{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T19:35:22Z","timestamp":1787859322218,"version":"build-2784847793"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Insect Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.ibmb.2021.103673","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T12:52:16Z","timestamp":1635166336000},"page":"103673","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Differential activity on trypanosomatid parasites of a novel recombinant defensin type 1 from the insect Triatoma (Meccus) pallidipennis"],"prefix":"10.1016","volume":"139","author":[{"given":"Paulina","family":"D\u00edaz-Garrido","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Elena","family":"C\u00e1rdenas-Guerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebasti\u00e1n","family":"Poggio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla","family":"Rodr\u00edguez-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucio","family":"Rivera-Santiago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Ortega-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"S\u00e1nchez-Esquivel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertha","family":"Espinoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ibmb.2021.103673_bib1","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.ibmb.2006.04.003","article-title":"Sequence characterization and expression patterns of defensin and lysozyme encoding genes from the gut of the reduviid bug, Triatoma brasiliensis","volume":"36","author":"Ara\u00fajo","year":"2006","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.ibmb.2021.103673_bib2","doi-asserted-by":"crossref","first-page":"4503","DOI":"10.1007\/s00436-015-4694-6","article-title":"Genes encoding defensins of important Chagas disease vectors used for phylogenetic studies","volume":"114","author":"Ara\u00fajo","year":"2015","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.ibmb.2021.103673_bib3","doi-asserted-by":"crossref","DOI":"10.1590\/0074-02760170332","article-title":"Complement system contributes to modulate the infectivity of susceptible TcI strains of Trypanosoma cruzi","volume":"113","author":"Arroyo-Olarte","year":"2018","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.ibmb.2021.103673_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003438","article-title":"Leishmania (L.) mexicana infected bats in Mexico: novel potential reservoirs","volume":"9","author":"Berzunza-Cruz","year":"2015","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.ibmb.2021.103673_bib5","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.pt.2006.04.003","article-title":"Antimicrobial peptides in the interactions between insects and flagellate parasites","volume":"22","author":"Boulanger","year":"2006","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.ibmb.2021.103673_bib6","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.biocel.2014.12.001","article-title":"The recombinant prepro region of TvCP4 is an inhibitor of cathepsin L-like cysteine proteinases of Trichomonas vaginalis that inhibits trichomonal haemolysis","volume":"59","author":"C\u00e1rdenas-Guerra","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.ibmb.2021.103673_bib7","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00726-010-0493-7","article-title":"Expression systems of human b-defensins: vectors, purification and biological activities","volume":"40","author":"Corrales-Garcia","year":"2011","journal-title":"Amino Acids"},{"key":"10.1016\/j.ibmb.2021.103673_bib8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.pep.2013.02.007","article-title":"Bacterial expression and antibiotic activities of recombinant variants of human b-defensins on pathogenic bacteria and M. tuberculosis","volume":"89","author":"Corrales-Garc\u00eda","year":"2013","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/j.ibmb.2021.103673_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2014.00063","article-title":"Fusion tags for protein solubility, purification and immunogenicity in Escherichia coli: the novel Fh8 system","volume":"5","author":"Costa","year":"2014","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ibmb.2021.103673_bib10","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.ttbdis.2018.03.011","article-title":"Antiplasmodial activity of tick defensins in a mouse model of malaria","volume":"9","author":"Couto","year":"2018","journal-title":"Ticks Tick Borne Dis"},{"key":"10.1016\/j.ibmb.2021.103673_bib11","first-page":"315","article-title":"A centipede toxin family defines an ancient class of CS\u03b1\u03b2 defensins","volume":"5","author":"Dash","year":"2014","journal-title":"Structure"},{"key":"10.1016\/j.ibmb.2021.103673_bib12","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.peptides.2006.09.022","article-title":"Evolutionary selective trends of insect\/mosquito antimicrobial defensin peptides containing cysteine-stabilized \u03b1\/\u03b2 motifs","volume":"28","author":"Dassanayake","year":"2007","journal-title":"Peptides"},{"key":"10.1016\/j.ibmb.2021.103673_bib13","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.1550-7408.2002.tb00369.x","article-title":"Infectivity and virulence of Leishmania donovani promastigotes: a role for media, source, and strain of parasite","volume":"49","author":"Dey","year":"2002","journal-title":"J. Eukaryot. Microbiol."},{"key":"10.1016\/j.ibmb.2021.103673_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BSR20180988","article-title":"Variability of defensin genes from a Mexican endemic Triatominae: Triatoma (Meccus) pallidipennis (Hemiptera: Reduviidae)","volume":"38","author":"D\u00edaz-Garrido","year":"2018","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.ibmb.2021.103673_bib15","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20150060","article-title":"PvD1 defensin, a plant antimicrobial peptide with inhibitory activity against Leishmania amazonensis","volume":"35","author":"Do Nascimento","year":"2015","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.ibmb.2021.103673_bib16","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.exppara.2013.08.014","article-title":"Trypanosoma rangeli: an alkaline ecto-phosphatase activity is involved with survival and growth of the parasite","volume":"135","author":"Dos-Santos","year":"2013","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.ibmb.2021.103673_bib17","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1093\/nar\/gkh340","article-title":"MUSCLE: multiple sequence alignment with high accuracy and high throughput","volume":"32","author":"Edgar","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ibmb.2021.103673_bib18","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1128\/AAC.49.1.269-275.2005","article-title":"Antibacterial activity and specificity of the six human {alpha}-defensins","volume":"49","author":"Ericksen","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ibmb.2021.103673_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2010\/890672","article-title":"Mexican Trypanosoma cruzi TcI strains with different degrees of virulence induce diverse humoral and cellular immune responses in a murine experimental infection model","volume":"890672","author":"Espinoza","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.ibmb.2021.103673_bib20","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S1046-5928(02)00521-1","article-title":"A fusion protein system for the recombinant production of short disulfide-containing peptides","volume":"26","author":"Fairlie","year":"2002","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/j.ibmb.2021.103673_bib21","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/nri1180","article-title":"Defensins: antimicrobial peptides of innate immunity","volume":"3","author":"Ganz","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ibmb.2021.103673_bib22","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0163-7258(94)00076-F","article-title":"Defensins","volume":"66","author":"Ganz","year":"1995","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ibmb.2021.103673_bib23","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nprot.2015.053","article-title":"The Phyre2 web portal for protein modeling, prediction and analysis","volume":"10","author":"Kelley","year":"2015","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ibmb.2021.103673_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fchem.2017.00045","article-title":"Structure-activity relationships of insect defensins","volume":"5","author":"Koehbach","year":"2017","journal-title":"Front Chem"},{"key":"10.1016\/j.ibmb.2021.103673_bib25","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/prot.21912","article-title":"Rational design of peptides active against the gram positive bacteria Staphylococcus aureus","volume":"72","author":"Landon","year":"2008","journal-title":"Proteins"},{"key":"10.1016\/j.ibmb.2021.103673_bib26","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1146\/annurev.immunol.25.022106.141615","article-title":"The host defense of Drosophila melanogaster","volume":"25","author":"Lemaitre","year":"2007","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.ibmb.2021.103673_bib27","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.pep.2011.08.001","article-title":"Recombinant production of antimicrobial peptides in Escherichia coli: a review","volume":"80","author":"Li","year":"2011","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/j.ibmb.2021.103673_bib28","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1021\/bi061441j","article-title":"Antifungal Pisum sativum defensin 1 interacts with Neurospora crassa cyclin F related to the cell cycle","volume":"46","author":"Lobo","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.ibmb.2021.103673_bib29","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0965-1748(03)00008-0","article-title":"Isolation and characterization of a novel insect defensin from Rhodnius prolixus, a vector of Chagas disease","volume":"33","author":"L\u00f3pez","year":"2003","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.ibmb.2021.103673_bib30","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1046\/j.1365-2583.1999.810107.x","article-title":"Insect immunity: molecular cloning, expression, and characterization of cDNAs and genomic DNA encoding three isoforms of insect defensin in Aedes aegypti","volume":"8","author":"Lowenberger","year":"2003","journal-title":"Insect Mol. Biol."},{"key":"10.1016\/j.ibmb.2021.103673_bib31","doi-asserted-by":"crossref","first-page":"4780","DOI":"10.1128\/IAI.00557-07","article-title":"Human defensin alpha-1 causes Trypanosoma cruzi membrane pore formation and induces DNA fragmentation, which leads to trypanosome destruction","volume":"75","author":"Madison","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ibmb.2021.103673_bib32","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1590\/S0074-02762011000400010","article-title":"Distribution and infection of triatomines (Hemiptera: Reduviidae) by Trypanosoma cruzi in the state of Michoac\u00e1n, M\u00e9xico","volume":"106","author":"Mart\u00ednez-Ibarra","year":"2011","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.ibmb.2021.103673_bib34","article-title":"FigTree: tree figure drawing tool","author":"Rambaut","year":"2006"},{"key":"10.1016\/j.ibmb.2021.103673_bib35","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.0269-283X.2005.00563.x","article-title":"Risk factors associated with house infestation by the Chagas disease vector Triatoma pallidipennis in Cuernavaca metropolitan area, Mexico","volume":"19","author":"Ramsey","year":"2005","journal-title":"Med. Vet. Entomol."},{"key":"10.1016\/j.ibmb.2021.103673_bib36","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1590\/0074-02760140404","article-title":"Atlas of Mexican Triatominae (Reduviidae: Hemiptera) and vector transmission of Chagas disease","volume":"110","author":"Ramsey","year":"2015","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.ibmb.2021.103673_bib37","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/bmb.20966","article-title":"Using the PyMOL application to reinforce visual understanding of protein structure","volume":"44","author":"Rigsby","year":"2016","journal-title":"Biochem. Mol. Biol. Educ."},{"key":"10.1016\/j.ibmb.2021.103673_bib38","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nprot.2010.5","article-title":"I-TASSER: a unified platform for automated protein structure and function prediction","volume":"5","author":"Roy","year":"2010","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ibmb.2021.103673_bib39","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/nprot.2006.4","article-title":"Tricine-SDS-PAGE","volume":"1","author":"Sch\u00e4gger","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ibmb.2021.103673_bib40","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.bbamem.2015.10.011","article-title":"An intimate link between antimicrobial peptide sequence diversity and binding to essential components of bacterial membranes","volume":"1858","author":"Schmitt","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ibmb.2021.103673_bib41","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.pep.2004.09.016","article-title":"A fusion protein system for the recombinant production of short disulfide bond rich cystine knot peptides using barnase as a purification handle","volume":"39","author":"Schmoldt","year":"2005","journal-title":"Protein Expr. Purif."},{"issue":"1 Pt A","key":"10.1016\/j.ibmb.2021.103673_bib42","doi-asserted-by":"crossref","first-page":"3429","DOI":"10.1016\/j.bbagen.2016.09.005","article-title":"Interaction between the plant ApDef 1 defensin and Saccharomyces cerevisiae results in yeast death through a cell cycle and caspase-dependent process occurring via uncontrolled oxidative stress","volume":"1861","author":"Soares","year":"2017","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.ibmb.2021.103673_bib43","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1590\/S0001-37652002000400007","article-title":"The surface charge of trypanosomatids","volume":"74","author":"Souto-Padr\u00f3n","year":"2002","journal-title":"An. Acad. Bras. Cienc."},{"issue":"10\u201312","key":"10.1016\/j.ibmb.2021.103673_bib44","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1007\/s00726-019-02800-8","article-title":"A synthetic peptide derived of the \u03b22-\u03b23 loop of the plant defensin from Vigna unguiculata seeds induces Leishmania amazonensis apoptosis-like cell death","volume":"51","author":"Souza","year":"2019","journal-title":"Amino Acids"},{"key":"10.1016\/j.ibmb.2021.103673_bib45","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1093\/molbev\/mst197","article-title":"MEGA6: molecular evolutionary genetics analysis version 6.0","volume":"30","author":"Tamura","year":"2013","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.ibmb.2021.103673_bib46","doi-asserted-by":"crossref","first-page":"554","DOI":"10.2174\/1568026616666160713123654","article-title":"The medical potential of antimicrobial peptides from insects","volume":"17","author":"Tonk","year":"2017","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.ibmb.2021.103673_bib47","first-page":"1","volume":"6","author":"Torres-Guerrero","year":"2017","journal-title":"Leishmaniasis: a review"},{"key":"10.1016\/j.ibmb.2021.103673_bib48","first-page":"208","article-title":"Trypanosoma (Herpetosoma) rangeli Tejera, 1920: study of the effects of the parasite on the vector","volume":"40","author":"Tovar","year":"1989","journal-title":"Acta Cient. Venez."},{"key":"10.1016\/j.ibmb.2021.103673_bib49","doi-asserted-by":"crossref","first-page":"111","DOI":"10.18257\/raccefyn.143","article-title":"Trypanosoma rangeli: un protozoo infectivo y no pat\u00f3geno para el humano que contribuye al entendimiento de la transmisi\u00f3n vectorial y la infecci\u00f3n por Trypanosoma cruzi, agente causal de la enfermedad de Chagas","volume":"39","author":"Vallejo","year":"2015","journal-title":"Rev Acad Colomb Cienc Ex Fis Nat"},{"key":"10.1016\/j.ibmb.2021.103673_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1756-3305-7-232","article-title":"Humoral responses in Rhodnius prolixus: bacterial feeding induces differential patterns of antibacterial activity and enhances mRNA levels of antimicrobial peptides in the midgut","volume":"7","author":"Vieira","year":"2014","journal-title":"Parasites Vectors"},{"key":"10.1016\/j.ibmb.2021.103673_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13071-016-1398-4","article-title":"Impact of Trypanosoma cruzi on antimicrobial peptide gene expression and activity in the fat body and midgut of Rhodnius prolixus","volume":"9","author":"Vieira","year":"2016","journal-title":"Parasites Vectors"},{"key":"10.1016\/j.ibmb.2021.103673_bib52","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1081\/PB-200026797","article-title":"Fusion expression of human b-defensin-2 from multiple joined genes in Escherichia coli","volume":"34","author":"Wang","year":"2004","journal-title":"Prep. Biochem. Biotechnol."},{"key":"10.1016\/j.ibmb.2021.103673_bib53","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.jinsphys.2009.05.015","article-title":"Two novel defensin-encoding genes of the Chagas disease vector Triatoma brasiliensis (Reduviidae, Triatominae): gene expression and peptide-structure modeling","volume":"55","author":"Waniek","year":"2009","journal-title":"J. Insect Physiol."},{"key":"10.1016\/j.ibmb.2021.103673_bib54","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1089\/vbz.2010.0020","article-title":"Trypanosoma cruzi infection modulates the expression of Triatoma brasiliensis def1 in the midgut","volume":"11","author":"Waniek","year":"2011","journal-title":"Vector Borne Zoonotic Dis."},{"key":"10.1016\/j.ibmb.2021.103673_bib55","doi-asserted-by":"crossref","first-page":"W296","DOI":"10.1093\/nar\/gky427","article-title":"SWISS-MODEL: homology modelling of protein structures and complexes","volume":"46","author":"Waterhouse","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ibmb.2021.103673_bib56","doi-asserted-by":"crossref","first-page":"W174","DOI":"10.1093\/nar\/gkv342","article-title":"I-TASSER server: new development for protein structure and function predictions","volume":"43","author":"Yang","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ibmb.2021.103673_bib57","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nmeth.3213","article-title":"The I-TASSER Suite: protein structure and function prediction","volume":"12","author":"Yang","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ibmb.2021.103673_bib58","doi-asserted-by":"crossref","first-page":"5807","DOI":"10.1007\/s00253-014-5792-6","article-title":"Insect antimicrobial peptides and their applications","volume":"98","author":"Yi","year":"2014","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"W1","key":"10.1016\/j.ibmb.2021.103673_bib59","doi-asserted-by":"crossref","first-page":"W291","DOI":"10.1093\/nar\/gkx366","article-title":"COFACTOR: improved protein function prediction by combining structure, sequence, and protein-protein interaction information","volume":"45","author":"Zhang","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ibmb.2021.103673_bib60","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s13071-017-2561-2","article-title":"Comparative genomics analysis of Triatomines reveals common first line and inducible immunity-related genes and the absence of Imd canonical components among hemimetabolous arthropods","volume":"11","author":"Zumaya-Estrada","year":"2018","journal-title":"Parasites Vectors"}],"container-title":["Insect Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0965174821001569?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0965174821001569?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T16:49:36Z","timestamp":1760806176000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0965174821001569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":59,"alternative-id":["S0965174821001569"],"URL":"https:\/\/doi.org\/10.1016\/j.ibmb.2021.103673","relation":{},"ISSN":["0965-1748"],"issn-type":[{"value":"0965-1748","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential activity on trypanosomatid parasites of a novel recombinant defensin type 1 from the insect Triatoma (Meccus) pallidipennis","name":"articletitle","label":"Article Title"},{"value":"Insect Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ibmb.2021.103673","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103673"}}