{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:54:46Z","timestamp":1790243686377,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","theclinics.com","clinicalkey.com.au","clinicalkey.fr","immunology.theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunology and Allergy Clinics of North America"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.iac.2016.08.007","type":"journal-article","created":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T23:15:17Z","timestamp":1478042117000},"page":"113-122","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":67,"title":["Itch in Atopic Dermatitis"],"prefix":"10.1016","volume":"37","author":[{"given":"Makiko","family":"Kido-Nakahara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masutaka","family":"Furue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dugarmaa","family":"Ulzii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Nakahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.iac.2016.08.007_bib1","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/j.1346-8138.2009.00706.x","article-title":"Guidelines for management of atopic dermatitis","volume":"36","author":"Saeki","year":"2009","journal-title":"J\u00a0Dermatol"},{"key":"10.1016\/j.iac.2016.08.007_bib2","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jdermsci.2009.09.008","article-title":"Collared mice: a model to assess the effects of scratching","volume":"57","author":"Takeuchi","year":"2010","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.iac.2016.08.007_bib3","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1111\/1346-8138.13060","article-title":"New therapies for controlling atopic itch","volume":"42","author":"Furue","year":"2015","journal-title":"J\u00a0Dermatol"},{"key":"10.1016\/j.iac.2016.08.007_bib4","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.neuroscience.2013.07.035","article-title":"Neural processing of itch","volume":"250","author":"Akiyama","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.iac.2016.08.007_bib5","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/1346-8138.12317","article-title":"Itch and nerve fibers with special reference to atopic dermatitis: therapeutic implications","volume":"41","author":"Tominaga","year":"2014","journal-title":"J\u00a0Dermatol"},{"key":"10.1016\/j.iac.2016.08.007_bib6","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/nn.3289","article-title":"A\u00a0subpopulation of nociceptors specifically linked to itch","volume":"16","author":"Han","year":"2012","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.iac.2016.08.007_bib7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/978-3-662-44605-8_3","article-title":"Neurophysiology and itch pathways","volume":"226","author":"Schmelz","year":"2015","journal-title":"Handb Exp Pharmacol"},{"key":"10.1016\/j.iac.2016.08.007_bib8","doi-asserted-by":"crossref","first-page":"11330","DOI":"10.1073\/pnas.0905605106","article-title":"TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms","volume":"106","author":"Imamachi","year":"2009","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"key":"10.1016\/j.iac.2016.08.007_bib9","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/ejp.777","article-title":"Evolving understanding on the aetiology of thermally provoked itch","volume":"20","author":"Murota","year":"2016","journal-title":"Eur J Pain"},{"key":"10.1016\/j.iac.2016.08.007_bib10","article-title":"Mediators of chronic pruritus in atopic dermatitis: getting the itch out?","author":"Mollanazar","year":"2015","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.iac.2016.08.007_bib11","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/jid.2009.358","article-title":"The histamine H4 receptor mediates inflammation and pruritus in Th2-dependent dermal inflammation","volume":"130","author":"Cowden","year":"2010","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.iac.2016.08.007_bib12","series-title":"Itch: mechanisms and treatment","article-title":"Role of PAR-2 in neuroimmune communication and itch","author":"Kempkes","year":"2014"},{"key":"10.1016\/j.iac.2016.08.007_bib13","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.0022-202X.2004.23539.x","article-title":"Agonists of proteinase-activated receptor-2 stimulate upregulation of intercellular cell adhesion molecule-1 in primary human keratinocytes via activation of NF-kappa B","volume":"124","author":"Buddenkotte","year":"2005","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.iac.2016.08.007_bib14","doi-asserted-by":"crossref","first-page":"6176","DOI":"10.1523\/JNEUROSCI.23-15-06176.2003","article-title":"Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin","volume":"23","author":"Steinhoff","year":"2003","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.iac.2016.08.007_bib15","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/all.12316","article-title":"Interleukin-31 does not induce immediate itch in atopic dermatitis patients and healthy controls after skin challenge","volume":"69","author":"Hawro","year":"2014","journal-title":"Allergy"},{"key":"10.1016\/j.iac.2016.08.007_bib16","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/bjd.14207","volume":"174","author":"Nemoto","year":"2016","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.iac.2016.08.007_bib17","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1038\/ncomms3847","article-title":"Skin thymic stromal lymphopoietin initiates Th2 responses through an orchestrated immune cascade","volume":"4","author":"Leyva-Castillo","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.iac.2016.08.007_bib18","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/1346-8138.12440","article-title":"Thymus and activation-regulated chemokine as a clinical biomarker in atopic dermatitis","volume":"41","author":"Kataoka","year":"2014","journal-title":"J\u00a0Dermatol"},{"key":"10.1016\/j.iac.2016.08.007_bib19","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cell.2013.08.057","article-title":"The epithelial cell-derived atopic dermatitis cytokine TSLP activates neurons to induce itch","volume":"155","author":"Wilson","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.iac.2016.08.007_bib20","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1172\/JCI67323","article-title":"Neural peptidase endothelin-converting enzyme 1 regulates endothelin 1-induced pruritus","volume":"124","author":"Kido-Nakahara","year":"2014","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.iac.2016.08.007_bib21","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1111\/all.12633","article-title":"Mutual upregulation of endothelin-1 and IL-25 in atopic dermatitis","volume":"70","author":"Aktar","year":"2015","journal-title":"Allergy"},{"key":"10.1016\/j.iac.2016.08.007_bib22","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1126\/science.1174868","article-title":"Cellular basis of itch sensation","volume":"325","author":"Sun","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.iac.2016.08.007_bib23","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/978-3-662-44605-8_8","article-title":"Transmission of pruriceptive signals","volume":"226","author":"Mishra","year":"2015","journal-title":"Handb Exp Pharmacol"},{"key":"10.1016\/j.iac.2016.08.007_bib24","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1126\/science.1233765","article-title":"The cells and circuitry for itch responses in mice","volume":"340","author":"Mishra","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.iac.2016.08.007_bib25","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.neuron.2010.02.025","article-title":"Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice","volume":"65","author":"Ross","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.iac.2016.08.007_bib26","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.neuron.2014.02.046","article-title":"Dynorphin acts as a neuromodulator to inhibit itch in the dorsal horn of the spinal cord","volume":"82","author":"Kardon","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.iac.2016.08.007_bib27","doi-asserted-by":"crossref","first-page":"e22665","DOI":"10.1371\/journal.pone.0022665","article-title":"Transmitters and pathways mediating inhibition of spinal itch-signaling neurons by scratching and other counterstimuli","volume":"6","author":"Akiyama","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.iac.2016.08.007_bib28","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/nm.3912","article-title":"STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch","volume":"21","author":"Shiratori-Hayashi","year":"2015","journal-title":"Nat Med"},{"key":"10.1016\/j.iac.2016.08.007_bib29","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1111\/j.1365-2133.2009.09308.x","article-title":"Distinct patterns of brain activity evoked by histamine-induced itch reveal an association with itch intensity and disease severity in atopic dermatitis","volume":"161","author":"Ishiuji","year":"2009","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.iac.2016.08.007_bib30","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1111\/1346-8138.12956","article-title":"Itch and brain","volume":"42","author":"Mochizuki","year":"2015","journal-title":"J\u00a0Dermatol"},{"key":"10.1016\/j.iac.2016.08.007_bib31","series-title":"Itch: mechanisms and treatment","first-page":"391","article-title":"Brain processing of itch and scratching","author":"Mochizuki","year":"2014"},{"key":"10.1016\/j.iac.2016.08.007_bib32","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/978-3-662-44605-8_18","article-title":"Current topical and systemic therapies for itch","volume":"226","author":"Leslie","year":"2015","journal-title":"Handb Exp Pharmacol"},{"issue":"6","key":"10.1016\/j.iac.2016.08.007_bib33","doi-asserted-by":"crossref","first-page":"506","DOI":"10.4062\/biomolther.2012.20.6.506","article-title":"Neuroimmunological mechanism of pruritus in atopic dermatitis focused on the role of serotonin","volume":"20","author":"Kim","year":"2012","journal-title":"Biomol Ther"},{"key":"10.1016\/j.iac.2016.08.007_bib34","doi-asserted-by":"crossref","first-page":"497","DOI":"10.2340\/00015555-1265","article-title":"Visual analogue scale: evaluation of the instrument for the assessment of pruritus","volume":"92","author":"Reich","year":"2012","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.iac.2016.08.007_bib35","doi-asserted-by":"crossref","first-page":"345","DOI":"10.2340\/00015555-1972","article-title":"Comparative cut-off value setting of pruritus intensity in visual analogue scale and verbal rating scale","volume":"95","author":"Kido-Nakahara","year":"2015","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.iac.2016.08.007_bib36","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1346-8138.2010.01052.x","article-title":"Questionnaire survey of the efficacy of emollients for adult patients with atopic dermatitis","volume":"38","author":"Kawakami","year":"2011","journal-title":"J\u00a0Dermatol"},{"key":"10.1016\/j.iac.2016.08.007_bib37","first-page":"64","article-title":"Topical application of emollients prevents dry skin-inducible intraepidermal nerve growth in acetone-treated mice","volume":"62","author":"Kamo","year":"2011","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.iac.2016.08.007_bib38","first-page":"171","article-title":"Effects of a novel formulation of fluocinonide 0.1% cream on skin barrier function in atopic dermatitis","volume":"10","author":"Woods","year":"2011","journal-title":"J\u00a0Drugs Dermatol"},{"key":"10.1016\/j.iac.2016.08.007_bib39","doi-asserted-by":"crossref","first-page":"144","DOI":"10.5021\/ad.2012.24.2.144","article-title":"A\u00a0randomized, open-label, multicenter trial of topical tacrolimus for the treatment of pruritis in patients with atopic dermatitis","volume":"24","author":"Takeuchi","year":"2012","journal-title":"Ann Dermatol"},{"key":"10.1016\/j.iac.2016.08.007_bib40","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1046\/j.1365-2133.2003.05293.x","article-title":"Addition of fexofenadine to a topical corticosteroid reduces the pruritus associated with atopic dermatitis in a 1-week randomized, multicentre, double-blind, placebo-controlled, parallel-group study","volume":"148","author":"Kawashima","year":"2003","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.iac.2016.08.007_bib41","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1684\/ejd.2011.1470","article-title":"Effects of cyclosporine on pruritus and serum IL-31 levels in patients with atopic dermatitis","volume":"21","author":"Otsuka","year":"2011","journal-title":"Eur J Dermatol"},{"key":"10.1016\/j.iac.2016.08.007_bib42","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0140-6736(15)00388-8","article-title":"Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled, dose-ranging phase 2b trial","volume":"387","author":"Tha\u00e7i","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.iac.2016.08.007_bib43","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.2217\/imt.15.69","article-title":"Drug evaluation review: dupilumab in atopic dermatitis","volume":"7","author":"Hamilton","year":"2015","journal-title":"Immunotherapy"},{"key":"10.1016\/j.iac.2016.08.007_bib44","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/1346-8138.12726","article-title":"Phase 2a, randomized, double-blind, placebo-controlled, multicenter, parallel-group study of a H4R-antagonist (JNJ-39758979) in Japanese adults with moderate atopic dermatitis","volume":"42","author":"Murata","year":"2015","journal-title":"J\u00a0Dermatol"},{"key":"10.1016\/j.iac.2016.08.007_bib45","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/1346-8138.12534","article-title":"Safety and efficacy of topical E6005, a phosphodiesterase 4 inhibitor, in Japanese adult patients with atopic dermatitis: results of a randomized, vehicle-controlled, multicenter clinical trial","volume":"41","author":"Furue","year":"2014","journal-title":"J\u00a0Dermatol"},{"issue":"2","key":"10.1016\/j.iac.2016.08.007_bib46","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.jaad.2016.04.001","article-title":"OPA-15406, a novel, topical, nonsteroidal, selective phosphodiesterase-4 (PDE4) inhibitor, in the treatment of adult and adolescent patients with mild to moderate atopic dermatitis (AD): a phase-II randomized, double-blind, placebo-controlled study","volume":"75","author":"Hanifin","year":"2016","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.iac.2016.08.007_bib47","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.jaci.2013.10.048","article-title":"A\u00a0sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: involvement of TRPV1 and TRPA1","volume":"133","author":"Cevikbas","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.iac.2016.08.007_bib48","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1093\/ndt\/gfp588","article-title":"Effect of a novel kappa-receptor agonist, nalfurafine hydrochloride, on severe itch in 337 haemodialysis patients: a Phase III, randomized, double-blind, placebo-controlled study","volume":"25","author":"Kumagai","year":"2010","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.iac.2016.08.007_bib49","doi-asserted-by":"crossref","first-page":"147","DOI":"10.2340\/00015555-1879","article-title":"Nalfurafine suppresses pruritogen- and touch-evoked scratching behavior in models of acute and chronic itch in mice","volume":"95","author":"Akiyama","year":"2015","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.iac.2016.08.007_bib50","doi-asserted-by":"crossref","first-page":"542","DOI":"10.2340\/00015555-2047","article-title":"Topical TrkA kinase inhibitor CT327 is an effective, novel therapy for the treatment of pruritus due to psoriasis: results from experimental studies, and efficacy and safety of CT327 in a phase 2b clinical trial in patients with psoriasis","volume":"95","author":"Roblin","year":"2015","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.iac.2016.08.007_bib51","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/1346-8138.12321","article-title":"Genome-wide association studies of atopic dermatitis","volume":"41","author":"Tamari","year":"2014","journal-title":"J\u00a0Dermatol"}],"container-title":["Immunology and Allergy Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889856116300704?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889856116300704?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T02:26:24Z","timestamp":1601173584000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889856116300704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["S0889856116300704"],"URL":"https:\/\/doi.org\/10.1016\/j.iac.2016.08.007","relation":{},"ISSN":["0889-8561"],"issn-type":[{"value":"0889-8561","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Itch in Atopic Dermatitis","name":"articletitle","label":"Article Title"},{"value":"Immunology and Allergy Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.iac.2016.08.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}