{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T09:32:13Z","timestamp":1783416733243,"version":"3.54.6"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T00:00:00Z","timestamp":1642377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ibroneuroreports.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["IBRO Neuroscience Reports"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.ibneur.2022.01.002","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T18:52:04Z","timestamp":1642618324000},"page":"108-120","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Multifaceted roles of orexin neurons in mediating methamphetamine-induced changes in body temperature and heart rate"],"prefix":"10.1016","volume":"12","author":[{"given":"Kohei","family":"Miyata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Ikoma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koshi","family":"Murata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikue","family":"Kusumoto-Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenta","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Kuwaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youichirou","family":"Ootsuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ibneur.2022.01.002_bib1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/ejn.12421","article-title":"Vesicular glutamate transporter 2 is required for the respiratory and parasympathetic activation produced by optogenetic stimulation of catecholaminergic neurons in the rostral ventrolateral medulla of mice in vivo","volume":"39","author":"Abbott","year":"2014","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ibneur.2022.01.002_bib2","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.neuropharm.2017.08.033","article-title":"Assessing the role of dopamine in the differential neurotoxicity patterns of methamphetamine, mephedrone, methcathinone and 4-methylmethamphetamine","volume":"134","author":"Anneken","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ibneur.2022.01.002_bib3","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0014-2999(01)01202-X","article-title":"Intravenous (+)-methamphetamine causes complex dose-dependent physiologic changes in awake rats","volume":"426","author":"Arora","year":"2001","journal-title":"Eur. .J Pharmacol."},{"key":"10.1016\/j.ibneur.2022.01.002_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0126719","article-title":"Orexinergic neurotransmission in temperature responses to methamphetamine and stress: mathematical modeling as a data assimilation approach","volume":"10","author":"Behrouzvaziri","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ibneur.2022.01.002_bib5","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1073\/pnas.0910986107","article-title":"VGLUT2 in dopamine neurons is required for psychostimulant-induced behavioral activation","volume":"107","author":"Birgner","year":"2010","journal-title":"Proc Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.ibneur.2022.01.002_bib6","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ibror.2018.05.001","article-title":"VGAT and VGLUT2 expression in MCH and orexin neurons in double transgenic reporter mice","volume":"4","author":"Blanco-Centurion","year":"2018","journal-title":"IBRO Reports"},{"key":"10.1016\/j.ibneur.2022.01.002_bib7","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1016\/j.neuroscience.2006.05.050","article-title":"Clozapine reverses increased brown adipose tissue thermogenesis induced by 3,4-methylenedioxymethamphetamine and by cold exposure in conscious rats","volume":"141","author":"Blessing","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.ibneur.2022.01.002_bib8","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0092-8674(00)81973-X","article-title":"Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation","volume":"98","author":"Chemelli","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.ibneur.2022.01.002_bib9","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.autneu.2006.02.010","article-title":"Stress-induced cardiac stimulation and fever: common hypothalamic origins and brainstem mechanisms","volume":"126\u2013127","author":"DiMicco","year":"2006","journal-title":"Auton Neurosci"},{"key":"10.1016\/j.ibneur.2022.01.002_bib10","doi-asserted-by":"crossref","first-page":"R47","DOI":"10.1152\/ajpregu.00498.2006","article-title":"The dorsomedial hypothalamus: a new player in thermoregulation","volume":"292","author":"Dimicco","year":"2007","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.ibneur.2022.01.002_bib11","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nrn2969","article-title":"From glutamate co-release to vesicular synergy: vesicular glutamate transporters","volume":"12","author":"El Mestikawy","year":"2011","journal-title":"Nature Rev. Neurosci."},{"key":"10.1016\/j.ibneur.2022.01.002_bib12","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1523\/JNEUROSCI.21-05-01656.2001","article-title":"Fos expression in orexin neurons varies with behavioral state","volume":"21","author":"Estabrooke","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ibneur.2022.01.002_bib13","doi-asserted-by":"crossref","first-page":"6742","DOI":"10.1523\/JNEUROSCI.22-15-06742.2002","article-title":"Differential activation of orexin neurons by antipsychotic drugs associated with weight gain","volume":"22","author":"Fadel","year":"2002","journal-title":"J. Neurosci.:\u00a0Official J. Soc. Neurosci."},{"key":"10.1016\/j.ibneur.2022.01.002_bib14","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.neuroscience.2007.11.007","article-title":"A comparison of the physiological, behavioral, neurochemical and microglial effects of methamphetamine and 3,4-methylenedioxymethamphetamine in the mouse","volume":"151","author":"Fantegrossi","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.ibneur.2022.01.002_bib15","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/27919","article-title":"Glutamate mediates an inhibitory postsynaptic potential in dopamine neurons","volume":"394","author":"Fiorillo","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.ibneur.2022.01.002_bib16","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0091-3057(90)90415-E","article-title":"Potentiating effect of morphine upon d-methamphetamine-induced hyperthermia in mice. Effects of naloxone and haloperidol","volume":"36","author":"Funahashi","year":"1990","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ibneur.2022.01.002_bib17","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0379-0738(88)90103-X","article-title":"Potentiation of lethality and increase in body temperature by combined use of d-methamphetamine and morphine in mice","volume":"37","author":"Funahashi","year":"1988","journal-title":"Forensic. Sci. Int."},{"key":"10.1016\/j.ibneur.2022.01.002_bib18","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1038\/sj.npp.1300672","article-title":"Group II and III metabotropic glutamate receptors suppress excitatory synaptic transmission in the dorsolateral bed nucleus of the stria terminalis","volume":"30","author":"Grueter","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ibneur.2022.01.002_bib19","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0896-6273(01)00293-8","article-title":"Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity","volume":"30","author":"Hara","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.ibneur.2022.01.002_bib20","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.neuron.2010.02.012","article-title":"Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo","volume":"65","author":"Hnasko","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.ibneur.2022.01.002_bib21","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1073\/pnas.042678699","article-title":"Adeno-associated virus effectively mediates conditional gene modification in the brain","volume":"99","author":"Kaspar","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.ibneur.2022.01.002_bib22","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.cmet.2014.05.018","article-title":"Psychological stress activates a dorsomedial hypothalamus-medullary raphe circuit driving brown adipose tissue thermogenesis and hyperthermia","volume":"20","author":"Kataoka","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.ibneur.2022.01.002_bib23","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1126\/science.aaz4639","article-title":"A central master driver of psychosocial stress responses in the rat","volume":"367","author":"Kataoka","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.ibneur.2022.01.002_bib24","doi-asserted-by":"crossref","first-page":"7627","DOI":"10.1523\/JNEUROSCI.0173-13.2013","article-title":"Glutamatergic signaling from the parabrachial nucleus plays a critical role in hypercapnic arousal","volume":"33","author":"Kaur","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ibneur.2022.01.002_bib25","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.neuropharm.2011.06.028","article-title":"CM156, a high affinity sigma ligand, attenuates the stimulant and neurotoxic effects of methamphetamine in mice","volume":"61","author":"Kaushal","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ibneur.2022.01.002_bib26","doi-asserted-by":"crossref","first-page":"R581","DOI":"10.1152\/ajpregu.00671.2002","article-title":"Attenuated defense response and low basal blood pressure in orexin knockout mice","volume":"285","author":"Kayaba","year":"2003","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.ibneur.2022.01.002_bib27","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.neulet.2016.07.020","article-title":"Survival of corticostriatal neurons by Rho\/Rho-kinase signaling pathway","volume":"630","author":"Kobayashi","year":"2016","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ibneur.2022.01.002_bib28","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1080\/23328940.2015.1066921","article-title":"Thermoregulation under pressure: a role for orexin neurons","volume":"2","author":"Kuwaki","year":"2015","journal-title":"Temperature"},{"key":"10.1016\/j.ibneur.2022.01.002_bib29","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/B978-0-12-394623-2.00008-1","article-title":"Orexin neurons and emotional stress","volume":"89","author":"Kuwaki","year":"2012","journal-title":"Vitam. Horm."},{"key":"10.1016\/j.ibneur.2022.01.002_bib30","doi-asserted-by":"crossref","first-page":"4459","DOI":"10.1073\/pnas.0811126106","article-title":"Selective loss of GABAB receptors in orexin-producing neurons results in disrupted sleep\/wakefulness architecture","volume":"106","author":"Matsuki","year":"2009","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.ibneur.2022.01.002_bib31","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.neuropharm.2009.08.009","article-title":"Monoaminergic neuronal changes in orexin deficient mice","volume":"58","author":"Mori","year":"2010","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ibneur.2022.01.002_bib32","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1002\/cne.24924","article-title":"Region- and neuronal-subtype-specific expression of Na,K-ATPase alpha and beta subunit isoforms in the mouse brain","volume":"528","author":"Murata","year":"2020","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.ibneur.2022.01.002_bib33","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00213-007-1061-z","article-title":"The effects of methamphetamine on core body temperature in the rat--part 1: chronic treatment and ambient temperature","volume":"198","author":"Myles","year":"2008","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.ibneur.2022.01.002_bib34","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1254\/jphs.FPJ05004X","article-title":"Underlying mechanism of combined effect of methamphetamine and morphine on lethality in mice and therapeutic potential of cooling","volume":"99","author":"Namiki","year":"2005","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.ibneur.2022.01.002_bib35","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.brainres.2010.08.017","article-title":"Relationship between methamphetamine-induced behavioral activation and hyperthermia","volume":"1357","author":"Phelps","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.ibneur.2022.01.002_bib36","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.brainres.2010.12.017","article-title":"Methamphetamine causes sustained depression in cerebral blood flow","volume":"1373","author":"Polesskaya","year":"2011","journal-title":"Brain Res."},{"key":"10.1016\/j.ibneur.2022.01.002_bib37","first-page":"12","article-title":"Eliminating the VGlut2-dependent glutamatergic transmission of parvalbumin-expressing neurons leads to deficits in locomotion and vocalization, decreased pain sensitivity, and increased dominance","author":"Roccaro-Waldmeyer","year":"2018","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.ibneur.2022.01.002_bib38","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/cne.10860","article-title":"Hypothalamic orexin (hypocretin) neurons express vesicular glutamate transporters VGLUT1 or VGLUT2","volume":"465","author":"Rosin","year":"2003","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.ibneur.2022.01.002_bib39","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.brainres.2008.06.011","article-title":"Microinjection of muscimol into the dorsomedial hypothalamus suppresses MDMA-evoked sympathetic and behavioral responses","volume":"1226","author":"Rusyniak","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.ibneur.2022.01.002_bib40","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.physbeh.2012.02.010","article-title":"The orexin-1 receptor antagonist SB-334867 decreases sympathetic responses to a moderate dose of methamphetamine and stress","volume":"107","author":"Rusyniak","year":"2012","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.ibneur.2022.01.002_bib41","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nrn2092","article-title":"The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness","volume":"8","author":"Sakurai","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ibneur.2022.01.002_bib42","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.celrep.2014.03.055","article-title":"Coreleased orexin and glutamate evoke nonredundant spike outputs and computations in histamine neurons","volume":"7","author":"Schone","year":"2014","journal-title":"Cell reports"},{"key":"10.1016\/j.ibneur.2022.01.002_bib43","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1800886115","article-title":"Genetic deletion of vesicular glutamate transporter in dopamine neurons increases vulnerability to MPTP-induced neurotoxicity in mice","volume":"115","author":"Shen","year":"2018","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.ibneur.2022.01.002_bib44","doi-asserted-by":"crossref","first-page":"5623","DOI":"10.1113\/jphysiol.2013.261271","article-title":"Orexin neurons are indispensable for prostaglandin E2-induced fever and defence against environmental cooling in mice","volume":"591","author":"Takahashi","year":"2013","journal-title":"J. Physiol."},{"key":"10.1016\/j.ibneur.2022.01.002_bib45","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.cmet.2007.04.001","article-title":"Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia","volume":"5","author":"Tong","year":"2007","journal-title":"Cell Metab."},{"key":"10.1016\/j.ibneur.2022.01.002_bib46","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0306-4522(03)00238-0","article-title":"Colocalization of orexin a and glutamate immunoreactivity in axon terminals in the tuberomammillary nucleus in rats","volume":"119","author":"Torrealba","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.ibneur.2022.01.002_bib47","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1124\/pr.109.001321","article-title":"Orexin\/hypocretin: a neuropeptide at the interface of sleep, energy homeostasis, and reward system","volume":"61","author":"Tsujino","year":"2009","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ibneur.2022.01.002_bib48","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.ymeth.2010.07.003","article-title":"Fluorescent in situ hybridization technique for cell type identification and characterization in the central nervous system","volume":"52","author":"Watakabe","year":"2010","journal-title":"Methods"},{"key":"10.1016\/j.ibneur.2022.01.002_bib49","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1016\/S0022-3565(25)39604-7","article-title":"Cardiovascular, thermal and behavioral sensitization to methamphetamine in freely moving rats","volume":"267","author":"Yoshida","year":"1993","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ibneur.2022.01.002_bib50","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.autneu.2006.02.021","article-title":"Multiple components of the defense response depend on orexin: evidence from orexin knockout mice and orexin neuron-ablated mice","volume":"126\u2013127","author":"Zhang","year":"2006","journal-title":"Auton Neurosci."},{"key":"10.1016\/j.ibneur.2022.01.002_bib51","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.1113\/jphysiol.2010.195099","article-title":"Orexin neurons are indispensable for stress-induced thermogenesis in mice","volume":"588","author":"Zhang","year":"2010","journal-title":"J. Physiol."}],"container-title":["IBRO Neuroscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667242122000021?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667242122000021?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T08:08:18Z","timestamp":1757405298000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667242122000021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":51,"alternative-id":["S2667242122000021"],"URL":"https:\/\/doi.org\/10.1016\/j.ibneur.2022.01.002","relation":{},"ISSN":["2667-2421"],"issn-type":[{"value":"2667-2421","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multifaceted roles of orexin neurons in mediating methamphetamine-induced changes in body temperature and heart rate","name":"articletitle","label":"Article Title"},{"value":"IBRO Neuroscience Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ibneur.2022.01.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Ltd on behalf of International Brain Research Organization.","name":"copyright","label":"Copyright"}]}}