{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:04:49Z","timestamp":1789963489835,"version":"4.0.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Pathology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.humpath.2026.106265","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T14:54:38Z","timestamp":1789397678000},"page":"106265","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Enteric glial cell remodeling at diagnosis is associated with reduced mucosal inflammation at follow-up in pediatric ulcerative colitis"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5844-4101","authenticated-orcid":false,"given":"Harry J.","family":"Rosenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongfang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riti S.","family":"Bhalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phinnara","family":"Has","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael I.","family":"Herzlinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason M.","family":"Shapiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murray B.","family":"Resnick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humpath.2026.106265_bib1","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1152\/physrev.00018.2022","article-title":"The enteric nervous system","volume":"103","author":"Sharkey","year":"2023","journal-title":"Physiol Rev"},{"key":"10.1016\/j.humpath.2026.106265_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.102863","article-title":"Enteric glia in homeostasis and disease: from fundamental biology to human pathology","volume":"24","author":"Rosenberg","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.humpath.2026.106265_bib3","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.97144.3","article-title":"Enteric glia regulate Paneth cell secretion and intestinal microbial ecology","volume":"13","author":"Prochera","year":"2025","journal-title":"eLife"},{"key":"10.1016\/j.humpath.2026.106265_bib4","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1053\/j.gastro.2024.12.011","article-title":"Human enteric glia diversity in health and disease: new avenues for the treatment of Hirschsprung disease","volume":"168","author":"Windster","year":"2025","journal-title":"Gastroenterology"},{"key":"10.1016\/j.humpath.2026.106265_bib5","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a041368","article-title":"Enteric glia","volume":"17","author":"Rao","year":"2025","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.humpath.2026.106265_bib6","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1053\/j.gastro.2017.07.002","article-title":"Enteric glia regulate gastrointestinal motility but are not required for maintenance of the epithelium in mice","volume":"153","author":"Rao","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.humpath.2026.106265_bib7","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1113\/JP273492","article-title":"Enteric glial activity regulates secretomotor function in the mouse colon but does not acutely affect gut permeability","volume":"595","author":"Grubi\u0161i\u0107","year":"2017","journal-title":"J Physiol"},{"key":"10.1016\/j.humpath.2026.106265_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2023.1228938","article-title":"Guardians of the gut: influence of the enteric nervous system on the intestinal epithelial barrier","volume":"10","author":"Bubeck","year":"2023","journal-title":"Front Med"},{"key":"10.1016\/j.humpath.2026.106265_bib9","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1002\/ueg2.12317","article-title":"Implications of the changing epidemiology of inflammatory bowel disease in a changing world","volume":"10","author":"Agrawal","year":"2022","journal-title":"United European Gastroenterol J"},{"key":"10.1016\/j.humpath.2026.106265_bib10","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/s41575-025-01097-1","article-title":"The global burden of inflammatory bowel disease: from 2025 to 2045","volume":"22","author":"Kaplan","year":"2025","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.humpath.2026.106265_bib11","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/S2468-1253(24)00355-8","article-title":"Overcoming the challenges of overtreating and undertreating inflammatory bowel disease","volume":"10","author":"Temido","year":"2025","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.humpath.2026.106265_bib12","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1093\/ibd\/izae084","article-title":"Challenges in IBD research 2024: precision medicine","volume":"30","author":"Syed","year":"2024","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.humpath.2026.106265_bib13","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/glia.10169","article-title":"Role of enteric glial cells in inflammatory bowel disease","volume":"41","author":"Cabarrocas","year":"2003","journal-title":"Glia"},{"key":"10.1016\/j.humpath.2026.106265_bib14","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1177\/0394632015599707","article-title":"Enteric glia: a new player in inflammatory bowel diseases","volume":"28","author":"Capoccia","year":"2015","journal-title":"Int J Immunopathol Pharmacol"},{"key":"10.1016\/j.humpath.2026.106265_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2023.137315","article-title":"Enteric glia at center stage of inflammatory bowel disease","volume":"809","author":"Le Berre","year":"2023","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.humpath.2026.106265_bib16","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3390\/cells11030335","article-title":"Increased numbers of enteric glial cells in the Peyer's patches and enhanced intestinal permeability by glial cell mediators in patients with ileal Crohn's disease","volume":"11","author":"Biskou","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.humpath.2026.106265_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2024.105789","article-title":"Inhibiting the activation of enteric glial cells alleviates intestinal inflammation and comorbid anxiety-and depressive-like behaviors in the ulcerative colitis mice","volume":"178","author":"Li","year":"2024","journal-title":"Neurochem Int"},{"key":"10.1016\/j.humpath.2026.106265_bib18","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.apsb.2019.08.006","article-title":"Protective role of berberine on ulcerative colitis through modulating enteric glial cells\u2013intestinal epithelial cells\u2013immune cells interactions","volume":"10","author":"Li","year":"2020","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.humpath.2026.106265_bib19","doi-asserted-by":"crossref","first-page":"28242","DOI":"10.1021\/acsnano.5c05032","article-title":"A colon-targeted oral nanosystem disrupts the inflammatory loop in enteric glia to alleviate ulcerative colitis","volume":"19","author":"Zhang","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.humpath.2026.106265_bib20","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1056\/NEJM198712243172603","article-title":"Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis","volume":"317","author":"Schroeder","year":"1987","journal-title":"N Engl J Med"},{"key":"10.1016\/j.humpath.2026.106265_bib21","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1136\/gut.47.3.404","article-title":"A reproducible grading scale for histological assessment of inflammation in ulcerative colitis","volume":"47","author":"Geboes","year":"2000","journal-title":"Gut"},{"key":"10.1016\/j.humpath.2026.106265_bib22","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1136\/gutjnl-2015-310187","article-title":"Development and validation of the Nancy histological index for UC","volume":"66","author":"Marchal-Bressenot","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.humpath.2026.106265_bib23","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/bs.acc.2018.07.005","article-title":"Fecal calprotectin","volume":"87","author":"Ayling","year":"2018","journal-title":"Adv Clin Chem"},{"key":"10.1016\/j.humpath.2026.106265_bib24","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1093\/ibd\/izad119","article-title":"Histological disease activity as predictor of clinical relapse, hospitalization, and surgery in inflammatory bowel disease: systematic review and meta-analysis","volume":"30","author":"Shehab","year":"2024","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.humpath.2026.106265_bib25","doi-asserted-by":"crossref","DOI":"10.1093\/ecco-jcc\/jjag074","article-title":"Histological activity predicts relapse in pediatric ulcerative colitis despite mucosal healing: a multicenter study from the pediatric IBD Porto group of ESPGHAN","volume":"20","author":"Trivi\u0107 Ma\u017eurani\u0107","year":"2026","journal-title":"J Crohns Colitis"},{"key":"10.1016\/j.humpath.2026.106265_bib26","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1053\/j.gastro.2007.01.051","article-title":"Enteric glia regulate intestinal barrier function and inflammation via release of S-nitrosoglutathione","volume":"132","author":"Savidge","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.humpath.2026.106265_bib27","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1136\/gut.2010.229237","article-title":"Enteric glia protect against Shigella flexneri invasion in intestinal epithelial cells: a role for S-nitrosoglutathione","volume":"60","author":"Flamant","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.humpath.2026.106265_bib28","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1053\/j.gastro.2015.09.038","article-title":"Defects in 15-HETE production and control of epithelial permeability by human enteric glial cells from patients with Crohn's disease","volume":"150","author":"Pochard","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.humpath.2026.106265_bib29","doi-asserted-by":"crossref","DOI":"10.1093\/ecco-jcc\/jjae190.0260","article-title":"P0086 the role of enteric glial cells in patients with ulcerative colitis","volume":"19","author":"Miyazaki","year":"2025","journal-title":"J Crohns Colitis"},{"key":"10.1016\/j.humpath.2026.106265_bib30","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1111\/apt.16248","article-title":"An expert consensus to standardise the assessment of histological disease activity in Crohn's disease clinical trials","volume":"53","author":"Almradi","year":"2021","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.humpath.2026.106265_bib31","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1093\/ecco-jcc\/jjac006","article-title":"ECCO position on harmonisation of Crohn's disease mucosal histopathology","volume":"16","author":"Magro","year":"2022","journal-title":"J Crohns Colitis"},{"key":"10.1016\/j.humpath.2026.106265_bib32","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.neuron.2008.10.013","article-title":"The mystery and magic of glia: a perspective on their roles in health and disease","volume":"60","author":"Barres","year":"2008","journal-title":"Neuron"}],"container-title":["Human Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817726002340?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0046817726002340?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T03:45:56Z","timestamp":1789962356000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0046817726002340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":32,"alternative-id":["S0046817726002340"],"URL":"https:\/\/doi.org\/10.1016\/j.humpath.2026.106265","relation":{},"ISSN":["0046-8177"],"issn-type":[{"value":"0046-8177","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enteric glial cell remodeling at diagnosis is associated with reduced mucosal inflammation at follow-up in pediatric ulcerative colitis","name":"articletitle","label":"Article Title"},{"value":"Human Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humpath.2026.106265","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106265"}}