{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T02:24:59Z","timestamp":1794018299263,"version":"4.8.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007234","name":"University of Chicago","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007234","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006537","name":"Vanderbilt University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006691","name":"Harvard Medical School","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007313","name":"University of Texas MD Anderson Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007313","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005294","name":"Massachusetts General Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005294","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018091","name":"School of Medicine, University of New Mexico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018091","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007914","name":"University of Texas Southwestern Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007914","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006668","name":"Oregon Health and Science University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007184","name":"Yale School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007184","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002345","name":"Eberhard Karls Universit\u00e4t T\u00fcbingen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002345","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006920","name":"University of Pennsylvania","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006920","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.humpath.2026.106204","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T06:43:52Z","timestamp":1781851432000},"page":"106204","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Evaluation of prognostic factors and outcomes in primary versus secondary myeloid sarcoma"],"prefix":"10.1016","volume":"177","author":[{"given":"Christine W.","family":"Kahlow","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Germans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximiliano","family":"Ramia de Cap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Bagg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Hurwitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Arber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Hermina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falko","family":"Fend","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Nann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weina","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel D.","family":"Cantu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne","family":"Tam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos R.","family":"Bueso-Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Kanagal-Shamanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp W.","family":"Raess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexa","family":"Siddon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy I.","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Foucar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P.","family":"Hasserjian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga K.","family":"Weinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"20","key":"10.1016\/j.humpath.2026.106204_bib1","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1182\/blood-2016-03-643544","article-title":"The 2016 revision to the world health organization classification of myeloid neoplasms and acute leukemia","volume":"127","author":"Arber","year":"2016","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.humpath.2026.106204_bib2","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1182\/blood.2022015850","article-title":"International consensus classification of myeloid neoplasms and acute leukemias: integrating morphologic, clinical, and genomic data","volume":"140","author":"Arber","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.humpath.2026.106204_bib3","series-title":"Hematolymphoid tumors, PART A, WHO classification of tumors","first-page":"958","volume":"vol. 11","author":"Khoury","year":"2024"},{"issue":"5","key":"10.1016\/j.humpath.2026.106204_bib4","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1080\/10428194.2023.2185091","article-title":"Myeloid sarcoma with NPM1 mutation may be clinically and genetically distinct from AML with NPM1 mutation: a study from the Bone marrow pathology group","volume":"64","author":"Ramia de Cap","year":"2023","journal-title":"Leuk Lymphoma"},{"issue":"3","key":"10.1016\/j.humpath.2026.106204_bib5","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/bjh.17742","article-title":"De novo isolated myeloid sarcoma: comparative analysis of survival in 19 consecutive cases","volume":"195","author":"Begna","year":"2021","journal-title":"Br J Haematol"},{"issue":"14","key":"10.1016\/j.humpath.2026.106204_bib6","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.1080\/10428194.2021.1961235","article-title":"Clinical and molecular characterization of myeloid sarcoma without medullary leukemia","volume":"62","author":"Abbas","year":"2021","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.humpath.2026.106204_bib7","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.humpath.2020.11.005","article-title":"Genomic analysis in myeloid sarcoma and comparison with paired acute myeloid leukemia","volume":"108","author":"Greenland","year":"2021","journal-title":"Hum Pathol"},{"issue":"6","key":"10.1016\/j.humpath.2026.106204_bib8","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1002\/cncr.23691","article-title":"Myeloid sarcoma is associated with superior event-free survival and overall survival compared with acute myeloid leukemia","volume":"113","author":"Tsimberidou","year":"2008","journal-title":"Cancer"},{"issue":"21","key":"10.1016\/j.humpath.2026.106204_bib9","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1182\/blood.V116.21.2165.2165","article-title":"Outcomes in acute myeloid leukemia (AML) patients diagnosed with myeloid sarcoma with and without bone marrow involvement","volume":"116","author":"Pharm","year":"2010","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.humpath.2026.106204_bib10","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/hon.994","article-title":"Clinical implications of acute myeloid leukemia presenting as myeloid sarcoma","volume":"30","author":"Avni","year":"2012","journal-title":"Hematol Oncol"},{"issue":"S1","key":"10.1016\/j.humpath.2026.106204_bib11","doi-asserted-by":"crossref","first-page":"4248","DOI":"10.1182\/blood-2024-205329","article-title":"Survival outcomes of patients diagnosed with myeloid sarcoma versus acute myeloid leukemia: a retrospective cohort study","volume":"144","author":"Batah","year":"2024","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.humpath.2026.106204_bib12","doi-asserted-by":"crossref","first-page":"6752","DOI":"10.1038\/s41598-022-10831-7","article-title":"Clinical characteristics, treatment, and prognosis of 118 cases of myeloid sarcoma","volume":"12","author":"Zhao","year":"2022","journal-title":"Sci Rep"},{"issue":"7","key":"10.1016\/j.humpath.2026.106204_bib13","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/ajh.23211","article-title":"Acute myeloid leukemia with myelodysplasia-related changes are characterized by a specific molecular pattern with high frequency of ASXL1 mutations","volume":"87","author":"Devillier","year":"2012","journal-title":"Am J Hematol"},{"issue":"9","key":"10.1016\/j.humpath.2026.106204_bib14","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1182\/blood-2014-11-610543","article-title":"Acute myeloid leukemia ontogeny is defined by distinct somatic mutations","volume":"125","author":"Lindsley","year":"2015","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.humpath.2026.106204_bib15","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1002\/ajh.25769","article-title":"Outcomes of acute myeloid leukemia with myelodysplasia related changes depend on diagnostic criteria and therapy","volume":"95","author":"Montalban-Bravo","year":"2020","journal-title":"Am J Hematol"},{"key":"10.1016\/j.humpath.2026.106204_bib16","series-title":"Leukemia [internet]","article-title":"Secondary acute myeloid leukemia: pathogenesis and treatment","author":"Capelli","year":"2022"},{"issue":"2","key":"10.1016\/j.humpath.2026.106204_bib17","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/sj.leu.2404491","article-title":"Myeloid sarcoma: clinico-pathologic, phenotypic and cytogenetic analysis of 92 adult patients","volume":"21","author":"Pileri","year":"2007","journal-title":"Leukemia"},{"issue":"10","key":"10.1016\/j.humpath.2026.106204_bib18","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1038\/leu.2015.81","article-title":"Next-generation sequencing reveals clinically actionable molecular markers in myeloid sarcoma","volume":"29","author":"Li","year":"2015","journal-title":"Leukemia"},{"issue":"1","key":"10.1016\/j.humpath.2026.106204_bib19","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/s13148-024-01771-2","article-title":"TET2 mutation in acute myeloid leukemia: biology, clinical significance, and therapeutic insights","volume":"16","author":"Gao","year":"2024","journal-title":"Clin Epigenetics"},{"issue":"17","key":"10.1016\/j.humpath.2026.106204_bib20","doi-asserted-by":"crossref","first-page":"4509","DOI":"10.1182\/blood-2010-12-325241","article-title":"Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies","volume":"118","author":"Li","year":"2011","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.humpath.2026.106204_bib21","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s10238-024-01297-0","article-title":"TET2 mutations contribute to adverse prognosis in acute myeloid leukemia (AML): results from a comprehensive analysis of 502 AML cases and the beat AML public database","volume":"24","author":"Pan","year":"2024","journal-title":"Clin Exp Med"},{"issue":"12","key":"10.1016\/j.humpath.2026.106204_bib22","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1038\/s41375-022-01734-7","article-title":"SF3B1 mutations in AML are strongly associated with MECOM rearrangements and may be indicative of an MDS pre-phase","volume":"36","author":"Huber","year":"2022","journal-title":"Leukemia"},{"key":"10.1016\/j.humpath.2026.106204_bib23","article-title":"SF3B1 mutations in myelodysplastic syndromes: a potential therapeutic target for modulating the entire disease process","volume":"13","author":"Jiang","year":"2023","journal-title":"Front Oncol"},{"issue":"5","key":"10.1016\/j.humpath.2026.106204_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/2056-4538.70044","article-title":"Myeloid sarcoma shows a high frequency of mutations activating the MAPK\/ERK pathway and association with clonal hematopoiesis","volume":"11","author":"Nann","year":"2025","journal-title":"J Pathol Clin Res"},{"issue":"4","key":"10.1016\/j.humpath.2026.106204_bib25","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1007\/s11864-023-01063-6","article-title":"Gene mutations and targeted therapies of myeloid sarcoma","volume":"24","author":"Fu","year":"2023","journal-title":"Curr Treat Options Oncol"},{"issue":"1","key":"10.1016\/j.humpath.2026.106204_bib26","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s44313-024-00044-4","article-title":"Acute myeloid leukemia and myelodysplastic neoplasms: clinical implications of myelodysplasia-related genes mutations and TP53 aberrations","volume":"59","author":"Kim","year":"2024","journal-title":"Blood Res"},{"issue":"4","key":"10.1016\/j.humpath.2026.106204_bib27","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.3390\/cancers15041177","article-title":"NPM 1 mutations in AML-the landscape in 2023","volume":"15","author":"Sharma","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"6","key":"10.1016\/j.humpath.2026.106204_bib28","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1080\/1042819031000067503","article-title":"Prognostic implications of the presence of FLT3 mutations in patients with acute myeloid leukemia","volume":"44","author":"Kottaridis","year":"2003","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.humpath.2026.106204_bib29","article-title":"FLT3-TKD in the prognosis of patients with acute myeloid leukemia: a meta-analysis","volume":"13","author":"Li","year":"2023","journal-title":"Front Oncol"},{"issue":"21","key":"10.1016\/j.humpath.2026.106204_bib30","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1182\/blood.2024025409","article-title":"Genetic risk classification for adults with AML receiving less-intensive therapies: the 2024 ELN recommendations","volume":"144","author":"D\u00f6hner","year":"2024","journal-title":"Blood"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817726001735?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817726001735?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T01:43:23Z","timestamp":1794015803000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817726001735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":30,"alternative-id":["S0046817726001735"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2026.106204","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of prognostic factors and outcomes in primary versus secondary myeloid sarcoma","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2026.106204","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106204"}}