2026.106192","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"GPNMB immunohistochemistry distinguishes diagnostically challenging cases of lymphangioleiomyomatosis from other mesenchymal neoplasms presenting with cystic lung metastases","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2026.106192","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106192"}}