{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T08:38:44Z","timestamp":1789029524278,"version":"build-2803163510"},"reference-count":111,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunology and Allergy Clinics of North America"],"published-print":{"date-parts":[[2007,8]]},"DOI":"10.1016\/j.iac.2007.07.007","type":"journal-article","created":{"date-parts":[[2007,9,15]],"date-time":"2007-09-15T11:23:54Z","timestamp":1189855434000},"page":"333-355","source":"Crossref","is-referenced-by-count":53,"title":["Clinical Overview of Hypereosinophilic Syndromes"],"prefix":"10.1016","volume":"27","author":[{"given":"Javed","family":"Sheikh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter F.","family":"Weller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.iac.2007.07.007_bib1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/00062752-200001000-00005","article-title":"Hypereosinophilia","volume":"7","author":"Bain","year":"2000","journal-title":"Curr Opin Hematol"},{"key":"10.1016\/j.iac.2007.07.007_bib2","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1146\/annurev.med.54.101601.152431","article-title":"The hypereosinophilic syndrome revisited","volume":"54","author":"Roufosse","year":"2003","journal-title":"Annu Rev Med"},{"issue":"10","key":"10.1016\/j.iac.2007.07.007_bib3","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1182\/blood.V83.10.2759.2759","article-title":"The idiopathic hypereosinophilic syndrome","volume":"83","author":"Weller","year":"1994","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.iac.2007.07.007_bib4","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.jaci.2006.02.042","article-title":"Approaches to the treatment of hypereosinophilic syndromes: a workshop summary report","volume":"117","author":"Klion","year":"2006","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"10.1016\/j.iac.2007.07.007_bib5","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1055\/s-2006-939519","article-title":"Hypereosinophilic syndrome: lymphoproliferative and myeloproliferative variants","volume":"27","author":"Roufosse","year":"2006","journal-title":"Semin Respir Crit Care Med"},{"key":"10.1016\/j.iac.2007.07.007_bib6","series-title":"Eosinophils. A comprehensive review and guide to the scientific and medical literature","author":"Spry","year":"1988"},{"issue":"6","key":"10.1016\/j.iac.2007.07.007_bib7","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.7326\/0003-4819-68-6-1220","article-title":"The hypereosinophilic syndromes","volume":"68","author":"Hardy","year":"1968","journal-title":"Ann Intern Med"},{"issue":"1","key":"10.1016\/j.iac.2007.07.007_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00005792-197501000-00001","article-title":"The hypereosinophilic syndrome: analysis of fourteen cases with review of the literature","volume":"54","author":"Chusid","year":"1975","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"10.1016\/j.iac.2007.07.007_bib9","doi-asserted-by":"crossref","first-page":"78","DOI":"10.7326\/0003-4819-97-1-78","article-title":"NIH conference. The idiopathic hypereosinophilic syndrome. Clinical, pathophysiologic, and therapeutic considerations","volume":"97","author":"Fauci","year":"1982","journal-title":"Ann Intern Med"},{"issue":"1","key":"10.1016\/j.iac.2007.07.007_bib10","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jpeds.2004.09.014","article-title":"Pediatric hypereosinophilic syndrome (HES) differs from adult HES","volume":"146","author":"Katz","year":"2005","journal-title":"J Pediatr"},{"issue":"12","key":"10.1016\/j.iac.2007.07.007_bib11","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1097\/01.mph.0000193467.06938.77","article-title":"Idiopathic hypereosinophilic syndrome in children: report of a 7-year-old boy with FIP1L1-PDGFRA rearrangement","volume":"27","author":"Rives","year":"2005","journal-title":"J Pediatr Hematol Oncol"},{"issue":"3","key":"10.1016\/j.iac.2007.07.007_bib12","first-page":"423","article-title":"Studies on blood eosinophils. II. Patients with Loffler's cardiomyopathy","volume":"24","author":"Spry","year":"1976","journal-title":"Clin Exp Immunol"},{"issue":"3","key":"10.1016\/j.iac.2007.07.007_bib13","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1182\/blood.V71.3.780.780","article-title":"Ultrastructural study of eosinophils from patients with the hypereosinophilic syndrome: a morphological basis of hypodense eosinophils","volume":"71","author":"Peters","year":"1988","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.iac.2007.07.007_bib14","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1159\/000205732","article-title":"Hypereosinophilic syndrome: case report and morphometric study","volume":"79","author":"Sokol","year":"1988","journal-title":"Acta Haematol"},{"key":"10.1016\/j.iac.2007.07.007_bib15","series-title":"Blood cell biochemistry: megakaryocytes, platelets, macrophages and eosinophils","first-page":"237","article-title":"Subcellular morphology and biochemistry of eosinophils","author":"Dvorak","year":"1990"},{"key":"10.1016\/j.iac.2007.07.007_bib16","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1182\/blood.V24.4.372.372","article-title":"Eosinophilic leukemia: a morphologic and histochemical study","volume":"24","author":"Ackerman","year":"1964","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.iac.2007.07.007_bib17","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/ajh.20088","article-title":"Relationship between idiopathic hypereosinophilic syndrome, eosinophilic leukemia, and systemic mastocytosis","volume":"77","author":"Bain","year":"2004","journal-title":"Am J Hematol"},{"issue":"5","key":"10.1016\/j.iac.2007.07.007_bib18","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1182\/blood.V58.5.1021.1021","article-title":"A clinicopathologic correlation of the idiopathic hypereosinophilic syndrome. II. Clinical manifestations","volume":"58","author":"Schooley","year":"1981","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.iac.2007.07.007_bib19","first-page":"487","article-title":"Eosinophil kinetics in the hypereosinophilic syndrome","volume":"87","author":"Dale","year":"1976","journal-title":"J\u00a0Lab Clin Med"},{"issue":"5","key":"10.1016\/j.iac.2007.07.007_bib20","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1182\/blood.V58.5.1012.1012","article-title":"A clinicopathologic correlation of the idiopathic hypereosinophilic syndrome. I. Hematologic manifestations","volume":"58","author":"Flaum","year":"1981","journal-title":"Blood"},{"issue":"205","key":"10.1016\/j.iac.2007.07.007_bib21","first-page":"1","article-title":"Clinical features of fifteen patients with the hypereosinophilic syndrome","volume":"52","author":"Spry","year":"1983","journal-title":"Q J Med"},{"issue":"4","key":"10.1016\/j.iac.2007.07.007_bib22","first-page":"253","article-title":"[Prognostic factors of hypereosinophilic syndrome. Study of 40 cases]","volume":"140","author":"Lefebvre","year":"1989","journal-title":"Ann Med Interne (Paris)"},{"issue":"566","key":"10.1016\/j.iac.2007.07.007_bib23","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1136\/pgmj.48.566.740","article-title":"Eosinophilia and endomyocardial fibrosis","volume":"48","author":"Brockington","year":"1972","journal-title":"Postgrad Med J"},{"issue":"4","key":"10.1016\/j.iac.2007.07.007_bib24","first-page":"572","article-title":"The cardiovascular manifestations of the hypereosinophilic syndrome. Prospective study of 26 patients, with review of the literature","volume":"67","author":"Parrillo","year":"1979","journal-title":"Am J\u00a0Med"},{"issue":"2","key":"10.1016\/j.iac.2007.07.007_bib25","first-page":"475","article-title":"[Giant left ventricular thrombi in the hypereosinophilic syndrome: report of two cases]","volume":"16","author":"Naito","year":"1986","journal-title":"J Cardiogr"},{"issue":"5","key":"10.1016\/j.iac.2007.07.007_bib26","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/S0003-4975(10)64701-7","article-title":"Aortic and mitral valve replacement in idiopathic hypereosinophilic syndrome","volume":"46","author":"Hendren","year":"1988","journal-title":"Ann Thorac Surg"},{"issue":"6","key":"10.1016\/j.iac.2007.07.007_bib27","first-page":"1233","article-title":"Hypereosinophilic syndrome with extensive myocardial involvement and mitral valve thrombus instead of mural thrombi","volume":"33","author":"Tanino","year":"1983","journal-title":"Acta Pathol Jpn"},{"issue":"205","key":"10.1016\/j.iac.2007.07.007_bib28","first-page":"23","article-title":"Cardiovascular features of 11 patients with eosinophilic endomyocardial disease","volume":"52","author":"Davies","year":"1983","journal-title":"Q J Med"},{"key":"10.1016\/j.iac.2007.07.007_bib29","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/BF02072402","article-title":"Eosinophilic disorders affecting the myocardium and endocardium: a review","volume":"1","author":"Spry","year":"1985","journal-title":"Heart Vessels Suppl"},{"issue":"12","key":"10.1016\/j.iac.2007.07.007_bib30","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1111\/j.1742-1241.1990.tb10224.x","article-title":"Loffler's eosinophilic endocarditis following carcinoma of the thyroid gland","volume":"44","author":"Jasim","year":"1990","journal-title":"Br J Clin Pract"},{"issue":"37","key":"10.1016\/j.iac.2007.07.007_bib31","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1055\/s-0028-1108054","article-title":"[Hypereosinophilic syndrome with Loffler's endocarditis in Hodgkin's disease (author's transl)]","volume":"99","author":"Keiser","year":"1974","journal-title":"Dtsch Med Wochenschr"},{"issue":"3-4","key":"10.1016\/j.iac.2007.07.007_bib32","first-page":"155","article-title":"Helminthiasis, the hypereosinophilic syndrome and endomyocardial fibrosis: some observations and an hypothesis","volume":"12","author":"Andy","year":"1983","journal-title":"Afr J Med Med Sci"},{"issue":"3","key":"10.1016\/j.iac.2007.07.007_bib33","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1182\/blood.V79.3.688.688","article-title":"Elevated serum levels of interleukin-5 in patients with the syndrome of episodic angioedema and eosinophilia","volume":"79","author":"Butterfield","year":"1992","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.iac.2007.07.007_bib34","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1111\/j.1572-0241.2001.03735.x","article-title":"Angioedema after interferon therapy for chronic hepatitis C","volume":"96","author":"Ohmoto","year":"2001","journal-title":"Am J Gastroenterol"},{"issue":"25","key":"10.1016\/j.iac.2007.07.007_bib35","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1056\/NEJM198406213102501","article-title":"Episodic angioedema associated with eosinophilia","volume":"310","author":"Gleich","year":"1984","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.iac.2007.07.007_bib36","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.iac.2006.09.001","article-title":"Cytokine-associated angioedema syndromes including episodic angioedema with eosinophilia (Gleich's syndrome)","volume":"26","author":"Banerji","year":"2006","journal-title":"Immunol Allergy Clin North Am"},{"issue":"5","key":"10.1016\/j.iac.2007.07.007_bib37","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/sj.leu.2403722","article-title":"Molecular characterization of the idiopathic hypereosinophilic syndrome (HES) in 35 French patients with normal conventional cytogenetics","volume":"19","author":"Roche-Lestienne","year":"2005","journal-title":"Leukemia"},{"issue":"4","key":"10.1016\/j.iac.2007.07.007_bib38","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1159\/000018025","article-title":"Nonepisodic angioedema associated with eosinophilia: report of 4 cases and review of 33 young female patients reported in Japan","volume":"197","author":"Chikama","year":"1998","journal-title":"Dermatology"},{"issue":"8","key":"10.1016\/j.iac.2007.07.007_bib39","first-page":"639","article-title":"[Five cases of nonepisodic angioedema with eosinophilia]","volume":"42","author":"Shimasaki","year":"2001","journal-title":"Rinsho Ketsueki"},{"issue":"1","key":"10.1016\/j.iac.2007.07.007_bib40","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1046\/j.1365-2133.2001.03969.x","article-title":"The cytokine profile in a transient variant of angioedema with eosinophilia","volume":"144","author":"Mizukawa","year":"2001","journal-title":"Br J Dermatol"},{"issue":"4","key":"10.1016\/j.iac.2007.07.007_bib41","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1001\/archderm.114.4.531","article-title":"Dermatologic manifestations of the hypereosinophilic syndrome","volume":"114","author":"Kazmierowski","year":"1978","journal-title":"Arch Dermatol"},{"issue":"7","key":"10.1016\/j.iac.2007.07.007_bib42","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1001\/jama.247.7.1018","article-title":"Recurrent incapacitating mucosal ulcerations. A prodrome of the hypereosinophilic syndrome","volume":"247","author":"Leiferman","year":"1982","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.iac.2007.07.007_bib43","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2169\/naika.76.421","article-title":"[Recurrent oral and genital ulcers as the prodrome of the hypereosinophilic syndrome: report of a probable case]","volume":"76","author":"Akahoshi","year":"1987","journal-title":"Nippon Naika Gakkai Zasshi"},{"issue":"1","key":"10.1016\/j.iac.2007.07.007_bib44","doi-asserted-by":"crossref","first-page":"109","DOI":"10.7326\/0003-4819-102-1-109","article-title":"Neurologic dysfunction in the idiopathic hypereosinophilic syndrome","volume":"102","author":"Moore","year":"1985","journal-title":"Ann Intern Med"},{"issue":"8","key":"10.1016\/j.iac.2007.07.007_bib45","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1212\/WNL.35.8.1140","article-title":"Peripheral neuropathy in hypereosinophilic syndrome","volume":"35","author":"Wichman","year":"1985","journal-title":"Neurology"},{"issue":"5","key":"10.1016\/j.iac.2007.07.007_bib46","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1159\/000116425","article-title":"Peripheral neuropathy in the hypereosinophilic syndrome: a case report","volume":"29","author":"Lupo","year":"1989","journal-title":"Eur Neurol"},{"issue":"715","key":"10.1016\/j.iac.2007.07.007_bib47","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1136\/pgmj.61.715.429","article-title":"Hypereosinophilic syndrome presenting as peripheral neuropathy","volume":"61","author":"Bell","year":"1985","journal-title":"Postgrad Med J"},{"issue":"4","key":"10.1016\/j.iac.2007.07.007_bib48","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/mus.880060408","article-title":"Neuropathy in the hypereosinophilic syndrome","volume":"6","author":"Dorfman","year":"1983","journal-title":"Muscle Nerve"},{"issue":"6","key":"10.1016\/j.iac.2007.07.007_bib49","first-page":"433","article-title":"Peripheral neuropathy associated with the hypereosinophilic syndrome","volume":"71","author":"Werner","year":"1990","journal-title":"Arch Phys Med Rehabil"},{"issue":"1","key":"10.1016\/j.iac.2007.07.007_bib50","first-page":"12","article-title":"Peripheral neuropathy associated with hypereosinophilia","volume":"91","author":"Guidetti","year":"1991","journal-title":"Acta Neurol Belg"},{"issue":"3","key":"10.1016\/j.iac.2007.07.007_bib51","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1212\/WNL.38.3.494","article-title":"Polyneuropathy in hypereosinophilic syndrome","volume":"38","author":"Monaco","year":"1988","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.iac.2007.07.007_bib52","doi-asserted-by":"crossref","first-page":"448","DOI":"10.7326\/0003-4819-104-3-448_2","article-title":"Neurologic dysfunction in the idiopathic hypereosinophilic syndrome","volume":"104","author":"Martin-Gonzalez","year":"1986","journal-title":"Ann Intern Med"},{"issue":"6","key":"10.1016\/j.iac.2007.07.007_bib53","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/BF00313706","article-title":"Multifocal neuropathy with vasculitis in hypereosinophilic syndrome. An entity or drug-induced effect?","volume":"231","author":"Grisold","year":"1985","journal-title":"J Neurol"},{"issue":"1","key":"10.1016\/j.iac.2007.07.007_bib54","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/BF02333876","article-title":"The idiopathic hypereosinophilic syndrome. Clinical, electrophysiological and histological study of a case","volume":"10","author":"Marolda","year":"1989","journal-title":"Ital J Neurol Sci"},{"issue":"3","key":"10.1016\/j.iac.2007.07.007_bib55","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1073\/pnas.76.3.1443","article-title":"Neurotoxicity of human eosinophils","volume":"76","author":"Durack","year":"1979","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.iac.2007.07.007_bib56","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1148\/radiology.140.1.6454164","article-title":"The hypereosinophilic syndrome","volume":"140","author":"Epstein","year":"1981","journal-title":"Radiology"},{"issue":"1","key":"10.1016\/j.iac.2007.07.007_bib57","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1183\/09031936.93.03010115","article-title":"Pleural effusions in an overlap syndrome of idiopathic hypereosinophilic syndrome and erythema elevatum diutinum","volume":"3","author":"Cordier","year":"1990","journal-title":"Eur Respir J"},{"issue":"4","key":"10.1016\/j.iac.2007.07.007_bib58","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1177\/000331978403500406","article-title":"Hypereosinophilic syndrome with pulmonary vascular involvement","volume":"35","author":"Hill","year":"1984","journal-title":"Angiology"},{"issue":"4","key":"10.1016\/j.iac.2007.07.007_bib59","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1378\/chest.101.4.1178","article-title":"Idiopathic hypereosinophilic syndrome-related pulmonary involvement diagnosed by bronchoalveolar lavage","volume":"101","author":"Slabbynck","year":"1992","journal-title":"Chest"},{"issue":"3","key":"10.1016\/j.iac.2007.07.007_bib60","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1378\/chest.105.3.656","article-title":"Pulmonary involvement in the hypereosinophilic syndrome","volume":"105","author":"Winn","year":"1994","journal-title":"Chest"},{"issue":"6\u20137","key":"10.1016\/j.iac.2007.07.007_bib61","first-page":"586","article-title":"[Idiopathic hypereosinophilic syndrome with predominant digestive manifestations or eosinophilic gastroenteritis? Apropos of 2\u00a0cases]","volume":"14","author":"Levesque","year":"1990","journal-title":"Gastroenterol Clin Biol"},{"issue":"1","key":"10.1016\/j.iac.2007.07.007_bib62","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/00004836-199201000-00015","article-title":"Hypereosinophilic syndrome resembling chronic inflammatory bowel disease with primary sclerosing cholangitis","volume":"14","author":"Scheurlen","year":"1992","journal-title":"J Clin Gastroenterol"},{"issue":"740","key":"10.1016\/j.iac.2007.07.007_bib63","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1136\/pgmj.63.740.485","article-title":"Eosinophilic colitis as a complication of the hypereosinophilic syndrome","volume":"63","author":"Shah","year":"1987","journal-title":"Postgrad Med J"},{"issue":"24","key":"10.1016\/j.iac.2007.07.007_bib64","first-page":"2433","article-title":"[Idiopathic hypereosinophilic syndrome. Enterocolitis\u2013a rare manifestation]","volume":"109","author":"Aksnes","year":"1989","journal-title":"Tidsskr Nor Laegeforen"},{"issue":"1","key":"10.1016\/j.iac.2007.07.007_bib65","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1080\/17843286.1991.11718139","article-title":"Massive eosinophilic ascites: differential diagnosis between idiopathic hypereosinophilic syndrome and eosinophilic gastroenteritis","volume":"46","author":"Vandewiele","year":"1991","journal-title":"Acta Clin Belg"},{"issue":"2","key":"10.1016\/j.iac.2007.07.007_bib66","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1097\/00005176-199102000-00023","article-title":"Hypereosinophilic syndrome in childhood appearing as inflammatory bowel disease","volume":"12","author":"Falade","year":"1991","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"2","key":"10.1016\/j.iac.2007.07.007_bib67","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/BF01535738","article-title":"Hypereosinophilic syndrome. Association with chronic active hepatitis","volume":"33","author":"Croffy","year":"1988","journal-title":"Dig Dis Sci"},{"issue":"6","key":"10.1016\/j.iac.2007.07.007_bib68","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1002\/hep.1840130614","article-title":"Eosinophil-induced chronic active hepatitis in the idiopathic hypereosinophilic syndrome","volume":"13","author":"Foong","year":"1991","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.iac.2007.07.007_bib69","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1001\/archinte.145.4.751","article-title":"Hepatic vein obstruction in idiopathic hypereosinophilic syndrome","volume":"145","author":"Elouaer-Blanc","year":"1985","journal-title":"Arch Intern Med"},{"issue":"2","key":"10.1016\/j.iac.2007.07.007_bib70","first-page":"239","article-title":"[A case of hypereosinophilic syndrome associated with pulmonary infarction and hepatic vein obstruction (Budd-Chiari syndrome)]","volume":"29","author":"Suenaga","year":"1991","journal-title":"Nihon Kyobu Shikkan Gakkai Zasshi"},{"issue":"12","key":"10.1016\/j.iac.2007.07.007_bib71","first-page":"966","article-title":"[Icterus disclosing pancreatic involvement in idiopathic hypereosinophilic syndrome]","volume":"8","author":"Eugene","year":"1984","journal-title":"Gastroenterol Clin Biol"},{"issue":"12","key":"10.1016\/j.iac.2007.07.007_bib72","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/S0161-6420(82)34625-4","article-title":"Ophthalmologic abnormalities in the hypereosinophilic syndrome","volume":"89","author":"Chaine","year":"1982","journal-title":"Ophthalmology"},{"issue":"4","key":"10.1016\/j.iac.2007.07.007_bib73","first-page":"309","article-title":"[Hypereosinophilic syndrome with ocular involvement]","volume":"8","author":"Binaghi","year":"1985","journal-title":"J Fr Ophtalmol"},{"issue":"1","key":"10.1016\/j.iac.2007.07.007_bib74","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/ana.410010106","article-title":"Eosinophilic polymyositis","volume":"1","author":"Layzer","year":"1977","journal-title":"Ann Neurol"},{"issue":"11","key":"10.1016\/j.iac.2007.07.007_bib75","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.2169\/internalmedicine.31.1262","article-title":"Hypereosinophilic syndrome accompanied with necrosis of finger tips","volume":"31","author":"Takekawa","year":"1992","journal-title":"Intern Med"},{"issue":"5","key":"10.1016\/j.iac.2007.07.007_bib76","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1093\/rheumatology\/26.5.384","article-title":"Eosinophilic polymyositis presenting as a pseudotumour in the hypereosinophilic syndrome","volume":"26","author":"Pye","year":"1987","journal-title":"Br J Rheumatol"},{"issue":"3","key":"10.1016\/j.iac.2007.07.007_bib77","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1097\/00007611-198803000-00029","article-title":"Idiopathic hypereosinophilic syndrome with polymyositis","volume":"81","author":"Peison","year":"1988","journal-title":"South Med J"},{"issue":"13","key":"10.1016\/j.iac.2007.07.007_bib78","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1056\/NEJMoa025217","article-title":"A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome","volume":"348","author":"Cools","year":"2003","journal-title":"N Engl J Med"},{"issue":"11","key":"10.1016\/j.iac.2007.07.007_bib79","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.4049\/jimmunol.139.11.3753","article-title":"T lymphocyte control of human eosinophilic granulopoiesis. Clonal analysis in an idiopathic hypereosinophilic syndrome","volume":"139","author":"Raghavachar","year":"1987","journal-title":"J Immunol"},{"issue":"2","key":"10.1016\/j.iac.2007.07.007_bib80","first-page":"358","article-title":"Interleukin-5 is the predominant eosinophilopoietin produced by cloned T lymphocytes in hypereosinophilic syndrome","volume":"21","author":"Schrezenmeier","year":"1993","journal-title":"Exp Hematol"},{"issue":"8","key":"10.1016\/j.iac.2007.07.007_bib81","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1056\/NEJM199402243300804","article-title":"Brief report: clonal proliferation of type 2 helper T cells in a man with the hypereosinophilic syndrome","volume":"330","author":"Cogan","year":"1994","journal-title":"N Engl J Med"},{"issue":"7","key":"10.1016\/j.iac.2007.07.007_bib82","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/j.1398-9995.2004.00465.x","article-title":"Recent advances in pathogenesis and management of hypereosinophilic syndromes","volume":"59","author":"Roufosse","year":"2004","journal-title":"Allergy"},{"issue":"15","key":"10.1016\/j.iac.2007.07.007_bib83","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1056\/NEJM199910073411503","article-title":"Abnormal clones of T cells producing interleukin-5 in idiopathic eosinophilia","volume":"341","author":"Simon","year":"1999","journal-title":"N Engl J Med"},{"issue":"11","key":"10.1016\/j.iac.2007.07.007_bib84","doi-asserted-by":"crossref","first-page":"4635","DOI":"10.1182\/blood-2006-10-050054","article-title":"Low-dose imatinib mesylate leads to rapid induction of major molecular responses and achievement of complete molecular remission in FIP1L1-PDGFRA-positive chronic eosinophilic leukemia","volume":"109","author":"Jovanovic","year":"2007","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.iac.2007.07.007_bib85","doi-asserted-by":"crossref","first-page":"4660","DOI":"10.1182\/blood-2003-01-0006","article-title":"Elevated serum tryptase levels identify a subset of patients with a myeloproliferative variant of idiopathic hypereosinophilic syndrome associated with tissue fibrosis, poor prognosis, and imatinib responsiveness","volume":"101","author":"Klion","year":"2003","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.iac.2007.07.007_bib86","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/sj.leu.2403313","article-title":"Clinical and molecular features of FIP1L1-PDFGRA (+) chronic eosinophilic leukemias","volume":"18","author":"Vandenberghe","year":"2004","journal-title":"Leukemia"},{"issue":"13","key":"10.1016\/j.iac.2007.07.007_bib87","doi-asserted-by":"crossref","first-page":"7830","DOI":"10.1073\/pnas.0932698100","article-title":"Discovery of a fusion kinase in EOL-1 cells and idiopathic hypereosinophilic syndrome","volume":"100","author":"Griffin","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1016\/j.iac.2007.07.007_bib88","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1182\/blood-2003-08-2798","article-title":"Molecular remission and reversal of myelofibrosis in response to imatinib mesylate treatment in patients with the myeloproliferative variant of hypereosinophilic syndrome","volume":"103","author":"Klion","year":"2004","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.iac.2007.07.007_bib89","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1182\/blood-2004-03-0787","article-title":"FIP1L1-PDGFRA fusion: prevalence and clinicopathologic correlates in 89 consecutive patients with moderate to severe eosinophilia","volume":"104","author":"Pardanani","year":"2004","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.iac.2007.07.007_bib90","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0002-9149(83)90131-5","article-title":"Noncardiovascular findings associated with heart disease in the idiopathic hypereosinophilic syndrome","volume":"52","author":"Harley","year":"1983","journal-title":"Am J Cardiol"},{"issue":"12","key":"10.1016\/j.iac.2007.07.007_bib91","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1080\/10428190400002293","article-title":"Rapid reversion of Loeffler's endocarditis by imatinib in early stage clonal hypereosinophilic syndrome","volume":"45","author":"Rotoli","year":"2004","journal-title":"Leuk Lymphoma"},{"issue":"4","key":"10.1016\/j.iac.2007.07.007_bib92","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1111\/j.1365-2133.2006.07416.x","article-title":"Platelet-derived growth factor receptor-alpha-associated hypereosinophilic syndrome and lymphomatoid papulosis","volume":"155","author":"McPherson","year":"2006","journal-title":"Br J Dermatol"},{"issue":"3","key":"10.1016\/j.iac.2007.07.007_bib93","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1046\/j.1365-2141.2000.02097.x","article-title":"Clonal Th2 lymphocytes in patients with the idiopathic hypereosinophilic syndrome","volume":"109","author":"Roufosse","year":"2000","journal-title":"Br J Haematol"},{"issue":"4","key":"10.1016\/j.iac.2007.07.007_bib94","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1182\/blood.V87.4.1416.bloodjournal8741416","article-title":"A case of hypereosinophilic syndrome is associated with the expansion of a CD3-CD4+ T-cell population able to secrete large amounts of interleukin-5","volume":"87","author":"Brugnoni","year":"1996","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.iac.2007.07.007_bib95","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/0002-9343(87)90458-X","article-title":"Peripheral T cell lymphoma presenting as hypereosinophilia with vasculitis. Clinical, pathologic, and immunologic features","volume":"82","author":"O'Shea","year":"1987","journal-title":"Am J Med"},{"issue":"11","key":"10.1016\/j.iac.2007.07.007_bib96","first-page":"883","article-title":"[Hypereosinophilic syndrome with pachyderma preceding lymphoma. Treatment with interferon alpha]","volume":"118","author":"Moraillon","year":"1991","journal-title":"Ann Dermatol Venereol"},{"issue":"4","key":"10.1016\/j.iac.2007.07.007_bib97","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1002\/1097-0142(19910215)67:4<1064::AID-CNCR2820670433>3.0.CO;2-P","article-title":"Idiopathic hypereosinophilic syndrome terminating as disseminated T-cell lymphoma","volume":"67","author":"Kim","year":"1991","journal-title":"Cancer"},{"issue":"2","key":"10.1016\/j.iac.2007.07.007_bib98","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/ajh.1157","article-title":"Diverse clinical outcomes of eosinophilic patients with T-cell receptor gene rearrangements: the emerging diagnostic importance of molecular genetics testing","volume":"68","author":"Butterfield","year":"2001","journal-title":"Am J\u00a0Hematol"},{"issue":"5","key":"10.1016\/j.iac.2007.07.007_bib99","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0002-9343(99)00263-6","article-title":"Indolent course of a patient with hypereosinophilic syndrome associated with clonal T-cell proliferation","volume":"107","author":"Zenone","year":"1999","journal-title":"Am J Med"},{"issue":"9","key":"10.1016\/j.iac.2007.07.007_bib100","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1080\/1042819031000083073","article-title":"Clonal T-helper lymphocytes and elevated IL-5 levels in episodic angioedema and eosinophilia (Gleich's syndrome)","volume":"44","author":"Morgan","year":"2003","journal-title":"Leuk Lymphoma"},{"issue":"1\u20132","key":"10.1016\/j.iac.2007.07.007_bib101","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3109\/10428190109097684","article-title":"The hypereosinophilic syndrome associated with CD4+CD3- helper type 2 (Th2) lymphocytes","volume":"42","author":"Bank","year":"2001","journal-title":"Leuk Lymphoma"},{"issue":"3","key":"10.1016\/j.iac.2007.07.007_bib102","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/(SICI)1096-8628(19980319)76:3<229::AID-AJMG6>3.0.CO;2-L","article-title":"Familial eosinophilia: clinical and laboratory results on a U.S. kindred","volume":"76","author":"Lin","year":"1998","journal-title":"Am J Med Genet"},{"issue":"11","key":"10.1016\/j.iac.2007.07.007_bib103","doi-asserted-by":"crossref","first-page":"4050","DOI":"10.1182\/blood-2003-11-3850","article-title":"Familial eosinophilia: a benign disorder?","volume":"103","author":"Klion","year":"2004","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.iac.2007.07.007_bib104","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1172\/JCI118417","article-title":"Recombinant interferon-alpha selectively inhibits the production of interleukin-5 by human CD4+ T cells","volume":"97","author":"Schandene","year":"1996","journal-title":"J Clin Invest"},{"issue":"13","key":"10.1016\/j.iac.2007.07.007_bib105","doi-asserted-by":"crossref","first-page":"4285","DOI":"10.1182\/blood.V96.13.4285","article-title":"Interferon alpha prevents spontaneous apoptosis of clonal Th2 cells associated with chronic hypereosinophilia","volume":"96","author":"Schandene","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.iac.2007.07.007_bib106","doi-asserted-by":"crossref","first-page":"S160","DOI":"10.1016\/j.jaci.2006.11.564","article-title":"Corticosteroid-sparing effects of mepolizumab, an anti-interleukin-5 monoclonal antibody, in patients with hypereosinophilic syndrome","volume":"119","author":"Rosenwasser","year":"2007","journal-title":"J Allergy Clin Immunol"},{"issue":"24","key":"10.1016\/j.iac.2007.07.007_bib107","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1056\/NEJMoa031261","article-title":"Use of an anti-interleukin-5 antibody in the hypereosinophilic syndrome with eosinophilic dermatitis","volume":"349","author":"Plotz","year":"2003","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.iac.2007.07.007_bib108","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jaci.2003.10.049","article-title":"Anti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes","volume":"113","author":"Garrett","year":"2004","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"10.1016\/j.iac.2007.07.007_bib109","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/j.1365-2141.2004.05206.x","article-title":"Alemtuzumab therapy for refractory idiopathic hypereosinophilic syndrome with abnormal T cells: a case report","volume":"127","author":"Pitini","year":"2004","journal-title":"Br J Haematol"},{"issue":"4","key":"10.1016\/j.iac.2007.07.007_bib110","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1046\/j.1365-2141.2003.04801.x","article-title":"Alemtuzumab therapy for refractory idiopathic hypereosinophilic syndrome","volume":"124","author":"Sefcick","year":"2004","journal-title":"Br J Haematol"},{"issue":"6","key":"10.1016\/j.iac.2007.07.007_bib111","first-page":"753","article-title":"6q- is an early and persistent chromosomal aberration in CD3-CD4+ T-cell clones associated with the lymphocytic variant of hypereosinophilic syndrome","volume":"90","author":"Ravoet","year":"2005","journal-title":"Haematologica"}],"container-title":["Immunology and Allergy Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889856107000550?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889856107000550?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,14]],"date-time":"2023-05-14T04:34:16Z","timestamp":1684038856000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889856107000550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8]]},"references-count":111,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["S0889856107000550"],"URL":"https:\/\/doi.org\/10.1016\/j.iac.2007.07.007","relation":{},"ISSN":["0889-8561"],"issn-type":[{"value":"0889-8561","type":"print"}],"subject":[],"published":{"date-parts":[[2007,8]]}}}