{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:18:01Z","timestamp":1788776281846,"version":"build-2803163510"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Insect Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.ibmb.2024.104126","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T15:29:06Z","timestamp":1713886146000},"page":"104126","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["An upstream signaling gene calmodulin regulates the synthesis of insect wax via activating fatty acid biosynthesis pathway"],"prefix":"10.1016","volume":"169","author":[{"given":"Min","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9685-9810","authenticated-orcid":false,"given":"Shuo","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinying","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinhong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ibmb.2024.104126_bib1","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ibmb.2024.104126_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0121354","article-title":"Ultrastructure of wax-producing structures on the integument of the melaleuca psyllid Boreioglycaspis melaleucae (Hemiptera: Psyllidae), with honeydew excretion behavior in males and females","volume":"10","author":"Ammar","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ibmb.2024.104126_bib3","doi-asserted-by":"crossref","first-page":"D115","DOI":"10.1093\/nar\/gkh131","article-title":"UniProt: the universal protein knowledgebase","volume":"32","author":"Apweiler","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ibmb.2024.104126_bib4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene Ontology: tool for the unification of biology","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ibmb.2024.104126_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12915-016-0306-x","article-title":"Insect odorant receptor trafficking requires calmodulin","volume":"14","author":"Bahk","year":"2016","journal-title":"BMC Biol."},{"key":"10.1016\/j.ibmb.2024.104126_bib6","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev-ento-031620-071754","article-title":"Chemical ecology, biochemistry, and molecular biology of insect hydrocarbons","volume":"66","author":"Blomquist","year":"2021","journal-title":"Annu. Rev. Entomol."},{"key":"10.1016\/j.ibmb.2024.104126_bib7","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1152\/jn.00820.2017","article-title":"Regulation of Eag by Ca2+\/calmodulin controls presynaptic excitability in Drosophila","volume":"119","author":"Bronk","year":"2018","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ibmb.2024.104126_bib8","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.jinsphys.2010.04.006","article-title":"Vitellogenesis in Oncopeltus fasciatus: PLC\/IP3, DAG\/PK-C pathway triggered by CaM","volume":"56","author":"Brown","year":"2010","journal-title":"J. Insect Physiol."},{"key":"10.1016\/j.ibmb.2024.104126_bib9","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/0965-1748(94)90135-X","article-title":"The lipid composition of the wax particles from adult whiteflies, Bemisia tabaci and Trialeurodes vaporariorum","volume":"24","author":"Buckner","year":"1994","journal-title":"Insect Biochem. Molec."},{"key":"10.1016\/j.ibmb.2024.104126_bib10","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1365-3032.1988.tb00478.x","article-title":"Particulate surface waxes of whiteflies: morphology, composition and waxing behavior","volume":"13","author":"Byrne","year":"1988","journal-title":"Physiol. Entomol."},{"key":"10.1016\/j.ibmb.2024.104126_bib11","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1127\/entomologia\/2023\/1906","article-title":"Establishment of star polycation-based RNA interference system in all developmental stages of fall armyworm Spodoptera frugiperda","volume":"43","author":"Chao","year":"2023","journal-title":"Entomol. Gen."},{"key":"10.1016\/j.ibmb.2024.104126_bib12","series-title":"An Introduction to Resource Entomology","first-page":"29","article-title":"The Chinese white wax scale Ericerus pela Chavannes","author":"Chen","year":"2009"},{"key":"10.1016\/j.ibmb.2024.104126_bib13","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.3390\/genes13081364","article-title":"Identification of the key pathways and genes involved in the wax biosynthesis of the Chinese white wax scale insect (Ericerus pela Chavannes) by integrated weighted gene coexpression network analysis","volume":"13","author":"Ding","year":"2022","journal-title":"Genes"},{"key":"10.1016\/j.ibmb.2024.104126_bib14","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/jmor.1051680205","article-title":"Ultrastructure of the wax-gland system in subterranean scale insects (Homoptera, Coccoidea, Margarodidae)","volume":"168","author":"Foldi","year":"1981","journal-title":"J. Morphol."},{"key":"10.1016\/j.ibmb.2024.104126_bib15","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.43045","article-title":"Molecular basis of wax-based color change and UV reflection in dragonflies","volume":"8","author":"Futahashi","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.ibmb.2024.104126_bib16","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/nbt.1883","article-title":"Trinity: reconstructing a full-length transcriptome without a genome from RNA-Seq data","volume":"29","author":"Grabherr","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ibmb.2024.104126_bib17","doi-asserted-by":"crossref","first-page":"D277","DOI":"10.1093\/nar\/gkh063","article-title":"The KEGG resource for deciphering the genome","volume":"32","author":"Kanehisa","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ibmb.2024.104126_bib18","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1146\/annurev.bi.49.070180.002421","article-title":"Calmodulin","volume":"49","author":"Klee","year":"1980","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.ibmb.2024.104126_bib19","series-title":"Lipids and Skin Health","first-page":"159","article-title":"Wax esters: chemistry and biosynthesis","author":"Kolattukudy","year":"2014"},{"key":"10.1016\/j.ibmb.2024.104126_bib20","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0163-7827(02)00045-0","article-title":"Biosynthesis and secretion of plant cuticular wax","volume":"42","author":"Kunst","year":"2003","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.ibmb.2024.104126_bib21","doi-asserted-by":"crossref","first-page":"6316","DOI":"10.1021\/acssuschemeng.9b00004","article-title":"A facile-synthesized star polycation constructed as a highly efficient gene vector in pest management","volume":"7","author":"Li","year":"2019","journal-title":"ACS Sustainable Chem. Eng."},{"key":"10.1016\/j.ibmb.2024.104126_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2022.101452","article-title":"A gene and drug co-delivery application helps to solve the short life disadvantage of RNA drug","volume":"43","author":"Li","year":"2022","journal-title":"Nano Today"},{"key":"10.1016\/j.ibmb.2024.104126_bib23","doi-asserted-by":"crossref","first-page":"650","DOI":"10.3390\/insects14070650","article-title":"Comparative morphology of wax gland heads in adult dustywings (Insecta: Neuroptera: Coniopterygidae)","volume":"14","author":"Li","year":"2023","journal-title":"Insects"},{"key":"10.1016\/j.ibmb.2024.104126_bib24","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.ibmb.2024.104126_bib25","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1242\/jcs.s3-101.55.333","article-title":"The cuticle and wax secretion in Calpodes ethlius (Lepidoptera, Hesperidae)","volume":"3","author":"Locke","year":"1960","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ibmb.2024.104126_bib26","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.ibmb.2024.104126_bib27","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1603\/0013-8746(2004)097[1294:WPIAOP]2.0.CO;2","article-title":"Wax production in adults of planthoppers (Homoptera: Fulgoroidea) with particular reference to Metcalfa pruinosa (Flatidae)","volume":"97","author":"Lucchi","year":"2004","journal-title":"Ann. Entomol. Soc. Am."},{"key":"10.1016\/j.ibmb.2024.104126_bib28","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s10340-022-01485-5","article-title":"A first greenhouse application of bacteria-expressed and nanocarrier-delivered RNA pesticide for Myzus persicae control","volume":"96","author":"Ma","year":"2023","journal-title":"J. Pest. Sci."},{"key":"10.1016\/j.ibmb.2024.104126_bib29","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s12951-022-01336-6","article-title":"Visualization of the process of a nanocarrier-mediated gene delivery: stabilization, endocytosis and endosomal escape of genes for intracellular spreading","volume":"20","author":"Ma","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.ibmb.2024.104126_bib30","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0305-0491(99)00177-7","article-title":"Waxes and lipids associated with the external waxy structures of nymphs and pupae of the giant whitefly, Aleurodicus dugesii","volume":"125","author":"Nelson","year":"2000","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"key":"10.1016\/j.ibmb.2024.104126_bib31","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S1096-4959(03)00216-1","article-title":"Characterization of the cuticular surface wax pores and the waxy particles of the dustywing, Semidalis flinti (Neuroptera: Coniopterygidae)","volume":"136","author":"Nelson","year":"2003","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"key":"10.1016\/j.ibmb.2024.104126_bib32","first-page":"4","article-title":"Chemical and physical analyses of wax ester properties. J","volume":"1","author":"Patel","year":"2001","journal-title":"Insect Sci."},{"key":"10.1016\/j.ibmb.2024.104126_bib33","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1139\/z83-232","article-title":"The wax-secreting glands of Eriocampa ovata L. (Hymenoptera: tenthredinidae): ultrastructural observations and chemical composition of the wax","volume":"61","author":"Percy","year":"1983","journal-title":"Can. J. Zool."},{"key":"10.1016\/j.ibmb.2024.104126_bib34","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1365-3113.1979.tb00632.x","article-title":"Wax production by coccinellid larvae (Coleoptera)","volume":"4","author":"Pope","year":"1979","journal-title":"Syst. Entomol."},{"key":"10.1016\/j.ibmb.2024.104126_bib35","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1080\/00222938300770431","article-title":"Some aphid waxes, their form and function (Homoptera: aphididae)","volume":"17","author":"Pope","year":"1983","journal-title":"J. Nat. Hist."},{"key":"10.1016\/j.ibmb.2024.104126_bib36","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/chemse\/bji042","article-title":"Biochemical and physiological evidence that calmodulin is involved in the taste response of the sugar receptor cells of the blowfly, Phormia regina","volume":"30","author":"Seno","year":"2005","journal-title":"Chem. Senses"},{"key":"10.1016\/j.ibmb.2024.104126_bib37","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1080\/002229399300227","article-title":"Wax glands, wax production and the functional significance of wax use in three aphid species (Homoptera: aphididae)","volume":"33","author":"Smith","year":"1999","journal-title":"J. Nat. Hist."},{"key":"10.1016\/j.ibmb.2024.104126_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/arch.940090102","article-title":"Fatty acids in insects: composition, metabolism, and biological significance","volume":"9","author":"Stanley\u2010Samuelson","year":"1988","journal-title":"Arch. Insect Biochem."},{"key":"10.1016\/j.ibmb.2024.104126_bib39","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1093\/nar\/28.1.33","article-title":"The COG database: a tool for genome scale analysis of protein functions and evolution","volume":"28","author":"Tatusov","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ibmb.2024.104126_bib40","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1038\/s42003-022-03956-y","article-title":"Fatty acyl-CoA reductase influences wax biosynthesis in the cotton mealybug, Phenacoccus solenopsis Tinsley","volume":"5","author":"Tong","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.ibmb.2024.104126_bib41","series-title":"Insect Ultrastructure","first-page":"303","article-title":"The fine structure of insect glands secreting waxy substances","author":"Waku","year":"1984"},{"key":"10.1016\/j.ibmb.2024.104126_bib42","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/B978-0-12-152815-7.50006-5","article-title":"Calmodulin and its role in the second-messenger system","volume":"15","author":"Wang","year":"1979","journal-title":"Curr. Top. Cell. Regul."},{"key":"10.1016\/j.ibmb.2024.104126_bib43","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1002\/ps.4865","article-title":"Double\u2010stranded RNA targeting calmodulin reveals a potential target for pest management of Nilaparvata lugens","volume":"74","author":"Wang","year":"2018","journal-title":"Pest Manag. Sci."},{"key":"10.1016\/j.ibmb.2024.104126_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.asd.2020.100976","article-title":"Wax glands of the horned gall aphid, Schlechtendalia chinensis, at different stages","volume":"58","author":"Wei","year":"2020","journal-title":"Arthropod Struct. Dev."},{"key":"10.1016\/j.ibmb.2024.104126_bib45","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1093\/aesa\/saw056","article-title":"Descriptions of the adult genitalia and immatures of the Asian planthopper Ricania speculum (Hemiptera: fulgoroidea: Ricaniidae) recently introduced to Italy","volume":"109","author":"Wilson","year":"2016","journal-title":"Ann. Entomol. Soc. Am."},{"key":"10.1016\/j.ibmb.2024.104126_bib46","first-page":"512","article-title":"A review on waxy secretions of scale insects and their chemical composition","volume":"41","author":"Xie","year":"2004","journal-title":"Entomological Knowledge"},{"key":"10.1016\/j.ibmb.2024.104126_bib47","series-title":"Epicopeia Hainesii Hainesii (Holland 1889) (Lepidoptera: Epicopeiidae), by Woolly Aphids, Colophina Clematis (Shinji 1922) (Hemiptera: Aphididae)","first-page":"431","article-title":"A possible collective mimicry of waxy caterpillars","volume":"vol. 88","author":"Yamazaki","year":"2013"},{"key":"10.1016\/j.ibmb.2024.104126_bib48","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s10340-019-01157-x","article-title":"Spray method application of transdermal dsRNA delivery system for efficient gene silencing and pest control on soybean aphid Aphis glycines","volume":"93","author":"Yan","year":"2020","journal-title":"J. Pest. Sci."},{"key":"10.1016\/j.ibmb.2024.104126_bib49","article-title":"Transcriptome analysis of the Chinese white wax scale Ericerus pela with focus on genes involved in wax biosynthesis","volume":"7","author":"Yang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ibmb.2024.104126_bib50","first-page":"13","article-title":"The structure of integument and wax glands of Phenacoccus fraxinus (Hemiptera: coccoidea: Pseudococcidae)","volume":"33","author":"Zhang","year":"2012","journal-title":"Zool. Res."},{"key":"10.1016\/j.ibmb.2024.104126_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.125816","article-title":"NPFR regulates the synthesis and metabolism of lipids and glycogen via AMPK: novel targets for efficient corn borer management","volume":"247","author":"Zhao","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ibmb.2024.104126_bib52","doi-asserted-by":"crossref","first-page":"651","DOI":"10.14411\/eje.2009.081","article-title":"The first holistic SEM study of Coniopterygidae (Neuroptera) - structural evidence and phylogenetic implications","volume":"106","author":"Zimmermann","year":"2009","journal-title":"Eur. J. Entomol."}],"container-title":["Insect Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0965174824000572?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0965174824000572?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T05:32:03Z","timestamp":1716010323000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0965174824000572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":52,"alternative-id":["S0965174824000572"],"URL":"https:\/\/doi.org\/10.1016\/j.ibmb.2024.104126","relation":{},"ISSN":["0965-1748"],"issn-type":[{"value":"0965-1748","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An upstream signaling gene calmodulin regulates the synthesis of insect wax via activating fatty acid biosynthesis pathway","name":"articletitle","label":"Article Title"},{"value":"Insect Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ibmb.2024.104126","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104126"}}