{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:13:52Z","timestamp":1790205232201,"version":"4.1.0"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T00:00:00Z","timestamp":1609286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS093314"],"award-info":[{"award-number":["R01NS093314"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ibroneuroreports.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["IBRO Neuroscience Reports"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.ibneur.2020.11.003","type":"journal-article","created":{"date-parts":[[2021,2,7]],"date-time":"2021-02-07T05:52:52Z","timestamp":1612677172000},"page":"18-30","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Intracisternal administration of tanshinone IIA-loaded nanoparticles leads to reduced tissue injury and functional deficits in a porcine model of ischemic stroke"],"prefix":"10.1016","volume":"10","author":[{"given":"Elizabeth S.","family":"Waters","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin E.","family":"Kaiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison M.","family":"Fagan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly M.","family":"Scheulin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie H.","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo K.","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly A.","family":"Kinder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon R.","family":"Platt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kylee J.","family":"Duberstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hea Jin","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franklin D.","family":"West","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ibneur.2020.11.003_bib1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1089\/neu.2017.5551","article-title":"Controlled cortical impact severity results in graded cellular, tissue, and functional responses in a piglet traumatic brain injury model","volume":"36","author":"Baker","year":"2019","journal-title":"J Neurotrauma"},{"issue":"1","key":"10.1016\/j.ibneur.2020.11.003_bib2","doi-asserted-by":"crossref","first-page":"10075","DOI":"10.1038\/s41598-017-10406-x","article-title":"Induced pluripotent stem cell-derived neural stem cell therapy enhances recovery in an ischemic stroke pig model","volume":"7","author":"Baker","year":"2017","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.ibneur.2020.11.003_bib3","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.pmrj.2013.12.017","article-title":"Gait disturbances in patients with stroke","volume":"6","author":"Balaban","year":"2014","journal-title":"PM R"},{"issue":"6","key":"10.1016\/j.ibneur.2020.11.003_bib4","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1523\/JNEUROSCI.5137-07.2008","article-title":"White matter vulnerability to ischemic injury increases with age because of enhanced excitotoxicity","volume":"28","author":"Baltan","year":"2008","journal-title":"J. Neurosci."},{"issue":"10","key":"10.1016\/j.ibneur.2020.11.003_bib5","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1161\/CIR.0000000000000659","article-title":"Heart disease and stroke statistics-2019 update: a report from the American Heart Association","volume":"139","author":"Benjamin","year":"2019","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.ibneur.2020.11.003_bib6","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1177\/0271678X17700432","article-title":"Neural stem cell transplantation in ischemic stroke: a role for preconditioning and cellular engineering","volume":"37","author":"Bernstock","year":"2017","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"6","key":"10.1016\/j.ibneur.2020.11.003_bib7","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1007\/s001340050625","article-title":"Mortality of space-occupying (\u2019malignant\u2019) middle cerebral artery infarction under conservative intensive care","volume":"24","author":"Berrouschot","year":"1998","journal-title":"Intensive Care Med."},{"issue":"4","key":"10.1016\/j.ibneur.2020.11.003_bib8","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1161\/STROKEAHA.110.604199","article-title":"Hemorrhagic transformation of childhood arterial ischemic stroke","volume":"42","author":"Beslow","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.ibneur.2020.11.003_bib9","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/978-1-4419-7756-4_22","article-title":"Oral pioglitazone reduces infarction volume and improves neurologic function following MCAO in rats","volume":"701","author":"Blankenship","year":"2011","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.ibneur.2020.11.003_bib10","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/978-3-319-18497-5_13","article-title":"Large animal stroke models vs. rodent stroke models, pros and cons, and combination?","volume":"121","author":"Cai","year":"2016","journal-title":"Acta Neurochir. Suppl."},{"key":"10.1016\/j.ibneur.2020.11.003_bib11","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1423-0127-16-9","article-title":"Neuroprotective mechanisms of puerarin in middle cerebral artery occlusion-induced brain infarction in rats","volume":"16","author":"Chang","year":"2009","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.ibneur.2020.11.003_bib12","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.biopha.2018.05.040","article-title":"Tanshinone IIA exerts neuroprotective effects on hippocampus-dependent cognitive impairments in diabetic rats by attenuating ER stress-induced apoptosis","volume":"104","author":"Chen","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.ibneur.2020.11.003_bib13","doi-asserted-by":"crossref","first-page":"134","DOI":"10.2174\/1570159X14666160620102055","article-title":"One-compound-multi-target: combination prospect of natural compounds with thrombolytic therapy in acute ischemic stroke","volume":"15","author":"Chen","year":"2017","journal-title":"Curr. Neuropharmacol."},{"issue":"2","key":"10.1016\/j.ibneur.2020.11.003_bib14","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1248\/bpb.35.164","article-title":"Neuroprotective capabilities of Tanshinone IIA against cerebral ischemia\/reperfusion injury via anti-apoptotic pathway in rats","volume":"35","author":"Chen","year":"2012","journal-title":"Biol. Pharm. Bull."},{"issue":"6","key":"10.1016\/j.ibneur.2020.11.003_bib15","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1080\/00498250701411258","article-title":"Role of P-glycoprotein in restricting the brain penetration of tanshinone IIA, a major active constituent from the root of Salvia miltiorrhiza Bunge, across the blood-brain barrier","volume":"37","author":"Chen","year":"2007","journal-title":"Xenobiotica"},{"issue":"3","key":"10.1016\/j.ibneur.2020.11.003_bib16","first-page":"307","article-title":"Treatment goals and selection of patients for rehabilitation with hemiplegia","volume":"3","author":"Cress","year":"1966","journal-title":"Ala J. Med. Sci."},{"issue":"2","key":"10.1016\/j.ibneur.2020.11.003_bib17","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.jconrel.2012.01.043","article-title":"PLGA-based nanoparticles: an overview of biomedical applications","volume":"161","author":"Danhier","year":"2012","journal-title":"J. Control Release"},{"issue":"9","key":"10.1016\/j.ibneur.2020.11.003_bib18","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0166-2236(99)01401-0","article-title":"Pathobiology of ischaemic stroke: an integrated view","volume":"22","author":"Dirnagl","year":"1999","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ibneur.2020.11.003_bib19","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.physbeh.2013.11.004","article-title":"Gait analysis in a pre- and post-ischemic stroke biomedical pig model","volume":"125","author":"Duberstein","year":"2014","journal-title":"Physiol. Behav."},{"issue":"1","key":"10.1016\/j.ibneur.2020.11.003_bib20","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.pbb.2007.04.015","article-title":"Acute ischemic stroke: overview of major experimental rodent models, pathophysiology, and therapy of focal cerebral ischemia","volume":"87","author":"Durukan","year":"2007","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ibneur.2020.11.003_bib21","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0072-9752(08)01902-7","article-title":"The ischemic cascade and mediators of ischemic injury","volume":"92","author":"Endres","year":"2009","journal-title":"Handb. Clin. Neurol."},{"issue":"5","key":"10.1016\/j.ibneur.2020.11.003_bib22","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/ana.20265","article-title":"The resistance to ischemia of white and gray matter after stroke","volume":"56","author":"Falcao","year":"2004","journal-title":"Ann. Neurol."},{"issue":"6","key":"10.1016\/j.ibneur.2020.11.003_bib23","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1152\/jn.1994.72.6.2609","article-title":"Modulation of anoxic injury in CNS white matter by adenosine and interaction between adenosine and GABA","volume":"72","author":"Fern","year":"1994","journal-title":"J. Neurophysiol."},{"issue":"2","key":"10.1016\/j.ibneur.2020.11.003_bib24","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0168-3659(98)00116-3","article-title":"PLGA nanoparticles prepared by nanoprecipitation: drug loading and release studies of a water soluble drug","volume":"57","author":"Govender","year":"1999","journal-title":"J. Controll. Release"},{"issue":"4","key":"10.1016\/j.ibneur.2020.11.003_bib25","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1001\/archneur.1996.00550040037012","article-title":"\"Malignant\u2019 middle cerebral artery territory infarction: clinical course and prognostic signs","volume":"53","author":"Hacke","year":"1996","journal-title":"Arch. Neurol."},{"issue":"2","key":"10.1016\/j.ibneur.2020.11.003_bib26","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.pharmthera.2007.09.008","article-title":"Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion","volume":"117","author":"Han","year":"2008","journal-title":"Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.ibneur.2020.11.003_bib27","doi-asserted-by":"crossref","first-page":"12587","DOI":"10.1038\/s41598-019-49028-w","article-title":"Fate of nanoparticles in the central nervous system after intrathecal injection in healthy mice","volume":"9","author":"Householder","year":"2019","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.ibneur.2020.11.003_bib28","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/S0003-9993(03)00030-3","article-title":"Analysis of impairments influencing gait velocity and asymmetry of hemiplegic patients after mild to moderate stroke","volume":"84","author":"Hsu","year":"2003","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"10.1016\/j.ibneur.2020.11.003_bib29","doi-asserted-by":"crossref","first-page":"4170156","DOI":"10.1155\/2020\/4170156","article-title":"The attenuation of traumatic brain injury via inhibition of oxidative stress and apoptosis by Tanshinone IIA","volume":"2020","author":"Huang","year":"2020","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.ibneur.2020.11.003_bib30","unstructured":"Jilani, T.N. and A.H. Siddiqui,\u00a02019. Tissue plasminogen activator. StatPearls. Treasure Island (FL)."},{"issue":"5\u20136","key":"10.1016\/j.ibneur.2020.11.003_bib31","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1159\/000356320","article-title":"Drug therapy in stroke: from preclinical to clinical studies","volume":"92","author":"Kaur","year":"2013","journal-title":"Pharmacology"},{"key":"10.1016\/j.ibneur.2020.11.003_bib32","doi-asserted-by":"crossref","DOI":"10.1089\/neu.2018.6303","article-title":"Traumatic brain injury results in dynamic brain structure changes leading to acute and chronic motor function deficits in a pediatric piglet model","author":"Kinder","year":"2019","journal-title":"J. Neurotrauma"},{"issue":"7","key":"10.1016\/j.ibneur.2020.11.003_bib33","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1161\/STROKEAHA.118.024351","article-title":"Effect of edaravone on neurological symptoms in real-world patients with acute ischemic stroke","volume":"50","author":"Kobayashi","year":"2019","journal-title":"Stroke"},{"issue":"11","key":"10.1016\/j.ibneur.2020.11.003_bib34","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1161\/STROKEAHA.117.018562","article-title":"Neuronal SIRT1 (Silent Information Regulator 2 Homologue 1) regulates glycolysis and mediates resveratrol-induced ischemic tolerance","volume":"48","author":"Koronowski","year":"2017","journal-title":"Stroke"},{"issue":"4","key":"10.1016\/j.ibneur.2020.11.003_bib35","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1078\/094471103322004776","article-title":"Neuroprotective effects of tanshinones in transient focal cerebral ischemia in mice","volume":"10","author":"Lam","year":"2003","journal-title":"Phytomedicine"},{"issue":"3","key":"10.1016\/j.ibneur.2020.11.003_bib36","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s12975-012-0209-2","article-title":"RIGOR guidelines: escalating STAIR and STEPS for effective translational research","volume":"4","author":"Lapchak","year":"2013","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.ibneur.2020.11.003_bib37","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.clineuro.2018.02.026","article-title":"Effects of edaravone, the free radical scavenger, on outcomes in acute cerebral infarction patients treated with ultra-early thrombolysis of recombinant tissue plasminogen activator","volume":"167","author":"Lee","year":"2018","journal-title":"Clin. Neurol. Neurosurg."},{"issue":"6","key":"10.1016\/j.ibneur.2020.11.003_bib38","doi-asserted-by":"crossref","first-page":"850","DOI":"10.14336\/AD.2017.0829","article-title":"The effects of Baicalin and Baicalein on cerebral ischemia: a review","volume":"8","author":"Liang","year":"2017","journal-title":"Aging Dis."},{"issue":"5","key":"10.1016\/j.ibneur.2020.11.003_bib39","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.neubiorev.2007.02.003","article-title":"The use of pigs in neuroscience: modeling brain disorders","volume":"31","author":"Lind","year":"2007","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"3\u20134","key":"10.1016\/j.ibneur.2020.11.003_bib40","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.brainresbull.2010.04.005","article-title":"The neuroprotective effects of Tanshinone IIA are associated with induced nuclear translocation of TORC1 and upregulated expression of TORC1, pCREB and BDNF in the acute stage of ischemic stroke","volume":"82","author":"Liu","year":"2010","journal-title":"Brain Res. Bull."},{"issue":"12","key":"10.1016\/j.ibneur.2020.11.003_bib41","doi-asserted-by":"crossref","DOI":"10.1007\/s11051-012-1316-4","article-title":"Biodegradable PLGA-b-PEG polymeric nanoparticles: synthesis, properties, and nanomedical applications as drug delivery system","volume":"14","author":"Locatelli","year":"2012","journal-title":"J. Nanopart. Res."},{"key":"10.1016\/j.ibneur.2020.11.003_bib42","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.phrs.2017.11.018","article-title":"Down regulation of pro-inflammatory pathways by tanshinone IIA and cryptotanshinone in a non-genetic mouse model of Alzheimer\u2019s disease","volume":"129","author":"Maione","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ibneur.2020.11.003_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2015.02.003","article-title":"The role of immune cells, glia and neurons in white and gray matter pathology in multiple sclerosis","volume":"127\u2013128","author":"Mallucci","year":"2015","journal-title":"Prog. Neurobiol."},{"issue":"2","key":"10.1016\/j.ibneur.2020.11.003_bib44","first-page":"1621","article-title":"Tanshinone IIA attenuates cerebral aneurysm formation by inhibiting the NFkappaBmediated inflammatory response","volume":"20","author":"Ma","year":"2019","journal-title":"Mol. Med. Rep."},{"issue":"8","key":"10.1016\/j.ibneur.2020.11.003_bib45","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1097\/nen.0b013e3181256b32","article-title":"Distinct types of microglial activation in white and grey matter of rat lumbosacral cord after mid-thoracic spinal transection","volume":"66","author":"McKay","year":"2007","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"6","key":"10.1016\/j.ibneur.2020.11.003_bib46","doi-asserted-by":"crossref","first-page":"488","DOI":"10.3171\/2008.6.PEDS0834","article-title":"Experimental investigation of encephalomyosynangiosis using gyrencephalic brain of the miniature pig: histopathological evaluation of dynamic reconstruction of vessels for functional anastomosis. Laboratory investigation","volume":"3","author":"Nakamura","year":"2009","journal-title":"J. Neurosurg. Pediatr."},{"issue":"1","key":"10.1016\/j.ibneur.2020.11.003_bib47","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/2040-7378-6-5","article-title":"Development and characterization of a Yucatan miniature biomedical pig permanent middle cerebral artery occlusion stroke model","volume":"6","author":"Platt","year":"2014","journal-title":"Exp. Transl. Stroke Med."},{"issue":"3","key":"10.1016\/j.ibneur.2020.11.003_bib48","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/0166-2236(95)93890-A","article-title":"Cytokines and the nervous system II: actions and mechanisms of action","volume":"18","author":"Rothwell","year":"1995","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ibneur.2020.11.003_bib49","article-title":"Drug solubility: importance and enhancement techniques","volume":"2012","author":"Savjani","year":"2012","journal-title":"ISRN Pharm."},{"issue":"6","key":"10.1016\/j.ibneur.2020.11.003_bib50","doi-asserted-by":"crossref","first-page":"588","DOI":"10.3724\/SP.J.1009.2013.00588","article-title":"Progress on the protective effect of compounds from natural medicines on cerebral ischemia","volume":"11","author":"Shang","year":"2013","journal-title":"Chin. J. Nat. Med."},{"issue":"12","key":"10.1016\/j.ibneur.2020.11.003_bib51","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1161\/01.STR.30.12.2752","article-title":"Recommendations for standards regarding preclinical neuroprotective and restorative drug development","volume":"30","author":"Stroke Therapy Academic Industry","year":"1999","journal-title":"Stroke"},{"issue":"2","key":"10.1016\/j.ibneur.2020.11.003_bib52","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1600-0404.2004.00369.x","article-title":"Does Danshen improve disability after acute ischaemic stroke?","volume":"111","author":"Sze","year":"2005","journal-title":"Acta Neurol. Scand."},{"issue":"5","key":"10.1016\/j.ibneur.2020.11.003_bib53","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.3892\/etm.2014.1936","article-title":"Protective effect of tanshinone IIA on the brain and its therapeutic time window in rat models of cerebral ischemia-reperfusion","volume":"8","author":"Tang","year":"2014","journal-title":"Exp. Ther. Med."},{"issue":"14","key":"10.1016\/j.ibneur.2020.11.003_bib54","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.phymed.2010.03.017","article-title":"The effects of Tanshinone IIA on blood-brain barrier and brain edema after transient middle cerebral artery occlusion in rats","volume":"17","author":"Tang","year":"2010","journal-title":"Phytomedicine"},{"issue":"3","key":"10.1016\/j.ibneur.2020.11.003_bib55","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1159\/000229781","article-title":"Frequency and determinants for hemorrhagic transformation of cerebral infarction","volume":"33","author":"Terruso","year":"2009","journal-title":"Neuroepidemiology"},{"issue":"9","key":"10.1016\/j.ibneur.2020.11.003_bib56","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1161\/01.STR.31.9.2087","article-title":"Stroke incidence on the east coast of Australia: the North East Melbourne Stroke Incidence Study (NEMESIS)","volume":"31","author":"Thrift","year":"2000","journal-title":"Stroke"},{"issue":"11","key":"10.1016\/j.ibneur.2020.11.003_bib57","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1007\/s11064-011-0526-y","article-title":"Effect of baicalin on matrix metalloproteinase-9 expression and blood-brain barrier permeability following focal cerebral ischemia in rats","volume":"36","author":"Tu","year":"2011","journal-title":"Neurochem. Res."},{"issue":"9","key":"10.1016\/j.ibneur.2020.11.003_bib58","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1007\/s11064-009-9953-4","article-title":"Neuroprotective effect of baicalin in a rat model of permanent focal cerebral ischemia","volume":"34","author":"Tu","year":"2009","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ibneur.2020.11.003_bib59","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.brainres.2009.12.046","article-title":"Tanshinone II A down-regulates HMGB1, RAGE, TLR4, NF-kappaB expression, ameliorates BBB permeability and endothelial cell function, and protects rat brains against focal ischemia","volume":"1321","author":"Wang","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.ibneur.2020.11.003_bib60","article-title":"Dan Shen agents for acute ischaemic stroke","volume":"2","author":"Wu","year":"2007","journal-title":"Cochrane Database Syst. Rev."},{"issue":"5","key":"10.1016\/j.ibneur.2020.11.003_bib61","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1161\/CIRCULATIONAHA.117.030458","article-title":"Pioglitazone prevents stroke in patients with a recent transient ischemic attack or ischemic stroke: a planned secondary analysis of the IRIS trial (Insulin Resistance Intervention After Stroke)","volume":"137","author":"Yaghi","year":"2018","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.ibneur.2020.11.003_bib62","doi-asserted-by":"crossref","first-page":"491","DOI":"10.4196\/kjpp.2015.19.6.491","article-title":"Epigallocatechin-3-Gallate (EGCG) attenuates traumatic brain injury by inhibition of Edema formation and oxidative stress","volume":"19","author":"Zhang","year":"2015","journal-title":"Korean J. Physiol. Pharmacol."},{"issue":"1","key":"10.1016\/j.ibneur.2020.11.003_bib63","article-title":"Efficacy and safety of puerarin injection in curing acute ischemic stroke: a meta-analysis of randomized controlled trials","volume":"96","author":"Zheng","year":"2017","journal-title":"Medicine ((Baltimore))"},{"key":"10.1016\/j.ibneur.2020.11.003_bib64","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.taap.2018.04.037","article-title":"Sodium tanshinone IIA sulfonate promotes endothelial integrity via regulating VE-cadherin dynamics and RhoA\/ROCK-mediated cellular contractility and prevents atorvastatin-induced intracerebral hemorrhage in zebrafish","volume":"350","author":"Zhou","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"12","key":"10.1016\/j.ibneur.2020.11.003_bib65","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1177\/0091270005282630","article-title":"Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use","volume":"45","author":"Zhou","year":"2005","journal-title":"J. Clin. Pharmacol."}],"container-title":["IBRO Neuroscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667242120000056?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667242120000056?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T12:11:54Z","timestamp":1742040714000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667242120000056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":65,"alternative-id":["S2667242120000056"],"URL":"https:\/\/doi.org\/10.1016\/j.ibneur.2020.11.003","relation":{},"ISSN":["2667-2421"],"issn-type":[{"value":"2667-2421","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intracisternal administration of tanshinone IIA-loaded nanoparticles leads to reduced tissue injury and functional deficits in a porcine model of ischemic stroke","name":"articletitle","label":"Article Title"},{"value":"IBRO Neuroscience Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ibneur.2020.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier Ltd on behalf of International Brain Research Organization.","name":"copyright","label":"Copyright"}]}}