{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T21:06:28Z","timestamp":1793048788934,"version":"4.5.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunology and Allergy Clinics of North America"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.iac.2014.01.011","type":"journal-article","created":{"date-parts":[[2014,3,17]],"date-time":"2014-03-17T11:30:52Z","timestamp":1395055852000},"page":"383-396","source":"Crossref","is-referenced-by-count":89,"title":["Bone Involvement and Osteoporosis in Mastocytosis"],"prefix":"10.1016","volume":"34","author":[{"given":"Maurizio","family":"Rossini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Zanotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ombretta","family":"Viapiana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaia","family":"Tripi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Orsolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Idolazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Bonadonna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donatella","family":"Schena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Escribano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvano","family":"Adami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Gatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.iac.2014.01.011_bib1","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0046-8177(81)80084-6","article-title":"Systemic mastocytosis associated with generalized osteopenia. Histopathological characterization of the skeletal lesion using undecalcified bone from two patients","volume":"12","author":"Fallon","year":"1981","journal-title":"Hum Pathol"},{"key":"10.1016\/j.iac.2014.01.011_bib2","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1210\/jcem-72-1-140","article-title":"Systemic mastocytosis presenting as osteoporosis: a clinical and histomorphometric study","volume":"72","author":"Chines","year":"1991","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.iac.2014.01.011_bib3","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1007\/BF02206850","article-title":"Systemic mastocytosis, an unusual cause of osteoporosis","volume":"6","author":"Schoenaers","year":"1987","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.iac.2014.01.011_bib4","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/8756-3282(89)90059-8","article-title":"Osteoporosis associated with mastocytosis confined to bone: report of two cases","volume":"10","author":"Harvey","year":"1989","journal-title":"Bone"},{"key":"10.1016\/j.iac.2014.01.011_bib5","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1002\/jbmr.5650050811","article-title":"Osteoporosis as the sole presentation of bone marrow mastocytosis","volume":"5","author":"Lidor","year":"1990","journal-title":"J\u00a0Bone Miner Res"},{"key":"10.1016\/j.iac.2014.01.011_bib6","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/00002517-199109000-00016","article-title":"Systemic mastocytosis presenting with severe spinal osteopenia and multiple compression fractures","volume":"4","author":"Floman","year":"1991","journal-title":"J\u00a0Spinal Disord"},{"key":"10.1016\/j.iac.2014.01.011_bib7","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1136\/ard.2004.029116","article-title":"Systemic mastocytosis: a rare cause of osteoporosis and its response to bisphosphonate treatment","volume":"64","author":"Lim","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.iac.2014.01.011_bib8","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1159\/000091172","article-title":"Elevated tryptase levels are associated with greater bone density in a cohort of patients with mastocytosis","volume":"139","author":"Kushnir-Sukhov","year":"2006","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.iac.2014.01.011_bib9","first-page":"216","article-title":"Osteoporosis as a first manifestation of systemic mastocytosis. Study of 6 cases","volume":"128","author":"Salles","year":"2007","journal-title":"Med Clin (Barc)"},{"key":"10.1016\/j.iac.2014.01.011_bib10","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/BLO.0b013e3180487ced","article-title":"Pathologic long bone fracture in a patient with systemic mastocytosis","volume":"459","author":"King","year":"2007","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.iac.2014.01.011_bib11","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s00774-007-0800-x","article-title":"Two patients with osteoporosis: initial presentation of systemic mastocytosis","volume":"26","author":"Donker","year":"2008","journal-title":"J\u00a0Bone Miner Metab"},{"key":"10.1016\/j.iac.2014.01.011_bib12","doi-asserted-by":"crossref","first-page":"2","DOI":"10.5070\/D360F3R72D","article-title":"Mastocytosis with urticaria pigmentosa and osteoporosis","volume":"14","author":"Stein","year":"2008","journal-title":"Dermatol Online J"},{"key":"10.1016\/j.iac.2014.01.011_bib13","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1007\/s10067-009-1165-4","article-title":"Systemic mastocytosis presenting as osteoporosis-a case report","volume":"28","author":"Mathew","year":"2009","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.iac.2014.01.011_bib14","first-page":"97","article-title":"Osteoporosis with vertebral fractures in young males, due to bone marrow mastocytosis: a report of two cases","volume":"28","author":"Manara","year":"2010","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.iac.2014.01.011_bib15","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.jaci.2009.05.003","article-title":"Prognosis in adult indolent systemic mastocytosis: a long-term study of the Spanish Network on Mastocytosis in a series of 145 patients","volume":"124","author":"Escribano","year":"2009","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.iac.2014.01.011_bib16","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1136\/ard.2009.124511","article-title":"Systemic mastocytosis and bone involvement in a cohort of 75 patients","volume":"69","author":"Barete","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.iac.2014.01.011_bib17","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.bone.2011.07.004","article-title":"Bone mineral density, bone turnover markers and fractures in patients with indolent systemic mastocytosis","volume":"49","author":"Rossini","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.iac.2014.01.011_bib18","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1398-9995.2011.02780.x","article-title":"High prevalence of fractures and osteoporosis in patients with indolent systemic mastocytosis","volume":"67","author":"van der Veer","year":"2012","journal-title":"Allergy"},{"key":"10.1016\/j.iac.2014.01.011_bib19","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/BF01622200","article-title":"Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: synopsis of a WHO report. WHO study Group","volume":"4","author":"Kanis","year":"1994","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.iac.2014.01.011_bib20","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.bone.2008.08.106","article-title":"International society for clinical densitometry 2007 adult and pediatric official positions","volume":"43","author":"Lewiecki","year":"2008","journal-title":"Bone"},{"key":"10.1016\/j.iac.2014.01.011_bib21","unstructured":"Report of the UK Cystic Fibrosis Trust Bone Mineralisation Working Group. Bone mineralisation in cystic fibrosis. Cystic Fibrosis Trust 2007. Available at: www.cftrust.org.uk. Accessed February 20, 2014."},{"key":"10.1016\/j.iac.2014.01.011_bib22","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/S8756-3282(02)00875-X","article-title":"A\u00a0potential role for the mast cell in the pathogenesis of idiopathic osteoporosis in men","volume":"31","author":"Brumsen","year":"2002","journal-title":"Bone"},{"key":"10.1016\/j.iac.2014.01.011_bib23","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/j.1365-2362.2007.01807.x","article-title":"Standards and standardization in mastocytosis: consensus statements on diagnostics, treatment recommendations and response criteria","volume":"37","author":"Valent","year":"2007","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.iac.2014.01.011_bib24","doi-asserted-by":"crossref","first-page":"482","DOI":"10.3324\/haematol.2010.034553","article-title":"Isolated bone marrow mastocytosis: an underestimated subvariant of indolent systemic mastocytosis","volume":"96","author":"Zanotti","year":"2011","journal-title":"Haematologica"},{"key":"10.1016\/j.iac.2014.01.011_bib25","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.jaci.2008.11.018","article-title":"Clonal mast cell disorders in patients with systemic reactions to hymenoptera stings and raised serum tryptase","volume":"123","author":"Bonadonna","year":"2009","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.iac.2014.01.011_bib26","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1007\/s00198-013-2305-x","article-title":"Increased osteoblast and osteoclast indices in individuals with systemic mastocytosis","volume":"24","author":"Seitz","year":"2013","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.iac.2014.01.011_bib27","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s002920000439","article-title":"Histological characteristics and prevalence of secondary osteoporosis in systemic mastocytosis. A retrospective analysis of 158 cases","volume":"22","author":"Delling","year":"2001","journal-title":"Pathologe"},{"key":"10.1016\/j.iac.2014.01.011_bib28","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/00005792-198811000-00001","article-title":"Systemic mast cell disease. Analysis of 58 cases and literature review","volume":"67","author":"Travis","year":"1988","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.iac.2014.01.011_bib29","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/8756-3282(87)90014-7","article-title":"Osteopenia in systemic mastocytosis: natural history and responses to treatment with inhibitors of bone resorption","volume":"8","author":"Cundy","year":"1987","journal-title":"Bone"},{"key":"10.1016\/j.iac.2014.01.011_bib30","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1182\/blood-2007-11-078097","article-title":"Mast cells and mastocytosis","volume":"112","author":"Metcalfe","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.iac.2014.01.011_bib31","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1159\/000063858","article-title":"Serum interleukin-6 reflects disease severity and osteoporosis in mastocytosis patients","volume":"128","author":"Theoharides","year":"2002","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.iac.2014.01.011_bib32","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.clim.2005.01.011","article-title":"IL-6 levels predict disease variant and extent of organ involvement in patients with mastocytosis","volume":"115","author":"Brockow","year":"2005","journal-title":"Clin Immunol"},{"key":"10.1016\/j.iac.2014.01.011_bib33","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/(SICI)1097-4652(199710)173:1<10::AID-JCP2>3.0.CO;2-M","article-title":"H1 and H2 histamine receptors modulate osteoclastic resorption by different pathways: evidence obtained by using receptor antagonists in a rat synchronized resorption model","volume":"173","author":"Dobigny","year":"1997","journal-title":"J\u00a0Cell Physiol"},{"key":"10.1016\/j.iac.2014.01.011_bib34","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.2353\/ajpath.2009.080871","article-title":"Histamine promotes osteoclastogenesis through the differential expression of histamine receptors on osteoclasts and osteoblasts","volume":"174","author":"Biosse-Duplan","year":"2009","journal-title":"Am J Pathol"},{"key":"10.1016\/j.iac.2014.01.011_bib35","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1002\/jcp.21468","article-title":"Heparin inhibits BMP-2 osteogenic bioactivity by binding to both BMP-2 and BMP receptor","volume":"216","author":"Kanzaki","year":"2008","journal-title":"J\u00a0Cell Physiol"},{"key":"10.1016\/j.iac.2014.01.011_bib36","doi-asserted-by":"crossref","first-page":"6027","DOI":"10.1073\/pnas.0934373100","article-title":"Targeted deletion of histamine decarboxylase gene in mice increases bone formation and protects against ovariectomy-induced bone loss","volume":"100","author":"Fitzpatrick","year":"2003","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"key":"10.1016\/j.iac.2014.01.011_bib37","first-page":"281","article-title":"Bone mastocytosis. A report of nine cases with a bone histomorphometric study","volume":"279","author":"De Gennes","year":"1992","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.iac.2014.01.011_bib38","doi-asserted-by":"crossref","first-page":"75.e1","DOI":"10.1016\/j.amjmed.2012.07.018","article-title":"Bone complications of mastocytosis: a link between clinical and biological characteristics","volume":"126","author":"Guillaume","year":"2013","journal-title":"Am J Med"},{"key":"10.1016\/j.iac.2014.01.011_bib39","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s002770050428","article-title":"c-Kit mutation and osteopetrosis-like osteopathy in a patient with systemic mast cell disease","volume":"77","author":"Reinacher-Schick","year":"1998","journal-title":"Ann Hematol"},{"key":"10.1016\/j.iac.2014.01.011_bib40","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.semarthrit.2006.03.004","article-title":"The role of mast cells in osteoporosis","volume":"36","author":"Chiappetta","year":"2006","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.iac.2014.01.011_bib41","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00223-013-9749-z","article-title":"Involvement of WNT\/\u03b2-catenin signaling in the treatment of osteoporosis","volume":"93","author":"Rossini","year":"2013","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.iac.2014.01.011_bib42","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.jaci.2013.06.019","article-title":"Serum levels of bone cytokines are increased in indolent systemic mastocytosis associated with osteopenia or osteoporosis","volume":"132","author":"Rabenhorst","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.iac.2014.01.011_bib43","article-title":"Serum levels of bone cytokines in indolent systemic mastocytosis associated with osteopenia or osteoporosis","author":"Rossini","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"5","key":"10.1016\/j.iac.2014.01.011_bib44","doi-asserted-by":"crossref","first-page":"e2266","DOI":"10.1371\/journal.pone.0002266","article-title":"Case-control cohort study of patients\u2019 perceptions of disability in mastocytosis","volume":"3","author":"Hermine","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.iac.2014.01.011_bib45","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1002\/jbmr.5650080915","article-title":"Vertebral fracture assessment using a semiquantitative technique","volume":"8","author":"Genant","year":"1993","journal-title":"J\u00a0Bone Miner Res"},{"key":"10.1016\/j.iac.2014.01.011_bib46","first-page":"1471","article-title":"A\u00a0retrospective analysis of bone scan abnormalities in mastocytosis: correlation with disease category and prognosis","volume":"35","author":"Chen","year":"1994","journal-title":"J\u00a0Nucl Med"},{"key":"10.1016\/j.iac.2014.01.011_bib47","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1002\/jbmr.5650051104","article-title":"Inhibition of mediator release in systemic mastocytosis is associated with reversal of bone changes","volume":"5","author":"Graves","year":"1990","journal-title":"J\u00a0Bone Miner Res"},{"key":"10.1016\/j.iac.2014.01.011_bib48","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1359\/jbmr.2002.17.4.567","article-title":"Osteoporosis and bone marrow mastocytosis: dissociation of skeletal responses and mast cell activity during long-term bisphosphonate therapy","volume":"17","author":"Brumsen","year":"2002","journal-title":"J\u00a0Bone Miner Res"},{"key":"10.1016\/j.iac.2014.01.011_bib49","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1093\/rheumatology\/36.3.393","article-title":"The effect of pamidronate on lumbar spine bone density and pain in osteoporosis secondary to systemic mastocytosis","volume":"36","author":"Marshall","year":"1997","journal-title":"Br J Rheumatol"},{"key":"10.1016\/j.iac.2014.01.011_bib50","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1182\/blood-2013-01-453183","article-title":"How I treat patients with indolent and smoldering mastocytosis (rare conditions but difficult to manage)","volume":"121","author":"Pardanani","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.iac.2014.01.011_bib51","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/BF00663015","article-title":"Successful treatment of osteoporosis in systemic mastocytosis with interferon alpha-2b","volume":"72","author":"Weide","year":"1996","journal-title":"Ann Hematol"},{"key":"10.1016\/j.iac.2014.01.011_bib52","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1093\/rheumatology\/35.9.898","article-title":"Severe osteoporosis due to systemic mast cell disease: successful treatment with interferon alpha-2B","volume":"35","author":"Lehmann","year":"1996","journal-title":"Br J Rheumatol"},{"key":"10.1016\/j.iac.2014.01.011_bib53","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1159\/000085560","article-title":"Interferon treatment for hypereosinophilic syndromes and systemic mastocytosis","volume":"114","author":"Butterfield","year":"2005","journal-title":"Acta Haematol"},{"key":"10.1016\/j.iac.2014.01.011_bib54","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/s10067-006-0369-0","article-title":"Clinical and densitometric efficacy of the association of interferon alpha and pamidronate in the treatment of osteoporosis in patients with systemic mastocytosis","volume":"26","author":"Laroche","year":"2007","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.iac.2014.01.011_bib55","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.amjmed.2011.02.038","article-title":"Interferon alpha and pamidronate in osteoporosis with fracture secondary to mastocytosis","volume":"124","author":"Laroche","year":"2011","journal-title":"Am J Med"}],"container-title":["Immunology and Allergy Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889856114000125?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889856114000125?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T01:28:16Z","timestamp":1648603696000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889856114000125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S0889856114000125"],"URL":"https:\/\/doi.org\/10.1016\/j.iac.2014.01.011","relation":{},"ISSN":["0889-8561"],"issn-type":[{"value":"0889-8561","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]}}}