{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:12:29Z","timestamp":1786990349378,"version":"build-2736575974"},"reference-count":94,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2572020AW04"],"award-info":[{"award-number":["2572020AW04"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32170484"],"award-info":[{"award-number":["32170484"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Insect Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.ibmb.2024.104176","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T19:22:12Z","timestamp":1724354532000},"page":"104176","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Notch signaling promotes differentiation, cell death and autophagy in Drosophila hematopoietic system"],"prefix":"10.1016","volume":"173","author":[{"given":"Fangzhou","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengcheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengqi","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li Hua","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ibmb.2024.104176_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110958","article-title":"Disruption of the lipolysis pathway results in stem cell death through a sterile immunity-like pathway in adult Drosophila","volume":"39","author":"Aggarwal","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.ibmb.2024.104176_bib2","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1242\/jeb.001586","article-title":"The role of larval fat cells in adult Drosophila melanogaster","volume":"210","author":"Aguila","year":"2007","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.ibmb.2024.104176_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/cells9071737","article-title":"The leukemic fly: promises and challenges","volume":"9","author":"Al Outa","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.ibmb.2024.104176_bib4","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1534\/genetics.113.157859","article-title":"Regulation of Toll signaling and inflammation by \u03b2-arrestin and the SUMO protease Ulp1","volume":"195","author":"Anjum","year":"2013","journal-title":"Genetics"},{"key":"10.1016\/j.ibmb.2024.104176_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0136593","article-title":"Apoptosis in hemocytes induces a shift in effector mechanisms in the Drosophila immune system and leads to a pro-inflammatory state","volume":"10","author":"Arefin","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ibmb.2024.104176_bib6","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1534\/g3.117.039487","article-title":"The immune phenotype of three Drosophila leukemia models","volume":"7","author":"Arefin","year":"2017","journal-title":"G3 (Bethesda)"},{"key":"10.1016\/j.ibmb.2024.104176_bib7","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/genetics\/163.1.203","article-title":"Analysis of Ras-induced overproliferation in Drosophila hemocytes","volume":"163","author":"Asha","year":"2003","journal-title":"Genetics"},{"key":"10.1016\/j.ibmb.2024.104176_bib8","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1534\/genetics.118.300223","article-title":"Drosophila as a genetic model for hematopoiesis","volume":"211","author":"Banerjee","year":"2019","journal-title":"Genetics"},{"key":"10.1016\/j.ibmb.2024.104176_bib9","doi-asserted-by":"crossref","first-page":"4635","DOI":"10.1242\/dev.02034","article-title":"Resolving embryonic blood cell fate choice in Drosophila: interplay of GCM and RUNX factors","volume":"132","author":"Bataill\u00e9","year":"2005","journal-title":"Development (Cambridge, England)"},{"key":"10.1016\/j.ibmb.2024.104176_bib10","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1182\/blood-2013-07-505099","article-title":"Notch signals are required for in vitro but not in vivo maintenance of human hematopoietic stem cells and delay the appearance of multipotent progenitors","volume":"123","author":"Benveniste","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.ibmb.2024.104176_bib11","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ydbio.2020.03.018","article-title":"Context-specific functions of Notch in Drosophila blood cell progenitors","volume":"462","author":"Blanco-Obregon","year":"2020","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ibmb.2024.104176_bib12","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.1016\/j.cub.2019.07.012","article-title":"The taiman transcriptional coactivator engages Toll signals to promote apoptosis and intertissue invasion in Drosophila","volume":"29","author":"Byun","year":"2019","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ibmb.2024.104176_bib13","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.canlet.2004.07.022","article-title":"A wide role for NOTCH1 signaling in acute leukemia","volume":"219","author":"Chiaramonte","year":"2005","journal-title":"Cancer letters"},{"issue":"8","key":"10.1016\/j.ibmb.2024.104176_bib14","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.devcel.2024.02.013","article-title":"S-nitrosylation-triggered unfolded protein response maintains hematopoietic progenitors in Drosophila","volume":"59","author":"Cho","year":"2024","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ibmb.2024.104176_bib15","doi-asserted-by":"crossref","first-page":"4483","DOI":"10.1038\/s41467-020-18135-y","article-title":"Single-cell transcriptome maps of myeloid blood cell lineages in Drosophila","volume":"11","author":"Cho","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ibmb.2024.104176_bib16","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/j.cub.2009.08.042","article-title":"Autophagy, not apoptosis, is essential for midgut cell death in Drosophila","volume":"19","author":"Denton","year":"2009","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ibmb.2024.104176_bib17","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.ibmb.2024.104176_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0106211","article-title":"Notch inhibits Yorkie activity in Drosophila wing discs","volume":"9","author":"Djiane","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ibmb.2024.104176_bib19","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1182\/blood-2017-06-788505","article-title":"Canonical Notch signaling is dispensable for adult steady-state and stress myelo-erythropoiesis","volume":"131","author":"Duarte","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.ibmb.2024.104176_bib20","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/ni1164","article-title":"Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance","volume":"6","author":"Duncan","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ibmb.2024.104176_bib21","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/j.cub.2008.08.052","article-title":"Warts is required for PI3K-regulated growth arrest, autophagy, and autophagic cell death in Drosophila","volume":"18","author":"Dutta","year":"2008","journal-title":"Curr. Biol. : CB"},{"key":"10.1016\/j.ibmb.2024.104176_bib22","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1016\/S0960-9822(02)01297-6","article-title":"Notch signaling controls lineage specification during Drosophila larval hematopoiesis","volume":"12","author":"Duvic","year":"2002","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ibmb.2024.104176_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2021.167333","article-title":"Proto-pyroptosis: an ancestral origin for mammalian inflammatory cell death mechanism in Drosophila melanogaster","volume":"434","author":"Dziedziech","year":"2022","journal-title":"Journal of molecular biology"},{"key":"10.1016\/j.ibmb.2024.104176_bib24","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S1534-5807(03)00335-6","article-title":"Thicker than blood: conserved mechanisms in Drosophila and vertebrate hematopoiesis","volume":"5","author":"Evans","year":"2003","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ibmb.2024.104176_bib25","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1016\/j.cub.2014.09.081","article-title":"Yorkie and Scalloped signaling regulates Notch-dependent lineage specification during Drosophila hematopoiesis","volume":"24","author":"Ferguson","year":"2014","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ibmb.2024.104176_bib26","first-page":"575","volume":"vol. 26","author":"Fogarty","year":"2016"},{"key":"10.1016\/j.ibmb.2024.104176_bib27","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/365555a0","article-title":"An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye","volume":"365","author":"Fortini","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.ibmb.2024.104176_bib28","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","article-title":"Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018","volume":"25","author":"Galluzzi","year":"2018","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ibmb.2024.104176_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0037615","article-title":"Notch signaling activates Yorkie non-cell autonomously in Drosophila","volume":"7","author":"Graves","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ibmb.2024.104176_bib30","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1146\/annurev.cellbio.21.012804.093845","article-title":"Caspase-dependent cell death in Drosophila","volume":"22","author":"Hay","year":"2006","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.ibmb.2024.104176_bib31","doi-asserted-by":"crossref","first-page":"263","DOI":"10.4161\/fly.25654","article-title":"Variation of NimC1 expression in Drosophila stocks and transgenic strains","volume":"7","author":"Honti","year":"2013","journal-title":"Fly"},{"key":"10.1016\/j.ibmb.2024.104176_bib32","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.dci.2013.06.005","article-title":"The cell-mediated immunity of Drosophila melanogaster: hemocyte lineages, immune compartments, microanatomy and regulation","volume":"42","author":"Honti","year":"2014","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.ibmb.2024.104176_bib33","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1242\/dev.01837","article-title":"The Drosophila lymph gland as a developmental model of hematopoiesis","volume":"132","author":"Jung","year":"2005","journal-title":"Development (Cambridge, England)"},{"key":"10.1016\/j.ibmb.2024.104176_bib34","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1084\/jem.20121527","article-title":"Notch activation inhibits AML growth and survival: a potential therapeutic approach","volume":"210","author":"Kannan","year":"2013","journal-title":"The Journal of experimental medicine"},{"key":"10.1016\/j.ibmb.2024.104176_bib35","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.it.2021.06.001","article-title":"The 'cytokine storm': molecular mechanisms and therapeutic prospects","volume":"42","author":"Karki","year":"2021","journal-title":"Trends Immunol."},{"key":"10.1016\/j.ibmb.2024.104176_bib36","doi-asserted-by":"crossref","DOI":"10.1242\/dev.166819","article-title":"Septate junction components control Drosophila hematopoiesis through the Hippo pathway","volume":"146","author":"Khadilkar","year":"2019","journal-title":"Development (Cambridge, England)"},{"key":"10.1016\/j.ibmb.2024.104176_bib37","doi-asserted-by":"crossref","first-page":"101","DOI":"10.14348\/molcells.2022.2039","article-title":"Intrinsic and extrinsic regulation of hematopoiesis in Drosophila","volume":"45","author":"Koranteng","year":"2022","journal-title":"Mol. Cell."},{"key":"10.1016\/j.ibmb.2024.104176_bib38","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nature17638","article-title":"Age-dependent modulation of vascular niches for haematopoietic stem cells","volume":"532","author":"Kusumbe","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.ibmb.2024.104176_bib39","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s40778-017-0090-8","article-title":"Notch signaling in the regulation of hematopoietic stem cell","volume":"3","author":"Lampreia","year":"2017","journal-title":"Current stem cell reports"},{"key":"10.1016\/j.ibmb.2024.104176_bib40","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1101\/gad.1052803","article-title":"A Serrate-expressing signaling center controls Drosophila hematopoiesis","volume":"17","author":"Lebestky","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.ibmb.2024.104176_bib41","doi-asserted-by":"crossref","first-page":"4034","DOI":"10.1002\/1873-3468.12327","article-title":"Drosophila hematopoiesis under normal conditions and in response to immune stress","volume":"590","author":"Letourneau","year":"2016","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ibmb.2024.104176_bib42","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/s41419-019-1862-0","article-title":"Characterization of TNF-induced cell death in Drosophila reveals caspase- and JNK-dependent necrosis and its role in tumor suppression","volume":"10","author":"Li","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ibmb.2024.104176_bib43","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13008-020-00062-5","article-title":"Toll signaling promotes JNK-dependent apoptosis in Drosophila","volume":"15","author":"Li","year":"2020","journal-title":"Cell Div."},{"key":"10.1016\/j.ibmb.2024.104176_bib44","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1084\/jem.20121484","article-title":"Notch pathway activation targets AML-initiating cell homeostasis and differentiation","volume":"210","author":"Lobry","year":"2013","journal-title":"The Journal of experimental medicine"},{"key":"10.1016\/j.ibmb.2024.104176_bib45","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.stem.2008.02.011","article-title":"Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells","volume":"2","author":"Maillard","year":"2008","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ibmb.2024.104176_bib46","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1016\/j.cub.2014.10.031","article-title":"The Hippo pathway regulates hematopoiesis in Drosophila melanogaster","volume":"24","author":"Milton","year":"2014","journal-title":"Curr. Biol. : CB"},{"key":"10.1016\/j.ibmb.2024.104176_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2021.109937","article-title":"Signaling cross-talk during development: context-specific networking of Notch, NF-\u03baB and JNK signaling pathways in Drosophila","volume":"82","author":"Mishra","year":"2021","journal-title":"Cell. Signal."},{"key":"10.1016\/j.ibmb.2024.104176_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3001635","article-title":"Integrin-ECM interactions and membrane-associated Catalase cooperate to promote resilience of the Drosophila intestinal epithelium","volume":"20","author":"Mlih","year":"2022","journal-title":"PLoS Biol."},{"key":"10.1016\/j.ibmb.2024.104176_bib49","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1016\/j.cell.2011.11.041","article-title":"Interaction between differentiating cell- and niche-derived signals in hematopoietic progenitor maintenance","volume":"147","author":"Mondal","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.ibmb.2024.104176_bib50","doi-asserted-by":"crossref","first-page":"4597","DOI":"10.1242\/jcs.00783","article-title":"DIAP1 suppresses ROS-induced apoptosis caused by impairment of the selD\/sps1 homolog in Drosophila","volume":"116","author":"Morey","year":"2003","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ibmb.2024.104176_bib51","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1038\/ncb1327","article-title":"Regulation of Notch signalling by non-visual beta-arrestin","volume":"7","author":"Mukherjee","year":"2005","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ibmb.2024.104176_bib52","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1126\/science.1199643","article-title":"Interaction between Notch and Hif-alpha in development and survival of Drosophila blood cells","volume":"332","author":"Mukherjee","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.ibmb.2024.104176_bib53","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.devcel.2020.12.007","article-title":"Homeostatic regulation of ROS-triggered hippo-yki pathway via autophagic clearance of ref(2)P\/p62 in the Drosophila intestine","volume":"56","author":"Nagai","year":"2021","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ibmb.2024.104176_bib54","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.cub.2022.01.016","article-title":"Yorkie drives supercompetition by non-autonomous induction of autophagy via bantam microRNA in Drosophila","volume":"32","author":"Nagata","year":"2022","journal-title":"Curr. Biol. : CB"},{"key":"10.1016\/j.ibmb.2024.104176_bib55","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1007024","article-title":"p53-dependent programmed necrosis controls germ cell homeostasis during spermatogenesis","volume":"13","author":"Napoletano","year":"2017","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ibmb.2024.104176_bib56","doi-asserted-by":"crossref","DOI":"10.1242\/bio.058809","article-title":"Chk2-p53 and JNK in irradiation-induced cell death of hematopoietic progenitors and differentiated cells in Drosophila larval lymph gland","volume":"10","author":"Nguyen","year":"2021","journal-title":"Biology open"},{"key":"10.1016\/j.ibmb.2024.104176_bib57","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1615\/CritRevOncog.2016016987","article-title":"Cell death induction in cancer therapy - past, present, and future","volume":"21","author":"Nonnenmacher","year":"2016","journal-title":"Crit. Rev. Oncog."},{"key":"10.1016\/j.ibmb.2024.104176_bib58","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.stem.2013.05.015","article-title":"In vivo mapping of notch pathway activity in normal and stress hematopoiesis","volume":"13","author":"Oh","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ibmb.2024.104176_bib59","doi-asserted-by":"crossref","first-page":"652","DOI":"10.3389\/fimmu.2018.00652","article-title":"Notch signaling in macrophages in the context of cancer immunity","volume":"9","author":"Palaga","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ibmb.2024.104176_bib60","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.gene.2014.07.057","article-title":"Rgn gene is required for gut cell homeostasis after ingestion of sodium dodecyl sulfate in Drosophila","volume":"549","author":"Pan","year":"2014","journal-title":"Gene"},{"key":"10.1016\/j.ibmb.2024.104176_bib61","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.celrep.2013.07.048","article-title":"Endothelial Jagged-1 is necessary for homeostatic and regenerative hematopoiesis","volume":"4","author":"Poulos","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.ibmb.2024.104176_bib62","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1242\/jcs.035014","article-title":"Hairless induces cell death by downregulation of EGFR signalling activity","volume":"121","author":"Protzer","year":"2008","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ibmb.2024.104176_bib63","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0092-8674(93)90423-N","article-title":"Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor","volume":"74","author":"Rebay","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.ibmb.2024.104176_bib64","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2018101346","article-title":"Notch and EGFR regulate apoptosis in progenitor cells to ensure gut homeostasis in Drosophila","volume":"38","author":"Reiff","year":"2019","journal-title":"The EMBO journal"},{"key":"10.1016\/j.ibmb.2024.104176_bib65","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1534\/genetics.119.302209","article-title":"Cell adhesion-mediated actomyosin assembly regulates the activity of cubitus interruptus for hematopoietic progenitor maintenance in Drosophila","volume":"212","author":"Sharma","year":"2019","journal-title":"Genetics"},{"key":"10.1016\/j.ibmb.2024.104176_bib66","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/gtc.12837","article-title":"Deltex positively regulates Toll signaling in a JNK independent manner in Drosophila","volume":"26","author":"Sharma","year":"2021","journal-title":"Gene Cell. : devoted to molecular & cellular mechanisms"},{"key":"10.1016\/j.ibmb.2024.104176_bib67","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/embor.2011.223","article-title":"Oxidative stress in the haematopoietic niche regulates the cellular immune response in Drosophila","volume":"13","author":"Sinenko","year":"2011","journal-title":"EMBO Rep."},{"key":"10.1016\/j.ibmb.2024.104176_bib68","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1534\/genetics.113.159210","article-title":"An unexpected link between notch signaling and ROS in restricting the differentiation of hematopoietic progenitors in Drosophila","volume":"197","author":"Small","year":"2014","journal-title":"Genetics"},{"key":"10.1016\/j.ibmb.2024.104176_bib69","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1126\/science.275.5299.536","article-title":"DCP-1, a Drosophila cell death protease essential for development","volume":"275","author":"Song","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.ibmb.2024.104176_bib70","doi-asserted-by":"crossref","DOI":"10.1242\/dev.200216","article-title":"Intermediate progenitor cells provide a transition between hematopoietic progenitors and their differentiated descendants","volume":"148","author":"Spratford","year":"2021","journal-title":"Development (Cambridge, England)"},{"key":"10.1016\/j.ibmb.2024.104176_bib71","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.molcel.2020.05.014","article-title":"Cell death in the origin and treatment of cancer","volume":"78","author":"Strasser","year":"2020","journal-title":"Mol Cell"},{"key":"10.1016\/j.ibmb.2024.104176_bib72","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1007\/s11095-009-9895-1","article-title":"Programmed cell death pathways and current antitumor targets","volume":"26","author":"Tan","year":"2009","journal-title":"Pharmaceutical research"},{"key":"10.1016\/j.ibmb.2024.104176_bib73","article-title":"A mechanosensitive vascular niche for Drosophila hematopoiesis","volume":"120","author":"Tian","year":"2023","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.ibmb.2024.104176_bib74","doi-asserted-by":"crossref","first-page":"3222","DOI":"10.1038\/emboj.2010.202","article-title":"\u03b2-arrestin Kurtz inhibits MAPK and Toll signalling in Drosophila development","volume":"29","author":"Tipping","year":"2010","journal-title":"The EMBO journal"},{"key":"10.1016\/j.ibmb.2024.104176_bib75","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0041604","article-title":"Gene regulatory networks controlling hematopoietic progenitor niche cell production and differentiation in the Drosophila lymph gland","volume":"7","author":"Tokusumi","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ibmb.2024.104176_bib76","doi-asserted-by":"crossref","first-page":"4729","DOI":"10.1242\/dev.128.23.4729","article-title":"The protein kinase Pelle mediates feedback regulation in the Drosophila Toll signaling pathway","volume":"128","author":"Towb","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.ibmb.2024.104176_bib77","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0067789","article-title":"Notch and PKC are involved in formation of the lateral region of the dorso-ventral axis in Drosophila embryos","volume":"8","author":"Tremmel","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ibmb.2024.104176_bib78","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1126\/science.abf0529","article-title":"Copper induces cell death by targeting lipoylated TCA cycle proteins","volume":"375","author":"Tsvetkov","year":"2022","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.ibmb.2024.104176_bib79","doi-asserted-by":"crossref","first-page":"R568","DOI":"10.1016\/j.cub.2016.02.019","article-title":"Pyroptosis","volume":"26","author":"Vande Walle","year":"2016","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ibmb.2024.104176_bib80","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.imlet.2015.12.005","article-title":"Cytokines in Drosophila immunity","volume":"170","author":"Vanha-aho","year":"2016","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.ibmb.2024.104176_bib81","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1093\/genetics\/144.3.1127","article-title":"Analysis of dominant enhancers and suppressors of activated Notch in Drosophila","volume":"144","author":"Verheyen","year":"1996","journal-title":"Genetics"},{"key":"10.1016\/j.ibmb.2024.104176_bib82","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S0968-0004(97)01107-9","article-title":"Caspases and caspase inhibitors","volume":"22","author":"Villa","year":"1997","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.ibmb.2024.104176_bib83","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/s41419-020-03069-6","article-title":"Emerging role of the Hippo pathway in autophagy","volume":"11","author":"Wang","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ibmb.2024.104176_bib84","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.140171","article-title":"Toll pathway modulates TNF-induced JNK-dependent cell death in Drosophila","volume":"5","author":"Wu","year":"2015","journal-title":"Open Biol"},{"key":"10.1016\/j.ibmb.2024.104176_bib85","doi-asserted-by":"crossref","first-page":"78","DOI":"10.4161\/fly.3.1.7800","article-title":"Genetic control of programmed cell death (apoptosis) in Drosophila","volume":"3","author":"Xu","year":"2009","journal-title":"Fly"},{"key":"10.1016\/j.ibmb.2024.104176_bib86","doi-asserted-by":"crossref","first-page":"5328","DOI":"10.1038\/s41467-023-41103-1","article-title":"Nac\u03b1 protects the larval fat body from cell death by maintaining cellular proteostasis in Drosophila","volume":"14","author":"Yamada","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ibmb.2024.104176_bib87","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s40364-020-00196-2","article-title":"Advances in targeted therapy for acute myeloid leukemia","volume":"8","author":"Yu","year":"2020","journal-title":"Biomark. Res."},{"key":"10.1016\/j.ibmb.2024.104176_bib88","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.dci.2017.11.017","article-title":"The Drosophila lymph gland is an ideal model for studying hematopoiesis","volume":"83","author":"Yu","year":"2018","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.ibmb.2024.104176_bib89","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.60870","article-title":"Rab5 and Rab11 maintain hematopoietic homeostasis by restricting multiple signaling pathways in Drosophila","volume":"10","author":"Yu","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.ibmb.2024.104176_bib90","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ymeth.2014.03.029","article-title":"Tools and methods for studying Notch signaling in Drosophila melanogaster","volume":"68","author":"Zacharioudaki","year":"2014","journal-title":"Methods"},{"key":"10.1016\/j.ibmb.2024.104176_bib91","doi-asserted-by":"crossref","first-page":"14192","DOI":"10.1073\/pnas.0403789101","article-title":"A directed screen for genes involved in Drosophila blood cell activation","volume":"101","author":"Zettervall","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ibmb.2024.104176_bib92","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ibmb.2016.08.002","article-title":"Overexpression of jumu induces melanotic nodules by activating Toll signaling in Drosophila","volume":"77","author":"Zhang","year":"2016","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.ibmb.2024.104176_bib93","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/cdd.2015.77","article-title":"Tousled-like kinase mediated a new type of cell death pathway in Drosophila","volume":"23","author":"Zhang","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ibmb.2024.104176_bib94","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41392-022-00934-y","article-title":"Notch signaling pathway: architecture, disease, and therapeutics","volume":"7","author":"Zhou","year":"2022","journal-title":"Signal Transduct Target Ther"}],"container-title":["Insect Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0965174824001073?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0965174824001073?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T20:11:09Z","timestamp":1725999069000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0965174824001073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":94,"alternative-id":["S0965174824001073"],"URL":"https:\/\/doi.org\/10.1016\/j.ibmb.2024.104176","relation":{},"ISSN":["0965-1748"],"issn-type":[{"value":"0965-1748","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Notch signaling promotes differentiation, cell death and autophagy in Drosophila hematopoietic system","name":"articletitle","label":"Article Title"},{"value":"Insect Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ibmb.2024.104176","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104176"}}