{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:17:25Z","timestamp":1790745445760,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100006477","name":"NTU","doi-asserted-by":"publisher","award":["103R7616-3"],"award-info":[{"award-number":["103R7616-3"]}],"id":[{"id":"10.13039\/501100006477","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"MOST","doi-asserted-by":"publisher","award":["671 104-2627-M-002-013"],"award-info":[{"award-number":["671 104-2627-M-002-013"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"MOST","doi-asserted-by":"publisher","award":["105-2627-M-002-011"],"award-info":[{"award-number":["105-2627-M-002-011"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Insect Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.ibmb.2017.06.016","type":"journal-article","created":{"date-parts":[[2017,7,19]],"date-time":"2017-07-19T00:47:21Z","timestamp":1500425241000},"page":"12-20","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":97,"special_numbering":"C","title":["Gene expression changes in honey bees induced by sublethal imidacloprid exposure during the larval stage"],"prefix":"10.1016","volume":"88","author":[{"given":"Ming-Cheng","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Wen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuang-Hui","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5793-5427","authenticated-orcid":false,"given":"En-Cheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ibmb.2017.06.016_bib1","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1111\/j.1462-2920.2009.01953.x","article-title":"Immune suppression in the honey bee (Apis mellifera) following infection by Nosema ceranae (Microsporidia)","volume":"11","author":"Antunez","year":"2009","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.ibmb.2017.06.016_bib2","doi-asserted-by":"crossref","first-page":"e91686","DOI":"10.1371\/journal.pone.0091686","article-title":"Transcriptome analyses of the honeybee response to Nosema ceranae and insecticides","volume":"9","author":"Aufauvre","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ibmb.2017.06.016_bib3","first-page":"107","article-title":"Improvement of artificial feeding in a standard in\u00a0vitro method for rearing Apis mellifera larvae","volume":"58","author":"Aupinel","year":"2005","journal-title":"Bull. Insectology"},{"key":"10.1016\/j.ibmb.2017.06.016_bib4","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jinsphys.2016.01.001","article-title":"The neonicotinoids thiacloprid, imidacloprid, and clothianidin affect the immunocompetence of honey bees (Apis mellifera L.)","volume":"86","author":"Brandt","year":"2016","journal-title":"J.\u00a0Insect Physiol."},{"key":"10.1016\/j.ibmb.2017.06.016_bib5","doi-asserted-by":"crossref","first-page":"12574","DOI":"10.1038\/srep12574","article-title":"Evidence for pollinator cost and farming benefits of neonicotinoid seed coatings on oilseed rape","volume":"5","author":"Budge","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ibmb.2017.06.016_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1742-9994-10-72","article-title":"More than royal food- Major royal jelly protein genes in sexuals and workers of the honeybee Apis mellifera","volume":"10","author":"Buttstedt","year":"2013","journal-title":"Front. Zool."},{"key":"10.1016\/j.ibmb.2017.06.016_bib7","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/brv.12052","article-title":"Origin and function of the major royal jelly proteins of the honeybee (Apis mellifera) as members of the yellow gene family","volume":"89","author":"Buttstedt","year":"2014","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"key":"10.1016\/j.ibmb.2017.06.016_bib8","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s13592-012-0187-0","article-title":"Stable reference genes for the measurement of transcript abundance during larval caste development in the honeybee","volume":"44","author":"Cameron","year":"2013","journal-title":"Apidologie"},{"key":"10.1016\/j.ibmb.2017.06.016_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jinsphys.2016.03.004","article-title":"Sperm viability and gene expression in honey bee queens (Apis mellifera) following exposure to the neonicotinoid insecticide imidacloprid and the organophosphate acaricide coumaphos","volume":"89","author":"Chaimanee","year":"2016","journal-title":"J.\u00a0Insect Physiol."},{"key":"10.1016\/j.ibmb.2017.06.016_bib10","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.aspen.2016.06.005","article-title":"The impact of pyriproxyfen on the development of honey bee (Apis mellifera L.) colony in field","volume":"19","author":"Chen","year":"2016","journal-title":"J.\u00a0Asia Pac. Entomol."},{"key":"10.1016\/j.ibmb.2017.06.016_bib11","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/j.1365-2583.2006.00672.x","article-title":"A\u00a0deficit of detoxification enzymes: pesticide sensitivity and environmental response in the honeybee","volume":"15","author":"Claudianos","year":"2006","journal-title":"Insect Mol. Biol."},{"key":"10.1016\/j.ibmb.2017.06.016_bib12","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1111\/j.1365-2583.2006.00695.x","article-title":"Genes of the antioxidant system of the honey bee: annotation and physiology","volume":"15","author":"Corona","year":"2006","journal-title":"Insect Mol. Biol."},{"key":"10.1016\/j.ibmb.2017.06.016_bib13","doi-asserted-by":"crossref","first-page":"e68191","DOI":"10.1371\/journal.pone.0068191","article-title":"Transient exposure to low levels of insecticide affects metabolic networks of honeybee larvae","volume":"8","author":"Derecka","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ibmb.2017.06.016_bib14","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1146\/annurev.ento.52.110405.091440","article-title":"The sublethal effects of pesticides on beneficial arthropods","volume":"52","author":"Desneux","year":"2007","journal-title":"Annu. Rev. Entomol."},{"key":"10.1016\/j.ibmb.2017.06.016_bib15","doi-asserted-by":"crossref","first-page":"18466","DOI":"10.1073\/pnas.1314923110","article-title":"Neonicotinoid clothianidin adversely affects insect immunity and promotes replication of a viral pathogen in honey bees","volume":"110","author":"Di Prisco","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ibmb.2017.06.016_bib16","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.neuint.2012.09.020","article-title":"A\u00a0potential link among biogenic amines-based pesticides, learning and memory, and colony collapse disorder: a unique hypothesis","volume":"62","author":"Farooqui","year":"2013","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ibmb.2017.06.016_bib17","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1186\/1471-2164-10-645","article-title":"Proteomic analysis of honeybee worker (Apis mellifera) hypopharyngeal gland development","volume":"10","author":"Feng","year":"2009","journal-title":"BMC Genomics"},{"key":"10.1016\/j.ibmb.2017.06.016_bib18","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.peptides.2004.03.016","article-title":"Jelleines: a family of antimicrobial peptides from the Royal Jelly of honeybees (Apis mellifera)","volume":"25","author":"Fontana","year":"2004","journal-title":"Peptides"},{"key":"10.1016\/j.ibmb.2017.06.016_bib19","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2144\/000114090","article-title":"The choice of reference gene affects statistical efficiency in quantitative PCR data analysis","volume":"55","author":"Guo","year":"2013","journal-title":"Biotechniques"},{"key":"10.1016\/j.ibmb.2017.06.016_bib20","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1126\/science.1215039","article-title":"A\u00a0common pesticide decreases foraging success and survival in honey bees","volume":"336","author":"Henry","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.ibmb.2017.06.016_bib21","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1051\/apido\/2009075","article-title":"Reduced expression of major royal jelly protein 1 gene in the mushroom bodies of worker honeybees with reduced learning ability","volume":"41","author":"Hojo","year":"2010","journal-title":"Apidologie"},{"key":"10.1016\/j.ibmb.2017.06.016_bib22","doi-asserted-by":"crossref","first-page":"6139","DOI":"10.1021\/jf300815b","article-title":"Growth stimulating effect on queen bee larvae of histone deacetylase inhibitors","volume":"60","author":"Huang","year":"2012","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.ibmb.2017.06.016_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1673\/031.011.9601","article-title":"Rearing honey bees, Apis mellifera, in\u00a0vitro: effects of sugar concentrations on survival and development","volume":"2","author":"Kaftanoglu","year":"2011","journal-title":"J.\u00a0Insect Sci."},{"key":"10.1016\/j.ibmb.2017.06.016_bib24","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/nature10093","article-title":"Royalactin induces queen differentiation in honeybees","volume":"473","author":"Kamakura","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ibmb.2017.06.016_bib25","first-page":"119","article-title":"Toxicity of neonicotinoid insecticides on different honey bee genotypes","volume":"66","author":"Laurino","year":"2013","journal-title":"Bull. Insectology"},{"key":"10.1016\/j.ibmb.2017.06.016_bib26","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1365-2583.2011.01074.x","article-title":"Social immunity in honeybees (Apis mellifera): transcriptome analysis of varroa-hygienic behaviour","volume":"20","author":"Le Conte","year":"2011","journal-title":"Insect Mol. Biol."},{"key":"10.1016\/j.ibmb.2017.06.016_bib27","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.ibmb.2017.06.016_bib28","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1051\/apido:2008015","article-title":"Validation of reference genes for gene expression studies in the honey bee, Apis mellifera, by quantitative real-time RT-PCR","volume":"39","author":"Louren\u00e7o","year":"2008","journal-title":"Apidologie"},{"key":"10.1016\/j.ibmb.2017.06.016_bib29","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.1111\/j.1742-4658.2009.07232.x","article-title":"The gene road to royalty\u2013differential expression of hydroxylating genes in the mandibular glands of the honeybee","volume":"276","author":"Malka","year":"2009","journal-title":"FEBS J."},{"key":"10.1016\/j.ibmb.2017.06.016_bib30","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1111\/imb.12183","article-title":"Task-related differential expression of four cytochrome P450 genes in honeybee appendages","volume":"24","author":"Mao","year":"2015","journal-title":"Insect Mol. Biol."},{"key":"10.1016\/j.ibmb.2017.06.016_bib31","first-page":"1","article-title":"Reduction in homing flights in the honey bee Apis mellifera after a sublethal dose of neonicotinoid insecticides","volume":"66","author":"Matsumoto","year":"2013","journal-title":"Bull. Insectology"},{"key":"10.1016\/j.ibmb.2017.06.016_bib32","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cois.2015.01.015","article-title":"Honey bee colony losses and associated viruses","volume":"8","author":"McMenamin","year":"2015","journal-title":"Curr. Opin. Insect Sci."},{"key":"10.1016\/j.ibmb.2017.06.016_bib33","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3389\/fgene.2014.00445","article-title":"Developmental regulation of ecdysone receptor (EcR) and EcR-controlled gene expression during pharate-adult development of honeybees (Apis mellifera)","volume":"5","author":"Mello","year":"2014","journal-title":"Front. Genet."},{"key":"10.1016\/j.ibmb.2017.06.016_bib34","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1096\/fj.14-267179","article-title":"Chronic exposure to neonicotinoids increases neuronal vulnerability to mitochondrial dysfunction in the bumblebee (Bombus terrestris)","volume":"29","author":"Moffat","year":"2015","journal-title":"FASEB J."},{"key":"10.1016\/j.ibmb.2017.06.016_bib35","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nmeth.1226","article-title":"Mapping and quantifying mammalian transcriptomes by RNA-Seq","volume":"5","author":"Mortazavi","year":"2008","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ibmb.2017.06.016_bib36","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1038\/ncomms2648","article-title":"Cholinergic pesticides cause mushroom body neuronal inactivation in honeybees","volume":"4","author":"Palmer","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ibmb.2017.06.016_bib37","doi-asserted-by":"crossref","first-page":"19298","DOI":"10.1038\/srep19298","article-title":"Sublethal dosage of imidacloprid reduces the microglomerular density of honey bee mushroom bodies","volume":"6","author":"Peng","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ibmb.2017.06.016_bib38","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1007\/s13592-016-0435-9","article-title":"Combined effect of pollen quality and thiamethoxam on hypopharyngeal gland development and protein content in Apis mellifera","volume":"47","author":"Renzi","year":"2016","journal-title":"Apidologie"},{"key":"10.1016\/j.ibmb.2017.06.016_bib39","doi-asserted-by":"crossref","first-page":"e0139841","DOI":"10.1371\/journal.pone.0139841","article-title":"Genetics, synergists, and age affect insecticide sensitivity of the honey bee, Apis mellifera","volume":"10","author":"Rinkevich","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ibmb.2017.06.016_bib40","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jip.2009.07.016","article-title":"Biology and control of Varroa destructor","volume":"103","author":"Rosenkranz","year":"2010","journal-title":"J.\u00a0Invertebr. Pathol."},{"key":"10.1016\/j.ibmb.2017.06.016_bib41","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.envint.2016.01.009","article-title":"Are bee diseases linked to pesticides? - A brief review","volume":"89","author":"Sanchez-Bayo","year":"2016","journal-title":"Environ. Int."},{"key":"10.1016\/j.ibmb.2017.06.016_bib42","doi-asserted-by":"crossref","first-page":"e103592","DOI":"10.1371\/journal.pone.0103592","article-title":"Impact of chronic neonicotinoid exposure on honeybee colony performance and queen supersedure","volume":"9","author":"Sandrock","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ibmb.2017.06.016_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1673\/031.008.3301","article-title":"Reference gene selection for insect expression studies using quantitative real-time PCR: the head of the honeybee, Apis mellifera, after a bacterial challenge","volume":"8","author":"Scharlaken","year":"2008","journal-title":"J.\u00a0Insect Sci."},{"key":"10.1016\/j.ibmb.2017.06.016_bib44","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/ps.270","article-title":"Risk posed to honeybees (Apis mellifera L, Hymenoptera) by an imidacloprid seed dressing of sunflowers","volume":"57","author":"Schmuck","year":"2001","journal-title":"Pest Manag. Sci."},{"key":"10.1016\/j.ibmb.2017.06.016_bib45","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1080\/00218839.2016.1153294","article-title":"A\u00a0national survey of managed honey bee 2014\u20132015 annual colony losses in the USA","volume":"54","author":"Seitz","year":"2016","journal-title":"J.\u00a0Apic. Res."},{"key":"10.1016\/j.ibmb.2017.06.016_bib46","doi-asserted-by":"crossref","first-page":"e26314","DOI":"10.1371\/journal.pone.0026314","article-title":"ConDeTri - a content dependent read trimmer for illumina data","volume":"6","author":"Smeds","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ibmb.2017.06.016_bib47","doi-asserted-by":"crossref","first-page":"e38406","DOI":"10.1371\/journal.pone.0038406","article-title":"Imidacloprid-induced impairment of mushroom bodies and behavior of the native stingless bee Melipona quadrifasciata anthidioides","volume":"7","author":"Tome","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ibmb.2017.06.016_bib48","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nprot.2012.016","article-title":"Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks","volume":"7","author":"Trapnell","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ibmb.2017.06.016_bib49","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3896\/IBRA.1.51.1.12","article-title":"Managed honey bee colony losses in Canada, China, Europe, Israel and Turkey, for the winters of 2008-9 and 2009-10","volume":"51","author":"van der Zee","year":"2012","journal-title":"J.\u00a0Apic. Res."},{"key":"10.1016\/j.ibmb.2017.06.016_bib50","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"Vandesompele","year":"2002","journal-title":"Genome Biol."},{"key":"10.1016\/j.ibmb.2017.06.016_bib51","doi-asserted-by":"crossref","first-page":"14621","DOI":"10.1038\/srep14621","article-title":"Neonicotinoid pesticides severely affect honey bee queens","volume":"5","author":"Williams","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ibmb.2017.06.016_bib52","first-page":"1799","article-title":"Exposure to multiple cholinergic pesticides impairs olfactory learning and memory in honeybees","volume":"216","author":"Williamson","year":"2013","journal-title":"J.\u00a0Exp. Biol."},{"key":"10.1016\/j.ibmb.2017.06.016_bib53","doi-asserted-by":"crossref","first-page":"12459","DOI":"10.1038\/ncomms12459","article-title":"Impacts of neonicotinoid use on long-term population changes in wild bees in England","volume":"7","author":"Woodcock","year":"2016","journal-title":"Nat. Commun"},{"key":"10.1016\/j.ibmb.2017.06.016_bib54","doi-asserted-by":"crossref","first-page":"e14720","DOI":"10.1371\/journal.pone.0014720","article-title":"Sub-lethal effects of pesticide residues in brood comb on worker honey bee (Apis mellifera) development and longevity","volume":"6","author":"Wu","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ibmb.2017.06.016_bib55","doi-asserted-by":"crossref","first-page":"e49472","DOI":"10.1371\/journal.pone.0049472","article-title":"Impaired olfactory associative behavior of honeybee workers due to contamination of imidacloprid in the larval stage","volume":"7","author":"Yang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ibmb.2017.06.016_bib56","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1603\/0022-0493-101.6.1743","article-title":"Abnormal foraging behavior induced by sublethal dosage of imidacloprid in the honey bee","volume":"101","author":"Yang","year":"2008","journal-title":"J.\u00a0Econ. Entomol."}],"container-title":["Insect Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0965174817301005?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0965174817301005?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T16:41:51Z","timestamp":1760805711000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0965174817301005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":56,"alternative-id":["S0965174817301005"],"URL":"https:\/\/doi.org\/10.1016\/j.ibmb.2017.06.016","relation":{},"ISSN":["0965-1748"],"issn-type":[{"value":"0965-1748","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gene expression changes in honey bees induced by sublethal imidacloprid exposure during the larval stage","name":"articletitle","label":"Article Title"},{"value":"Insect Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ibmb.2017.06.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}