{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:14:41Z","timestamp":1791227681340,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100019081","name":"Science and Technology Program of Hunan Province","doi-asserted-by":"publisher","award":["2022RC1025"],"award-info":[{"award-number":["2022RC1025"]}],"id":[{"id":"10.13039\/501100019081","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFD1400900"],"award-info":[{"award-number":["2024YFD1400900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32472557"],"award-info":[{"award-number":["32472557"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31801736"],"award-info":[{"award-number":["31801736"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Insect Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.ibmb.2025.104356","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T20:38:33Z","timestamp":1751661513000},"page":"104356","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Doublesex knockout via CRISPR\/Cas9 disrupts fertility and sexual dimorphism of wings in the rice stem borer, Chilo suppressalis"],"prefix":"10.1016","volume":"182","author":[{"given":"Yatao","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suijie","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuotian","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HongShuai","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbing","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HuaLiang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youzhi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3920-0950","authenticated-orcid":false,"given":"Lin","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.ibmb.2025.104356_bib1","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aau3753","article-title":"Genetic architecture and sex-specific selection govern modular, male-biased evolution of doublesex","volume":"5","author":"Baral","year":"2019","journal-title":"Sci. Adv."},{"issue":"6","key":"10.1016\/j.ibmb.2025.104356_bib2","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/0092-8674(88)90248-6","article-title":"Sex-lethal, a Drosophila sex determination switch gene, exhibits sex-specific RNA splicing and sequence similarity to RNA binding proteins","volume":"55","author":"Bell","year":"1988","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.ibmb.2025.104356_bib3","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/0092-8674(89)90633-8","article-title":"Drosophila doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNAs encoding related sex-specific polypeptides","volume":"56","author":"Burtis","year":"1989","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.ibmb.2025.104356_bib4","doi-asserted-by":"crossref","first-page":"8053","DOI":"10.1038\/s41467-024-52473-5","article-title":"Population suppression by release of insects carrying a dominant sterile homing gene drive targeting doublesex in Drosophila","volume":"15","author":"Chen","year":"2024","journal-title":"Nat. Commun."},{"issue":"49","key":"10.1016\/j.ibmb.2025.104356_bib5","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2311166120","article-title":"Female semiochemicals stimulate male courtship but dampen female sexual receptivity","volume":"120","author":"Chen","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.ibmb.2025.104356_bib6","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1101\/gad.7.1.42","article-title":"Sex-specific transcriptional regulation by the male and female doublesex proteins of Drosophila","volume":"7","author":"Coschigano","year":"1993","journal-title":"Genes Dev."},{"issue":"9","key":"10.1016\/j.ibmb.2025.104356_bib8","article-title":"Tissue-specific developmental regulation and isoform usage underlie the role of doublesex in sex differentiation and mimicry in Papilio swallowtails. R Soc. Open","volume":"7","author":"Deshmukh","year":"2020","journal-title":"Sci."},{"issue":"2","key":"10.1016\/j.ibmb.2025.104356_bib10","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/j.1460-2075.1993.tb05684.x","article-title":"The Drosophila doublesex proteins share a novel zinc finger related DNA binding domain","volume":"12","author":"Erdman","year":"1993","journal-title":"EMBO J."},{"issue":"4","key":"10.1016\/j.ibmb.2025.104356_bib11","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1093\/genetics\/144.4.1639","article-title":"Functional and genetic characterization of the oligomerization and DNA binding properties of the Drosophila doublesex proteins","volume":"144","author":"Erdman","year":"1996","journal-title":"Genetics"},{"key":"10.1016\/j.ibmb.2025.104356_bib12","doi-asserted-by":"crossref","DOI":"10.1111\/1744-7917.70053","article-title":"20-Hydroxyecdysone regulates pupal fatty acid metabolism, maintaining lipid metabolic homeostasis in Chilo suppressalis","author":"Gong","year":"2025","journal-title":"Insect Sci."},{"issue":"37","key":"10.1016\/j.ibmb.2025.104356_bib13","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2201513119","article-title":"The doublesex gene regulates dimorphic sexual and aggressive behaviors in Drosophila","volume":"119","author":"Han","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.ibmb.2025.104356_bib14","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1603\/AN10170","article-title":"New artificial diet for continuous rearing of Chilo suppressalis (Lepidoptera: crambidae)","volume":"105","author":"Han","year":"2012","journal-title":"Ann. Entomol. Soc. Am."},{"key":"10.1016\/j.ibmb.2025.104356_bib16","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/s42003-019-0510-7","article-title":"The mimetic wing pattern of Papilio polytes butterflies is regulated by a doublesex-orchestrated gene network","volume":"2","author":"Iijima","year":"2019","journal-title":"Commun. Biol."},{"issue":"4","key":"10.1016\/j.ibmb.2025.104356_bib18","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1093\/molbev\/mst010","article-title":"MAFFT multiple sequence alignment software version 7: improvements in performance and usability","volume":"30","author":"Katoh","year":"2013","journal-title":"Mol. Biol. Evol."},{"issue":"6294","key":"10.1016\/j.ibmb.2025.104356_bib19","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1126\/science.aaf5605","article-title":"A maleness gene in the malaria mosquito Anopheles gambiae","volume":"353","author":"Krzywinska","year":"2016","journal-title":"Science"},{"issue":"7491","key":"10.1016\/j.ibmb.2025.104356_bib20","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/nature13112","article-title":"Doublesex is a mimicry supergene","volume":"507","author":"Kunte","year":"2014","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.ibmb.2025.104356_bib21","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1038\/nbt.4245","article-title":"A CRISPR-Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes","volume":"36","author":"Kyrou","year":"2018","journal-title":"Nat. Biotechnol."},{"issue":"5","key":"10.1016\/j.ibmb.2025.104356_bib23","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1002\/ps.5687","article-title":"Mutation of doublesex in Hyphantria cunea results in sex-specific sterility","volume":"76","author":"Li","year":"2020","journal-title":"Pest Manag. Sci."},{"issue":"4","key":"10.1016\/j.ibmb.2025.104356_bib24","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.devcel.2010.09.010","article-title":"The mammalian doublesex homolog DMRT1 is a transcriptional gatekeeper that controls the mitosis versus meiosis decision in male germ cells","volume":"19","author":"Matson","year":"2010","journal-title":"Dev. Cell"},{"issue":"1","key":"10.1016\/j.ibmb.2025.104356_bib25","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/s41467-023-44399-1","article-title":"Gene drive and genetic sex conversion in the global agricultural pest Ceratitis capitata","volume":"15","author":"Meccariello","year":"2024","journal-title":"Nat. Commun."},{"issue":"6460","key":"10.1016\/j.ibmb.2025.104356_bib26","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1126\/science.aax1318","article-title":"Maleness-on-the-Y (MoY) orchestrates male sex determination in major agricultural fruit fly pests","volume":"365","author":"Meccariello","year":"2019","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.ibmb.2025.104356_bib27","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1093\/molbev\/msaa015","article-title":"IQ-TREE 2: new models and efficient methods for phylogenetic inference in the genomic era","volume":"37","author":"Minh","year":"2020","journal-title":"Mol. Biol. Evol."},{"issue":"4","key":"10.1016\/j.ibmb.2025.104356_bib28","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/ng.3241","article-title":"A genetic mechanism for female-limited Batesian mimicry in Papilio butterfly","volume":"47","author":"Nishikawa","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ibmb.2025.104356_bib30","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jip.2017.03.001","article-title":"RNA interference knockdown of aminopeptidase N genes decrease the susceptibility of Chilo suppressalis larvae to Cry1Ab\/Cry1Ac and Cry1Ca-expressing transgenic rice","volume":"145","author":"Qiu","year":"2017","journal-title":"J. Invertebr. Pathol."},{"issue":"6668","key":"10.1016\/j.ibmb.2025.104356_bib31","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/35618","article-title":"Evidence for evolutionary conservation of sex-determining genes","volume":"391","author":"Raymond","year":"1998","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.ibmb.2025.104356_bib32","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/nn.2515","article-title":"Control of sexual differentiation and behavior by the doublesex gene in Drosophila melanogaster","volume":"13","author":"Rideout","year":"2010","journal-title":"Nat. Neurosci."},{"issue":"11","key":"10.1016\/j.ibmb.2025.104356_bib33","doi-asserted-by":"crossref","first-page":"5021","DOI":"10.1093\/molbev\/msab228","article-title":"Novel doublesex duplication associated with sexually dimorphic development of dogface butterfly wings","volume":"38","author":"Rodriguez-Caro","year":"2021","journal-title":"Mol. Biol. Evol."},{"issue":"4","key":"10.1016\/j.ibmb.2025.104356_bib35","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1534\/genetics.115.177972","article-title":"An unusual role for doublesex in sex determination in the dipteran Sciara","volume":"200","author":"Ruiz","year":"2015","journal-title":"Genetics"},{"issue":"2","key":"10.1016\/j.ibmb.2025.104356_bib36","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.jaci.2015.12.1305","article-title":"Doublesex and mab-3 related transcription factor 1 (DMRT1) is a sex-specific genetic determinant of childhood-onset asthma and is expressed in testis and macrophages","volume":"138","author":"Schieck","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"issue":"6","key":"10.1016\/j.ibmb.2025.104356_bib37","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"issue":"6","key":"10.1016\/j.ibmb.2025.104356_bib38","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.devcel.2016.05.012","article-title":"Doublesex regulates the connectivity of a neural circuit controlling drosophila Male courtship song","volume":"37","author":"Shirangi","year":"2016","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ibmb.2025.104356_bib39","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1038\/srep00948","article-title":"Doublesex target genes in the red flour beetle, Tribolium castaneum","volume":"2","author":"Shukla","year":"2012","journal-title":"Sci. Rep-Uk"},{"issue":"12","key":"10.1016\/j.ibmb.2025.104356_bib40","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1111\/pbi.13906","article-title":"FAR knockout significantly inhibits Chilo suppressalis survival and transgene expression of double-stranded FAR in rice exhibits strong pest resistance","volume":"20","author":"Sun","year":"2022","journal-title":"Plant Biotechnol. J."},{"issue":"1","key":"10.1016\/j.ibmb.2025.104356_bib41","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1525-142X.2005.05007.x","article-title":"Role of the male BmDSX protein in the sexual differentiation of Bombyx mori","volume":"7","author":"Suzuki","year":"2005","journal-title":"Evol. Dev."},{"issue":"9","key":"10.1016\/j.ibmb.2025.104356_bib42","doi-asserted-by":"crossref","DOI":"10.1098\/rsbl.2022.0116","article-title":"Masculinizer-induced dosage compensation is achieved by transcriptional downregulation of both copies of Z-linked genes in the silkworm, Bombyx mori","volume":"18","author":"Tomihara","year":"2022","journal-title":"Biol. Lett."},{"issue":"9","key":"10.1016\/j.ibmb.2025.104356_bib43","doi-asserted-by":"crossref","first-page":"msad196","DOI":"10.1093\/molbev\/msad196","article-title":"Acute and long-term consequences of Co-opted doublesex on the development of mimetic butterfly color patterns","volume":"40","author":"VanKuren","year":"2023","journal-title":"Mol. Biol. Evol."},{"issue":"2","key":"10.1016\/j.ibmb.2025.104356_bib44","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/07391102.2012.677770","article-title":"The DMRT gene family in amphioxus","volume":"30","author":"Wang","year":"2012","journal-title":"J. Biomol. Struct. Dyn."},{"issue":"D1","key":"10.1016\/j.ibmb.2025.104356_bib45","doi-asserted-by":"crossref","first-page":"D384","DOI":"10.1093\/nar\/gkac1096","article-title":"The conserved domain database in 2023","volume":"51","author":"Wang","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ibmb.2025.104356_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.ibmb.2019.103180","article-title":"Mutation of doublesex induces sex-specific sterility of the diamondback moth Plutella xylostella","volume":"112","author":"Wang","year":"2019","journal-title":"Insect Biochem. Mol. Biol."},{"issue":"6","key":"10.1016\/j.ibmb.2025.104356_bib47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0100448","article-title":"sgRNAcas9: a software package for designing CRISPR sgRNA and evaluating potential off-target cleavage sites","volume":"9","author":"Xie","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ibmb.2025.104356_bib48","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ibmb.2016.11.005","article-title":"Sexually dimorphic traits in the silkworm, Bombyx mori, are regulated by doublesex","volume":"80","author":"Xu","year":"2017","journal-title":"Insect Biochem. Mol. Biol."},{"issue":"25","key":"10.1016\/j.ibmb.2025.104356_bib49","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2301525120","article-title":"CRISPR\/Cas9-based split homing gene drive targeting doublesex for population suppression of the global fruit pest Drosophila suzukii","volume":"120","author":"Yadav","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.ibmb.2025.104356_bib50","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3390\/genes12020315","article-title":"The sex determination Cascade in the silkworm","volume":"12","author":"Yang","year":"2021","journal-title":"Genes"},{"issue":"Pt 2","key":"10.1016\/j.ibmb.2025.104356_bib51","article-title":"Functional and evolutionary analysis of key enzymes triacylglycerol lipase, glycogen hydrolases in the glycerol and glucose biosynthesis pathway and cellular chaperones for freeze-tolerance of the rice stem borer, Chilo suppressalis","volume":"282","author":"Yao","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ibmb.2025.104356_bib52","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/1471-2105-13-134","article-title":"Primer-BLAST: a tool to design target-specific primers for polymerase chain reaction","volume":"13","author":"Ye","year":"2012","journal-title":"BMC Bioinf."},{"issue":"1","key":"10.1016\/j.ibmb.2025.104356_bib54","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.neuron.2014.05.038","article-title":"Central brain neurons expressing doublesex regulate female receptivity in Drosophila","volume":"83","author":"Zhou","year":"2014","journal-title":"Neuron"},{"issue":"14","key":"10.1016\/j.ibmb.2025.104356_bib55","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1101\/gad.14.14.1750","article-title":"Sexual dimorphism in diverse metazoans is regulated by a novel class of intertwined zinc fingers","volume":"14","author":"Zhu","year":"2000","journal-title":"Genes Dev."},{"issue":"3","key":"10.1016\/j.ibmb.2025.104356_bib57","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1534\/genetics.117.300328","article-title":"Tra-2 mediates cross-talk between sex determination and wing polyphenism in female Nilaparvata lugens","volume":"207","author":"Zhuo","year":"2017","journal-title":"Genetics"},{"issue":"48","key":"10.1016\/j.ibmb.2025.104356_bib58","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abf9237","article-title":"A feminizing switch in a hemimetabolous insect","volume":"7","author":"Zhuo","year":"2021","journal-title":"Sci. Adv."},{"issue":"6520","key":"10.1016\/j.ibmb.2025.104356_bib59","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1126\/science.abb8949","article-title":"A chimeric gene paternally instructs female sex determination in the haplodiploid wasp Nasonia","volume":"370","author":"Zou","year":"2020","journal-title":"Science"}],"container-title":["Insect Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0965174825001006?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0965174825001006?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T10:55:46Z","timestamp":1752922546000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0965174825001006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":50,"alternative-id":["S0965174825001006"],"URL":"https:\/\/doi.org\/10.1016\/j.ibmb.2025.104356","relation":{},"ISSN":["0965-1748"],"issn-type":[{"value":"0965-1748","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Doublesex knockout via CRISPR\/Cas9 disrupts fertility and sexual dimorphism of wings in the rice stem borer, Chilo suppressalis","name":"articletitle","label":"Article Title"},{"value":"Insect Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ibmb.2025.104356","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104356"}}