{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:18:20Z","timestamp":1791274700534,"version":"4.1.0"},"reference-count":124,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","theclinics.com","clinicalkey.com.au","clinicalkey.fr","immunology.theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunology and Allergy Clinics of North America"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.iac.2015.07.009","type":"journal-article","created":{"date-parts":[[2015,9,4]],"date-time":"2015-09-04T12:21:50Z","timestamp":1441369310000},"page":"637-658","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":81,"title":["Common Variable Immunodeficiency"],"prefix":"10.1016","volume":"35","author":[{"given":"Jordan K.","family":"Abbott","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin W.","family":"Gelfand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.iac.2015.07.009_bib1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1006\/clim.1999.4799","article-title":"Diagnostic criteria for primary immunodeficiencies. Representing PAGID (Pan-American Group for Immunodeficiency) and ESID (European Society for Immunodeficiencies)","volume":"93","author":"Conley","year":"1999","journal-title":"Clin Immunol"},{"issue":"4","key":"10.1016\/j.iac.2015.07.009_bib2","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.jaci.2013.02.028","article-title":"Controversies in IgG replacement therapy in patients with antibody deficiency diseases","volume":"131","author":"Gelfand","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"2","key":"10.1016\/j.iac.2015.07.009_bib3","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/cei.12178","article-title":"New diagnostic criteria for common variable immune deficiency (CVID), which may assist with decisions to treat with intravenous or subcutaneous immunoglobulin","volume":"174","author":"Ameratunga","year":"2013","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.iac.2015.07.009_bib4","unstructured":"European Society for Immunodeficiencies Registry Working Party. Available at: http:\/\/esid.org\/Working-Parties\/Registry\/Diagnosis-criteria. Accessed August 10, 2015."},{"issue":"1","key":"10.1016\/j.iac.2015.07.009_bib5","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0889-8561(05)70197-1","article-title":"Secondary hypogammaglobulinemia","volume":"21","author":"Jaffe","year":"2001","journal-title":"Immunol Allergy Clin N Am"},{"issue":"5","key":"10.1016\/j.iac.2015.07.009_bib6","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1007\/s10875-011-9565-z","article-title":"Lymphoid proliferations of indeterminate malignant potential arising in adults with common variable immunodeficiency disorders: unusual case studies and immunohistological review in the light of possible causative events","volume":"31","author":"da Silva","year":"2011","journal-title":"J\u00a0Clin Immunol"},{"issue":"7","key":"10.1016\/j.iac.2015.07.009_bib7","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1128\/CVI.00235-14","article-title":"Multilaboratory assessment of threshold versus fold-change algorithms for minimizing analytical variability in multiplexed pneumococcal IgG measurements","volume":"21","author":"Daly","year":"2014","journal-title":"Clin Vaccin Immunol"},{"issue":"2","key":"10.1016\/j.iac.2015.07.009_bib8","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s10875-012-9806-9","article-title":"Serotype-specific anti-pneumococcal IgG and immune competence: critical differences in interpretation criteria when different methods are used","volume":"33","author":"Balloch","year":"2013","journal-title":"J\u00a0Clin Immunol"},{"issue":"2","key":"10.1016\/j.iac.2015.07.009_bib9","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0090-1229(90)90145-G","article-title":"Classification of patients with common variable immunodeficiency by B cell secretion of IgM and IgG in response to anti-IgM and interleukin-2","volume":"56","author":"Bryant","year":"1990","journal-title":"Clin Immunol Immunopathol"},{"issue":"5","key":"10.1016\/j.iac.2015.07.009_bib10","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1182\/blood.V99.5.1544","article-title":"Severe deficiency of switched memory B cells (CD27(+)IgM(\u2212)IgD(\u2212)) in subgroups of patients with common variable immunodeficiency: a new approach to classify a heterogeneous disease","volume":"99","author":"Warnatz","year":"2002","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.iac.2015.07.009_bib11","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1023\/A:1025373601374","article-title":"Common variable immunodeficiency patient classification based on impaired B cell memory differentiation correlates with clinical aspects","volume":"23","author":"Piqueras","year":"2003","journal-title":"J\u00a0Clin Immunol"},{"issue":"5","key":"10.1016\/j.iac.2015.07.009_bib12","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1078\/0171-2985-00198","article-title":"Expansion of CD19(hi)CD21(lo\/neg) B cells in common variable immunodeficiency (CVID) patients with autoimmune cytopenia","volume":"206","author":"Warnatz","year":"2002","journal-title":"Immunobiology"},{"issue":"1","key":"10.1016\/j.iac.2015.07.009_bib13","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1182\/blood-2007-06-091744","article-title":"The EUROclass trial: defining subgroups in common variable immunodeficiency","volume":"111","author":"Wehr","year":"2008","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.iac.2015.07.009_bib14","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/sji.12028","article-title":"Variability of memory B cell markers in a cohort of common variable immune deficiency patients over 6 months","volume":"77","author":"Koopmans","year":"2013","journal-title":"Scand J Immunol"},{"issue":"2","key":"10.1016\/j.iac.2015.07.009_bib15","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1182\/blood-2007-11-124545","article-title":"Common variable immunodeficiency disorders: division into distinct clinical phenotypes","volume":"112","author":"Chapel","year":"2008","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.iac.2015.07.009_bib16","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.jaci.2012.05.046","article-title":"Confirmation and improvement of criteria for clinical phenotyping in common variable immunodeficiency disorders in replicate cohorts","volume":"130","author":"Chapel","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"7","key":"10.1016\/j.iac.2015.07.009_bib17","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1182\/blood-2011-09-377945","article-title":"Morbidity and mortality in common variable immune deficiency over 4 decades","volume":"119","author":"Resnick","year":"2012","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.iac.2015.07.009_bib18","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s10875-011-9511-0","article-title":"Effectiveness of immunoglobulin replacement therapy on clinical outcome in patients with primary antibody deficiencies: results from a multicenter prospective cohort study","volume":"31","author":"Quinti","year":"2011","journal-title":"J\u00a0Clin Immunol"},{"issue":"1","key":"10.1016\/j.iac.2015.07.009_bib19","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jaci.2013.12.1077","article-title":"Clinical picture and treatment of 2212 patients with common variable immunodeficiency","volume":"134","author":"Gathmann","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"10","key":"10.1016\/j.iac.2015.07.009_bib20","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1586\/1744666X.2014.958469","article-title":"Long-term evaluation of a historical cohort of Iranian common variable immunodeficiency patients","volume":"10","author":"Aghamohammadi","year":"2014","journal-title":"Exp Rev Clin Immunol"},{"issue":"3","key":"10.1016\/j.iac.2015.07.009_bib21","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/ni902","article-title":"Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency","volume":"4","author":"Grimbacher","year":"2003","journal-title":"Nat Immunol"},{"issue":"33","key":"10.1016\/j.iac.2015.07.009_bib22","doi-asserted-by":"crossref","first-page":"13945","DOI":"10.1073\/pnas.0903543106","article-title":"B-cell activating factor receptor deficiency is associated with an adult-onset antibody deficiency syndrome in humans","volume":"106","author":"Warnatz","year":"2009","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"issue":"18","key":"10.1016\/j.iac.2015.07.009_bib23","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1056\/NEJMoa051568","article-title":"An antibody-deficiency syndrome due to mutations in the CD19 gene","volume":"354","author":"van Zelm","year":"2006","journal-title":"N\u00a0Engl J Med"},{"issue":"1","key":"10.1016\/j.iac.2015.07.009_bib24","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1172\/JCI40231","article-title":"CD20 deficiency in humans results in impaired T cell-independent antibody responses","volume":"120","author":"Kuijpers","year":"2010","journal-title":"J\u00a0Clin Invest"},{"issue":"3","key":"10.1016\/j.iac.2015.07.009_bib25","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.jaci.2011.09.027","article-title":"Genetic CD21 deficiency is associated with hypogammaglobulinemia","volume":"129","author":"Thiel","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"4","key":"10.1016\/j.iac.2015.07.009_bib26","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1172\/JCI39748","article-title":"CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody deficiency","volume":"120","author":"van Zelm","year":"2010","journal-title":"J\u00a0Clin Invest"},{"issue":"8","key":"10.1016\/j.iac.2015.07.009_bib27","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/ng1601","article-title":"TACI is mutant in common variable immunodeficiency and IgA deficiency","volume":"37","author":"Castigli","year":"2005","journal-title":"Nat Genet"},{"issue":"8","key":"10.1016\/j.iac.2015.07.009_bib28","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/ng1600","article-title":"Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans","volume":"37","author":"Salzer","year":"2005","journal-title":"Nat Genet"},{"issue":"2","key":"10.1016\/j.iac.2015.07.009_bib29","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1006\/clin.1995.1142","article-title":"Family and linkage study of selective IgA deficiency and common variable immunodeficiency","volume":"77","author":"Vorechovsky","year":"1995","journal-title":"Clin Immunol Immunopathol"},{"issue":"4","key":"10.1016\/j.iac.2015.07.009_bib30","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.jaci.2013.11.021","article-title":"A\u00a0common single nucleotide polymorphism impairs B-cell activating factor receptor's multimerization, contributing to common variable immunodeficiency","volume":"133","author":"Pieper","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"6","key":"10.1016\/j.iac.2015.07.009_bib31","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/j.jaci.2011.02.039","article-title":"Genome-wide association identifies diverse causes of common variable immunodeficiency","volume":"127","author":"Orange","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"6","key":"10.1016\/j.iac.2015.07.009_bib32","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.ajhg.2012.04.015","article-title":"Deleterious mutations in LRBA are associated with a syndrome of immune deficiency and autoimmunity","volume":"90","author":"Lopez-Herrera","year":"2012","journal-title":"Am J Hum Genet"},{"issue":"3","key":"10.1016\/j.iac.2015.07.009_bib33","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.jaci.2011.11.013","article-title":"CD27 deficiency is associated with combined immunodeficiency and persistent symptomatic EBV viremia","volume":"129","author":"van Montfrans","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"6204","key":"10.1016\/j.iac.2015.07.009_bib34","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1126\/science.1255904","article-title":"Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4","volume":"345","author":"Kuehn","year":"2014","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.iac.2015.07.009_bib35","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1038\/nm.3746","article-title":"Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations","volume":"20","author":"Schubert","year":"2014","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.iac.2015.07.009_bib36","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/ni.2771","article-title":"Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110\u03b4 result in T cell senescence and human immunodeficiency","volume":"15","author":"Lucas","year":"2013","journal-title":"Nat Immunol"},{"issue":"4","key":"10.1016\/j.iac.2015.07.009_bib37","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1056\/NEJMoa1102140","article-title":"Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions","volume":"366","author":"Ombrello","year":"2012","journal-title":"N\u00a0Engl J Med"},{"issue":"Suppl 1","key":"10.1016\/j.iac.2015.07.009_bib38","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/cei.12491","article-title":"Common variable immunodeficiency (CVID): new genetic insight and unanswered questions","volume":"178","author":"Ochs","year":"2014","journal-title":"Clin Exp Immunol"},{"issue":"1","key":"10.1016\/j.iac.2015.07.009_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1586\/1744666X.2014.870478","article-title":"Is there a need to redefine the diagnostic criteria for common variable immunodeficiency?","volume":"10","author":"Sepp\u00e4nen","year":"2014","journal-title":"Exp Rev Clin Immunol"},{"issue":"1","key":"10.1016\/j.iac.2015.07.009_bib40","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1440-1843.2011.02067.x","article-title":"Magnetic resonance imaging is an accurate and reliable method to evaluate non-cystic fibrosis paediatric lung disease","volume":"17","author":"Montella","year":"2012","journal-title":"Respirology"},{"key":"10.1016\/j.iac.2015.07.009_bib41","first-page":"672458","article-title":"Idiopathic non cirrhotic portal hypertension and splenoportal axis abnormalities in patients with severe primary antibody deficiencies","volume":"2014","author":"Pulvirenti","year":"2014","journal-title":"J\u00a0Immunol Res"},{"issue":"3","key":"10.1016\/j.iac.2015.07.009_bib42","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/s10875-007-9075-1","article-title":"Long-term follow-up and outcome of a large cohort of patients with common variable immunodeficiency","volume":"27","author":"Quinti","year":"2007","journal-title":"J\u00a0Clin Immunol"},{"issue":"10","key":"10.1016\/j.iac.2015.07.009_bib43","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1086\/587669","article-title":"Infections in 252 patients with common variable immunodeficiency","volume":"46","author":"Oksenhendler","year":"2008","journal-title":"Clin Infect Dis"},{"issue":"3","key":"10.1016\/j.iac.2015.07.009_bib44","doi-asserted-by":"crossref","first-page":"310","DOI":"10.4103\/0366-6999.150092","article-title":"Clinical and immunological features of common variable immunodeficiency in China","volume":"128","author":"Lin","year":"2015","journal-title":"Chin Med J"},{"issue":"3","key":"10.1016\/j.iac.2015.07.009_bib45","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.aller.2013.01.007","article-title":"Clinical and immunological features of common variable immunodeficiency in Mexican patients","volume":"42","author":"Ram\u00edrez-Vargas","year":"2014","journal-title":"Allergol Immunopathol (Madr)"},{"issue":"3","key":"10.1016\/j.iac.2015.07.009_bib46","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.jaci.2011.10.020","article-title":"Defective calcium signaling and disrupted CD20-B-cell receptor dissociation in patients with common variable immunodeficiency disorders","volume":"129","author":"van de Ven","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"12","key":"10.1016\/j.iac.2015.07.009_bib47","doi-asserted-by":"crossref","first-page":"7305","DOI":"10.4049\/jimmunol.1000434","article-title":"B\u00a0cell receptor-mediated calcium signaling is impaired in B lymphocytes of type Ia patients with common variable immunodeficiency","volume":"184","author":"Foerster","year":"2010","journal-title":"J\u00a0Immunol"},{"issue":"2","key":"10.1016\/j.iac.2015.07.009_bib48","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jaci.2009.05.019","article-title":"Toll-like receptor 7 and 9 defects in common variable immunodeficiency","volume":"124","author":"Yu","year":"2009","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"1","key":"10.1016\/j.iac.2015.07.009_bib49","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1046\/j.1365-2249.2002.01883.x","article-title":"Impaired up-regulation of CD70 and CD86 in naive (CD27-) B cells from patients with common variable immunodeficiency (CVID)","volume":"129","author":"Groth","year":"2002","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.iac.2015.07.009_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2014.12.1943","article-title":"Key stages of bone marrow B-cell maturation are defective in patients with common variable immunodeficiency disorders","author":"Anzilotti","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"2","key":"10.1016\/j.iac.2015.07.009_bib51","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1046\/j.1365-2249.2002.01893.x","article-title":"Assessment of thymic output in common variable immunodeficiency patients by evaluation of T cell receptor excision circles","volume":"129","author":"Guazzi","year":"2002","journal-title":"Clin Exp Immunol"},{"issue":"8","key":"10.1016\/j.iac.2015.07.009_bib52","doi-asserted-by":"crossref","first-page":"5074","DOI":"10.4049\/jimmunol.174.8.5074","article-title":"Bone marrow clonogenic capability, cytokine production, and thymic output in patients with common variable immunodeficiency","volume":"174","author":"Isgr\u00f2","year":"2005","journal-title":"J\u00a0Immunol"},{"issue":"3","key":"10.1016\/j.iac.2015.07.009_bib53","first-page":"160","article-title":"Naive CD4+ T cells and recent thymic emigrants in common variable immunodeficiency","volume":"22","author":"Oraei","year":"2012","journal-title":"J\u00a0Investig Allergol Clin Immunol"},{"issue":"4","key":"10.1016\/j.iac.2015.07.009_bib54","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1007\/s10875-011-9526-6","article-title":"Thymic and bone marrow output in patients with common variable immunodeficiency","volume":"31","author":"Serana","year":"2011","journal-title":"J\u00a0Clin Immunol"},{"issue":"2","key":"10.1016\/j.iac.2015.07.009_bib55","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1182\/blood-2010-11-321695","article-title":"T\u00a0and B lymphocyte abnormalities in bone marrow biopsies of common variable immunodeficiency","volume":"118","author":"Ochtrop","year":"2011","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.iac.2015.07.009_bib56","doi-asserted-by":"crossref","first-page":"e6269","DOI":"10.1371\/journal.pone.0006269","article-title":"A\u00a0decreased frequency of regulatory T cells in patients with common variable immunodeficiency","volume":"4","author":"Melo","year":"2009","journal-title":"PLoS ONE"},{"issue":"3","key":"10.1016\/j.iac.2015.07.009_bib57","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/j.1365-2249.2009.03913.x","article-title":"Decrease in phenotypic regulatory T cells in subsets of patients with common variable immunodeficiency","volume":"156","author":"Horn","year":"2009","journal-title":"Clin Exp Immunol"},{"issue":"2","key":"10.1016\/j.iac.2015.07.009_bib58","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.cellimm.2013.03.003","article-title":"Evaluation of CD4+CD25+FOXP3+ regulatory T cells function in patients with common variable immunodeficiency","volume":"281","author":"Arandi","year":"2013","journal-title":"Cell Immunol"},{"issue":"3","key":"10.1016\/j.iac.2015.07.009_bib59","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1073\/pnas.91.3.1099","article-title":"CD40 ligand expression is defective in a subset of patients with common variable immunodeficiency","volume":"91","author":"Farrington","year":"1994","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"issue":"1","key":"10.1016\/j.iac.2015.07.009_bib60","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1046\/j.1365-3083.1997.d01-95.x","article-title":"IL-10 production and CD40L expression in patients with common variable immunodeficiency","volume":"46","author":"Oliva","year":"1997","journal-title":"Scand J Immunol"},{"issue":"3","key":"10.1016\/j.iac.2015.07.009_bib61","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1046\/j.1365-2249.2000.01239.x","article-title":"Enhanced apoptosis of T cells in common variable immunodeficiency (CVID): role of defective CD28 co-stimulation","volume":"120","author":"Di Renzo","year":"2000","journal-title":"Clin Exp Immunol"},{"issue":"6","key":"10.1016\/j.iac.2015.07.009_bib62","doi-asserted-by":"crossref","first-page":"3932","DOI":"10.4049\/jimmunol.178.6.3932","article-title":"Unravelling the complexity of T cell abnormalities in common variable immunodeficiency","volume":"178","author":"Giovannetti","year":"2007","journal-title":"J\u00a0Immunol"},{"issue":"3","key":"10.1016\/j.iac.2015.07.009_bib63","first-page":"244","article-title":"Cytokine production by activated T cells in common variable immunodeficiency","volume":"20","author":"Rezaei","year":"2010","journal-title":"J\u00a0Investig Allergol Clin Immunol"},{"issue":"10","key":"10.1016\/j.iac.2015.07.009_bib64","doi-asserted-by":"crossref","first-page":"4283","DOI":"10.1172\/JCI69854","article-title":"CVID-associated TACI mutations affect autoreactive B cell selection and activation","volume":"123","author":"Romberg","year":"2013","journal-title":"J\u00a0Clin Invest"},{"issue":"5","key":"10.1016\/j.iac.2015.07.009_bib65","doi-asserted-by":"crossref","first-page":"R1052","DOI":"10.1186\/ar1774","article-title":"Altered dendritic cell distribution in patients with common variable immunodeficiency","volume":"7","author":"Viallard","year":"2005","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"10.1016\/j.iac.2015.07.009_bib66","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1365-2249.2006.03063.x","article-title":"Elevated serum interleukin (IL)-12p40 levels in common variable immunodeficiency disease and decreased peripheral blood dendritic cells: analysis of IL-12p40 and interferon-gamma gene","volume":"144","author":"Martinez-Pomar","year":"2006","journal-title":"Clin Exp Immunol"},{"issue":"3","key":"10.1016\/j.iac.2015.07.009_bib67","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/cei.12239","article-title":"Common variable immunodeficiency revisited: normal generation of naturally occurring dendritic cells that respond to Toll-like receptors 7 and 9","volume":"175","author":"Taraldsrud","year":"2014","journal-title":"Clin Exp Immunol"},{"issue":"10","key":"10.1016\/j.iac.2015.07.009_bib68","doi-asserted-by":"crossref","first-page":"e75199","DOI":"10.1371\/journal.pone.0075199","article-title":"IVIG immune reconstitution treatment alleviates the state of persistent immune activation and suppressed CD4 T cell counts in CVID","volume":"8","author":"Paquin-Proulx","year":"2013","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.iac.2015.07.009_bib69","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1084\/jem.20140039","article-title":"Exhaustion of bacteria-specific CD4 T cells and microbial translocation in common variable immunodeficiency disorders","volume":"211","author":"Perreau","year":"2014","journal-title":"J\u00a0Exp Med"},{"issue":"3","key":"10.1016\/j.iac.2015.07.009_bib70","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1365-2249.2012.04620.x","article-title":"Monocyte activation is a feature of common variable immunodeficiency irrespective of plasma lipopolysaccharide levels","volume":"169","author":"Barbosa","year":"2012","journal-title":"Clin Exp Immunol"},{"issue":"2","key":"10.1016\/j.iac.2015.07.009_bib71","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.clim.2011.01.002","article-title":"Preparations of intravenous immunoglobulins diminish the number and proinflammatory response of CD14+CD16++ monocytes in common variable immunodeficiency (CVID) patients","volume":"139","author":"Siedlar","year":"2011","journal-title":"Clin Immunol"},{"issue":"5","key":"10.1016\/j.iac.2015.07.009_bib72","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/BF03256928","article-title":"Intravenous immunoglobulin replacement therapy in the treatment of patients with common variable immunodeficiency disease: an open-label prospective study","volume":"31","author":"Kasztalska","year":"2011","journal-title":"Clin Drug Investig"},{"issue":"5","key":"10.1016\/j.iac.2015.07.009_bib73","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/j.jaci.2013.10.059","article-title":"Common variable immunodeficiency is associated with a functional deficiency of invariant natural killer T cells","volume":"133","author":"Gao","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.iac.2015.07.009_bib74","doi-asserted-by":"crossref","first-page":"637","DOI":"10.3389\/fimmu.2014.00637","article-title":"Persistent immune activation in CVID and the role of IVIG in its suppression","volume":"5","author":"Paquin-Proulx","year":"2014","journal-title":"Front Immunol"},{"issue":"21","key":"10.1016\/j.iac.2015.07.009_bib75","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1056\/NEJMra1009433","article-title":"Intravenous immune globulin in autoimmune and inflammatory diseases","volume":"367","author":"Gelfand","year":"2012","journal-title":"N\u00a0Engl J Med"},{"issue":"Suppl 2","key":"10.1016\/j.iac.2015.07.009_bib76","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1365-2249.2011.04387.x","article-title":"Intravenous immunoglobulins in immunodeficiencies: more than mere replacement therapy","volume":"164","author":"Kaveri","year":"2011","journal-title":"Clin Exp Immunol"},{"issue":"1","key":"10.1016\/j.iac.2015.07.009_bib77","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1006\/clim.1999.4725","article-title":"Common variable immunodeficiency: clinical\u00a0and immunological features of 248 patients","volume":"92","author":"Cunningham-Rundles","year":"1999","journal-title":"Clin Immunol"},{"issue":"6","key":"10.1016\/j.iac.2015.07.009_bib78","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/j.jaci.2011.07.055","article-title":"Outcome of allogeneic stem cell transplantation in adults with common variable immunodeficiency","volume":"128","author":"Rizzi","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"4","key":"10.1016\/j.iac.2015.07.009_bib79","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.jaci.2014.11.029","article-title":"Multicenter experience in hematopoietic stem cell transplantation for serious complications of common variable immunodeficiency","volume":"135","author":"Wehr","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"10","key":"10.1016\/j.iac.2015.07.009_bib80","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1038\/ajg.2010.214","article-title":"The enteropathy associated with common variable immunodeficiency: the delineated frontiers with celiac disease","volume":"105","author":"Malamut","year":"2010","journal-title":"Am J Gastroenterol"},{"issue":"9","key":"10.1016\/j.iac.2015.07.009_bib81","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.cgh.2013.02.024","article-title":"Diagnosis and treatment of gastrointestinal disorders in patients with primary immunodeficiency","volume":"11","author":"Agarwal","year":"2013","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"8","key":"10.1016\/j.iac.2015.07.009_bib82","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1007\/s10875-014-0087-3","article-title":"Increased prevalence of gastrointestinal viruses and diminished secretory immunoglobulin A levels in antibody deficiencies","volume":"34","author":"van de Ven","year":"2014","journal-title":"J\u00a0Clin Immunol"},{"issue":"2","key":"10.1016\/j.iac.2015.07.009_bib83","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/ajg.2014.432","article-title":"The role of chronic norovirus infection in the enteropathy associated with common variable immunodeficiency","volume":"110","author":"Woodward","year":"2015","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"10.1016\/j.iac.2015.07.009_bib84","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/j.1365-2249.2007.03481.x","article-title":"Anti-tumour necrosis factor-alpha therapy for severe enteropathy in patients with common variable immunodeficiency (CVID)","volume":"150","author":"Chua","year":"2007","journal-title":"Clin Exp Immunol"},{"issue":"4","key":"10.1016\/j.iac.2015.07.009_bib85","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1007\/s10875-013-9873-6","article-title":"Nodular regenerative hyperplasia in common variable immunodeficiency","volume":"33","author":"Fuss","year":"2013","journal-title":"J\u00a0Clin Immunol"},{"issue":"4","key":"10.1016\/j.iac.2015.07.009_bib86","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.humpath.2008.09.008","article-title":"Hepatitis in common variable immunodeficiency","volume":"40","author":"Daniels","year":"2009","journal-title":"Hum Pathol"},{"issue":"3","key":"10.1016\/j.iac.2015.07.009_bib87","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1365-2249.2008.03711.x","article-title":"Abnormal liver function in common variable immunodeficiency disorders due to nodular regenerative hyperplasia","volume":"153","author":"Ward","year":"2008","journal-title":"Clin Exp Immunol"},{"issue":"6","key":"10.1016\/j.iac.2015.07.009_bib88","doi-asserted-by":"crossref","first-page":"E210","DOI":"10.1111\/j.1399-3046.2011.01545.x","article-title":"Liver transplantation for severe hepatitis in patients with common variable immunodeficiency","volume":"16","author":"Murakawa","year":"2012","journal-title":"Pediatr Transplant"},{"issue":"6","key":"10.1016\/j.iac.2015.07.009_bib89","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1007\/s10875-014-0068-6","article-title":"CT screening for pulmonary pathology in common variable immunodeficiency disorders and the correlation with clinical and immunological parameters","volume":"34","author":"Maarschalk-Ellerbroek","year":"2014","journal-title":"J\u00a0Clin Immunol"},{"issue":"6","key":"10.1016\/j.iac.2015.07.009_bib90","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.crad.2011.10.028","article-title":"Respiratory disease in common variable immunodeficiency and other primary immunodeficiency disorders","volume":"67","author":"Hampson","year":"2012","journal-title":"Clin Radiol"},{"issue":"2","key":"10.1016\/j.iac.2015.07.009_bib91","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jaci.2013.08.022","article-title":"Tertiary lymphoid neogenesis is a component of pulmonary lymphoid hyperplasia in patients with common variable immunodeficiency","volume":"133","author":"Maglione","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"2","key":"10.1016\/j.iac.2015.07.009_bib92","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.jaci.2004.05.057","article-title":"Granulomatous- lymphocytic lung disease shortens survival in common variable immunodeficiency","volume":"114","author":"Bates","year":"2004","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"1","key":"10.1016\/j.iac.2015.07.009_bib93","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1183\/09031936.00189011","article-title":"Granulomatosis-associated common variable immunodeficiency disorder: a case-control study versus sarcoidosis","volume":"41","author":"Bouvry","year":"2013","journal-title":"Eur Respir J"},{"issue":"8541","key":"10.1016\/j.iac.2015.07.009_bib94","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/S0140-6736(87)90494-6","article-title":"High-dose versus low-dose intravenous immunoglobulin in hypogammaglobulinaemia and chronic lung disease","volume":"1","author":"Roifman","year":"1987","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.iac.2015.07.009_bib95","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s10875-012-9755-3","article-title":"Use of combination chemotherapy for treatment of granulomatous and lymphocytic interstitial lung disease (GLILD) in patients with common variable immunodeficiency (CVID)","volume":"33","author":"Chase","year":"2012","journal-title":"J\u00a0Clin Immunol"},{"issue":"5","key":"10.1016\/j.iac.2015.07.009_bib96","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1097\/MCP.0b013e3283642c47","article-title":"Common variable immunodeficiency-associated granulomatous and interstitial lung disease","volume":"19","author":"Prasse","year":"2013","journal-title":"Curr Opin Pulm Med"},{"issue":"1","key":"10.1016\/j.iac.2015.07.009_bib97","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jaut.2010.10.002","article-title":"Autoimmunity in common variable immunodeficiency: correlation with lymphocyte phenotype in the French DEFI study","volume":"36","author":"Boileau","year":"2011","journal-title":"J\u00a0Autoimmun"},{"issue":"1","key":"10.1016\/j.iac.2015.07.009_bib98","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jaut.2005.04.006","article-title":"Treatment and outcome of autoimmune hematologic disease in common variable immunodeficiency (CVID)","volume":"25","author":"Wang","year":"2005","journal-title":"J\u00a0Autoimmun"},{"issue":"4","key":"10.1016\/j.iac.2015.07.009_bib99","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/j.1365-2141.2011.08880.x","article-title":"Efficacy and safety of rituximab in common variable immunodeficiency-associated immune cytopenias: a retrospective multicentre study on 33 patients","volume":"155","author":"Gobert","year":"2011","journal-title":"Br J Haematol"},{"issue":"1","key":"10.1016\/j.iac.2015.07.009_bib100","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1054\/blre.2001.0185","article-title":"Hematologic complications of primary immune deficiencies","volume":"16","author":"Cunningham-Rundles","year":"2002","journal-title":"Blood Rev"},{"issue":"1","key":"10.1016\/j.iac.2015.07.009_bib101","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s10875-012-9778-9","article-title":"Granulomatous disease in CVID: retrospective analysis of clinical characteristics and treatment efficacy in a cohort of 59 patients","volume":"33","author":"Boursiquot","year":"2013","journal-title":"J\u00a0Clin Immunol"},{"issue":"2","key":"10.1016\/j.iac.2015.07.009_bib102","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.clim.2009.05.001","article-title":"Granulomatous disease in common variable immunodeficiency","volume":"133","author":"Ardeniz","year":"2009","journal-title":"Clin Immunol"},{"issue":"6","key":"10.1016\/j.iac.2015.07.009_bib103","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s10875-014-0052-1","article-title":"Ill-defined germinal centers and severely reduced plasma cells are histological hallmarks of lymphadenopathy in patients with common variable immunodeficiency","volume":"34","author":"Unger","year":"2014","journal-title":"J\u00a0Clin Immunol"},{"issue":"5","key":"10.1016\/j.iac.2015.07.009_bib104","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.jaci.2005.08.041","article-title":"Caseating granulomatous disease in common variable immunodeficiency treated with infliximab","volume":"116","author":"Hatab","year":"2005","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"8 Pt 1","key":"10.1016\/j.iac.2015.07.009_bib105","doi-asserted-by":"crossref","first-page":"613","DOI":"10.7326\/0003-4819-127-8_Part_1-199710150-00005","article-title":"Granulomatous disease in common variable immunodeficiency","volume":"127","author":"Mechanic","year":"1997","journal-title":"Ann Intern Med"},{"issue":"7","key":"10.1016\/j.iac.2015.07.009_bib106","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1007\/s10875-014-0079-3","article-title":"Infliximab for treatment of granulomatous disease in patients with common variable immunodeficiency","volume":"34","author":"Franxman","year":"2014","journal-title":"J\u00a0Clin Immunol"},{"issue":"4","key":"10.1016\/j.iac.2015.07.009_bib107","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.jaci.2006.01.034","article-title":"Etanercept treatment of cutaneous granulomas in common variable immunodeficiency","volume":"117","author":"Lin","year":"2006","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"3","key":"10.1016\/j.iac.2015.07.009_bib108","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S1081-1206(10)61228-8","article-title":"Infliximab treatment for severe granulomatous disease in common variable immunodeficiency: a case report and review of the literature","volume":"95","author":"Thatayatikom","year":"2005","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"9","key":"10.1016\/j.iac.2015.07.009_bib109","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1182\/blood-2012-05-431064","article-title":"Malignancies are the major cause of death in patients with adult onset common variable immunodeficiency","volume":"120","author":"Quinti","year":"2012","journal-title":"Blood"},{"issue":"8423","key":"10.1016\/j.iac.2015.07.009_bib110","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0140-6736(85)91037-2","article-title":"Prospective study of cancer in patients with hypogammaglobulinaemia","volume":"1","author":"Kinlen","year":"1985","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.iac.2015.07.009_bib111","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1182\/blood-2010-03-272351","article-title":"Are antibody deficiency disorders associated with a narrower range of cancers than other forms of immunodeficiency?","volume":"116","author":"Vajdic","year":"2010","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.iac.2015.07.009_bib112","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1097\/BOR.0b013e3282fd6e70","article-title":"Osteoarticular infectious complications in patients with primary immunodeficiencies","volume":"20","author":"Bloom","year":"2008","journal-title":"Curr Opin Rheumatol"},{"issue":"4","key":"10.1016\/j.iac.2015.07.009_bib113","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/0049-0172(93)80073-O","article-title":"Hypogammaglobulinemia and rheumatic disease","volume":"22","author":"Lee","year":"1993","journal-title":"Semin Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.iac.2015.07.009_bib114","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s10067-005-1141-6","article-title":"Rheumatoid arthritis in a patient with common variable immunodeficiency: difficulty in diagnosis and therapy","volume":"25","author":"Swierkot","year":"2006","journal-title":"Clin Rheumatol"},{"issue":"8","key":"10.1016\/j.iac.2015.07.009_bib115","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.autrev.2014.04.006","article-title":"Common variable immunodeficiency and autoimmunity-an inconvenient truth","volume":"13","author":"Xiao","year":"2014","journal-title":"Autoimmun Rev"},{"issue":"5","key":"10.1016\/j.iac.2015.07.009_bib116","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s11882-009-0051-0","article-title":"Autoimmunity in common variable immunodeficiency","volume":"9","author":"Agarwal","year":"2009","journal-title":"Curr Allergy Asthma Rep"},{"issue":"6","key":"10.1016\/j.iac.2015.07.009_bib117","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/j.jaci.2010.02.040","article-title":"Infection outcomes in patients with common variable immunodeficiency disorders: relationship to immunoglobulin therapy over 22 years","volume":"125","author":"Lucas","year":"2010","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"1","key":"10.1016\/j.iac.2015.07.009_bib118","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.clim.2010.06.012","article-title":"Impact of trough IgG on pneumonia incidence in primary immunodeficiency: A meta-analysis of clinical studies","volume":"137","author":"Orange","year":"2010","journal-title":"Clin Immunol"},{"issue":"6 Suppl","key":"10.1016\/j.iac.2015.07.009_bib119","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.anai.2013.06.013","article-title":"Optimizing immunoglobulin treatment for patients with primary immunodeficiency disease to prevent pneumonia and infection incidence: review of the current data","volume":"111","author":"Ballow","year":"2013","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"4","key":"10.1016\/j.iac.2015.07.009_bib120","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/ng0407-430","article-title":"Reexamining the role of TACI coding variants in common variable immunodeficiency and selective IgA deficiency","volume":"39","author":"Castigli","year":"2007","journal-title":"Nat Genet"},{"issue":"4","key":"10.1016\/j.iac.2015.07.009_bib121","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/ng0407-429","article-title":"Reexamining the role of TACI coding variants in common variable immunodeficiency and selective IgA deficiency","volume":"39","author":"Pan-Hammarstr\u00f6m","year":"2007","journal-title":"Nat Genet"},{"issue":"9","key":"10.1016\/j.iac.2015.07.009_bib122","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1182\/blood-2008-02-141937","article-title":"Relevance of biallelic versus monoallelic TNFRSF13B mutations in distinguishing disease-causing from risk-increasing TNFRSF13B variants in antibody deficiency syndromes","volume":"113","author":"Salzer","year":"2009","journal-title":"Blood"},{"issue":"13","key":"10.1016\/j.iac.2015.07.009_bib123","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1182\/blood-2009-05-213025","article-title":"Role of TNFRSF13B variants in patients with common variable immunodeficiency","volume":"114","author":"Martinez-Pomar","year":"2009","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.iac.2015.07.009_bib124","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.jaci.2012.10.029","article-title":"TACI mutations and impaired B-cell function in subjects with CVID and healthy heterozygotes","volume":"131","author":"Martinez-Gallo","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"}],"container-title":["Immunology and Allergy Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889856115000582?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889856115000582?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T11:48:57Z","timestamp":1653133737000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889856115000582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":124,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["S0889856115000582"],"URL":"https:\/\/doi.org\/10.1016\/j.iac.2015.07.009","relation":{},"ISSN":["0889-8561"],"issn-type":[{"value":"0889-8561","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Common Variable Immunodeficiency","name":"articletitle","label":"Article Title"},{"value":"Immunology and Allergy Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.iac.2015.07.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}