{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T20:30:22Z","timestamp":1787689822647,"version":"build-2784847793"},"reference-count":118,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunology and Allergy Clinics of North America"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.iac.2022.10.013","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T18:16:30Z","timestamp":1688148990000},"page":"513-532","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Angiotensin-Converting Enzyme Inhibitor\u2013Induced Angioedema"],"prefix":"10.1016","volume":"43","author":[{"given":"R. Gentry","family":"Wilkerson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Winters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.iac.2022.10.013_bib1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1476-5381.1965.tb02091.x","article-title":"A\u00a0Bradykinin-Potentiating Factor (BPF) Present int eh Venom of Bothrops Jararaca","volume":"24","author":"Ferreira","year":"1965","journal-title":"Br J Pharm Chemoth"},{"issue":"2","key":"10.1016\/j.iac.2022.10.013_bib2","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1084\/jem.104.2.193","article-title":"THE amino acid sequence of hypertensin II","volume":"104","author":"Skeggs","year":"1956","journal-title":"J\u00a0Exp Med"},{"issue":"4","key":"10.1016\/j.iac.2022.10.013_bib3","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1161\/01.HYP.17.4.589","article-title":"History of the design of captopril and related inhibitors of angiotensin converting enzyme","volume":"17","author":"Cushman","year":"2018","journal-title":"Hypertension"},{"issue":"7","key":"10.1016\/j.iac.2022.10.013_bib4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s11906-018-0859-x","article-title":"ACE inhibitor-induced angioedema: a review","volume":"20","author":"Kostis","year":"2018","journal-title":"Curr Hypertens Rep"},{"issue":"8","key":"10.1016\/j.iac.2022.10.013_bib5","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1001\/archderm.1980.01640320052013","article-title":"The captopril-induced eruption. A possible mechanism: cutaneous kinin potentiation","volume":"116","author":"Wilkin","year":"1980","journal-title":"Arch Dermatol"},{"issue":"2","key":"10.1016\/j.iac.2022.10.013_bib6","doi-asserted-by":"crossref","first-page":"150","DOI":"10.2500\/aap.2013.34.3640","article-title":"National estimates of emergency department visits for angioedema and allergic reactions in the United States","volume":"34","author":"Kelly","year":"2013","journal-title":"Allergy asthma Proc"},{"issue":"4","key":"10.1016\/j.iac.2022.10.013_bib7","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S1081-1206(10)60594-7","article-title":"Multicenter study of patients with angiotensin-converting enzyme inhibitor-induced angioedema who present to the emergency department","volume":"100","author":"Banerji","year":"2008","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"1","key":"10.1016\/j.iac.2022.10.013_bib8","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1080\/20009666.2020.1711641","article-title":"ACE inhibitor angioedema: characterization and treatment versus non-ACE angioedema in acute hospitalized patients","volume":"10","author":"Weisman","year":"2020","journal-title":"J\u00a0Community Hosp Intern Med Perspect"},{"issue":"7","key":"10.1016\/j.iac.2022.10.013_bib9","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1001\/jama.1988.03410070095035","article-title":"Clinical profile of angioedema associated with angiotensin converting-enzyme inhibition","volume":"260","author":"Slater","year":"1988","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.iac.2022.10.013_bib10","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.jaip.2017.02.018","article-title":"Epidemiology of ACE Inhibitor Angioedema Utilizing a Large Electronic Health Record","volume":"5","author":"Banerji","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"issue":"10","key":"10.1016\/j.iac.2022.10.013_bib11","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1093\/ajh\/hpx085","article-title":"Current trends of hypertension treatment in the United States","volume":"30","author":"Shah","year":"2017","journal-title":"Am J Hypertens"},{"issue":"2","key":"10.1016\/j.iac.2022.10.013_bib12","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/cea.13326","article-title":"Pharmacogenetics of angiotensin-converting enzyme inhibitor-induced angioedema","volume":"49","author":"Liau","year":"2019","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.iac.2022.10.013_bib13","doi-asserted-by":"crossref","unstructured":"Asad H, Gohar A. Incidence of angiotensin-converting enzyme-associated angioedema among African Americans compared to other races. Presented at: CHEST Annual Meeting 2020; October 18\u201321, 2020. Presentation 1123A.","DOI":"10.1016\/j.chest.2019.08.1026"},{"issue":"14","key":"10.1016\/j.iac.2022.10.013_bib14","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1001\/archinte.165.14.1637","article-title":"Incidence and characteristics of angioedema associated with enalapril","volume":"165","author":"Kostis","year":"2005","journal-title":"Arch Intern Med"},{"issue":"3","key":"10.1016\/j.iac.2022.10.013_bib15","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s40256-017-0256-x","article-title":"A\u00a0database cohort study to assess the risk of angioedema among patients with heart failure initiating angiotensin-converting enzyme inhibitors in the USA","volume":"18","author":"Do","year":"2018","journal-title":"Am J Cardiovasc Drugs"},{"key":"10.1016\/j.iac.2022.10.013_bib16","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2147\/JAA.S245161","article-title":"Clinical features and disease course of primary angioedema patients in a tertiary care hospital","volume":"13","author":"Pall","year":"2020","journal-title":"J\u00a0asthma Allergy"},{"issue":"6","key":"10.1016\/j.iac.2022.10.013_bib17","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1111\/j.1525-1497.2004.30016.x","article-title":"Development and validation of a Clinical prediction rule for angiotensin-converting enzyme inhibitor-induced cough","volume":"19","author":"Morimoto","year":"2004","journal-title":"J\u00a0Gen Intern Med"},{"issue":"2","key":"10.1016\/j.iac.2022.10.013_bib18","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1177\/0003489414543069","article-title":"Angiotensin converting enzyme inhibitor-related angioedema: onset, presentation, and management","volume":"124","author":"Chan","year":"2015","journal-title":"Ann Otology Rhinology Laryngol"},{"issue":"1","key":"10.1016\/j.iac.2022.10.013_bib19","doi-asserted-by":"crossref","first-page":"169S","DOI":"10.1378\/chest.129.1_suppl.169S","article-title":"Angiotensin-Converting Enzyme Inhibitor-Induced Cough ACCP Evidence-Based Clinical Practice Guidelines","volume":"129","author":"Dicpinigaitis","year":"2006","journal-title":"Chest"},{"issue":"11","key":"10.1016\/j.iac.2022.10.013_bib20","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1093\/ajh\/7.11.1012","article-title":"Female preponderance for lisinopril-induced cough in hypertension","volume":"7","author":"Os","year":"1994","journal-title":"Am J Hypertens"},{"issue":"6","key":"10.1016\/j.iac.2022.10.013_bib21","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1590\/S0100-879X2000000600008","article-title":"Towards understanding the kallikrein-kinin system: insights from measurement of kinin peptides","volume":"33","author":"Campbell","year":"2000","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.iac.2022.10.013_bib22","doi-asserted-by":"crossref","first-page":"358","DOI":"10.3389\/fmed.2020.00358","article-title":"Measurement of Bradykinin Formation and Degradation in Blood Plasma: Relevance for Acquired Angioedema Associated With Angiotensin Converting Enzyme Inhibition and for Hereditary Angioedema Due to Factor XII or Plasminogen Gene Variants","volume":"7","author":"Marceau","year":"2020","journal-title":"Front Med"},{"issue":"1","key":"10.1016\/j.iac.2022.10.013_bib23","doi-asserted-by":"crossref","first-page":"H275","DOI":"10.1152\/ajpheart.2001.281.1.H275","article-title":"Bradykinin and des-Arg9-bradykinin metabolic pathways and kinetics of activation of human plasma","volume":"281","author":"Cyr","year":"2001","journal-title":"Am J Physiol-heart C"},{"issue":"3","key":"10.1016\/j.iac.2022.10.013_bib24","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S1567-5769(02)00162-5","article-title":"Bradykinin and the pathophysiology of angioedema","volume":"3","author":"Cugno","year":"2003","journal-title":"Int Immunopharmacology"},{"issue":"5","key":"10.1016\/j.iac.2022.10.013_bib25","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1016\/j.jaci.2018.06.037","article-title":"Endogenous bradykinin and B1-B5 during angiotensin-converting enzyme inhibitor-associated angioedema","volume":"142","author":"Hubers","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"7","key":"10.1016\/j.iac.2022.10.013_bib26","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1139\/y95-110","article-title":"Expression of B1 kinin receptors mediating paw edema and Formalin-induced nociception. Modulation by glucocorticoids","volume":"73","author":"Campos","year":"1995","journal-title":"Can J Physiol Pharm"},{"issue":"1","key":"10.1016\/j.iac.2022.10.013_bib27","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1365-2222.2009.03323.x","article-title":"Angiotensin converting enzyme inhibitor induced angio-oedema: a review of the pathophysiology and risk factors","volume":"40","author":"Hoover","year":"2010","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.iac.2022.10.013_bib28","article-title":"Association of angiotensin-converting enzyme inhibitor-associated angioedema with transplant and immunosuppressant use","volume":"19","author":"Byrd","year":"2010","journal-title":"Allergy Published Online June"},{"issue":"1","key":"10.1016\/j.iac.2022.10.013_bib29","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1161\/HYPERTENSIONAHA.107.096552","article-title":"Dipeptidyl peptidase IV in angiotensin-converting enzyme inhibitor associated angioedema","volume":"51","author":"Byrd","year":"2008","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.iac.2022.10.013_bib30","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1161\/HYPERTENSIONAHA.109.134197","article-title":"Dipeptidyl peptidase-IV inhibitor use associated with increased risk of ACE inhibitor-associated angioedema","volume":"54","author":"Brown","year":"2009","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.iac.2022.10.013_bib31","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1097\/ACI.0000000000000292","article-title":"Angioedema associated with nonsteroidal anti-inflammatory drugs","volume":"16","author":"Giavina-Bianchi","year":"2016","journal-title":"Curr Opin Allergy Clin Immunol"},{"issue":"11","key":"10.1016\/j.iac.2022.10.013_bib32","first-page":"1","article-title":"Angioedema in the emergency department: an evidence-based review","volume":"14","author":"Wilkerson","year":"2012","journal-title":"Emerg Med Pract"},{"issue":"45","key":"10.1016\/j.iac.2022.10.013_bib33","doi-asserted-by":"crossref","first-page":"e1939","DOI":"10.1097\/MD.0000000000001939","article-title":"Angioedema related to angiotensin-converting enzyme inhibitors: attack severity, treatment, and hospital admission in a prospective multicenter study","volume":"94","author":"Javaud","year":"2015","journal-title":"Medicine"},{"issue":"21","key":"10.1016\/j.iac.2022.10.013_bib34","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.1001\/jama.1988.03720210021021","article-title":"Acute small-bowel mucosal edema following enalapril use","volume":"259","author":"Farraye","year":"1988","journal-title":"Jama"},{"issue":"11","key":"10.1016\/j.iac.2022.10.013_bib35","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.4065\/75.11.1201","article-title":"Isolated visceral angioedema: an underdiagnosed complication of ACE inhibitors?","volume":"75","author":"Byrne","year":"2000","journal-title":"Mayo Clinic Proc Mayo Clinic"},{"key":"10.1016\/j.iac.2022.10.013_bib36","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ejim.2019.05.007","article-title":"Hereditary angioedema, emergency management of attacks by a call center","volume":"67","author":"Javaud","year":"2019","journal-title":"Eur J Intern Med"},{"issue":"10","key":"10.1016\/j.iac.2022.10.013_bib37","doi-asserted-by":"crossref","first-page":"rjaa348","DOI":"10.1093\/jscr\/rjaa348","article-title":"ACE inhibitor-induced small bowel angioedema, mimicking an acute abdomen","volume":"2020","author":"Parreira","year":"2020","journal-title":"J\u00a0Surg Case Rep"},{"issue":"6","key":"10.1016\/j.iac.2022.10.013_bib38","doi-asserted-by":"crossref","first-page":"e127","DOI":"10.1016\/j.jemermed.2015.01.016","article-title":"Angiotensin-converting enzyme inhibitor\u2013induced angioedema of the small bowel\u2014a surgical abdomen mimic","volume":"48","author":"Bloom","year":"2015","journal-title":"J\u00a0Emerg Med"},{"issue":"4","key":"10.1016\/j.iac.2022.10.013_bib39","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1524-6175.2001.00830.x","article-title":"Angioneurotic edema","volume":"3","author":"Prisant","year":"2001","journal-title":"J\u00a0Clin Hypertens (Greenwich, Conn)"},{"issue":"7","key":"10.1016\/j.iac.2022.10.013_bib40","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s001340050413","article-title":"Angioedema: the role of ACE inhibitors and factors associated with poor clinical outcome","volume":"23","author":"Agah","year":"1997","journal-title":"Intensive Care Med"},{"issue":"1","key":"10.1016\/j.iac.2022.10.013_bib41","first-page":"68","article-title":"Acquired angioedema induced by angiotensin-converting enzyme inhibitors - experience of a hospital-based allergy center","volume":"20","author":"Leru","year":"2020","journal-title":"Exp Ther Med"},{"issue":"5","key":"10.1016\/j.iac.2022.10.013_bib42","doi-asserted-by":"crossref","first-page":"760","DOI":"10.5811\/westjem.2019.6.42852","article-title":"Clinical features and outcomes associated with angioedema in the emergency department","volume":"20","author":"Sandefur","year":"2019","journal-title":"West J Emerg Med"},{"issue":"12","key":"10.1016\/j.iac.2022.10.013_bib43","first-page":"860","article-title":"ACE inhibitor angioedema - a very late presentation","volume":"42","author":"Howarth","year":"2013","journal-title":"Aust Fam Physician"},{"issue":"6","key":"10.1016\/j.iac.2022.10.013_bib44","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.2500\/aap.2020.41.200062","article-title":"Hereditary angioedema: differential diagnosis, diagnostic tests, and family screening","volume":"41","author":"Manning","year":"2020","journal-title":"Allergy Asthma Proc"},{"issue":"3","key":"10.1016\/j.iac.2022.10.013_bib45","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/j.1365-2249.2007.03438.x","article-title":"An evaluation of tests used for the diagnosis and monitoring of C1 inhibitor deficiency: normal serum C4 does not exclude hereditary angio-oedema","volume":"149","author":"Tarzi","year":"2007","journal-title":"Clin Exp Immunol"},{"issue":"4","key":"10.1016\/j.iac.2022.10.013_bib46","doi-asserted-by":"crossref","first-page":"595","DOI":"10.2332\/allergolint.14-OA-0700","article-title":"Clinical and laboratory characteristics that differentiate hereditary angioedema in 72 patients with angioedema","volume":"63","author":"Ohsawa","year":"2014","journal-title":"Allergol Int"},{"issue":"1","key":"10.1016\/j.iac.2022.10.013_bib47","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13023-015-0233-x","article-title":"A\u00a0nationwide survey of hereditary angioedema due to C1 inhibitor deficiency in Italy","volume":"10","author":"Zanichelli","year":"2015","journal-title":"Orphanet J Rare Dis"},{"issue":"9","key":"10.1016\/j.iac.2022.10.013_bib48","first-page":"2023","article-title":"The genetics of hereditary angioedema: a review","volume":"10","author":"Santacroce","year":"2021","journal-title":"J\u00a0Clin Med"},{"issue":"6","key":"10.1016\/j.iac.2022.10.013_bib49","doi-asserted-by":"crossref","first-page":"441","DOI":"10.2500\/aap.2019.40.4267","article-title":"Hereditary and acquired angioedema","volume":"40","author":"Patel","year":"2019","journal-title":"Allergy asthma Proc"},{"issue":"1","key":"10.1016\/j.iac.2022.10.013_bib50","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1710-1492-6-24","article-title":"2010 International consensus algorithm for the diagnosis, therapy and management of hereditary angioedema","volume":"6","author":"Bowen","year":"2010","journal-title":"Allergy asthma, Clin Immunol"},{"issue":"2","key":"10.1016\/j.iac.2022.10.013_bib51","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1365-2125.2004.02268.x","article-title":"Increased C-reactive protein in ACE-inhibitor-induced angioedema","volume":"59","author":"Bas","year":"2005","journal-title":"Br J Clin Pharmacol"},{"issue":"4","key":"10.1016\/j.iac.2022.10.013_bib52","first-page":"138","article-title":"A\u00a0rare cause of abdominal pain: intestinal angioedema","volume":"12","author":"Ferreira","year":"2021","journal-title":"J\u00a0Med Cases"},{"issue":"1","key":"10.1016\/j.iac.2022.10.013_bib53","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1177\/0897190017690641","article-title":"ACE inhibitor-induced angioedema of the small bowel: a case report and review of the literature","volume":"31","author":"Wilin","year":"2018","journal-title":"J\u00a0Pharm Pract"},{"issue":"3","key":"10.1016\/j.iac.2022.10.013_bib54","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s13244-014-0329-1","article-title":"Radiologic manifestations of angioedema","volume":"5","author":"Ishigami","year":"2014","journal-title":"Insights into Imaging"},{"issue":"2","key":"10.1016\/j.iac.2022.10.013_bib55","doi-asserted-by":"crossref","first-page":"393","DOI":"10.2214\/AJR.10.4451","article-title":"Angiotensin-converting enzyme inhibitor-induced small-bowel angioedema: clinical and imaging findings in 20 patients","volume":"197","author":"Scheirey","year":"2011","journal-title":"AJR Am J roentgenology"},{"issue":"5","key":"10.1016\/j.iac.2022.10.013_bib56","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1148\/radiographics.22.5.g02se201093","article-title":"Algorithmic Approach to CT Diagnosis of the Abnormal Bowel Wall","volume":"22","author":"Wittenberg","year":"2002","journal-title":"Radiographics"},{"issue":"9","key":"10.1016\/j.iac.2022.10.013_bib57","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/(SICI)1097-0096(199911\/12)27:9<537::AID-JCU9>3.0.CO;2-L","article-title":"Sonographic findings in abdominal hereditary angioedema","volume":"27","author":"Sofia","year":"1999","journal-title":"J\u00a0Clin Ultrasound"},{"issue":"7","key":"10.1016\/j.iac.2022.10.013_bib58","doi-asserted-by":"crossref","first-page":"816","DOI":"10.5811\/westjem.2014.7.21636","article-title":"Gastrointestinal manifestations of hereditary angioedema diagnosed by ultrasound in the emergency department","volume":"15","author":"Riguzzi","year":"2014","journal-title":"The West J Emerg Med"},{"issue":"6","key":"10.1016\/j.iac.2022.10.013_bib59","first-page":"822","article-title":"Point-of-care sonographic findings in acute upper airway edema","volume":"17","author":"Schick","year":"2016"},{"issue":"4","key":"10.1016\/j.iac.2022.10.013_bib60","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/acem.12341","article-title":"A\u00a0consensus parameter for the evaluation and management of angioedema in the emergency department. Goldstein JN","volume":"21","author":"Moellman","year":"2014","journal-title":"Acad Emerg Med"},{"issue":"5","key":"10.1016\/j.iac.2022.10.013_bib61","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.jemermed.2013.05.052","article-title":"Emergency department management of patients with ace-inhibitor angioedema","volume":"45","author":"Winters","year":"2013","journal-title":"J\u00a0Emerg Med"},{"issue":"3","key":"10.1016\/j.iac.2022.10.013_bib62","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0194-5998(99)70182-8","article-title":"Predicting airway risk in angioedema: staging system based on presentation","volume":"121","author":"Ishoo","year":"1999","journal-title":"Otolaryngology--head neck Surg"},{"issue":"1","key":"10.1016\/j.iac.2022.10.013_bib63","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jemermed.2021.02.038","article-title":"Clinical practice statement: what is the emergency department management of patients with angioedema secondary to an ACE-Inhibitor?","volume":"61","author":"Rosenbaum","year":"2021","journal-title":"J\u00a0Emerg Med"},{"issue":"5","key":"10.1016\/j.iac.2022.10.013_bib64","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1067\/mai.2001.119409","article-title":"Epinephrine absorption in adults: intramuscular versus subcutaneous injection","volume":"108","author":"Simons","year":"2001","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"4","key":"10.1016\/j.iac.2022.10.013_bib65","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.jaci.2020.01.017","article-title":"Anaphylaxis\u2014a 2020 practice parameter update, systematic review, and Grading of Recommendations, Assessment, Development and Evaluation (GRADE) analysis","volume":"145","author":"Shaker","year":"2020","journal-title":"J\u00a0Allergy Clin Immun"},{"issue":"10","key":"10.1016\/j.iac.2022.10.013_bib66","doi-asserted-by":"crossref","first-page":"100472","DOI":"10.1016\/j.waojou.2020.100472","article-title":"World allergy organization anaphylaxis guidance 2020","volume":"13","author":"Cardona","year":"2020","journal-title":"World Allergy Organ J"},{"issue":"7590","key":"10.1016\/j.iac.2022.10.013_bib67","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S0140-6736(69)91295-1","article-title":"Replacement therapy in hereditary angioedema. Successful treatment of two patients with fresh frozen plasma","volume":"1","author":"Pickering","year":"1969","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.iac.2022.10.013_bib68","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1046\/j.1365-2796.1997.76893000.x","article-title":"Type I hereditary angio-oedema. Variability of clinical presentation and course within two large kindreds","volume":"241","author":"Winnewisser","year":"1997","journal-title":"J\u00a0Intern Med"},{"issue":"2","key":"10.1016\/j.iac.2022.10.013_bib69","first-page":"92","article-title":"Fresh frozen plasma for the treatment of hereditary angioedema acute attacks","volume":"27","author":"Tang","year":"2012","journal-title":"Chin Med Sci J"},{"issue":"4","key":"10.1016\/j.iac.2022.10.013_bib70","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S1081-1206(10)60886-1","article-title":"Fresh frozen plasma for the treatment of hereditary angioedema","volume":"98","author":"Prematta","year":"2007","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"9","key":"10.1016\/j.iac.2022.10.013_bib71","doi-asserted-by":"crossref","first-page":"100049","DOI":"10.1016\/j.waojou.2019.100049","article-title":"Fresh frozen plasma for on-demand hereditary angioedema treatment in South Africa and Iran","volume":"12","author":"Wentzel","year":"2019","journal-title":"World Allergy Organ J"},{"issue":"1","key":"10.1016\/j.iac.2022.10.013_bib72","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jaip.2020.08.046","article-title":"US HAEA Medical Advisory Board 2020 Guidelines for the Management of Hereditary Angioedema","volume":"9","author":"Busse","year":"2021","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"issue":"11","key":"10.1016\/j.iac.2022.10.013_bib73","first-page":"6091510","article-title":"Using fresh frozen plasma for acute airway angioedema to prevent intubation in the emergency department: a retrospective cohort study","volume":"2016","author":"Saeb","year":"2016","journal-title":"Emerg Med Int"},{"issue":"5","key":"10.1016\/j.iac.2022.10.013_bib74","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1093\/bja\/aes371","article-title":"Treatment of a life-threatening laryngeal bradykinin angio-oedema precipitated by dipeptidylpeptidase-4 inhibitor and angiotensin-I converting enzyme inhibitor with prothrombin complex concentrates","volume":"109","author":"Millot","year":"2012","journal-title":"Br J Anaesth"},{"issue":"12","key":"10.1016\/j.iac.2022.10.013_bib75","first-page":"584","article-title":"Recurrent angiotensin-converting enzyme inhibitor-induced angioedema refractory to fresh frozen plasma","volume":"36","author":"V\u00e1zquez-Ramos","year":"2019","journal-title":"Fed Pract"},{"issue":"1","key":"10.1016\/j.iac.2022.10.013_bib76","doi-asserted-by":"crossref","first-page":"192.e1","DOI":"10.1016\/j.ajem.2016.06.089","article-title":"Angiotensin-converting enzyme inhibitor\u2013induced angioedema worsened with fresh frozen plasma","volume":"35","author":"Adebayo","year":"2016","journal-title":"Am J Emerg Med"},{"issue":"6","key":"10.1016\/j.iac.2022.10.013_bib77","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1016\/j.jaip.2019.02.027","article-title":"Possible donor-dependent differences in efficacy of fresh frozen plasma for treatment of ACE inhibitor-induced angioedema","volume":"7","author":"Chen","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"issue":"5","key":"10.1016\/j.iac.2022.10.013_bib78","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.jemermed.2017.05.037","article-title":"Novel therapies for angiotensin-converting enzyme inhibitor\u2013induced angioedema: a systematic review of current evidence","volume":"53","author":"Riha","year":"2017","journal-title":"J\u00a0Emerg Med"},{"issue":"1","key":"10.1016\/j.iac.2022.10.013_bib79","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jemermed.2018.01.048","article-title":"Treatment of angioedema induced by angiotensin-converting enzyme inhibitor","volume":"55","author":"Wilkerson","year":"2018","journal-title":"J\u00a0Emerg Med"},{"issue":"1","key":"10.1016\/j.iac.2022.10.013_bib80","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0002-9343(63)90162-1","article-title":"A\u00a0biochemical abnormality in hereditary angioeneurotic edema: absence of serum inhibitor of c\u2019 1-esterase","volume":"35","author":"Donaldson","year":"1963","journal-title":"Am J Med"},{"issue":"7830","key":"10.1016\/j.iac.2022.10.013_bib81","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/S0140-6736(73)92519-1","article-title":"Hereditary angioneurotic oedema","volume":"2","author":"Brackertz","year":"1973","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.iac.2022.10.013_bib82","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1055\/s-0028-1103919","article-title":"Klinik sowie erweiterte diagnostische und therapeutische Moglichkeiten [Hereditary angioneurotic edema. Clinical aspects and extended diagnostic and therapeutic possibilities] In German","volume":"104","author":"Bork","year":"1979","journal-title":"Deutsche medizinische Wochenschrift"},{"issue":"10","key":"10.1016\/j.iac.2022.10.013_bib83","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1056\/NEJM198003063021002","article-title":"Replacement therapy in hereditary angioedema: successful treatment of acute episodes of angioedema with partly purified C1 inhibitor","volume":"302","author":"Gadek","year":"1980","journal-title":"New Engl J Med"},{"issue":"5","key":"10.1016\/j.iac.2022.10.013_bib84","first-page":"299","article-title":"Treatment of acute attacks of hereditary angioedema with C1-inhibitor concentrate","volume":"44","author":"Agostoni","year":"1980","journal-title":"Ann Allergy"},{"issue":"Suppl 3","key":"10.1016\/j.iac.2022.10.013_bib85","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1097\/1939-4551-3-S3-S29","article-title":"Recombinant and Plasma-Purified Human C1 Inhibitor for the Treatment of Hereditary Angioedema","volume":"3","author":"Frank","year":"2010","journal-title":"World Allergy Organ J"},{"issue":"4","key":"10.1016\/j.iac.2022.10.013_bib86","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.jaci.2009.07.017","article-title":"Efficacy of human C1 esterase inhibitor concentrate compared with placebo in acute hereditary angioedema attacks","volume":"124","author":"Craig","year":"2009","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"12","key":"10.1016\/j.iac.2022.10.013_bib87","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1111\/j.1398-9995.2011.02702.x","article-title":"C1 esterase inhibitor concentrate in 1085 Hereditary Angioedema attacks - final results of the I.M.P.A.C.T.2 study","volume":"66","author":"Craig","year":"2011","journal-title":"Allergy"},{"issue":"6","key":"10.1016\/j.iac.2022.10.013_bib88","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1111\/bcp.12132","article-title":"Population pharmacokinetics of recombinant human C1 inhibitor in patients with hereditary angioedema","volume":"76","author":"Farrell","year":"2013","journal-title":"Br J Clin Pharmaco"},{"issue":"3","key":"10.1016\/j.iac.2022.10.013_bib89","doi-asserted-by":"crossref","first-page":"e121","DOI":"10.1016\/j.jemermed.2019.10.031","article-title":"C1 esterase inhibitor for ace-inhibitor angioedema: a case series and literature review","volume":"58","author":"Perza","year":"2020","journal-title":"J\u00a0Emerg Med"},{"issue":"1","key":"10.1016\/j.iac.2022.10.013_bib90","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13223-021-00521-w","article-title":"Effectiveness of C1-INH therapy in angiotensin converting enzyme inhibitor induced angioedema","volume":"17","author":"Kovaltchouk","year":"2021","journal-title":"Allergy Asthma Clin Immunol"},{"issue":"9","key":"10.1016\/j.iac.2022.10.013_bib92","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1517\/13543784.15.9.1077","article-title":"The therapeutic potential of a kallikrein inhibitor for treating hereditary angioedema","volume":"15","author":"Levy","year":"2006","journal-title":"Expert Opin Investig Drugs"},{"issue":"2","key":"10.1016\/j.iac.2022.10.013_bib93","doi-asserted-by":"crossref","first-page":"S103","DOI":"10.1016\/j.jaci.2007.12.1190","article-title":"Results of a 2-Stage, Phase 3 Pivotal Trial, EDEMA3: A Study of Subcutaneous DX-88 (Ecallantide), a Plasma Kallikrein Inhibitor, in Patients with Hereditary Angioedema (HAE)","volume":"121","author":"Levy","year":"2008","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"6","key":"10.1016\/j.iac.2022.10.013_bib94","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.anai.2010.04.012","article-title":"EDEMA4: a phase 3, double-blind study of subcutaneous ecallantide treatment for acute attacks of hereditary angioedema","volume":"104","author":"Levy","year":"2010","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.iac.2022.10.013_bib95","first-page":"115","article-title":"Management of acute attacks of hereditary angioedema: role of ecallantide","volume":"6","author":"Duffey","year":"2015","journal-title":"J\u00a0Blood Med"},{"issue":"2","key":"10.1016\/j.iac.2022.10.013_bib96","doi-asserted-by":"crossref","first-page":"AB220","DOI":"10.1016\/j.jaci.2011.12.105","article-title":"Hypersensitivity reactions to ecallantide: an update of the clinical trial experience and post-market surveillance for treatment of attacks of hereditary angioedema","volume":"129","author":"Craig","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"3","key":"10.1016\/j.iac.2022.10.013_bib97","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.anai.2014.12.007","article-title":"Effectiveness of ecallantide in treating angiotensin-converting enzyme inhibitor-induced angioedema in the emergency department","volume":"114","author":"Bernstein","year":"2015","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"2","key":"10.1016\/j.iac.2022.10.013_bib98","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.annemergmed.2014.07.014","article-title":"Ecallantide for the acute treatment of Angiotensin-converting enzyme inhibitor-induced angioedema: a multicenter, randomized, controlled trial","volume":"65","author":"Lewis","year":"2015","journal-title":"Ann Emerg Med"},{"issue":"6","key":"10.1016\/j.iac.2022.10.013_bib99","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1016\/j.jaci.2007.02.012","article-title":"Treatment of acute edema attacks in hereditary angioedema with a bradykinin receptor-2 antagonist (Icatibant)","volume":"119","author":"Bork","year":"2007","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.iac.2022.10.013_bib100","first-page":"795","article-title":"Management of acute attacks of hereditary angioedema: potential role of icatibant","volume":"6","author":"Longhurst","year":"2010"},{"issue":"6","key":"10.1016\/j.iac.2022.10.013_bib101","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1056\/NEJMoa0906393","article-title":"Icatibant, a new bradykinin-receptor antagonist, in hereditary angioedema","volume":"363","author":"Cicardi","year":"2010","journal-title":"New Engl J Med"},{"issue":"6","key":"10.1016\/j.iac.2022.10.013_bib102","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.anai.2011.08.015","article-title":"Randomized placebo-controlled trial of the bradykinin B\u2082 receptor antagonist icatibant for the treatment of acute attacks of hereditary angioedema: the FAST-3 trial","volume":"107","author":"Lumry","year":"2011","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"2","key":"10.1016\/j.iac.2022.10.013_bib103","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1600-0625.2011.01410.x","article-title":"Inflammatory skin responses induced by icatibant injection are mast cell mediated and attenuated by H1-antihistamines","volume":"21","author":"Maurer","year":"2012","journal-title":"Exp Dermatol"},{"issue":"3","key":"10.1016\/j.iac.2022.10.013_bib104","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.annemergmed.2010.03.032","article-title":"Therapeutic efficacy of icatibant in angioedema induced by angiotensin-converting enzyme inhibitors: a case series","volume":"56","author":"Bas","year":"2010","journal-title":"Ann Emerg Med"},{"issue":"5","key":"10.1016\/j.iac.2022.10.013_bib105","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.jaad.2010.03.023","article-title":"Treatment of angiotensin-converting enzyme inhibitor\u2013related angioedema with the bradykinin B2 receptor antagonist icatibant","volume":"63","author":"Schmidt","year":"2010","journal-title":"J\u00a0Am Dermatol"},{"issue":"5","key":"10.1016\/j.iac.2022.10.013_bib106","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1056\/NEJMoa1312524","article-title":"A\u00a0randomized trial of icatibant in ace-inhibitor\u2013induced angioedema","volume":"372","author":"Bas","year":"2015","journal-title":"New Engl J Med"},{"issue":"1","key":"10.1016\/j.iac.2022.10.013_bib107","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jaci.2016.09.051","article-title":"Effect of bradykinin receptor antagonism on ACE inhibitor-associated angioedema","volume":"140","author":"Straka","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"5","key":"10.1016\/j.iac.2022.10.013_bib108","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.jaip.2017.03.003","article-title":"Randomized trial of icatibant for angiotensin-converting enzyme inhibitor\u2013induced upper airway angioedema","volume":"5","author":"Sinert","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"issue":"4","key":"10.1016\/j.iac.2022.10.013_bib109","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1177\/0194599815588909","article-title":"Predictors of airway intervention in angiotensin-converting enzyme inhibitor\u2013induced angioedema","volume":"153","author":"Kieu","year":"2015","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"2","key":"10.1016\/j.iac.2022.10.013_bib110","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1002\/lary.21277","article-title":"Site involvement as a predictor of airway intervention in angioedema","volume":"121","author":"McCormick","year":"2011","journal-title":"Laryngoscope"},{"issue":"9","key":"10.1016\/j.iac.2022.10.013_bib111","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1177\/000348940111000906","article-title":"Angiotensin-converting enzyme inhibitor-induced angioedema: a multicenter review and an algorithm for airway management","volume":"110","author":"Chiu","year":"2001","journal-title":"Ann otology, rhinology, Laryngol"},{"issue":"2","key":"10.1016\/j.iac.2022.10.013_bib112","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1097\/00000542-200508000-00027","article-title":"Predicting difficult intubation in apparently normal patients: a meta-analysis of bedside screening test performance","volume":"103","author":"Shiga","year":"2005","journal-title":"Anesthesiology"},{"issue":"4","key":"10.1016\/j.iac.2022.10.013_bib113","doi-asserted-by":"crossref","first-page":"587","DOI":"10.5811\/westjem.2019.5.42650","article-title":"Evaluation and management of angioedema in the emergency department","volume":"20","author":"Long","year":"2019","journal-title":"West J Emerg Med"},{"issue":"4","key":"10.1016\/j.iac.2022.10.013_bib114","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/anae.14904","article-title":"Difficult airway society guidelines for awake tracheal intubation (ati) in adults","volume":"75","author":"Ahmad","year":"2020","journal-title":"Anaesthesia"},{"issue":"1","key":"10.1016\/j.iac.2022.10.013_bib115","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.chest.2019.06.018","article-title":"A\u00a0randomized trial of nebulized lignocaine, lignocaine spray, or their combination for topical anesthesia during diagnostic flexible bronchoscopy","volume":"157","author":"Dhooria","year":"2020","journal-title":"Chest"},{"issue":"5","key":"10.1016\/j.iac.2022.10.013_bib116","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.annemergmed.2016.11.027","article-title":"Emergency department airway management of severe angioedema: a video review of 45 intubations","volume":"69","author":"Driver","year":"2017","journal-title":"Ann Emerg Med"},{"issue":"20","key":"10.1016\/j.iac.2022.10.013_bib117","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1001\/2013.jamainternmed.34","article-title":"Comparative risk for angioedema associated with the use of drugs that target the Renin-Angiotensin-aldosterone system","volume":"172","author":"Toh","year":"2012","journal-title":"Arch Intern Med"},{"issue":"3","key":"10.1016\/j.iac.2022.10.013_bib118","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.amjcard.2012.03.034","article-title":"Meta-analysis of randomized trials of angioedema as an adverse event of renin-angiotensin system inhibitors","volume":"110","author":"Makani","year":"2012","journal-title":"Am J Cardiol"},{"issue":"5","key":"10.1016\/j.iac.2022.10.013_bib119","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S1081-1206(10)60288-8","article-title":"Risk of angioedema with angiotensin receptor blockers in patients with prior angioedema associated with angiotensin-converting enzyme inhibitors: a meta-analysis","volume":"101","author":"Haymore","year":"2008","journal-title":"Ann Allergy Asthma Immunol"}],"container-title":["Immunology and Allergy Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889856122009109?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889856122009109?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:53:45Z","timestamp":1760180025000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889856122009109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":118,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S0889856122009109"],"URL":"https:\/\/doi.org\/10.1016\/j.iac.2022.10.013","relation":{},"ISSN":["0889-8561"],"issn-type":[{"value":"0889-8561","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Angiotensin-Converting Enzyme Inhibitor\u2013Induced Angioedema","name":"articletitle","label":"Article Title"},{"value":"Immunology and Allergy Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.iac.2022.10.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}