{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:33:56Z","timestamp":1788910436430,"version":"build-2803163510"},"reference-count":54,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100010836","name":"Triological Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010836","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunology and Allergy Clinics of North America"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.iac.2019.12.010","type":"journal-article","created":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T14:06:31Z","timestamp":1579010791000},"page":"201-214","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["The Role of Allergic Rhinitis in Chronic Rhinosinusitis"],"prefix":"10.1016","volume":"40","author":[{"given":"Samuel N.","family":"Helman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Barrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"DelGaudio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua M.","family":"Levy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah K.","family":"Wise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.iac.2019.12.010_bib1","first-page":"108","article-title":"International consensus statement on allergy and rhinology: allergic rhinitis","volume":"8","author":"Wise","year":"2018","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.iac.2019.12.010_bib2","first-page":"S22","article-title":"International consensus statement on allergy and rhinology: rhinosinusitis","volume":"6","author":"Orlandi","year":"2016","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.iac.2019.12.010_bib3","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/j.jaci.2017.10.006","article-title":"Chronic rhinosinusitis: endotypes, biomarkers, and treatment response","volume":"140","author":"Gurrola","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.iac.2019.12.010_bib4","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/alr.21258","article-title":"The association between allergy and chronic rhinosinusitis with and without nasal polyposis: an evidence-based review with recommendations","volume":"4","author":"Wilson","year":"2014","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.iac.2019.12.010_bib5","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.jaci.2017.03.050","article-title":"Allergic rhinitis and its impact on asthma (ARIA) guidelines\u2013\u20132016 revision","volume":"140","author":"Brozek","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.iac.2019.12.010_bib6","doi-asserted-by":"crossref","first-page":"367","DOI":"10.2500\/108854100778249088","article-title":"Allergic rhinitis update: epidemiology and natural history","volume":"21","author":"Bellanti","year":"2000","journal-title":"Allergy Asthma Proc"},{"key":"10.1016\/j.iac.2019.12.010_bib7","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1177\/000348941112000701","article-title":"Incremental health care utilization and expenditures for chronic rhinosinusitis in the United States","volume":"120","author":"Bhattacharyya","year":"2011","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"suppl 6","key":"10.1016\/j.iac.2019.12.010_bib8","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.otohns.2004.09.067","article-title":"Rhinosinusitis: establishing definitions for clinical research and patient care","volume":"131","author":"Meltzer","year":"2004","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"5","key":"10.1016\/j.iac.2019.12.010_bib9","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.otohns.2009.01.023","article-title":"Undertreatment of allergy: exploring the utility of sublingual immunotherapy","volume":"140","author":"Emanuel","year":"2009","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.iac.2019.12.010_bib10","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1165\/ajrcmb.12.6.7539273","article-title":"Eosinophil infiltration is related to increased expression of vascular cell adhesion molecule-1 in nasal polyps","volume":"12","author":"Jahnsen","year":"1995","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.iac.2019.12.010_bib11","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1165\/ajrcmb.21.4.3622","article-title":"Allergen-induced increase in airway responsiveness, airway eosinophilia, and bone-marrow eosinophil progenitors in mice","volume":"21","author":"Inman","year":"1999","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.iac.2019.12.010_bib12","doi-asserted-by":"crossref","first-page":"367","DOI":"10.2500\/ajra.2013.27.3906","article-title":"Chronic sinusitis pathophysiology: the role of allergy","volume":"27","author":"Kennedy","year":"2013","journal-title":"Am J Rhinol"},{"key":"10.1016\/j.iac.2019.12.010_bib13","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1165\/ajrcmb.17.6.2865","article-title":"Eotaxin mRNA and protein expression in chronic sinusitis and allergen-induced nasal responses in seasonal allergic rhinitis","volume":"17","author":"Minshall","year":"1997","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.iac.2019.12.010_bib14","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1001\/archotol.131.10.905","article-title":"Acute bacterial rhinosinusitis causes hyperresponsiveness to histamine challenge in mice","volume":"131","author":"Klemens","year":"2005","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.iac.2019.12.010_bib15","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1067\/mai.2001.117793","article-title":"Allergic inflammation enhances bacterial sinusitis in mice","volume":"108","author":"Blair","year":"2001","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.iac.2019.12.010_bib16","first-page":"110","article-title":"Allergenic profile of nasal polyposis","volume":"19","author":"Munoz del Castillo","year":"2009","journal-title":"J\u00a0Investig Allergol Clin Immunol"},{"key":"10.1016\/j.iac.2019.12.010_bib17","first-page":"13","article-title":"Role of allergy in nasal polyps of Thai patients","volume":"17","author":"Pumhirun","year":"1999","journal-title":"Asian Pac J Allergy Immunol"},{"key":"10.1016\/j.iac.2019.12.010_bib18","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/alr.20025","article-title":"Atopic profile of patients failing medical therapy for chronic rhinosinusitis","volume":"1","author":"Tan","year":"2011","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.iac.2019.12.010_bib19","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s11882-002-0024-z","article-title":"Local IgE synthesis in allergic rhinitis and asthma","volume":"2","author":"Smurthwaite","year":"2002","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.iac.2019.12.010_bib20","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/MOO.0b013e32832ad23d","article-title":"Localized immunoglobulin E expression in allergic rhinitis and nasal polyposis","volume":"17","author":"Wise","year":"2009","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.iac.2019.12.010_bib21","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1398-9995.2010.02448.x","article-title":"Mucosal tissue polyclonal IgE is functional in response to allergen and SEB","volume":"66","author":"Zhang","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.iac.2019.12.010_bib22","first-page":"631","article-title":"Are nasal polyps an allergic phenomenon?","volume":"29","author":"Caplin","year":"1971","journal-title":"Ann Allergy"},{"key":"10.1016\/j.iac.2019.12.010_bib23","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S1081-1206(10)62807-4","article-title":"Does inhaled pollen enter the sinus cavities?","volume":"81","author":"Adkins","year":"1998","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.iac.2019.12.010_bib24","doi-asserted-by":"crossref","first-page":"686","DOI":"10.2500\/ajr.2007.21.3062","article-title":"The role of allergy in the severity of nasal polyposis","volume":"21","author":"Erbek","year":"2007","journal-title":"Am J Rhinol"},{"key":"10.1016\/j.iac.2019.12.010_bib25","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1080\/00016480500504226","article-title":"Influence of allergy on the symptoms and treatment of nasal polyposis","volume":"126","author":"Bonfils","year":"2006","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.iac.2019.12.010_bib26","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1017\/S0022215116008112","article-title":"Role of atopy in chronic rhinosinusitis with nasal polyps: does an atopic condition affect the severity and recurrence of disease?","volume":"130","author":"Li","year":"2016","journal-title":"J\u00a0Laryngol Otol"},{"key":"10.1016\/j.iac.2019.12.010_bib27","first-page":"204","article-title":"The relationship between allergy and rhinosinusitis","volume":"46","author":"Kirtsreesakul","year":"2008","journal-title":"Rhinology"},{"key":"10.1016\/j.iac.2019.12.010_bib28","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1034\/j.1398-9995.1999.00813.x","article-title":"Perennial allergic rhinitis and chronic sinusitis: correlation with rhinologic risk factors","volume":"54","author":"Berrettini","year":"1999","journal-title":"Allergy"},{"key":"10.1016\/j.iac.2019.12.010_bib29","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S1081-1206(10)60829-0","article-title":"Allergic vs nonallergic rhinitis: which is more predisposing to chronic rhinosinusitis?","volume":"101","author":"Gelincik","year":"2008","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"1","key":"10.1016\/j.iac.2019.12.010_bib30","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/lio2.236","article-title":"The relationship between allergy and chronic rhinosinusitis","volume":"4","author":"Marcus","year":"2018","journal-title":"Laryngoscope Investig Otolaryngol"},{"issue":"5","key":"10.1016\/j.iac.2019.12.010_bib31","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1177\/019459989411100508","article-title":"Diagnosis of allergic fungal sinusitis","volume":"111","author":"Bent","year":"1994","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.iac.2019.12.010_bib32","doi-asserted-by":"crossref","first-page":"405","DOI":"10.2500\/ajra.2010.24.3533","article-title":"Distinctions between allergic fungal rhinosinusitis and chronic rhinosinusitis","volume":"24","author":"Hutcheson","year":"2010","journal-title":"Am J Rhinol Allergy"},{"key":"10.1016\/j.iac.2019.12.010_bib33","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1002\/alr.21290","article-title":"Polypoid changes of the middle turbinate as an indicator of atopic disease","volume":"4","author":"White","year":"2014","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.iac.2019.12.010_bib34","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1002\/alr.21988","article-title":"Positive allergen reaction in allergic and nonallergic rhinitis: a systematic review","volume":"7","author":"Hamizan","year":"2017","journal-title":"Int Forum Allergy Rhinol"},{"issue":"3","key":"10.1016\/j.iac.2019.12.010_bib35","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1177\/0194599817711887","article-title":"Polypoid change of the middle turbinate and paranasal sinus polyposis are distinct entities","volume":"157","author":"Brunner","year":"2017","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"4","key":"10.1016\/j.iac.2019.12.010_bib36","doi-asserted-by":"crossref","first-page":"228","DOI":"10.2500\/ajra.2017.31.4443","article-title":"Central compartment atopic disease","volume":"31","author":"DelGaudio","year":"2017","journal-title":"Am J Rhinol Allergy"},{"issue":"9","key":"10.1016\/j.iac.2019.12.010_bib37","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1002\/alr.22367","article-title":"Central compartment involvement in aspirin-associated respiratory disease: the roll of allergy and previous sinus surgery","volume":"9","author":"DelGaudio","year":"2019","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.iac.2019.12.010_bib38","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.2500\/ajra.2013.27.3929","article-title":"Chapter 16: determining the role of allergy in sinonasal disease","volume":"27","author":"Settipane","year":"2013","journal-title":"Am J Rhinol Allergy"},{"key":"10.1016\/j.iac.2019.12.010_bib39","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.otohns.2004.02.007","article-title":"Prevalence of allergy in patients with chronic rhinosinusitis","volume":"130","author":"Gutman","year":"2004","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.iac.2019.12.010_bib40","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1097\/MLG.0b013e31817d01b8","article-title":"The role of allergy and smoking in chronic rhinosinusitis and polyposis","volume":"118","author":"Houser","year":"2008","journal-title":"Laryngoscope"},{"key":"10.1016\/j.iac.2019.12.010_bib41","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/alr.21835","article-title":"Middle turbinate edema as a diagnostic marker of inhalant allergy","volume":"7","author":"Hamizan","year":"2016","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.iac.2019.12.010_bib42","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1007\/s11882-014-0430-z","article-title":"Skin testing versus serum-specific IgE testing: which is better for diagnosing aeroallergen sensitization and predicting clinical allergy?","volume":"14","author":"de Vos","year":"2014","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.iac.2019.12.010_bib43","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1177\/000348941212100909","article-title":"Analysis of the roles of smoking and allergy in nasal polyposis","volume":"121","author":"Gorgulu","year":"2012","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"10.1016\/j.iac.2019.12.010_bib44","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.jaci.2016.05.041","article-title":"Diversity of TH cytokine profiles in patients with chronic rhinosinusitis: a multicenter study in Europe, Asia, and Oceania","volume":"138","author":"Wang","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.iac.2019.12.010_bib45","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.jaci.2008.02.010","article-title":"Nasal challenge with allergen leads to maxillary sinus inflammation","volume":"121","author":"Baroody","year":"2008","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.iac.2019.12.010_bib46","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1067\/mai.2001.112374","article-title":"Total and specific IgE in nasal polyps is related to local eosinophilic inflammation","volume":"107","author":"Bachert","year":"2001","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"suppl 2","key":"10.1016\/j.iac.2019.12.010_bib47","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1136\/thorax.55.suppl_2.S79","article-title":"Nasal polyposis, eosinophil dominated inflammation, and allergy","volume":"55","author":"Mygind","year":"2000","journal-title":"Thorax"},{"key":"10.1016\/j.iac.2019.12.010_bib48","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1111\/j.1398-9995.2004.00509.x","article-title":"Sinus CT scans and mediator release in nasal secretions after nasal challenge with cypress pollens","volume":"59","author":"Piette","year":"2004","journal-title":"Allergy"},{"key":"10.1016\/j.iac.2019.12.010_bib49","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/00005537-199702000-00007","article-title":"Computed tomography and magnetic resonance diagnosis of allergic fungal sinusitis","volume":"107","author":"Manning","year":"1997","journal-title":"Laryngoscope"},{"key":"10.1016\/j.iac.2019.12.010_bib50","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1002\/lary.27180","article-title":"Allergic phenotype of chronic rhinosinusitis based on radiologic pattern of disease","volume":"128","author":"Hamizan","year":"2018","journal-title":"Laryngoscope"},{"issue":"4","key":"10.1016\/j.iac.2019.12.010_bib51","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s00405-006-0189-5","article-title":"Respiratory epithelial adenomatoid hamartomas of the sinonasal tract","volume":"264","author":"Mortuaire","year":"2007","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"10.1016\/j.iac.2019.12.010_bib52","article-title":"Respiratory epithelial adenomatoid hamartoma is frequent in olfactory cleft after nasalization","author":"Nguyen","year":"2019","journal-title":"Laryngoscope"},{"key":"10.1016\/j.iac.2019.12.010_bib53","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1002\/alr.21352","article-title":"Medical management of allergic fungal rhinosinusitis following endoscopic sinus surgery: an evidence-based review and recommendations","volume":"4","author":"Gan","year":"2014","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.iac.2019.12.010_bib54","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jaci.2012.07.047","article-title":"Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma","volume":"131","author":"Gevaert","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"}],"container-title":["Immunology and Allergy Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889856119301018?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889856119301018?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:42:33Z","timestamp":1760179353000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889856119301018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":54,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["S0889856119301018"],"URL":"https:\/\/doi.org\/10.1016\/j.iac.2019.12.010","relation":{},"ISSN":["0889-8561"],"issn-type":[{"value":"0889-8561","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Role of Allergic Rhinitis in Chronic Rhinosinusitis","name":"articletitle","label":"Article Title"},{"value":"Immunology and Allergy Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.iac.2019.12.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}