{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:28:46Z","timestamp":1793413726236,"version":"4.5.0"},"reference-count":239,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","award":["FRGS19-125-0734"],"award-info":[{"award-number":["FRGS19-125-0734"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ibroneuroreports.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["IBRO Neuroscience Reports"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.ibneur.2022.12.003","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T03:20:05Z","timestamp":1671160805000},"page":"95-110","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Neurodegeneration and inflammation crosstalk: Therapeutic targets and perspectives"],"prefix":"10.1016","volume":"14","author":[{"given":"Wael","family":"Mohamed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaya","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Badrah S.","family":"Alghamdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Al-Hassan","family":"Soliman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamashita","family":"Toshihide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ibneur.2022.12.003_bib1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1046\/j.1469-7580.2002.00064.x","article-title":"Astrocyte-endothelial interactions and bloodbrain barrier permeability","volume":"200","author":"Abbott","year":"2002","journal-title":"J. Anat."},{"issue":"7878","key":"10.1016\/j.ibneur.2022.12.003_bib2","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/s41586-021-03892-7","article-title":"A lymphocyte-microglia-astrocyte axis in chronic active multiple sclerosis","volume":"597","author":"Absinta","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.ibneur.2022.12.003_bib3","doi-asserted-by":"crossref","unstructured":"Alzheimer's Association. Alzheimer's disease facts and figures. Alzheimers Dement. (2020). 16:391\u2013460. doi: 10.1002\/alz.12068.","DOI":"10.1002\/alz.12068"},{"issue":"2","key":"10.1016\/j.ibneur.2022.12.003_bib4","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a036434","article-title":"Cell death and neurodegeneration","volume":"12","author":"Andreone","year":"2020","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.ibneur.2022.12.003_bib5","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0166-2236(98)01349-6","article-title":"Tripartite synapses: glia, the unacknowledged partner","volume":"22","author":"Araque","year":"1999","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ibneur.2022.12.003_bib6","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1212\/WNL.0b013e31827f0fd1","article-title":"Criteria for the diagnosis of corticobasal degeneration","volume":"80","author":"Armstrong","year":"2013","journal-title":"Neurology"},{"issue":"5","key":"10.1016\/j.ibneur.2022.12.003_bib7","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1097\/WCO.0000000000000598","article-title":"Stem cell transplantation for amyotrophic lateral sclerosis","volume":"31","author":"Baloh","year":"2018","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.ibneur.2022.12.003_bib8","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s11481-008-9105-7","article-title":"CD38\/Cyclic ADP-ribose regulates astrocyte calciumsignaling: implications for neuroinflammation andHIV-1-associated dementia","volume":"3","author":"Banerjee","year":"2008","journal-title":"J. Neuroimmun. Pharmacol."},{"key":"10.1016\/j.ibneur.2022.12.003_bib9","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/s41593-020-0602-1","article-title":"Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map","volume":"23","author":"Bayraktar","year":"2020","journal-title":"Nat. Neurosci."},{"issue":"24","key":"10.1016\/j.ibneur.2022.12.003_bib10","doi-asserted-by":"crossref","first-page":"e2944","DOI":"10.1212\/WNL.0000000000012109","article-title":"Astrocyte biomarkers in Alzheimer disease: a systematic review and meta-analysis","volume":"96","author":"Bellaver","year":"2021","journal-title":"Neurology"},{"key":"10.1016\/j.ibneur.2022.12.003_bib11","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1007\/s12035-017-0526-2","article-title":"Systemic Inflammation as a Driver of Brain Injury: The Astrocyte as an Emerging Player","volume":"55","author":"Bellaver","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ibneur.2022.12.003_bib12","first-page":"1","article-title":"The accuracy and robustness of plasma biomarker models for amyloid PET positivity","volume":"no. 1","author":"Benedet","year":"2022","journal-title":"Alzheimer'S. Res. Ther."},{"key":"10.1016\/j.ibneur.2022.12.003_bib13","doi-asserted-by":"crossref","first-page":"9435Y40","DOI":"10.1073\/pnas.0400569101","article-title":"Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson\u2019s disease","volume":"101","author":"Benner","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"Suppl. 1","key":"10.1016\/j.ibneur.2022.12.003_bib14","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/j.expneurol.2004.08.021","article-title":"Ubiquitin-proteasome system and Parkinson\u2019s diseases","volume":"191","author":"Betarbet","year":"2005","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ibneur.2022.12.003_bib15","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nn1246","article-title":"Astrocytes contain a vesicular compartment that is competent for regulated exocytosis of glutamate","volume":"7","author":"Bezzi","year":"2004","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ibneur.2022.12.003_bib16","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1002\/ijc.29095","article-title":"Inhibition of glioma progression by a newly discovered CD38 inhibitor","volume":"136","author":"Blacher","year":"2015","journal-title":"Int. J. Cancer"},{"issue":"3","key":"10.1016\/j.ibneur.2022.12.003_bib17","doi-asserted-by":"crossref","first-page":"379e391","DOI":"10.1007\/s00401-015-1504-2","article-title":"Age-dependent defects of alpha-synuclein oligomer uptake in microglia and monocytes","volume":"131","author":"Bliederhaeuser","year":"2016","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.ibneur.2022.12.003_bib18","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/jnc.14207","article-title":"Vaccination strategies in tauopathies and synucleinopathies","volume":"143","author":"Braczynski","year":"2017","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ibneur.2022.12.003_bib19","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0021-9258(18)97611-8","article-title":"The Metabolism of Glucocerebrosides. I. Purification and properties of a glucocerebroside-cleaving enzyme from spleen tissue","volume":"240","author":"Brady","year":"1965","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ibneur.2022.12.003_bib20","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s10522-013-9489-5","article-title":"Mapping NAD+ metabolism in the brain of ageing Wistar rats: potential targets for influencing brain senescence","volume":"15","author":"Braidy","year":"2014","journal-title":"Biogerontology"},{"key":"10.1016\/j.ibneur.2022.12.003_bib21","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.brainres.2013.08.025","article-title":"Serum nicotinamide adenine dinucleotide levels through disease course in multiple sclerosis","volume":"1537","author":"Braidy","year":"2013","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.ibneur.2022.12.003_bib22","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/j.2040-4603.2019.tb00063.x","article-title":"Lymphatic vessel network structure and physiology","volume":"9","author":"Breslin","year":"2018","journal-title":"Compr. Physiol."},{"issue":"3","key":"10.1016\/j.ibneur.2022.12.003_bib23","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.trci.2017.05.001","article-title":"The effects of noncoding aquaporin-4 single-nucleotide polymorphisms on cognition and functional progression of Alzheimer\u2019s disease","volume":"3","author":"Burfeind","year":"2017","journal-title":"Alzheimers Dement (N.Y.)"},{"key":"10.1016\/j.ibneur.2022.12.003_bib24","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.3389\/fnins.2019.01125","article-title":"Generating brain waves, the power of astrocytes","volume":"13","author":"Buskila","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.ibneur.2022.12.003_bib25","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1523\/JNEUROSCI.4178-07.2008","article-title":"A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function","volume":"28","author":"Cahoy","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ibneur.2022.12.003_bib26","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.cmet.2016.05.006","article-title":"CD38 Dictates age-related NAD decline and mitochondrial dysfunction through an SIRT3-dependent mechanism","volume":"23","author":"Camacho-Pereira","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.ibneur.2022.12.003_bib27","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1520760112","article-title":"Human cerebral organoids recapitulate gene expression programs of fetal neocortex development","volume":"112","author":"Camp","year":"2015","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.ibneur.2022.12.003_bib28","doi-asserted-by":"crossref","first-page":"973e973","DOI":"10.1038\/s41467-019-08858-y","article-title":"Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson\u2019s disease pathogenesis","volume":"10","author":"Carballo-Carbajal","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ibneur.2022.12.003_bib29","article-title":"A clinical primer for the glymphatic system","author":"Carlstrom","year":"2021","journal-title":"Brain"},{"key":"10.1016\/j.ibneur.2022.12.003_bib30","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s00401-014-1330-y","article-title":"The role of microglia in human disease: therapeutic tool or target?","volume":"128","author":"Cartier","year":"2014","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.ibneur.2022.12.003_bib31","doi-asserted-by":"crossref","first-page":"4857","DOI":"10.1523\/JNEUROSCI.4989-14.2015","article-title":"Tau immunotherapy modulates both pathological tau and upstream amyloid pathology in an Alzheimer\u2019s disease mouse model","volume":"35","author":"Castillo-Carranza","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ibneur.2022.12.003_bib32","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.489","article-title":"Molecular analysis of axonal-intrinsic and glial-associated co-regulation of axon degeneration","volume":"8","author":"Catenaccio","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ibneur.2022.12.003_bib33","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1042\/bj20020604","article-title":"CD38-dependent ADP-ribosyl cyclase activity in developing and adult mouse brain","volume":"370","author":"Ceni","year":"2003","journal-title":"Biochem. J."},{"issue":"3","key":"10.1016\/j.ibneur.2022.12.003_bib34","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.neuron.2017.06.029","article-title":"Neural circuit-specialized astrocytes: transcriptomic, proteomic, morphological, and functional evidence","volume":"95","author":"Chai","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.ibneur.2022.12.003_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2020.06.007","article-title":"Aquaporin-4 polymorphisms predict amyloid burden and clinical outcome in the Alzheimer\u2019s disease spectrum","volume":"97","author":"Chandra","year":"2021","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ibneur.2022.12.003_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2019.104587","article-title":"Immunotherapy in Parkinson\u2019s disease: current status and future directions","volume":"132","author":"Chatterjee","year":"2019","journal-title":"Neurobiol. Dis."},{"issue":"1","key":"10.1016\/j.ibneur.2022.12.003_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41398-020-01137-1","article-title":"Plasma glial fibrillary acidic protein is elevated in cognitively normal older adults at risk of Alzheimer\u2019s disease","volume":"11","author":"Chatterjee","year":"2021","journal-title":"Transl. Psychiatry"},{"issue":"4","key":"10.1016\/j.ibneur.2022.12.003_bib38","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.exger.2008.12.004","article-title":"Agerelated changes in choroid plexus and blood-cerebrospinal fluid barrier function in the sheep","volume":"44","author":"Chen","year":"2009","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.ibneur.2022.12.003_bib39","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1742-2094-7-6","article-title":"SerumlevelsofS100BandNSEproteins in Alzheimer\u2019s disease patients","volume":"7","author":"Chaves","year":"2010","journal-title":"J. Neuroinflamm."},{"issue":"976","key":"10.1016\/j.ibneur.2022.12.003_bib40","first-page":"e19","article-title":"Spatial transcriptomics and in situ sequencing to study Alzheimer's disease","volume":"182","author":"Chen","year":"2020","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.ibneur.2022.12.003_bib41","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1038\/s41467-020-15119-w","article-title":"Microglia clear neuron-released a-synuclein via selective autophagy and prevent neurodegeneration","volume":"11","author":"Choi","year":"2020","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.ibneur.2022.12.003_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0055375","article-title":"Triggering of inflammasome by aggregated a-synuclein, an inflammatory response in synucleinopathies","volume":"8","author":"Codolo","year":"2013","journal-title":"PLoSOne"},{"key":"10.1016\/j.ibneur.2022.12.003_bib43","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.neulet.2014.01.014","article-title":"Astrogliosis as a therapeutic target for neurodegenerative diseases","volume":"565","author":"Colangelo","year":"2014","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ibneur.2022.12.003_bib44","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.biopsych.2010.08.025","article-title":"YKL-40: a novel prognostic fluid biomarker for preclinical Alzheimer\u2019s disease","volume":"68","author":"Craig-Schapiro","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ibneur.2022.12.003_bib45","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1111\/nan.12541","article-title":"Invited Review: long non-coding RNAs: important regulators in the development, function and disorders of the central nervous system","volume":"45","author":"Cuevas-Diaz Duran","year":"2019","journal-title":"Neuropathol. Appl. Neurobiol."},{"issue":"12","key":"10.1016\/j.ibneur.2022.12.003_bib46","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1007\/s12031-021-01836-4","article-title":"Decreased AQP4 expression aggravates \u0251-synuclein pathology in Parkinson\u2019s disease mice, possibly via impaired glymphatic clearance","volume":"71","author":"Cui","year":"2021","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.ibneur.2022.12.003_bib47","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1177\/1073858418809941","article-title":"Astrocytes: heterogeneous and dynamic phenotypes in neurodegeneration and innate immunity","volume":"no. 5","author":"Cunningham","year":"2019","journal-title":"Neuroscientist"},{"key":"10.1016\/j.ibneur.2022.12.003_bib48","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jphs.2021.03.006","article-title":"Microglial heterogeneity in aging and Alzheimer\u2019s disease: is sex relevant?","volume":"146","author":"Delage","year":"2021","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.ibneur.2022.12.003_bib49","doi-asserted-by":"crossref","first-page":"4259","DOI":"10.1007\/s00018-013-1352-y","article-title":"The role of inflammation in sporadic and familial Parkinson\u2019s disease","volume":"70","author":"Deleidi","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ibneur.2022.12.003_bib50","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0126423","article-title":"MicroRNA profiling of CSF reveals potential biomarkers to detect Alzheimer\u2018s disease","volume":"10","author":"Denk","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ibneur.2022.12.003_bib51","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.cell.2015.12.056","article-title":"The cellular phase of Alzheimer's disease","volume":"164","author":"De Strooper","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.ibneur.2022.12.003_bib52","first-page":"2","article-title":"Parkinson\u2019s disease and parkinsonism: neuropathology","author":"Dickson","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med"},{"issue":"10","key":"10.1016\/j.ibneur.2022.12.003_bib53","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0205276","article-title":"A control mechanism for intra-mural peri-arterial drainage via astrocytes: how neuronal activity could improve waste clearance from the brain","volume":"13","author":"Diem","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.ibneur.2022.12.003_bib54","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s12931-014-0107-0","article-title":"MicroRNA-708 regulates CD38 expression through signaling pathways JNK MAP kinase and PTEN\/AKT in human airway smooth muscle cells","volume":"15","author":"Dileepan","year":"2014","journal-title":"Respir. Res."},{"key":"10.1016\/j.ibneur.2022.12.003_bib55","doi-asserted-by":"crossref","first-page":"41008","DOI":"10.1038\/srep41008","article-title":"The systematic analysis of coding and long non-coding RNAs in the sub-chronic and chronic stages of spinal cord injury","volume":"7","author":"Duran","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ibneur.2022.12.003_bib56","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.3390\/cells10051138","article-title":"Microglia in aging and Alzheimer\u2019s disease: a comparative species review","volume":"10","author":"Edler","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.ibneur.2022.12.003_bib57","doi-asserted-by":"crossref","first-page":"12885","DOI":"10.1073\/pnas.0812530106","article-title":"IL-9 induces di\u2002erentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells","volume":"106","author":"Elyaman","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ibneur.2022.12.003_bib58","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00281-016-0604-y","article-title":"Th9 cells in the pathogenesis of EAE and multiple sclerosis","volume":"39","author":"Elyaman","year":"2017","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.ibneur.2022.12.003_bib59","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/s41593-020-00783-4","article-title":"Reactive astrocyte nomenclature, definitions, and future directions","volume":"24","author":"Escartin","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ibneur.2022.12.003_bib60","doi-asserted-by":"crossref","DOI":"10.1186\/s12881-018-0547-3","article-title":"S100B polymorphisms are associated with age of onset of Parkinson\u2019s disease","author":"Fardell","year":"2018","journal-title":"BMC Med. Genet."},{"issue":"2","key":"10.1016\/j.ibneur.2022.12.003_bib61","doi-asserted-by":"crossref","first-page":"109e124","DOI":"10.1016\/j.pneurobio.2005.02.001","article-title":"Neuromelanin in human dopamine neurons: comparison with peripheral melanins and relevance to Parkinson\u2019s disease","volume":"75","author":"Fedorow","year":"2005","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.ibneur.2022.12.003_bib62","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1471-4159.2008.05830.x","article-title":"Communication between neurons and astrocytes: relevance to the modulation of synaptic and network activity","volume":"108","author":"Fellin","year":"2009","journal-title":"J. Neurochem"},{"key":"10.1016\/j.ibneur.2022.12.003_bib63","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1146\/annurev.pharmtox.011008.145602","article-title":"Sorting out astrocyte physiology from pharmacology","volume":"49","author":"Fiacco","year":"2009","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"12","key":"10.1016\/j.ibneur.2022.12.003_bib64","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0052664","article-title":"Cerebrospinal fluid pressure decreases with older age","volume":"7","author":"Fleischman","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ibneur.2022.12.003_bib65","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s12031-019-01364-2","article-title":"Long non-coding RNA BACE1-AS may serve as an Alzheimer's disease blood-based biomarker","volume":"69","author":"Fotuhi","year":"2019","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.ibneur.2022.12.003_bib66","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000050753","article-title":"The cerebrospinal fluid level of glial fibrillary acidic protein is increased in cerebrospinal fluid from Alzheimer\u2019s disease patients and correlates with severity of dementia","volume":"46","author":"Fukuyama","year":"2001","journal-title":"Eur. Neurol."},{"key":"10.1016\/j.ibneur.2022.12.003_bib67","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3233\/JAD-2007-12206","article-title":"Cajal's contributions to the study of Alzheimer's disease","volume":"12","author":"Garcia-Marin","year":"2007","journal-title":"J. Alzheimers Dis."},{"issue":"1","key":"10.1016\/j.ibneur.2022.12.003_bib68","first-page":"88","article-title":"Global, regional, and national burden of Alzheimer\u2019s disease and other dementias, 1990\u20132016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"18","author":"GBD","year":"2016","journal-title":"Lancet Neurol."},{"issue":"5","key":"10.1016\/j.ibneur.2022.12.003_bib69","doi-asserted-by":"crossref","first-page":"686e689","DOI":"10.1212\/01.WNL.0000078192.95645.E6","article-title":"[11C](R)-PK11195 PET imaging of microglial activation in multiple system atrophy","volume":"61","author":"Gerhard","year":"2003","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.ibneur.2022.12.003_bib70","doi-asserted-by":"crossref","first-page":"404e412","DOI":"10.1016\/j.nbd.2005.08.002","article-title":"In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson\u2019s disease","volume":"21","author":"Gerhard","year":"2006","journal-title":"Neurobiol. Dis."},{"issue":"2","key":"10.1016\/j.ibneur.2022.12.003_bib71","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3390\/cells9020471","article-title":"CD38 in neurodegeneration and neuroinflammation","volume":"9","author":"Guerreiro","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.ibneur.2022.12.003_bib72","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/s41593-019-0350-2","article-title":"Cerebral organoids at the air\u2013liquid interface generate diverse nerve tracts with functional output","volume":"22","author":"Giandomenico","year":"2019","journal-title":"Nat. Neurosci."},{"issue":"9","key":"10.1016\/j.ibneur.2022.12.003_bib73","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.3390\/ijms17091411","article-title":"Aquaporin- 4 in astroglial cells in the CNS and supporting cells of sensory organs-a comparative perspective","volume":"17","author":"Gleiser","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.ibneur.2022.12.003_bib74","doi-asserted-by":"crossref","first-page":"266e278","DOI":"10.1093\/brain\/aww230","article-title":"Like prions: the propagation of aggregated tau and alpha-synuclein in neurodegeneration","volume":"140","author":"Goedert","year":"2017","journal-title":"Brain"},{"key":"10.1016\/j.ibneur.2022.12.003_bib75","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.2174\/092986708785909111","article-title":"Hyperphosphorylation of microtubule-associated protein tau: a promising therapeutic target for Alzheimer disease","volume":"15","author":"Gong","year":"2008","journal-title":"Curr. Med Chem."},{"issue":"465","key":"10.1016\/j.ibneur.2022.12.003_bib76","doi-asserted-by":"crossref","first-page":"eaah4066","DOI":"10.1126\/scitranslmed.aah4066","article-title":"Inflammasome inhibition prevents a-synuclein pathology and dopaminergic neurodegeneration in mice","volume":"10","author":"Gordon","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ibneur.2022.12.003_bib77","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1002\/mds.20820","article-title":"Translated mutation in the Nurr1 gene as a cause for Parkinson\u2019s disease","volume":"21","author":"Grimes","year":"2006","journal-title":"Mov. Disord."},{"key":"10.1016\/j.ibneur.2022.12.003_bib78","first-page":"25938","article-title":"CD73 Protein as a Source of Extracellular Precursors for Sustained NAD + Biosynthesis in FK866-treated","volume":"288","author":"Grozio","year":"2013","journal-title":"Tumor Cells J. Biol. Chem."},{"key":"10.1016\/j.ibneur.2022.12.003_bib79","doi-asserted-by":"crossref","first-page":"3798","DOI":"10.1016\/j.febslet.2011.08.033","article-title":"Role of Microglia in CNS Inflammation","volume":"585","author":"Graeber","year":"2011","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ibneur.2022.12.003_bib80","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1038\/s41593-019-0539-4","article-title":"A single-cell atlas of entorhinal cortex from individuals with Alzheimer's disease reveals cell-type-specific gene expression regulation","volume":"22","author":"Grubman","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ibneur.2022.12.003_bib81","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/1742-2094-10-124","article-title":"The plasminogen activator system: Involvement in central nervous system inflammation and a potential site for therapeutic intervention","volume":"10","author":"Gur-Wahnon","year":"2013","journal-title":"J. Neuroinflamm."},{"issue":"37","key":"10.1016\/j.ibneur.2022.12.003_bib82","doi-asserted-by":"crossref","first-page":"7698","DOI":"10.1523\/JNEUROSCI.0619-21.2021","article-title":"The glymphatic system: a novel component of fundamental neurobiology","volume":"41","author":"Hablitz","year":"2021","journal-title":"J. Neurosci."},{"issue":"20","key":"10.1016\/j.ibneur.2022.12.003_bib83","doi-asserted-by":"crossref","first-page":"R1371","DOI":"10.1016\/j.cub.2021.08.026","article-title":"The glymphatic system","volume":"31","author":"Hablitz","year":"2021","journal-title":"Curr. Biol."},{"issue":"11","key":"10.1016\/j.ibneur.2022.12.003_bib84","doi-asserted-by":"crossref","DOI":"10.1080\/15548627.2019.1596481","article-title":"Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease","volume":"15","author":"Han","year":"2019","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.ibneur.2022.12.003_bib85","doi-asserted-by":"crossref","first-page":"85e85","DOI":"10.1186\/s40478-017-0494-9","article-title":"alpha-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration","volume":"5","author":"Harms","year":"2017","journal-title":"Acta Neuropathol. Commun."},{"issue":"8","key":"10.1016\/j.ibneur.2022.12.003_bib86","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1093\/brain\/awaa179","article-title":"Impaired glymphatic function and clearance of tau in an Alzheimer\u2019s disease model","volume":"143","author":"Harrison","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.ibneur.2022.12.003_bib87","doi-asserted-by":"crossref","first-page":"5818","DOI":"10.3390\/ijms22115818","article-title":"Microglia in neurodegenerative events-an initiator or a significant other?","volume":"22","author":"Harry","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ibneur.2022.12.003_bib88","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.bbi.2011.11.006","article-title":"Age related changes in microglial phenotype vary between CNS regions: grey versus white matter differences","volume":"26","author":"Hart","year":"2012","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ibneur.2022.12.003_bib89","doi-asserted-by":"crossref","DOI":"10.1177\/09636897221105499","article-title":"Therapeutic potential of astrocyte transplantation","volume":"31","author":"Hastings","year":"2022","journal-title":"Cell Transplant."},{"key":"10.1016\/j.ibneur.2022.12.003_bib90","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nature18928","article-title":"Transfer of mitochondria from astrocytes to neurons after stroke","volume":"535","author":"Hayakawa","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.ibneur.2022.12.003_bib91","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1152\/physrev.00011.2010","article-title":"Physiology of Microglia","volume":"91","author":"Helmut","year":"2011","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ibneur.2022.12.003_bib92","first-page":"1211","article-title":"Identification of gene expression patterns crucially involved in experimental autoimmune encephalomyelitis and multiple sclerosis","volume":"9","author":"Herrmann","year":"2016","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.ibneur.2022.12.003_bib93","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1146\/annurev-pathol-012615-044216","article-title":"Dendritic spine pathology in neurodegenerative diseases","volume":"11","author":"Herms","year":"2016","journal-title":"Annu Rev. Pathol."},{"issue":"6180","key":"10.1016\/j.ibneur.2022.12.003_bib94","doi-asserted-by":"crossref","first-page":"345e348","DOI":"10.1038\/334345a0","article-title":"Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease","volume":"334","author":"Hirsch","year":"1988","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.ibneur.2022.12.003_bib95","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41582-019-0244-7","article-title":"Ageing as a risk factor for neurodegenerative disease","volume":"15","author":"Hou","year":"2019","journal-title":"Nat. Rev. Neurol."},{"issue":"3","key":"10.1016\/j.ibneur.2022.12.003_bib96","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1159\/000481853","article-title":"Cerebrospinal fluid S100B and Alzheimer\u2019s disease biomarkers in hip fracture patients with delirium","volume":"7","author":"Hov","year":"2017","journal-title":"Dement. Geriatr. Cogn. Disord. Extra"},{"key":"10.1016\/j.ibneur.2022.12.003_bib97","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/humu.20676","article-title":"Gaucher disease: Mutation and polymorphism spectrum in the glucocerebrosidase gene (GBA)","volume":"29","author":"Hruska","year":"2008","journal-title":"Hum. Mutat."},{"issue":"992","key":"10.1016\/j.ibneur.2022.12.003_bib98","first-page":"e9","article-title":"Region-specific transcriptional control of astrocyte function oversees local circuit activities","volume":"106","author":"Huang","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.ibneur.2022.12.003_bib99","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s00401-004-0919-y","article-title":"Cytokine production of activated microglia and decrease in neurotrophic factors of neurons in the hippocampus of Lewy body disease brains","volume":"109","author":"Imamura","year":"2005","journal-title":"Acta Neuropathol."},{"issue":"1","key":"10.1016\/j.ibneur.2022.12.003_bib100","doi-asserted-by":"crossref","first-page":"47e52","DOI":"10.1016\/j.parkreldis.2012.07.002","article-title":"In vivo microglia activation in very early dementia with Lewy bodies, comparison with Parkinson\u2019s disease","volume":"19","author":"Iannaccone","year":"2013","journal-title":"Park. Relat. Disord."},{"issue":"147","key":"10.1016\/j.ibneur.2022.12.003_bib101","first-page":"147ra11","article-title":"A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta","volume":"4","author":"I liff","year":"2012","journal-title":"Sci. Transl. Med"},{"issue":"6 Suppl 1","key":"10.1016\/j.ibneur.2022.12.003_bib102","first-page":"S93","article-title":"Is there a cerebral lymphatic system?","volume":"44","author":"Iliff","year":"2013","journal-title":"Stroke"},{"issue":"46","key":"10.1016\/j.ibneur.2022.12.003_bib103","doi-asserted-by":"crossref","first-page":"18190","DOI":"10.1523\/JNEUROSCI.1592-13.2013","article-title":"Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain","volume":"33","author":"Iliff","year":"2013","journal-title":"J. Neurosci."},{"issue":"49","key":"10.1016\/j.ibneur.2022.12.003_bib104","doi-asserted-by":"crossref","first-page":"16180","DOI":"10.1523\/JNEUROSCI.3020-14.2014","article-title":"Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury","volume":"34","author":"Iliff","year":"2014","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.ibneur.2022.12.003_bib105","doi-asserted-by":"crossref","first-page":"518e526","DOI":"10.1007\/s00401-003-0766-2","article-title":"Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson\u2019s disease brains","volume":"106","author":"Imamura","year":"2003","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.ibneur.2022.12.003_bib106","doi-asserted-by":"crossref","first-page":"735","DOI":"10.3389\/fnins.2019.00735","article-title":"Targeting the synapse in Alzheimer\u2019s disease","volume":"13","author":"Jackson","year":"2019","journal-title":"Front Neurosci."},{"issue":"12","key":"10.1016\/j.ibneur.2022.12.003_bib107","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1007\/s11064-015-1581-6","article-title":"The glymphatic system: a Beginner\u2019s guide","volume":"40","author":"Jessen","year":"2015","journal-title":"Neurochem Res"},{"key":"10.1016\/j.ibneur.2022.12.003_bib108","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1159\/000113679","article-title":"Neuropathological aspects of Alzheimer disease, Parkinson disease and frontotemporal dementia","volume":"5","author":"Jellinger","year":"2008","journal-title":"Neurodegener. Dis."},{"key":"10.1016\/j.ibneur.2022.12.003_bib109","first-page":"12","article-title":"Isobavachalcone attenuates MPTP-induced Parkinson\u2019s disease in mice by inhibition of microglial activation through NF-\u2002B pathway","author":"Jing","year":"2017","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ibneur.2022.12.003_bib110","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/nn.4493","article-title":"Identification of diverse astrocyte populations and their malignant analogs","volume":"20","author":"John Lin","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ibneur.2022.12.003_bib111","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1111\/j.1468-1331.2006.01640.x","article-title":"PECAM-1, a key player in neuroinflammation","volume":"13","author":"Kalinowska","year":"2006","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.ibneur.2022.12.003_bib112","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.cellimm.2018.02.011","article-title":"Interleukin-1,interleukin-1 receptor antagonist, interleukin-6, interleukin-10, and tumor necrosis factor- levels in CSF and serum in relation to the clinical diversity of Parkinson\u2019s disease","volume":"327","author":"Karpenko","year":"2018","journal-title":"Cell. Immunol."},{"issue":"3","key":"10.1016\/j.ibneur.2022.12.003_bib113","doi-asserted-by":"crossref","first-page":"1080e1089","DOI":"10.1111\/j.1471-4159.1992.tb08350.x","article-title":"Is the vulnerability of neurons in the substantia nigra of patients with Parkinson\u2019s disease related to their neuromelanin content?","volume":"59","author":"Kastner","year":"1992","journal-title":"J. Neurochem"},{"key":"10.1016\/j.ibneur.2022.12.003_bib114","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1152\/physrev.00011.2010","article-title":"Physiology of microglia","volume":"91","author":"Kettenmann","year":"2011","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ibneur.2022.12.003_bib115","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1146\/annurev-neuro-070918-050443","article-title":"The emerging nature of astrocyte diversity","volume":"42","author":"Khakh","year":"2019","journal-title":"Annu Rev. Neurosci."},{"key":"10.1016\/j.ibneur.2022.12.003_bib116","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.brainres.2005.08.029","article-title":"Anti-inflammatory Mechanism is Involved in Ethyl Pyruvate-Mediated Efficacious Neuroprotection in the Postischemic Brain","volume":"1060","author":"Kim","year":"2005","journal-title":"Brain Res"},{"issue":"1","key":"10.1016\/j.ibneur.2022.12.003_bib117","doi-asserted-by":"crossref","first-page":"179e187","DOI":"10.1096\/fj.06-5865com","article-title":"A pivotal role of matrix metalloproteinase-3 activity in dopaminergic neuronal degeneration via microglial activation","volume":"21","author":"Kim","year":"2007","journal-title":"FASEB J."},{"key":"10.1016\/j.ibneur.2022.12.003_bib118","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1038\/ncomms2534","article-title":"Neuron-released oligomeric a-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia","volume":"4","author":"Kim","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ibneur.2022.12.003_bib119","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13041-016-0195-5","article-title":"Impaired learning and memory in CD38 null mutant mice","volume":"9","author":"Kim","year":"2016","journal-title":"Mol. Brain"},{"key":"10.1016\/j.ibneur.2022.12.003_bib120","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/3851262","article-title":"Distinct pattern of microgliosis in the olfactory bulb of neurodegenerative proteinopathies","volume":"2017","author":"Kohl","year":"2017","journal-title":"Neural Plast."},{"key":"10.1016\/j.ibneur.2022.12.003_bib121","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1002\/jnr.22060","article-title":"CD38 regulation in activated astrocytes: Implications for neuroinflammation and HIV-1 brain infection","volume":"87","author":"Kou","year":"2009","journal-title":"J. Neurosci. Res."},{"issue":"6","key":"10.1016\/j.ibneur.2022.12.003_bib122","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1002\/ana.24271","article-title":"Impairment of paravascular clearance pathways in the aging brain","volume":"76","author":"Kress","year":"2014","journal-title":"Ann. Neurol."},{"issue":"7","key":"10.1016\/j.ibneur.2022.12.003_bib123","doi-asserted-by":"crossref","first-page":"1649e1658","DOI":"10.1523\/JNEUROSCI.5205-07.2008","article-title":"Nuclear factor-kappaB activation and postischemic inflammation are suppressed in CD36-null mice after middle cerebral artery occlusion","volume":"28","author":"Kunz","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ibneur.2022.12.003_bib124","doi-asserted-by":"crossref","first-page":"137e161","DOI":"10.1146\/annurev-cellbio-101011-155745","article-title":"Inflammasomes and their roles in health and disease","volume":"28","author":"Lamkanfi","year":"2012","journal-title":"Annu Rev. Cell Dev. Biol."},{"key":"10.1016\/j.ibneur.2022.12.003_bib125","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.cmet.2019.09.001","article-title":"NAD+ in brain aging and neurodegenerative disorders","volume":"30","author":"Lautrup","year":"2019","journal-title":"Cell Metab."},{"issue":"10","key":"10.1016\/j.ibneur.2022.12.003_bib126","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0025968","article-title":"Human Glial-restricted progenitor transplantation into cervical spinal cord of the SOD1 G93A mouse model of ALS","volume":"6","author":"Lepore","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ibneur.2022.12.003_bib127","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.ibneur.2022.12.003_bib128","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.neuint.2012.08.001","article-title":"CCL28 in the mouse hippocampal CA1 area and the dentate gyrus during and after pilocarpine-induced status epilepticus","volume":"61","author":"Liu","year":"2012","journal-title":"Neurochem. Int."},{"issue":"1","key":"10.1016\/j.ibneur.2022.12.003_bib129","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13024-017-0226-4","article-title":"YKL-40 in the brain and cerebrospinal fluid of neurodegenerative dementias","volume":"12","author":"Llorens","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.ibneur.2022.12.003_bib130","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.bbrc.2012.01.084","article-title":"CD38 is a key enzyme for the survival of mouse microglial BV2 cells","volume":"418","author":"Ma","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ibneur.2022.12.003_bib131","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1152\/physrev.00035.2007","article-title":"Evolution and function of the ADP Ribosyl Cyclase\/CD38 gene family in physiology and pathology","volume":"88","author":"Malavasi","year":"2008","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ibneur.2022.12.003_bib132","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/1742-2094-8-145","article-title":"HIV-1 and IL-1\u2002regulate astrocytic CD38 through mitogen-activated protein kinases and nuclear factor-\u2002B signaling mechanisms","volume":"8","author":"Mamik","year":"2011","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.ibneur.2022.12.003_bib133","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1007\/s00401-014-1256-4","article-title":"Next-generation active immunization approach for synucleinopathies: implications for Parkinson\u2019s disease clinical trials","volume":"127","author":"Mandler","year":"2014","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.ibneur.2022.12.003_bib134","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/nbt.4127","article-title":"An in vivo model of functional and vascularized human brain organoids","volume":"36","author":"Mansour","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ibneur.2022.12.003_bib135","unstructured":"Marschallinger, J.; Iram, T.; Zardeneta, M.; Lee, S.E.; Lehallier, B.; Haney, M.S.; Pluvinage, J.V.; Mathur, V.; Hahn, O.;"},{"key":"10.1016\/j.ibneur.2022.12.003_bib136","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1002\/glia.20990","article-title":"The perivascular astroglial sheath provides a complete covering of the brain microvessels: an electron microscopic 3D reconstruction","volume":"58","author":"Mathiisen","year":"2010","journal-title":"Glia"},{"key":"10.1016\/j.ibneur.2022.12.003_bib137","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3389\/fnagi.2019.00059","article-title":"Astrocyte heterogeneity: Input to brain aging and disease","volume":"11","author":"Mathias","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.ibneur.2022.12.003_bib138","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/s41586-019-1195-2","article-title":"Single-cell transcriptomic analysis of Alzheimer's disease","volume":"570","author":"Mathys","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.ibneur.2022.12.003_bib139","doi-asserted-by":"crossref","first-page":"92","DOI":"10.4049\/jimmunol.181.1.92","article-title":"Dual Role of CD38 in microglial activation and activation-induced cell death","volume":"181","author":"Mayo","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.ibneur.2022.12.003_bib140","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cell.2011.06.001","article-title":"Gaucher disease glucocerebrosidase and alpha-synuclein form a bidirectional pathogenic loop in synucleinopathies","volume":"146","author":"Mazzulli","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.ibneur.2022.12.003_bib141","doi-asserted-by":"crossref","first-page":"9365","DOI":"10.1523\/JNEUROSCI.1504-06.2006","article-title":"Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson\u2019s disease","volume":"26","author":"McCoy","year":"2006","journal-title":"J. Neurosci. O. J. Soc. Neurosci."},{"key":"10.1016\/j.ibneur.2022.12.003_bib142","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1196\/annals.1332.007","article-title":"Inflammation and the degenerative diseases of aging","volume":"1035","author":"McGeer","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"12","key":"10.1016\/j.ibneur.2022.12.003_bib143","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1212\/01.wnl.0000187889.17253.b1","article-title":"Diagnosis and management of dementia with Lewy bodies","volume":"65","author":"McKeith","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.ibneur.2022.12.003_bib144","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0165-5728(94)00180-V","article-title":"Serum anti-GFAP and anti-S100 autoantibodies in brain aging, Alzheimer\u2019s disease and vascular dementia","volume":"57","author":"Mecocci","year":"1995","journal-title":"J. Neuroimmunol."},{"issue":"10","key":"10.1016\/j.ibneur.2022.12.003_bib145","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3390\/biomedicines8100394","article-title":"Astrocytes: news about brain health and diseases","volume":"8","author":"Meldolesi","year":"2020","journal-title":"Biomedicines"},{"key":"10.1016\/j.ibneur.2022.12.003_bib146","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.40070","article-title":"Aquaporin- 4-dependent glymphatic solute transport in the rodent brain","volume":"7","author":"Mestre","year":"2018","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.ibneur.2022.12.003_bib147","doi-asserted-by":"crossref","first-page":"4878","DOI":"10.1038\/s41467-018-07318-3","article-title":"Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension","volume":"9","author":"Mestre","year":"2018","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.ibneur.2022.12.003_bib148","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.tins.2020.04.003","article-title":"The brain\u2019s glymphatic system: current controversies","volume":"43","author":"Mestre","year":"2020","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ibneur.2022.12.003_bib149","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3325\/cmj.2019.60.87","article-title":"Therapies for multiple sclerosis targeting B cells","volume":"60","author":"Milo","year":"2019","journal-title":"Croat. Med. J."},{"key":"10.1016\/j.ibneur.2022.12.003_bib150","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0006-8993(95)00885-T","article-title":"Neuronal localization of CD38 antigen in the human brain","volume":"697","author":"Mizuguchi","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.ibneur.2022.12.003_bib151","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.intimp.2017.08.012","article-title":"CCL28 chemokine: an anchoring point bridging innate and adaptive immunity","volume":"51","author":"Mohan","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ibneur.2022.12.003_bib152","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.parkreldis.2014.01.011","article-title":"CSF -synuclein and UCH-L1 levels in Parkinson\u2019s disease and atypical parkinsonian disorders","volume":"20","author":"Mondello","year":"2014","journal-title":"Park. Relat. Disord."},{"issue":"6","key":"10.1016\/j.ibneur.2022.12.003_bib153","doi-asserted-by":"crossref","first-page":"569e576","DOI":"10.1002\/gps.4039","article-title":"Clinical presentation and differential diagnosis of dementia with Lewy bodies: a review","volume":"29","author":"Morra","year":"2014","journal-title":"Int J. Geriatr. Psychiatr."},{"issue":"5","key":"10.1016\/j.ibneur.2022.12.003_bib154","doi-asserted-by":"crossref","first-page":"559e566","DOI":"10.1007\/s00234-013-1138-9","article-title":"Discrimination of dementia with Lewy bodies from Alzheimer\u2019s disease using voxel-based morphometry of white matter by statistical parametric mapping plus diffeomorphic anatomic registration through exponentiated Liealgebra","volume":"55","author":"Nakatsuka","year":"2013","journal-title":"Neuroradiology"},{"issue":"6512","key":"10.1016\/j.ibneur.2022.12.003_bib155","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1126\/science.abb8739","article-title":"Glymphatic failure as a final common pathway to dementia","volume":"370","author":"Nedergaard","year":"2020","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.ibneur.2022.12.003_bib156","doi-asserted-by":"crossref","first-page":"380","DOI":"10.4252\/wjsc.v7.i2.380","article-title":"Transplantation of stem cell-derived astrocytes for the treatment of amyotrophic lateral sclerosis and spinal cord injury","volume":"7","author":"Nicaise","year":"2015","journal-title":"World J. Stem Cells"},{"key":"10.1016\/j.ibneur.2022.12.003_bib157","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S1474-4422(16)00070-3","article-title":"CSF and blood biomarkers for the diagnosis of Alzheimer\u2019s disease: a systematic review and meta-analysis","volume":"15","author":"Olsson","year":"2016","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ibneur.2022.12.003_bib158","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s40478-018-0636-8","article-title":"Forced turnover of aged microglia induces an intermediate phenotype but does not rebalance CNS environmental cues driving priming to immune challenge","volume":"6","author":"O\u2019Neil","year":"2018","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.ibneur.2022.12.003_bib159","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3389\/fphys.2014.00193","article-title":"Hemichannels: new roles in astroglial function","volume":"5","author":"Orellana","year":"2014","journal-title":"Front Physiol."},{"key":"10.1016\/j.ibneur.2022.12.003_bib160","first-page":"558","article-title":"Immunoreactivity in Alzheimer\u2019s neurofibrillary tangles (abstract)","volume":"4","author":"Otsuka","year":"1994","journal-title":"Brain Pathol."},{"issue":"2","key":"10.1016\/j.ibneur.2022.12.003_bib161","doi-asserted-by":"crossref","first-page":"168e175","DOI":"10.1002\/ana.20338","article-title":"Microglial activation and dopamine terminal loss in early Parkinson\u2019s disease","volume":"57","author":"Ouchi","year":"2005","journal-title":"Ann. Neurol."},{"issue":"7","key":"10.1016\/j.ibneur.2022.12.003_bib162","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/nn.2583","article-title":"Amyloid-beta-induced neuronal dysfunction in Alzheimer\u2019s disease: from synapses toward neural networks","volume":"13","author":"Palop","year":"2010","journal-title":"Nat. Neurosci."},{"issue":"1","key":"10.1016\/j.ibneur.2022.12.003_bib163","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s40478-021-01180-z","article-title":"Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer\u2019s disease","volume":"9","author":"Park","year":"2021","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.ibneur.2022.12.003_bib164","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1002\/mds.25772","article-title":"Cerebrospinal fluid lysosomal enzymes and alpha-synuclein in Parkinson\u2019s disease","volume":"29","author":"Parnetti","year":"2014","journal-title":"Mov. Disord."},{"key":"10.1016\/j.ibneur.2022.12.003_bib165","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1152\/physrev.00041.2013","article-title":"Astrocyte reactivity and reactive astrogliosis: costs and benefits","volume":"94","author":"Pekny","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ibneur.2022.12.003_bib166","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00401-015-1513-1","article-title":"Astrocytes: a central element in neurological diseases","volume":"131","author":"Pekny","year":"2016","journal-title":"Acta Neuropathol."},{"issue":"Pt B","key":"10.1016\/j.ibneur.2022.12.003_bib167","first-page":"209e218","article-title":"Distinct alpha-Synuclein strains and implications for heterogeneity among alpha-Synucleinopathies","volume":"109","author":"Peng","year":"2018","journal-title":"Neurobiol. Dis."},{"issue":"11","key":"10.1016\/j.ibneur.2022.12.003_bib168","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1093\/brain\/awab223","article-title":"Plasma GFAP is an early marker of amyloid-\u03b2 but not tau pathology in Alzheimer\u2019s disease","volume":"144","author":"Pereira","year":"2021","journal-title":"Brain"},{"key":"10.1016\/j.ibneur.2022.12.003_bib169","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/glia.440070111","article-title":"Altered antigen expression of microglia in the aged rodent CNS","volume":"7","author":"Perry","year":"1993","journal-title":"Glia"},{"key":"10.1016\/j.ibneur.2022.12.003_bib170","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1001\/jamaneurol.2018.0605","article-title":"Anti\u2013tumor necrosis factor therapy and incidence of Parkinson disease among patients with inflammatory Bowel disease","volume":"75","author":"Peter","year":"2018","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.ibneur.2022.12.003_bib171","doi-asserted-by":"crossref","first-page":"504","DOI":"10.3390\/jcm9020504","article-title":"Mitochondrial signatures in circulating extracellular vesicles of older adults with Parkinson\u2019s disease: results from the exosomes in Parkinson\u2019s disease (EXPAND) study","volume":"9","author":"Picca","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.ibneur.2022.12.003_bib172","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1146\/annurev-pathol-051217-111018","article-title":"The glymphatic system in central nervous system health and disease: past, present, and future","volume":"13","author":"Plog","year":"2018","journal-title":"Annu Rev. Pathol."},{"key":"10.1016\/j.ibneur.2022.12.003_bib173","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00228-018-2561-y","article-title":"Non-steroidal anti-inflammatory drugs and risk of Parkinson\u2019s disease in the elderly population: a meta-analysis","volume":"75","author":"Poly","year":"2019","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.ibneur.2022.12.003_bib174","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s12974-017-0893-7","article-title":"YKL-40 (chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer\u2019s disease and other tauopathies","volume":"14","author":"Querol-Vilaseca","year":"2017","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.ibneur.2022.12.003_bib175","doi-asserted-by":"crossref","first-page":"418","DOI":"10.3389\/fphar.2018.00418","article-title":"Microglia P2Y(13) receptors prevent astrocyte proliferation mediated by P2Y(1) receptors","volume":"9","author":"Quintas","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ibneur.2022.12.003_bib176","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/s41467-019-08503-8","article-title":"Oxytocin pathway gene networks in the human brain","volume":"10","author":"Quintana","year":"2019","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.ibneur.2022.12.003_bib177","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41398-018-0094-x","article-title":"Genetic variation in Aquaporin-4 moderates the relationship between sleep and brain A\u03b2-amyloid burden","volume":"8","author":"Rainey-Smith","year":"2018","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.ibneur.2022.12.003_bib178","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1152\/physrev.00031.2020","article-title":"Fluid transport in the brain","volume":"102","author":"Rasmussen","year":"2021","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ibneur.2022.12.003_bib179","first-page":"11","article-title":"Non-steroidal anti-inflammatory drugs as disease-modifying agents for Parkinson\u2019s disease: evidence from observational studies","author":"Rees","year":"2011","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.ibneur.2022.12.003_bib180","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1002\/mds.26054","article-title":"Movement Disorder Society-endorsed PSP study group. The phenotypic spectrum of progressive supranuclear palsy: a retrospective multicenter study of 100 definite cases","volume":"29","author":"Respondek","year":"2014","journal-title":"Mov. Disord."},{"key":"10.1016\/j.ibneur.2022.12.003_bib181","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3389\/fncel.2019.00258","article-title":"Deletion of CD38 suppresses glial activation and neuroinflammation in a mouse model of demyelination","volume":"13","author":"Roboon","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.ibneur.2022.12.003_bib182","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.3390\/cells9071717","article-title":"Microglia: agents of the CNS pro-inflammatory response","volume":"9","author":"Rodr\u00edguez-G\u00f3mez","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.ibneur.2022.12.003_bib183","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1093\/hmg\/ddq497","article-title":"Genome-wide association study confirms BST1 and suggests a locus on 12q24 as the risk loci for Parkinson\u2019s disease in the European population","volume":"20","author":"Saad","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ibneur.2022.12.003_bib184","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nri3086","article-title":"Microglial cell origin and phenotypes in health and disease","volume":"11","author":"Saijo","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ibneur.2022.12.003_bib185","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1460-9568.2011.07738.x","article-title":"Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype","volume":"34","author":"Salminen","year":"2011","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ibneur.2022.12.003_bib186","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/nm.4397","article-title":"Microglia emerge as central players in brain disease","volume":"23","author":"Salter","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.ibneur.2022.12.003_bib187","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1097\/NEN.0b013e31829768d2","article-title":"Synuclein vaccination prevents the accumulation of Parkinson disease like pathologic inclusions in striatum in association with regulatory T Cell recruitment in a rat model","volume":"72","author":"Sanchez-Guajardo","year":"2013","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.ibneur.2022.12.003_bib188","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12883-020-1608-8","article-title":"Inflammation biomarker discovery in Parkinson\u2019s disease and atypical parkinsonisms","author":"Santaella","year":"2020","journal-title":"BMC Neurol."},{"key":"10.1016\/j.ibneur.2022.12.003_bib189","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.brainresbull.2017.01.014","article-title":"Carnosine modulates glutamine synthetase expression in senescent astrocytes exposed to oxygen-glucose deprivation\/recovery","volume":"130","author":"Shi","year":"2017","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.ibneur.2022.12.003_bib190","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.ymgme.2004.11.007","article-title":"Gaucher disease and parkinsonism","volume":"84","author":"Sidransky","year":"2005","journal-title":"Mol. Genet. Metab."},{"issue":"5","key":"10.1016\/j.ibneur.2022.12.003_bib191","doi-asserted-by":"crossref","first-page":"563e579","DOI":"10.1111\/j.1755-148X.2009.00610.x","article-title":"Current challenges in understanding melanogenesis: bridging chemistry, biological control, morphology, and function","volume":"22","author":"Simon","year":"2009","journal-title":"Pigment Cell Melanoma Res."},{"key":"10.1016\/j.ibneur.2022.12.003_bib192","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.neurobiolaging.2008.05.015","article-title":"Astrocyte phenotype in relation to alzheimer-type pathology in the ageing brain","volume":"31","author":"Simpson","year":"2010","journal-title":"Neurobiol. Aging"},{"issue":"6","key":"10.1016\/j.ibneur.2022.12.003_bib193","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1007\/s00221-017-4928-1","article-title":"\"Astrocytes and synaptic plasticity in health and disease.\"","volume":"235","author":"Singh","year":"2017","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.ibneur.2022.12.003_bib194","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.27679","article-title":"Test of the \u201cglymphatic\u201d hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma","volume":"6","author":"Smith","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.ibneur.2022.12.003_bib195","article-title":"Astrogliosis","volume":"7","author":"Sofroniew","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.ibneur.2022.12.003_bib196","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1177\/1073858413504466","article-title":"Multiple roles for astrocytes as effectors of cytokines and inflammatory mediators","volume":"20","author":"Sofroniew","year":"2014","journal-title":"Neuroscientist"},{"key":"10.1016\/j.ibneur.2022.12.003_bib197","doi-asserted-by":"crossref","first-page":"14038","DOI":"10.1038\/s41598-017-14420-x","article-title":"Late-onset Alzheimer\u2019s disease is associated with inherent changes in bioenergetics profiles","volume":"7","author":"Sonntag","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ibneur.2022.12.003_bib198","doi-asserted-by":"crossref","first-page":"16e27","DOI":"10.1111\/j.1749-6632.2000.tb06900.x","article-title":"The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy","volume":"920","author":"Spillantini","year":"2000","journal-title":"Ann. N. Y Acad. Sci."},{"key":"10.1016\/j.ibneur.2022.12.003_bib199","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1742-2094-1-14","article-title":"Microglia and neuroinflammation: a pathological perspective","volume":"1","author":"Streit","year":"2004","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.ibneur.2022.12.003_bib200","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1002\/glia.21009","article-title":"Effects of axon degeneration on oligodendrocyte lineage cells: dorsal rhizotomy evokes a repair response while axon degeneration rostral to spinal contusion induces both repair and apoptosis","volume":"58","author":"Sun","year":"2010","journal-title":"Glia"},{"issue":"11","key":"10.1016\/j.ibneur.2022.12.003_bib201","doi-asserted-by":"crossref","first-page":"1690e1701","DOI":"10.1016\/j.neurobiolaging.2007.04.006","article-title":"Synuclein activates microglia in a model of Parkinson\u2019s disease","volume":"29","author":"Su","year":"2008","journal-title":"Neurobiol. Aging"},{"issue":"12","key":"10.1016\/j.ibneur.2022.12.003_bib202","doi-asserted-by":"crossref","first-page":"3415e3427","DOI":"10.1093\/brain\/awy265","article-title":"Early microglial activation and peripheral inflammation in dementia with Lewy bodies","volume":"141","author":"Surendranathan","year":"2018","journal-title":"Brain J. Neurol."},{"key":"10.1016\/j.ibneur.2022.12.003_bib203","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.3233\/JAD-141134","article-title":"Epidemiological and economic burden of Alzheimer's disease: a systematic literature review of data across Europe and the United States of America","volume":"43","author":"Takizawa","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.ibneur.2022.12.003_bib204","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/208408","article-title":"Correlation between serum RANTES levels and the severity of Parkinson\u2019s disease","volume":"2014","author":"Tang","year":"2014","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.ibneur.2022.12.003_bib205","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.cmet.2018.03.016","article-title":"A potent and specific CD38 inhibitor ameliorates age-related metabolic dysfunction by reversing tissue NAD+ decline","volume":"27","author":"Tarrag\u00f3","year":"2018","journal-title":"Cell Metab."},{"issue":"8","key":"10.1016\/j.ibneur.2022.12.003_bib206","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nrneurol.2015.119","article-title":"Clearance systems in the brain-implications for Alzheimer disease","volume":"11","author":"Tarasoff-Conway","year":"2015","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.ibneur.2022.12.003_bib207","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S1096-7192(03)00071-4","article-title":"Gaucher disease with parkinsonian manifestations: does glucocerebrosidase deficiency contribute to a vulnerability to parkinsonism?","volume":"79","author":"Tayebi","year":"2003","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.ibneur.2022.12.003_bib208","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nature20413","article-title":"Decoding ALS: from genes to mechanism","volume":"539","author":"Taylor","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.ibneur.2022.12.003_bib209","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/glia.22287","article-title":"Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices","volume":"60","author":"Tremblay","year":"2012","journal-title":"Glia"},{"key":"10.1016\/j.ibneur.2022.12.003_bib210","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s12974-016-0580-0","article-title":"Remodeling of lipid bodies by docosahexaenoic acid in activated microglial cells","volume":"13","author":"Tremblay","year":"2016","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.ibneur.2022.12.003_bib211","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/cen3.12476","article-title":"Phenotypic heterogeneity of astrocytes in motor neuron disease","volume":"9","author":"Trias","year":"2018","journal-title":"Clin. Exp. Neuroimmunol."},{"issue":"8","key":"10.1016\/j.ibneur.2022.12.003_bib212","doi-asserted-by":"crossref","DOI":"10.3390\/cells10082019","article-title":"Challenges and opportunities of targeting astrocytes to halt neurodegenerative disorders","volume":"10","author":"Valori","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.ibneur.2022.12.003_bib213","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.3389\/fimmu.2018.02134","article-title":"CD38 antibodies in multiple myeloma: mechanisms of action and modes of resistance","volume":"9","author":"van de Donk","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ibneur.2022.12.003_bib214","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13195-020-00682-7","article-title":"Combination of plasma amyloid beta (1-42\/1-40) and glial fibrillary acidic protein strongly associates with cerebral amyloid pathology","volume":"12","author":"Verberk","year":"2020","journal-title":"Alzheimers Res Ther."},{"key":"10.1016\/j.ibneur.2022.12.003_bib215","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.neuint.2010.02.002","article-title":"Physiology of neuronal-glial networking","volume":"57","author":"Verkhratsky","year":"2010","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ibneur.2022.12.003_bib216","doi-asserted-by":"crossref","first-page":"149","DOI":"10.2217\/fnl.12.90","article-title":"Astroglia in neurological diseases","volume":"8","author":"Verkhratsky","year":"2013","journal-title":"Future Neurol."},{"key":"10.1016\/j.ibneur.2022.12.003_bib217","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.nbd.2015.03.025","article-title":"Astrogliopathology in neurological, neurodevelopmental and psychiatric disorders","volume":"85","author":"Verkhratsky","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ibneur.2022.12.003_bib218","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2015.0428","article-title":"The homeostatic astroglia emerges from evolutionary specialization of neural cells","volume":"371","author":"Verkhratsky","year":"2016","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.ibneur.2022.12.003_bib219","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1152\/physrev.00042.2016","article-title":"Physiology of astroglia","volume":"98","author":"Verkhratsky","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ibneur.2022.12.003_bib220","doi-asserted-by":"crossref","first-page":"239","DOI":"10.15252\/embj.201592705","article-title":"Astrocytes as secretory cells of the central nervous system: idiosyncrasies of vesicular secretion","volume":"35","author":"Verkhratsky","year":"2016","journal-title":"EMBO J."},{"issue":"June","key":"10.1016\/j.ibneur.2022.12.003_bib221","first-page":"1","article-title":"Pathological neuroinflammatory conversion of reactive astrocytes is induced by microglia and involves chromatin remodeling","volume":"12","author":"Villarreal","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ibneur.2022.12.003_bib222","series-title":"Cellular Pathology as Based Upon Physiological and Pathological Histology","author":"Virchow","year":"1860"},{"key":"10.1016\/j.ibneur.2022.12.003_bib223","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/978-3-319-40764-7_4","article-title":"Microglia function in the normal brain","volume":"949","author":"Von Bernhardi","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.ibneur.2022.12.003_bib224","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s00401-013-1114-9","article-title":"Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson\u2019s disease","volume":"125","author":"Wagner","year":"2013","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.ibneur.2022.12.003_bib225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0109818","article-title":"Upregulation of GPR109A in Parkinson\u2019s disease","volume":"9","author":"Wakade","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ibneur.2022.12.003_bib226","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.neuroscience.2017.08.010","article-title":"Blocking the CD38\/cADPR pathway plays a double-edged role in LPS stimulated microglia","volume":"361","author":"Wang","year":"2017","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.ibneur.2022.12.003_bib227","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41582-020-0312-z","article-title":"Perivascular spaces in the brain: anatomy, physiology and pathology","volume":"16","author":"Wardlaw","year":"2020","journal-title":"Nat. Rev. Neurol."},{"issue":"S 01","key":"10.1016\/j.ibneur.2022.12.003_bib228","doi-asserted-by":"crossref","first-page":"M394","DOI":"10.1055\/s-0028-1086654","article-title":"Second consensus statement on the diagnosis of multiple system atrophy","volume":"35","author":"Wenning","year":"2008","journal-title":"Akt. Neurol."},{"issue":"2","key":"10.1016\/j.ibneur.2022.12.003_bib229","first-page":"193","article-title":"The perivascular spaces of the mammalian central nervous system and their relation to the perineuronal and subarachnoid spaces","volume":"89","author":"Woollam","year":"1955","journal-title":"J. Anat."},{"issue":"7628","key":"10.1016\/j.ibneur.2022.12.003_bib230","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/nature20411","article-title":"Ageing, neurodegeneration and brain rejuvenation","volume":"539","author":"Wyss-Coray","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.ibneur.2022.12.003_bib231","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.neubiorev.2017.05.015","article-title":"Neural changes in Alzheimer's disease from circuit to molecule: perspective of optogenetics","volume":"79","author":"Yang","year":"2017","journal-title":"Neurosci. Biobehav Rev."},{"key":"10.1016\/j.ibneur.2022.12.003_bib232","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.14336\/AD.2021.04017","article-title":"Bioenergetic impairment in the neuro-glia-vascular unit: an emerging physiopathology during aging","volume":"12","author":"Yuan","year":"2021","journal-title":"Aging Dis."},{"issue":"6","key":"10.1016\/j.ibneur.2022.12.003_bib233","doi-asserted-by":"crossref","first-page":"533e542","DOI":"10.1096\/fj.04-2751com","article-title":"Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson\u2019s disease","volume":"19","author":"Zhang","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.ibneur.2022.12.003_bib234","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.conb.2010.06.005","article-title":"Astrocyte heterogeneity: an underappreciated topic in neurobiology","volume":"20","author":"Zhang","year":"2010","journal-title":"Curr. Opin. Neurobiol."},{"issue":"1","key":"10.1016\/j.ibneur.2022.12.003_bib235","doi-asserted-by":"crossref","first-page":"63e72","DOI":"10.1007\/s12640-009-9140-z","article-title":"Neuromelanin activates microglia and induces degeneration of dopaminergic neurons: implications for progression of Parkinson\u2019s disease","volume":"19","author":"Zhang","year":"2011","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.ibneur.2022.12.003_bib236","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1073\/pnas.1417921112","article-title":"In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences","volume":"112","author":"Zhu","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ibneur.2022.12.003_bib237","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41591-019-0695-9","article-title":"Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease","volume":"26","author":"Zhou","year":"2020","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.ibneur.2022.12.003_bib238","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/ana.25670","article-title":"Impairment of the glymphatic pathway and putative meningeal lymphatic vessels in the aging human","volume":"87","author":"Zhou","year":"2020","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ibneur.2022.12.003_bib239","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s40035-019-0147-y","article-title":"Blocking meningeal lymphatic drainage aggravates Parkinson\u2019s disease-like pathology in mice overexpressing mutated alpha-synuclein","volume":"8","author":"Zou","year":"2019","journal-title":"Transl. Neurodegener."}],"container-title":["IBRO Neuroscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667242122000999?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667242122000999?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T08:09:21Z","timestamp":1757405361000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667242122000999"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":239,"alternative-id":["S2667242122000999"],"URL":"https:\/\/doi.org\/10.1016\/j.ibneur.2022.12.003","relation":{},"ISSN":["2667-2421"],"issn-type":[{"value":"2667-2421","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neurodegeneration and inflammation crosstalk: Therapeutic targets and perspectives","name":"articletitle","label":"Article Title"},{"value":"IBRO Neuroscience Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ibneur.2022.12.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Ltd on behalf of International Brain Research Organization.","name":"copyright","label":"Copyright"}]}}