{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:20:52Z","timestamp":1787786452082,"version":"build-2784847793"},"reference-count":53,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","theclinics.com","clinicalkey.com.au","clinicalkey.fr","immunology.theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunology and Allergy Clinics of North America"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.iac.2015.05.006","type":"journal-article","created":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T06:30:24Z","timestamp":1437633024000},"page":"561-575","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Management of Hypereosinophilic Syndromes"],"prefix":"10.1016","volume":"35","author":[{"given":"Florence","family":"Roufosse","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.iac.2015.05.006_bib1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1586\/ehm.12.14","article-title":"Clinical management of the hypereosinophilic syndromes","volume":"5","author":"Cogan","year":"2012","journal-title":"Expert Rev Hematol"},{"issue":"2","key":"10.1016\/j.iac.2015.05.006_bib2","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1053\/j.seminhematol.2012.01.002","article-title":"Therapeutic approaches to patients with hypereosinophilic syndromes","volume":"49","author":"Simon","year":"2012","journal-title":"Semin Hematol"},{"key":"10.1016\/j.iac.2015.05.006_bib3","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1146\/annurev.med.60.062107.090340","article-title":"Hypereosinophilic syndrome: current approach to diagnosis and treatment","volume":"60","author":"Klion","year":"2009","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.iac.2015.05.006_bib4","doi-asserted-by":"crossref","unstructured":"Klion A. How I treat hypereosinophilic syndromes. Blood 2015. [Epub ahead of print].","DOI":"10.1182\/blood-2014-11-551614"},{"issue":"3","key":"10.1016\/j.iac.2015.05.006_bib5","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.jaci.2012.02.019","article-title":"Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes","volume":"130","author":"Valent","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"3","key":"10.1016\/j.iac.2015.05.006_bib6","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1159\/000369966","article-title":"Eosinophilic jejunitis presenting as intractable abdominal pain","volume":"8","author":"Mungan","year":"2014","journal-title":"Case Rep Gastroenterol"},{"issue":"1","key":"10.1016\/j.iac.2015.05.006_bib7","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1136\/gut.31.1.54","article-title":"Eosinophilic gastroenteritis: a clinicopathological study of patients with disease of the mucosa, muscle layer, and subserosal tissues","volume":"31","author":"Talley","year":"1990","journal-title":"Gut"},{"issue":"5","key":"10.1016\/j.iac.2015.05.006_bib8","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1136\/jcp.2008.060616","article-title":"Eosinophilia-associated muscle disorders: an immunohistological study with tissue localisation of major basic protein in distinct clinicopathological forms","volume":"62","author":"Cantarini","year":"2009","journal-title":"J\u00a0Clin Pathol"},{"issue":"2","key":"10.1016\/j.iac.2015.05.006_bib9","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1056\/NEJMc1103005","article-title":"Eosinophil granule protein localization in eosinophilic endomyocardial disease","volume":"365","author":"Wright","year":"2011","journal-title":"N\u00a0Engl J Med"},{"issue":"1","key":"10.1016\/j.iac.2015.05.006_bib10","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1710-1492-7-4","article-title":"The identification of eosinophilic gastroenteritis in prednisone-dependent eosinophilic bronchitis and asthma","volume":"7","author":"Nair","year":"2011","journal-title":"Allergy Asthma Clin Immunol"},{"issue":"1","key":"10.1016\/j.iac.2015.05.006_bib11","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1365-2249.2011.04391.x","article-title":"Activation of coagulation in bullous pemphigoid and other eosinophil-related inflammatory skin diseases","volume":"165","author":"Marzano","year":"2011","journal-title":"Clin Exp Immunol"},{"issue":"8","key":"10.1016\/j.iac.2015.05.006_bib12","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/nrrheum.2014.98","article-title":"Eosinophils in vasculitis: characteristics and roles in pathogenesis","volume":"10","author":"Khoury","year":"2014","journal-title":"Nat Rev Rheumatol"},{"issue":"4 Pt 2","key":"10.1016\/j.iac.2015.05.006_bib13","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.lpm.2013.01.005","article-title":"L4. Eosinophils: how they contribute to endothelial damage and dysfunction","volume":"42","author":"Roufosse","year":"2013","journal-title":"Presse Med"},{"issue":"7","key":"10.1016\/j.iac.2015.05.006_bib14","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s00392-010-0144-8","article-title":"Cardiac manifestation of the hypereosinophilic syndrome: new insights","volume":"99","author":"Kleinfeldt","year":"2010","journal-title":"Clin Res Cardiol"},{"issue":"4","key":"10.1016\/j.iac.2015.05.006_bib15","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1001\/archneurol.2009.36","article-title":"Cerebral arteriolar thromboembolism in idiopathic hypereosinophilic syndrome","volume":"66","author":"Grigoryan","year":"2009","journal-title":"Arch Neurol"},{"issue":"4","key":"10.1016\/j.iac.2015.05.006_bib16","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/bjh.12729","article-title":"Catastrophic thrombosis in idiopathic hypereosinophilic syndrome","volume":"165","author":"Todd","year":"2014","journal-title":"Br J Haematol"},{"issue":"4","key":"10.1016\/j.iac.2015.05.006_bib17","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.jvs.2005.05.050","article-title":"Brachial artery occlusion secondary to hypereosinophilic syndrome","volume":"42","author":"Ponsky","year":"2005","journal-title":"J\u00a0Vasc Surg"},{"issue":"4","key":"10.1016\/j.iac.2015.05.006_bib18","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.jaci.2013.06.037","article-title":"Marked and persistent eosinophilia in the absence of clinical manifestations","volume":"133","author":"Chen","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"1","key":"10.1016\/j.iac.2015.05.006_bib19","first-page":"50","article-title":"Benign idiopathic hypereosinophilia: a feeble masquerader or a smouldering form of the hypereosinophilic syndrome?","volume":"80","author":"Confalonieri","year":"1995","journal-title":"Haematologica"},{"key":"10.1016\/j.iac.2015.05.006_bib20","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jim.2014.05.020","article-title":"Development of a suspension array assay in multiplex for the simultaneous measurement of serum levels of four eosinophil granule proteins","volume":"411","author":"Makiya","year":"2014","journal-title":"J\u00a0Immunol Methods"},{"issue":"5","key":"10.1016\/j.iac.2015.05.006_bib21","doi-asserted-by":"crossref","first-page":"693.e1","DOI":"10.1016\/j.jaad.2013.01.033","article-title":"DRESS syndrome: part I. Clinical perspectives","volume":"68","author":"Husain","year":"2013","journal-title":"J\u00a0Am Acad Dermatol"},{"issue":"5","key":"10.1016\/j.iac.2015.05.006_bib22","first-page":"433","article-title":"Use of the lymphocyte transformation test in the diagnosis of DRESS syndrome induced by ceftriaxone and piperacillin-tazobactam: two case reports","volume":"20","author":"Jurado-Palomo","year":"2010","journal-title":"J\u00a0Investig Allergol Clin Immunol"},{"issue":"12","key":"10.1016\/j.iac.2015.05.006_bib23","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1111\/j.1398-9995.2007.01553.x","article-title":"Utility of the lymphocyte transformation test in the diagnosis of drug sensitivity: dependence on its timing and the type of drug eruption","volume":"62","author":"Kano","year":"2007","journal-title":"Allergy"},{"issue":"3","key":"10.1016\/j.iac.2015.05.006_bib24","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/ajh.20789","article-title":"Non-small-cell lung cancer associated with excessive eosinophilia and secretion of interleukin-5 as a paraneoplastic syndrome","volume":"82","author":"Pandit","year":"2007","journal-title":"Am J Hematol"},{"issue":"1","key":"10.1016\/j.iac.2015.05.006_bib25","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/ajh.22162","article-title":"Long-term remission of lymphocytic hypereosinophilic syndrome with imatinib mesylate","volume":"87","author":"Christoforidou","year":"2012","journal-title":"Am J Hematol"},{"issue":"3","key":"10.1016\/j.iac.2015.05.006_bib26","doi-asserted-by":"crossref","first-page":"e185","DOI":"10.1016\/j.oooo.2013.03.017","article-title":"Hypereosinophilic syndrome\u2014lymphocytic variant transforming into peripheral T-cell lymphoma with severe oral manifestations","volume":"116","author":"d'Elbee","year":"2013","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"issue":"3","key":"10.1016\/j.iac.2015.05.006_bib27","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.iac.2007.07.002","article-title":"Lymphocytic variant hypereosinophilic syndromes","volume":"27","author":"Roufosse","year":"2007","journal-title":"Immunol Allergy Clin North Am"},{"issue":"2","key":"10.1016\/j.iac.2015.05.006_bib28","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3892\/ol.2012.1020","article-title":"Rapidly evolving asymptomatic eosinophilia in a patient with lung adenocarcinoma causes cognitive disturbance and respiratory insufficiency: case report","volume":"5","author":"Lo","year":"2013","journal-title":"Oncol Lett"},{"issue":"2","key":"10.1016\/j.iac.2015.05.006_bib29","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.jaad.2014.10.032","article-title":"Therapeutic management of DRESS: a retrospective study of 38 cases","volume":"72","author":"Funck-Brentano","year":"2015","journal-title":"J\u00a0Am Acad Dermatol"},{"issue":"5","key":"10.1016\/j.iac.2015.05.006_bib30","doi-asserted-by":"crossref","first-page":"530","DOI":"10.2340\/00015555-0492","article-title":"Bullous Wells' syndrome associated with non-Hodgkin's lymphocytic lymphoma","volume":"88","author":"Spinelli","year":"2008","journal-title":"Acta Derm Venereol"},{"issue":"18","key":"10.1016\/j.iac.2015.05.006_bib31","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1056\/NEJMoa1208487","article-title":"Deep dermatophytosis and inherited CARD9 deficiency","volume":"369","author":"Lanternier","year":"2013","journal-title":"N\u00a0Engl J Med"},{"issue":"4","key":"10.1016\/j.iac.2015.05.006_bib32","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.autrev.2014.12.004","article-title":"Churg-Strauss syndrome","volume":"14","author":"Greco","year":"2015","journal-title":"Autoimmun Rev"},{"issue":"4","key":"10.1016\/j.iac.2015.05.006_bib33","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/sj.leu.2403313","article-title":"Clinical and molecular features of FIP1L1-PDFGRA (+) chronic eosinophilic leukemias","volume":"18","author":"Vandenberghe","year":"2004","journal-title":"Leukemia"},{"issue":"5","key":"10.1016\/j.iac.2015.05.006_bib34","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1097\/MD.0b013e3182a71eba","article-title":"The spectrum of FIP1L1-PDGFRA-associated chronic eosinophilic leukemia: new insights based on a survey of 44 cases","volume":"92","author":"Legrand","year":"2013","journal-title":"Medicine"},{"issue":"4","key":"10.1016\/j.iac.2015.05.006_bib35","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/s00280-011-1582-3","article-title":"Durable remission after treatment with very low doses of imatinib for FIP1L1-PDGFRalpha-positive chronic eosinophilic leukaemia","volume":"67","author":"Helbig","year":"2011","journal-title":"Cancer Chemother Pharmacol"},{"issue":"5","key":"10.1016\/j.iac.2015.05.006_bib36","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/ijlh.12057","article-title":"Myeloid neoplasms associated with eosinophilia and rearrangement of PDGFRA, PDGFRB, and FGFR1: a review","volume":"35","author":"Savage","year":"2013","journal-title":"Int J Lab Hematol"},{"issue":"1","key":"10.1016\/j.iac.2015.05.006_bib37","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/leu.2011.181","article-title":"Limited clinical activity of nilotinib and sorafenib in FIP1L1-PDGFRA positive chronic eosinophilic leukemia with imatinib-resistant T674I mutation","volume":"26","author":"Metzgeroth","year":"2012","journal-title":"Leukemia"},{"issue":"8","key":"10.1016\/j.iac.2015.05.006_bib38","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.3109\/10428194.2012.749469","article-title":"Sorafenib is effective for imatinib-resistant FIP1L1\/PDGFRA T674I mutation-positive acute myeloid leukemia with eosinophilia","volume":"54","author":"Al-Riyami","year":"2013","journal-title":"Leuk Lymphoma"},{"issue":"4","key":"10.1016\/j.iac.2015.05.006_bib39","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/sj.bmt.1705437","article-title":"Allogeneic bone marrow transplantation for hypereosinophilic syndrome: long-term follow-up with eradication of FIP1L1-PDGFRA fusion transcript","volume":"38","author":"Halaburda","year":"2006","journal-title":"Bone Marrow Transpl"},{"issue":"1","key":"10.1016\/j.iac.2015.05.006_bib40","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1365-2141.2007.06628.x","article-title":"Two novel imatinib-responsive PDGFRA fusion genes in chronic eosinophilic leukaemia","volume":"138","author":"Curtis","year":"2007","journal-title":"Br J Haematol"},{"issue":"23","key":"10.1016\/j.iac.2015.05.006_bib41","doi-asserted-by":"crossref","first-page":"3574","DOI":"10.1182\/blood-2014-02-555607","article-title":"Patients with myeloid malignancies bearing PDGFRB fusion genes achieve durable long-term remissions with imatinib","volume":"123","author":"Cheah","year":"2014","journal-title":"Blood"},{"issue":"17","key":"10.1016\/j.iac.2015.05.006_bib42","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/MD.0000000000000088","article-title":"The lymphoid variant of hypereosinophilic syndrome: study of 21 patients with CD3-CD4+ aberrant T-cell phenotype","volume":"93","author":"Lefevre","year":"2014","journal-title":"Medicine"},{"issue":"4","key":"10.1016\/j.iac.2015.05.006_bib43","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.jaci.2010.06.049","article-title":"Mepolizumab as a corticosteroid-sparing agent in lymphocytic variant hypereosinophilic syndrome","volume":"126","author":"Roufosse","year":"2010","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"11","key":"10.1016\/j.iac.2015.05.006_bib44","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1007\/s00277-008-0505-9","article-title":"Resolution of left and right ventricular thrombosis secondary to hypereosinophilic syndrome (lymphoproliferative variant) with reduced intensity conditioning allogenic stem cell transplantation","volume":"87","author":"Bergua","year":"2008","journal-title":"Ann Hematol"},{"issue":"6","key":"10.1016\/j.iac.2015.05.006_bib45","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.jaci.2009.09.022","article-title":"Hypereosinophilic syndrome: a multicenter, retrospective analysis of clinical characteristics and response to therapy","volume":"124","author":"Ogbogu","year":"2009","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"6","key":"10.1016\/j.iac.2015.05.006_bib46","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1097\/MD.0b013e31815d108c","article-title":"Management of hypereosinophilic syndrome: a prospective study in the era of molecular genetics","volume":"86","author":"Dahabreh","year":"2007","journal-title":"Medicine"},{"issue":"2","key":"10.1016\/j.iac.2015.05.006_bib47","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.leukres.2011.09.026","article-title":"Use of pegylated interferon in hypereosinophilic syndrome","volume":"36","author":"Butterfield","year":"2012","journal-title":"Leuk Res"},{"issue":"13","key":"10.1016\/j.iac.2015.05.006_bib48","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1056\/NEJMoa025217","article-title":"A\u00a0tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome","volume":"348","author":"Cools","year":"2003","journal-title":"N\u00a0Engl J Med"},{"issue":"8","key":"10.1016\/j.iac.2015.05.006_bib49","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.leukres.2008.12.001","article-title":"Success of short-term, higher-dose imatinib mesylate to induce clinical response in FIP1L1-PDGFRalpha-negative hypereosinophilic syndrome","volume":"33","author":"Butterfield","year":"2009","journal-title":"Leuk Res"},{"issue":"12","key":"10.1016\/j.iac.2015.05.006_bib50","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1007\/s00432-013-1529-7","article-title":"Effect of the tyrosine kinase inhibitor nilotinib in patients with hypereosinophilic syndrome\/chronic eosinophilic leukemia: analysis of the phase 2, open-label, single-arm A2101 study","volume":"139","author":"Hochhaus","year":"2013","journal-title":"J\u00a0Cancer Res Clin Oncol"},{"issue":"3","key":"10.1016\/j.iac.2015.05.006_bib51","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.clml.2012.09.018","article-title":"Long-term follow-up of patients with hypereosinophilic syndrome treated with Alemtuzumab, an anti-CD52 antibody","volume":"13","author":"Strati","year":"2013","journal-title":"Clin Lymphoma Myeloma Leuk"},{"issue":"12","key":"10.1016\/j.iac.2015.05.006_bib52","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1056\/NEJMoa070812","article-title":"Treatment of patients with the hypereosinophilic syndrome with mepolizumab","volume":"358","author":"Rothenberg","year":"2008","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.iac.2015.05.006_bib53","first-page":"1","article-title":"Treatment-refractory hypereosinophilic syndrome responding to fludarabine in a 12-year-old boy","volume":"25","author":"Sauvage","year":"2015","journal-title":"Leuk Lymphoma"}],"container-title":["Immunology and Allergy Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889856115000375?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889856115000375?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T16:34:11Z","timestamp":1567010051000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889856115000375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["S0889856115000375"],"URL":"https:\/\/doi.org\/10.1016\/j.iac.2015.05.006","relation":{},"ISSN":["0889-8561"],"issn-type":[{"value":"0889-8561","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Management of Hypereosinophilic Syndromes","name":"articletitle","label":"Article Title"},{"value":"Immunology and Allergy Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.iac.2015.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}