{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:31:04Z","timestamp":1787002264326,"version":"build-2736575974"},"reference-count":103,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Carlos Chagas Filho Foundation for Research Support of Rio de Janeiro State","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Insect Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ibmb.2026.104633","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:40:45Z","timestamp":1784130045000},"page":"104633","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["p53-associated metabolic checkpoint regulation in a tick embryo-derived cell line"],"prefix":"10.1016","volume":"194","author":[{"given":"Bruno","family":"Moraes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e9lica","family":"Arcanjo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Okagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cintia","family":"Nogueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Brumana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana L.","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariana A.","family":"Vasconcelos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio C.L.","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamila","family":"Guimar\u00e3es Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Filardy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robson Q.","family":"Monteiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Konnai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Itabajara","family":"da Silva Vaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3110-2371","authenticated-orcid":false,"given":"Carlos","family":"Logullo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.ibmb.2026.104633_bib1","doi-asserted-by":"crossref","first-page":"456","DOI":"10.3390\/biology10060456","article-title":"Beneficial effects of betaine: a comprehensive review","volume":"10","author":"Arumugam","year":"2021","journal-title":"Biology"},{"issue":"6","key":"10.1016\/j.ibmb.2026.104633_bib2","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a001198","article-title":"The origins and evolution of the p53 family of genes","volume":"2","author":"Belyi","year":"2010","journal-title":"Cold Spring Harbor Perspect. Biol."},{"issue":"1","key":"10.1016\/j.ibmb.2026.104633_bib3","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cell.2006.05.036","article-title":"TIGAR, a p53-inducible regulator of glycolysis and apoptosis","volume":"126","author":"Bensaad","year":"2006","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.ibmb.2026.104633_bib4","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.cmet.2013.06.019","article-title":"Metabolic regulation by p53 family members","volume":"18","author":"Berkers","year":"2013","journal-title":"Cell Metab."},{"issue":"5","key":"10.1016\/j.ibmb.2026.104633_bib5","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.cmet.2013.06.019","article-title":"Metabolic regulation by p53 family members","volume":"18","author":"Berkers","year":"2013","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.ibmb.2026.104633_bib6","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1080\/13510002.2017.1416773","article-title":"A systematic review of p53 regulation of oxidative stress in skeletal muscle","volume":"23","author":"Beyfuss","year":"2018","journal-title":"Redox Rep."},{"issue":"5","key":"10.1016\/j.ibmb.2026.104633_bib7","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nrc3711","article-title":"Unravelling mechanisms of p53-mediated tumour suppression","volume":"14","author":"Bieging","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ibmb.2026.104633_bib8","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1139\/y59-099","article-title":"A rapid method of total lipid extraction and purification","volume":"37","author":"Bligh","year":"1959","journal-title":"Can. J. Biochem. Physiol."},{"key":"10.1016\/j.ibmb.2026.104633_bib9","series-title":"Topspin","year":"2019"},{"issue":"3","key":"10.1016\/j.ibmb.2026.104633_bib10","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/nm0302-282","article-title":"Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound","volume":"8","author":"Bykov","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.ibmb.2026.104633_bib11","series-title":"Rhipicephalus (Boophilus) Microplus: Biologia, Controle E Resist\u00eancia","author":"Campos Pereira","year":"2008"},{"key":"10.1016\/j.ibmb.2026.104633_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.115020","article-title":"p53 as a potential target for treatment of cancer: a perspective on recent advancements in small molecules with structural insights and SAR studies","volume":"247","author":"Chahat","year":"2023","journal-title":"Eur. J. Med. Chem."},{"issue":"44","key":"10.1016\/j.ibmb.2026.104633_bib13","doi-asserted-by":"crossref","first-page":"12721","DOI":"10.1021\/bi035251+","article-title":"Structure and function of malic enzymes, a new class of oxidative decarboxylases","volume":"42","author":"Chang","year":"2003","journal-title":"Biochemistry"},{"issue":"24","key":"10.1016\/j.ibmb.2026.104633_bib14","doi-asserted-by":"crossref","first-page":"12919","DOI":"10.1128\/JVI.05385-11","article-title":"White spot syndrome virus induces metabolic changes resembling the warburg effect in shrimp hemocytes in the early stage of infection","volume":"85","author":"Chen","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.ibmb.2026.104633_bib15","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.virol.2018.04.011","article-title":"A novel p53 paralogue mediates antioxidant defense of mosquito cells to survive dengue virus replication","volume":"519","author":"Chen","year":"2018","journal-title":"Virology"},{"issue":"6","key":"10.1016\/j.ibmb.2026.104633_bib16","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.jmii.2017.06.006","article-title":"The p53 gene with emphasis on its paralogues in mosquitoes","volume":"50","author":"Chen","year":"2017","journal-title":"J. Microbiol. Immunol. Infect."},{"issue":"1","key":"10.1016\/j.ibmb.2026.104633_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-98738-7","article-title":"Aedes fluviatilis cell lines as new tools to study metabolic and immune interactions in mosquito-Wolbachia symbiosis","volume":"11","author":"Concei\u00e7\u00e3o","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ibmb.2026.104633_bib18","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1371\/journal.pbio.0060301","article-title":"Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor","volume":"6","author":"Copp\u00e9","year":"2008","journal-title":"PLoS Biol."},{"issue":"1","key":"10.1016\/j.ibmb.2026.104633_bib19","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.3390\/ijms16011821","article-title":"Non-classical gluconeogenesis-dependent glucose metabolism in rhipicephalus microplus embryonic cell line BME26","volume":"16","author":"da Silva","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.ibmb.2026.104633_bib20","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1016\/j.cmet.2024.07.024","article-title":"Mitochondrial membrane lipids in the regulation of bioenergetic flux","volume":"36","author":"Decker","year":"2024","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.ibmb.2026.104633_bib21","doi-asserted-by":"crossref","first-page":"4753","DOI":"10.1038\/s41598-019-41036-0","article-title":"Carbohydrate metabolic compensation coupled to high tolerance to oxidative stress in ticks","volume":"9","author":"Della Noce","year":"2019","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.ibmb.2026.104633_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.101599","article-title":"Redox imbalance induces remodeling of glucose metabolism in rhipicephalus microplus embryonic cell line","volume":"298","author":"Della Noce","year":"2022","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.ibmb.2026.104633_bib23","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.ibmb.2008.01.006","article-title":"Cellular and molecular characterization of an embryonic cell line (BME26) from the tick rhipicephalus (Boophilus) microplus","volume":"38","author":"Esteves","year":"2008","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.ibmb.2026.104633_bib24","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1603\/ME11223","article-title":"Reinstatement of Rhipicephalus (Boophilus) australis (Acari: ixodidae) with redescription of the adult and larval stages","volume":"49","author":"Estrada-Pe\u00f1a","year":"2012","journal-title":"J. Med. Entomol."},{"issue":"1","key":"10.1016\/j.ibmb.2026.104633_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/sj.onc.1209021","article-title":"p53 tumor suppressor protein regulates the levels of huntingtin gene expression","volume":"25","author":"Feng","year":"2006","journal-title":"Oncogene"},{"issue":"7","key":"10.1016\/j.ibmb.2026.104633_bib26","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.tcb.2010.03.004","article-title":"The regulation of energy metabolism and the IGF-1\/mTOR pathways by the p53 protein","volume":"20","author":"Feng","year":"2010","journal-title":"Trends Cell Biol."},{"issue":"Pt 2","key":"10.1016\/j.ibmb.2026.104633_bib27","article-title":"Comprehensive review on glucose 6 phosphate dehydrogenase: a critical immunometabolic and redox switch in insects","volume":"273","author":"Ghani","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"12","key":"10.1016\/j.ibmb.2026.104633_bib28","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/nrc3162","article-title":"Choline metabolism in malignant transformation","volume":"11","author":"Glunde","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ibmb.2026.104633_bib29","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3389\/fendo.2018.00124","article-title":"The p53 tumor suppressor in the control of metabolism and ferroptosis","volume":"9","author":"Gnanapradeepan","year":"2018","journal-title":"Front. Endocrinol."},{"issue":"3\u20134","key":"10.1016\/j.ibmb.2026.104633_bib30","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.vetpar.2015.05.022","article-title":"Vaccination with cyclin-dependent kinase tick antigen confers protection against Ixodes infestation","volume":"211","author":"Gomes","year":"2015","journal-title":"Vet. Parasitol."},{"issue":"10","key":"10.1016\/j.ibmb.2026.104633_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0076128","article-title":"Identification and structural-functional analysis of cyclin-dependent kinases of the cattle tick Rhipicephalus (Boophilus) microplus","volume":"8","author":"Gomes","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.ibmb.2026.104633_bib32","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.ibmb.2006.01.009","article-title":"Adaptations against heme toxicity in blood-feeding arthropods","volume":"36","author":"Gra\u00e7a-Souza","year":"2006","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.ibmb.2026.104633_bib33","first-page":"893","article-title":"Apoptosis: molecular aspects of cell death and disease","volume":"78","author":"Granville","year":"1998","journal-title":"Lab. Invest."},{"issue":"2","key":"10.1016\/j.ibmb.2026.104633_bib34","doi-asserted-by":"crossref","DOI":"10.1590\/S1984-29612014042","article-title":"Reassessment of the potential economic impact of cattle parasites in Brazil","volume":"23","author":"Grisi","year":"2014","journal-title":"Rev. Bras. Parasitol. Vet."},{"key":"10.1016\/j.ibmb.2026.104633_bib35","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1590\/S1984-29612014042","article-title":"Reassessment of the potential economic impact of cattle parasites in Brazil","volume":"23","author":"Grisi","year":"2014","journal-title":"Rev. Bras. Parasitol. Vet."},{"issue":"Pt 23","key":"10.1016\/j.ibmb.2026.104633_bib36","doi-asserted-by":"crossref","first-page":"5479","DOI":"10.1242\/jcs.01540","article-title":"The AMP-activated protein kinase pathway--new players upstream and downstream","volume":"117","author":"Hardie","year":"2004","journal-title":"J. Cell Sci."},{"issue":"1","key":"10.1016\/j.ibmb.2026.104633_bib37","article-title":"Tumor suppressor p53: biology, signaling pathways, and therapeutic targeting","volume":"1876","author":"Hern\u00e1ndez Borrero","year":"2021","journal-title":"Biochim. Biophys. Acta Rev. Canc"},{"issue":"5","key":"10.1016\/j.ibmb.2026.104633_bib38","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.ccr.2012.09.020","article-title":"Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth","volume":"22","author":"Hitosugi","year":"2012","journal-title":"Cancer Cell"},{"issue":"D1","key":"10.1016\/j.ibmb.2026.104633_bib39","doi-asserted-by":"crossref","first-page":"D368","DOI":"10.1093\/nar\/gkac1050","article-title":"Biological magnetic resonance data bank","volume":"51","author":"Hoch","year":"2022","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.ibmb.2026.104633_bib40","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1093\/ndt\/16.3.483","article-title":"Apoptosis induced by hypertonicity in Madin Darley canine kidney cells: protective effect of betaine","volume":"16","author":"Horio","year":"2001","journal-title":"Nephrol. Dial. Transplant."},{"issue":"8","key":"10.1016\/j.ibmb.2026.104633_bib41","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.ibmb.2011.03.014","article-title":"Characterization of cDNAs encoding p53 of Bombyx mori and Spodoptera frugiperda","volume":"41","author":"Huang","year":"2011","journal-title":"Insect Biochem. Mol. Biol."},{"issue":"2","key":"10.1016\/j.ibmb.2026.104633_bib42","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1006\/bbrc.2001.5627","article-title":"Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole- 4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line","volume":"287","author":"Imamura","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.ibmb.2026.104633_bib43","doi-asserted-by":"crossref","first-page":"776","DOI":"10.3390\/ijms19030776","article-title":"Emerging roles of p53 family members in glucose metabolism","volume":"19","author":"Itahana","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.ibmb.2026.104633_bib44","doi-asserted-by":"crossref","DOI":"10.1038\/ncb2172","article-title":"P53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase","volume":"13","author":"Jiang","year":"2011","journal-title":"Nat. Cell Biol."},{"issue":"7434","key":"10.1016\/j.ibmb.2026.104633_bib45","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/nature11776","article-title":"Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence","volume":"493","author":"Jiang","year":"2013","journal-title":"Nature"},{"issue":"13","key":"10.1016\/j.ibmb.2026.104633_bib46","doi-asserted-by":"crossref","first-page":"7301","DOI":"10.1073\/pnas.97.13.7301","article-title":"Identification and characterization of a p53 homologue in Drosophila melanogaster","volume":"97","author":"Jin","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8","key":"10.1016\/j.ibmb.2026.104633_bib47","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a026039","article-title":"p53 isoforms: key regulators of the cell fate decision","volume":"6","author":"Joruiz","year":"2016","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"1","key":"10.1016\/j.ibmb.2026.104633_bib48","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1186\/s13071-017-2575-9","article-title":"Immune-related redox metabolism of embryonic cells of the tick Rhipicephalus microplus (BME26) in response to infection with Anaplasma marginale","volume":"10","author":"Kalil","year":"2017","journal-title":"Parasites Vectors"},{"issue":"5","key":"10.1016\/j.ibmb.2026.104633_bib49","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1007\/s12192-019-01022-x","article-title":"Betaine suppresses cell proliferation by increasing oxidative stress-mediated apoptosis and inflammation in DU-145 human prostate cancer cell line","volume":"24","author":"Kar","year":"2019","journal-title":"Cell Stress Chaperones"},{"issue":"5","key":"10.1016\/j.ibmb.2026.104633_bib50","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/ncb1724","article-title":"p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation","volume":"10","author":"Kawauchi","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ibmb.2026.104633_bib51","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.893677","article-title":"Effect of TP53 deficiency and KRAS signaling on the bioenergetics of colon cancer cells in response to different substrates: a single cell study","volume":"10","author":"Kealey","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.ibmb.2026.104633_bib52","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s42255-024-01203-8","article-title":"Cellular and organismal function of choline metabolism","volume":"7","author":"Kenny","year":"2025","journal-title":"Nat. Metab."},{"issue":"2","key":"10.1016\/j.ibmb.2026.104633_bib53","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1079\/WPS19970013","article-title":"Nutritional and osmoregulatory functions of betaine","volume":"53","author":"Kidd","year":"1997","journal-title":"Worlds Poult. Sci. J."},{"issue":"1","key":"10.1016\/j.ibmb.2026.104633_bib54","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1158\/0008-5472.177.65.1","article-title":"Glycolytic enzymes can modulate cellular life span","volume":"65","author":"Kondoh","year":"2005","journal-title":"Cancer Res."},{"issue":"7","key":"10.1016\/j.ibmb.2026.104633_bib55","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/nrm4007","article-title":"p53 in survival, death and metabolic health: a lifeguard with a licence to kill","volume":"16","author":"Kruiswijk","year":"2015","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ibmb.2026.104633_bib56","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1590\/1808-1657v68n2p1152001","article-title":"Observa\u00e7\u00f5es sobre Boophilus microplus (Acari:Ixodidae) em bovinos mantidos em rota\u00e7\u00e3o de pastagem, sob alta densidade animal","volume":"68","author":"Labruna","year":"2001","journal-title":"Arq. Ins. Biol. USP"},{"issue":"5","key":"10.1016\/j.ibmb.2026.104633_bib57","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.ccr.2009.03.003","article-title":"PRIMA-1 reactivates mutant p53 by covalent binding to the core domain","volume":"15","author":"Lambert","year":"2009","journal-title":"Cancer Cell"},{"issue":"3","key":"10.1016\/j.ibmb.2026.104633_bib58","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1128\/jb.165.3.849-855.1986","article-title":"Choline-glycine betaine pathway confers a high level of osmotic tolerance in Escherichia coli","volume":"165","author":"Landfald","year":"1986","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ibmb.2026.104633_bib59","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/278261a0","article-title":"T antigen is bound to a host protein in SV40- transformed cells","volume":"278","author":"Lane","year":"1979","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.ibmb.2026.104633_bib60","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.molmet.2016.09.002","article-title":"Glucose-6-phosphate dehydrogenase contributes to the regulation of glucose uptake in skeletal muscle","volume":"5","author":"Lee-Young","year":"2016","journal-title":"Mol. Metabol."},{"issue":"5","key":"10.1016\/j.ibmb.2026.104633_bib61","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1002\/jcsm.13529","article-title":"Skeletal muscle p53-depletion uncovers a mechanism of fuel usage suppression that enables efficient energy conservation","volume":"15","author":"Lenihan-Geels","year":"2024","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.ibmb.2026.104633_bib62","doi-asserted-by":"crossref","DOI":"10.1093\/biohorizons\/hzv006","article-title":"PRIMA-1 as a cancer therapy restoring mutant p53: a review","volume":"8","author":"Lewis","year":"2015","journal-title":"Biosci. Horiz.: Int. J. Stud. Res."},{"issue":"2","key":"10.1016\/j.ibmb.2026.104633_bib63","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s12192-019-00982-4","article-title":"Betaine protects against heat exposure-induced oxidative stress and apoptosis in bovine mammary epithelial cells via regulation of ROS production","volume":"24","author":"Li","year":"2019","journal-title":"Cell Stress Chaperones"},{"issue":"5","key":"10.1016\/j.ibmb.2026.104633_bib64","first-page":"1015","article-title":"PRIMA-1 inhibits growth of breast cancer cells by re-activating mutant p53 protein","volume":"35","author":"Liang","year":"2009","journal-title":"Int. J. Oncol."},{"issue":"4","key":"10.1016\/j.ibmb.2026.104633_bib65","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1093\/jmcb\/mjy070","article-title":"Tumor suppressor p53 and metabolism","volume":"11","author":"Liu","year":"2019","journal-title":"J. Mol. Cell Biol."},{"key":"10.1016\/j.ibmb.2026.104633_bib66","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"7433","key":"10.1016\/j.ibmb.2026.104633_bib67","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/nature11743","article-title":"Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells","volume":"493","author":"Maddocks","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.ibmb.2026.104633_bib68","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41580-021-00404-3","article-title":"Cell cycle control in cancer","volume":"23","author":"Matthews","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ibmb.2026.104633_bib69","first-page":"1","article-title":"Aurora kinase as a putative target to tick control","volume":"15","author":"Moraes","year":"2024","journal-title":"Parasitology"},{"key":"10.1016\/j.ibmb.2026.104633_bib70","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1287090","article-title":"G6PDH as a key immunometabolic and redox trigger in arthropods","volume":"14","author":"Moraes","year":"2023","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ibmb.2026.104633_bib71","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/1471-2199-10-112","article-title":"Selection of reference genes for quantitative RT-PCR studies in Rhipicephalus (Boophilus) microplus and Rhipicephalus appendiculatus ticks and determination of the expression profile of Bm86","volume":"10","author":"Nijhof","year":"2009","journal-title":"BMC Mol. Biol."},{"key":"10.1016\/j.ibmb.2026.104633_bib72","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3390\/ijms26010087","article-title":"Starvation metabolism adaptations in tick embryonic cells BME26","volume":"26","author":"Nogueira","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.ibmb.2026.104633_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.102287","article-title":"Hepatic p53 is regulated by transcription factor FOXO1 and acutely controls glycogen homeostasis","volume":"298","author":"Oster","year":"2022","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ibmb.2026.104633_bib74","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkae253","article-title":"MetaboAnalyst 6.0: towards a unified platform for metabolomics data processing, analysis and interpretation","author":"Pang","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ibmb.2026.104633_bib75","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.tvjl.2012.05.023","article-title":"The quest for a universal vaccine against ticks: cross-Immunity insights","volume":"194","author":"Parizi","year":"2012","journal-title":"Vet. J."},{"issue":"4","key":"10.1016\/j.ibmb.2026.104633_bib76","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1177\/1947601911409738","article-title":"The role of p53 in Metabolic regulation","volume":"2","author":"Puzio-Kuter","year":"2011","journal-title":"Genes Cancer"},{"issue":"10","key":"10.1016\/j.ibmb.2026.104633_bib77","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1074\/jbc.RA118.004671","article-title":"p53 reactivation with induction of massive apoptosis-1 (PRIMA-1) inhibits amyloid aggregation of mutant p53 in cancer cells","volume":"294","author":"Rangel","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ibmb.2026.104633_bib78","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.prevetmed.2013.10.006","article-title":"Does Rhipicephalus microplus tick infestation increase the risk for myiasis caused by Cochliomyia hominivorax in cattle?","volume":"113","author":"Reck","year":"2014","journal-title":"Prev. Vet. Med."},{"issue":"23","key":"10.1016\/j.ibmb.2026.104633_bib79","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1038\/onc.2016.477","article-title":"6-Phosphofructo-2-kinase\/fructose-2,6-biphosphatase 4 is essential for p53-null cancer cells","volume":"36","author":"Ros","year":"2017","journal-title":"Oncogene"},{"issue":"7","key":"10.1016\/j.ibmb.2026.104633_bib80","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a001131","article-title":"Phylogeny and function of the invertebrate p53 superfamily","volume":"2","author":"Rutkowski","year":"2010","journal-title":"Cold Spring Harbor Perspect. Biol."},{"issue":"12","key":"10.1016\/j.ibmb.2026.104633_bib81","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1002\/dvg.22717","article-title":"The embryogenesis of the Tick Rhipicephalus (Boophilus) microplus: The establishment of a new chelicerate model system","volume":"51","author":"Santos","year":"2013","journal-title":"genesis"},{"key":"10.1016\/j.ibmb.2026.104633_bib82","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/0092-8674(90)90409-8","article-title":"The E6 oncoprotein encoded by human papillomavirus 16 or 18 promotes the degradation of p53","volume":"63","author":"Scheffner","year":"1990","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.ibmb.2026.104633_bib83","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1158\/0008-5472.CAN-03-0846","article-title":"The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression","volume":"64","author":"Schwartzenberg-Bar-Yoseph","year":"2004","journal-title":"Cancer Res."},{"issue":"6","key":"10.1016\/j.ibmb.2026.104633_bib84","first-page":"1169","article-title":"Life cycle of the southern cattle tick, Rhipicephalus (Boophilus) microplus Canestrini 1888 (Acari: ixodidae) under laboratory conditions","volume":"23","author":"Senbill","year":"2018","journal-title":"Syst. Appl. Acarol."},{"key":"10.1016\/j.ibmb.2026.104633_bib85","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0092-8674(00)81902-9","article-title":"Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a","volume":"88","author":"Serrano","year":"1997","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.ibmb.2026.104633_bib86","doi-asserted-by":"crossref","first-page":"3348","DOI":"10.1021\/acs.jproteome.8b00211","article-title":"Differential proteome analysis of Chikungunya Virus and Dengue Virus coinfection in Aedes mosquitoes","volume":"17","author":"Shrinet","year":"2018","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.ibmb.2026.104633_bib87","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/1471-2105-7-110","article-title":"18 IsoSVM--distinguishing isoforms and paralogs on the protein level","volume":"7","author":"Spitzer","year":"2006","journal-title":"BMC 19 Bioinformatics"},{"issue":"6","key":"10.1016\/j.ibmb.2026.104633_bib88","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004196","article-title":"An invertebrate warburg effect: a shrimp virus achieves successful replication by altering the host metabolome via the PI3K-Akt-mTOR pathway","volume":"10","author":"Su","year":"2014","journal-title":"PLoS Pathog."},{"issue":"1","key":"10.1016\/j.ibmb.2026.104633_bib89","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3892\/ijmm.2024.5448","article-title":"TP53 mutations in cancer: molecular features and therapeutic opportunities","volume":"55","author":"Tornesello","year":"2025","journal-title":"Int. J. Mol. Med."},{"issue":"3","key":"10.1016\/j.ibmb.2026.104633_bib90","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.cell.2014.05.051","article-title":"p53-dependent nestin regulation links tumor suppression to cellular plasticity in liver cancer","volume":"158","author":"Tschaharganeh","year":"2014","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.ibmb.2026.104633_bib91","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1016\/j.cmet.2024.07.010","article-title":"SLC25A48 controls mitochondrial choline import and metabolism","volume":"36","author":"Verkerke","year":"2024","journal-title":"Cell Metab."},{"issue":"3","key":"10.1016\/j.ibmb.2026.104633_bib92","doi-asserted-by":"crossref","first-page":"512","DOI":"10.3390\/cells12030512","article-title":"The role of TP53 in adaptation and evolution","volume":"12","author":"Voskarides","year":"2023","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.ibmb.2026.104633_bib93","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.cell.2009.04.037","article-title":"Blinded by the light: the growing complexity of p53","volume":"137","author":"Vousden","year":"2009","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.ibmb.2026.104633_bib94","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/nrc2715","article-title":"p53 and metabolism","volume":"9","author":"Vousden","year":"2009","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.ibmb.2026.104633_bib95","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41392-023-01347-1","article-title":"Targeting p53 pathways: mechanisms, structures, and advances in therapy","volume":"8","author":"Wang","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"1","key":"10.1016\/j.ibmb.2026.104633_bib96","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.cell.2005.10.043","article-title":"A global map of p53 transcription-factor binding sites in the human genome","volume":"124","author":"Wei","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.ibmb.2026.104633_bib97","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1126\/science.2157286","article-title":"Association of human papillomavirus types 16 and 18 E6 proteins with p53","volume":"248","author":"Werness","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.ibmb.2026.104633_bib98","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/nprot.2011.319","article-title":"Web-based inference of biological patterns, functions and pathways from metabolomic data using MetaboAnalyst","volume":"6","author":"Xia","year":"2011","journal-title":"Nat. Protoc."},{"issue":"28","key":"10.1016\/j.ibmb.2026.104633_bib99","doi-asserted-by":"crossref","first-page":"25395","DOI":"10.1074\/jbc.M302364200","article-title":"P53 activation in adipocytes of Obese mice","volume":"278","author":"Yahagi","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ibmb.2026.104633_bib100","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1234887","article-title":"Choline metabolism and its implications in cancer","volume":"13","author":"Yao","year":"2023","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ibmb.2026.104633_bib101","first-page":"60","article-title":"The role of p53 as a transcription factor in the induction of apoptosis","volume":"97","author":"Yonish-Rouach","year":"1996","journal-title":"Behring Inst. Mitt."},{"issue":"48","key":"10.1016\/j.ibmb.2026.104633_bib102","doi-asserted-by":"crossref","first-page":"41600","DOI":"10.1074\/jbc.M111.240812","article-title":"Inhibition of glycolytic enzymes mediated by pharmacologically activated p53: targeting Warburg effect to fight cancer","volume":"286","author":"Zawacka-Pankau","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"51","key":"10.1016\/j.ibmb.2026.104633_bib103","doi-asserted-by":"crossref","first-page":"40042","DOI":"10.1074\/jbc.M007505200","article-title":"High glucose inhibits glucose-6-phosphate dehydrogenase via cAMP in aortic endothelial cells","volume":"275","author":"Zhang","year":"2000","journal-title":"J. Biol. Chem."}],"container-title":["Insect Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0965174826001578?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0965174826001578?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:31:18Z","timestamp":1786998678000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0965174826001578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":103,"alternative-id":["S0965174826001578"],"URL":"https:\/\/doi.org\/10.1016\/j.ibmb.2026.104633","relation":{},"ISSN":["0965-1748"],"issn-type":[{"value":"0965-1748","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"p53-associated metabolic checkpoint regulation in a tick embryo-derived cell line","name":"articletitle","label":"Article Title"},{"value":"Insect Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ibmb.2026.104633","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"104633"}}