{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:21:03Z","timestamp":1758399663920,"version":"3.44.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T00:00:00Z","timestamp":1665360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ibroneuroreports.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["IBRO Neuroscience Reports"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.ibneur.2022.10.004","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T05:29:00Z","timestamp":1665552540000},"page":"373-377","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Effects of Allopurinol as a xanthine oxidase inhibitor on depressive-like behavior of rats and changes in serum BDNF level"],"prefix":"10.1016","volume":"13","author":[{"given":"Mahsa Hadipour","family":"Jahromy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahareh","family":"Baghchesara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6481-0737","authenticated-orcid":false,"given":"Salar","family":"Javanshir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ibneur.2022.10.004_bib1","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1007\/s11011-020-00595-2","article-title":"Morin hydrate attenuates chronic stress-induced memory impairment and degeneration of hippocampal subfields in mice: the role of oxidative, nitrergic and neuroinflammatory pathways","volume":"35","author":"Akinluyi","year":"2020","journal-title":"Metab. Brain Dis."},{"issue":"4","key":"10.1016\/j.ibneur.2022.10.004_bib2","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1080\/08039480500227733","article-title":"Depression in general practice","volume":"59","author":"Al-Windi","year":"2005","journal-title":"Nord J. Psychiatry"},{"issue":"38","key":"10.1016\/j.ibneur.2022.10.004_bib3","doi-asserted-by":"crossref","first-page":"5935","DOI":"10.2174\/1381612823666170918123307","article-title":"Allopurinol: old drug, new indication in neonates?","volume":"23","author":"Annink","year":"2017","journal-title":"Curr. Pharm. Des."},{"issue":"1","key":"10.1016\/j.ibneur.2022.10.004_bib4","article-title":"Repeated psychosocial stress causes glutamic acid decarboxylase isoform-67, oxidative-Nox-2 changes and neuroinflammation in mice: prevention by treatment with a neuroactive flavonoid, morin","volume":"1744","author":"Ben-Azu","year":"2020","journal-title":"Brain Res."},{"issue":"13","key":"10.1016\/j.ibneur.2022.10.004_bib5","first-page":"3796","article-title":"Stimulation of malignant growth in rodents by antidepressant drugs at clinically relevant doses","volume":"52","author":"Brandes","year":"1992","journal-title":"Cancer Res."},{"issue":"2 Suppl","key":"10.1016\/j.ibneur.2022.10.004_bib6","first-page":"651","article-title":"Current understanding of the neurobiology of major depressive disorder","volume":"56","author":"Chirita","year":"2015","journal-title":"Rom. J. Morphol. Embryol."},{"issue":"4","key":"10.1016\/j.ibneur.2022.10.004_bib7","first-page":"420","article-title":"Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis","volume":"16","author":"Cipriani","year":"2018","journal-title":"Focus (Am. Psychiatr. Publ.)"},{"issue":"7","key":"10.1016\/j.ibneur.2022.10.004_bib8","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1001\/archpsyc.1997.01830190015002","article-title":"A molecular and cellular theory of depression","volume":"54","author":"Duman","year":"1997","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.ibneur.2022.10.004_bib9","doi-asserted-by":"crossref","first-page":"433","DOI":"10.2147\/NDT.S5700","article-title":"Brain-derived neurotrophic factor: role in depression and suicide","volume":"5","author":"Dwivedi","year":"2009","journal-title":"Neuropsychiatr. Dis. Treat."},{"issue":"15","key":"10.1016\/j.ibneur.2022.10.004_bib10","doi-asserted-by":"crossref","first-page":"4088","DOI":"10.1523\/JNEUROSCI.5510-07.2008","article-title":"A causal role for brain-derived neurotrophic factor in the homeostatic regulation of sleep","volume":"28","author":"Faraguna","year":"2008","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.ibneur.2022.10.004_bib11","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.neuron.2014.01.027","article-title":"The genetics of major depression","volume":"81","author":"Flint","year":"2014","journal-title":"Neuron"},{"issue":"6","key":"10.1016\/j.ibneur.2022.10.004_bib12","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1017\/S1461145713001673","article-title":"Inhibition of stress-induced hepatic tryptophan 2,3-dioxygenase exhibits antidepressant activity in an animal model of depressive behaviour","volume":"17","author":"Gibney","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.ibneur.2022.10.004_bib13","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.pbb.2015.09.016","article-title":"Antidepressant-like effects of the xanthine oxidase enzyme inhibitor allopurinol in rats. A comparison with fluoxetine","volume":"138","author":"Gurbuz Ozgur","year":"2015","journal-title":"Pharm. Biochem. Behav."},{"issue":"2","key":"10.1016\/j.ibneur.2022.10.004_bib14","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.arcmed.2006.10.005","article-title":"Adenosine deaminase, nitric oxide, superoxide dismutase, and xanthine oxidase in patients with major depression: impact of antidepressant treatment","volume":"38","author":"Herken","year":"2007","journal-title":"Arch. Med. Res."},{"issue":"2","key":"10.1016\/j.ibneur.2022.10.004_bib15","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/sleep\/30.2.129","article-title":"Exploratory behavior, cortical BDNF expression, and sleep homeostasis","volume":"30","author":"Huber","year":"2007","journal-title":"Sleep"},{"issue":"1","key":"10.1016\/j.ibneur.2022.10.004_bib16","first-page":"127","article-title":"Preventive putative mechanisms involved in the psychopathologies of mice passively coping with psychosocial defeat stress by quercetin","volume":"183","author":"Ikechukwu Ugwua","year":"2022","journal-title":"Brain Res. Bull."},{"issue":"8","key":"10.1016\/j.ibneur.2022.10.004_bib17","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/da.22777","article-title":"Adult mental health outcomes of adolescent depression: a systematic review","volume":"35","author":"Johnson","year":"2018","journal-title":"Depress Anxiety"},{"issue":"1","key":"10.1016\/j.ibneur.2022.10.004_bib18","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/acps.12957","article-title":"New drug candidates for depression - a nationwide population-based study","volume":"139","author":"Kessing","year":"2019","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.ibneur.2022.10.004_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2018.02.012","article-title":"Uric acid and allopurinol aggravate absence epileptic activity in Wistar Albino Glaxo Rijswijk rats","volume":"1686","author":"Lakatos","year":"2018","journal-title":"Brain Res."},{"issue":"3","key":"10.1016\/j.ibneur.2022.10.004_bib20","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1017\/S1461145705005766","article-title":"Chronic treatment with fluoxetine up-regulates cellular BDNF mRNA expression in rat dopaminergic regions","volume":"9","author":"Molteni","year":"2006","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"1","key":"10.1016\/j.ibneur.2022.10.004_bib21","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1097\/00004850-200206001-00002","article-title":"The neuropharmacology of serotonin and noradrenaline in depression","volume":"17","author":"Nutt","year":"2002","journal-title":"Int. Clin. Psychopharmacol."},{"key":"10.1016\/j.ibneur.2022.10.004_bib22","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s12031-020-01664-y","article-title":"Naringin confers protection against psychosocial defeat stress-induced neurobehavioral deficits in mice: involvement of glutamic acid decarboxylase isoform-67, oxido-nitrergic stress, and neuroinflammatory mechanisms","volume":"71","author":"Oladapo","year":"2021","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.ibneur.2022.10.004_bib23","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ijdevneu.2013.11.001","article-title":"Long-term effects of prenatal allopurinol treatment on brain plasticity markers in low and normal birth weight piglets","volume":"33","author":"Prickaerts","year":"2014","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.ibneur.2022.10.004_bib24","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.jpsychires.2015.05.007","article-title":"Kynurenine pathway dysfunction in the pathophysiology and treatment of depression: Evidences from animal and human studies","volume":"68","author":"Reus","year":"2015","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.ibneur.2022.10.004_bib25","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.brainres.2011.06.024","article-title":"Potential contribution of oxidative stress and inflammation to anxiety and hypertension","volume":"1404","author":"Salim","year":"2011","journal-title":"Brain Res."},{"key":"10.1016\/j.ibneur.2022.10.004_bib26","doi-asserted-by":"crossref","first-page":"334","DOI":"10.3389\/fpsyt.2018.00334","article-title":"Genetics factors in major depression disease","volume":"9","author":"Shadrina","year":"2018","journal-title":"Front Psychiatry"},{"issue":"3","key":"10.1016\/j.ibneur.2022.10.004_bib27","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00428203","article-title":"The tail suspension test: a new method for screening antidepressants in mice","volume":"85","author":"Steru","year":"1985","journal-title":"Psychopharmacol. (Berl.)"},{"issue":"8","key":"10.1016\/j.ibneur.2022.10.004_bib28","doi-asserted-by":"crossref","first-page":"e75","DOI":"10.1111\/j.1528-1167.2011.03133.x","article-title":"The impact of depression and anxiety disorder symptoms on the health-related quality of life of children and adolescents with epilepsy","volume":"52","author":"Stevanovic","year":"2011","journal-title":"Epilepsia"},{"issue":"4","key":"10.1016\/j.ibneur.2022.10.004_bib29","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1515\/jbcpp-2012-0027","article-title":"The influence of oxonate-induced hyperuricemia and allopurinol on behavioral reactions of random-bred mice","volume":"23","author":"Tovchiga","year":"2012","journal-title":"J. Basic Clin. Physiol. Pharm."},{"issue":"1","key":"10.1016\/j.ibneur.2022.10.004_bib30","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0168-0102(99)00062-0","article-title":"Brain-derived neurotropic factor prevents superoxide anion-induced death of PC12h cells stably expressing TrkB receptor via modulation of reactive oxygen species","volume":"35","author":"Yamagata","year":"1999","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.ibneur.2022.10.004_bib31","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3389\/fncel.2020.00082","article-title":"The role of BDNF on neural plasticity in depression","volume":"14","author":"Yang","year":"2020","journal-title":"Front Cell Neurosci."}],"container-title":["IBRO Neuroscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266724212200077X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266724212200077X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T08:13:58Z","timestamp":1757405638000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S266724212200077X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":31,"alternative-id":["S266724212200077X"],"URL":"https:\/\/doi.org\/10.1016\/j.ibneur.2022.10.004","relation":{},"ISSN":["2667-2421"],"issn-type":[{"type":"print","value":"2667-2421"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of Allopurinol as a xanthine oxidase inhibitor on depressive-like behavior of rats and changes in serum BDNF level","name":"articletitle","label":"Article Title"},{"value":"IBRO Neuroscience Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ibneur.2022.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Ltd on behalf of International Brain Research Organization.","name":"copyright","label":"Copyright"}]}}