{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:08:11Z","timestamp":1788455291588,"version":"build-2803163510"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:00:00Z","timestamp":1709510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R15NS133859"],"award-info":[{"award-number":["R15NS133859"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NIHR01HL163159"],"award-info":[{"award-number":["NIHR01HL163159"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R15NS115032-01A1"],"award-info":[{"award-number":["R15NS115032-01A1"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ibroneuroreports.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["IBRO Neuroscience Reports"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.ibneur.2024.03.004","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T22:34:07Z","timestamp":1710196447000},"page":"468-475","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Aerobic exercise improves depressive symptoms in the unilateral 6-OHDA-lesioned rat model of Parkinson\u2019s disease"],"prefix":"10.1016","volume":"16","author":[{"given":"Hannah","family":"Loughlin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1250-6138","authenticated-orcid":false,"given":"Jacob","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0766-1177","authenticated-orcid":false,"given":"Chloe","family":"Looman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alayna","family":"Starll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Goldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9763-205X","authenticated-orcid":false,"given":"Zhiying","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxiu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ibneur.2024.03.004_bib1","first-page":"7","article-title":"Parkinson disease-associated cognitive impairment","author":"Aarsland","year":"2021","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.ibneur.2024.03.004_bib2","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1212\/WNL.0b013e318225ab66","article-title":"Does vigorous exercise have a neuroprotective effect in Parkinson disease","volume":"77","author":"Ahlskog","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.ibneur.2024.03.004_bib3","first-page":"378","article-title":"Effects of repeated voluntary or forced exercise on brainstem serotonergic systems in rats","author":"Arnold","year":"2020","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ibneur.2024.03.004_bib4","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.neubiorev.2007.09.002","article-title":"Studies of the neural mechanisms of deep brain stimulation in rodent models of Parkinson's disease","volume":"32","author":"Chang","year":"2008","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.ibneur.2024.03.004_bib5","first-page":"313","article-title":"Mechanism of Deep Brain Stimulation: Inhibition, Excitation, or Disruption?","volume":"22","author":"Chiken","year":"2016","journal-title":"Neurosci.\u00a0Rev. J. Bringing Neurobiol., Neurol. Psychiatry"},{"key":"10.1016\/j.ibneur.2024.03.004_bib6","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s11065-015-9302-0","article-title":"Cognition and depression following deep brain stimulation of the subthalamic nucleus and globus pallidus pars internus in Parkinson's disease: a meta-analysis","volume":"25","author":"Combs","year":"2015","journal-title":"Neuropsychol. Rev."},{"key":"10.1016\/j.ibneur.2024.03.004_bib7","first-page":"104","article-title":"The benefits of exercise for the clinically depressed","volume":"6","author":"Craft","year":"2004","journal-title":"Prim. Care Companion J. Clin. Psychiatry"},{"key":"10.1016\/j.ibneur.2024.03.004_bib8","first-page":"9","article-title":"Neuropsychiatric and cognitive deficits in Parkinson's disease and their modeling in rodents","author":"Decourt","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.ibneur.2024.03.004_bib9","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jns.2011.07.007","article-title":"Prevalence of depression in Parkinson's disease: effects of disease stage, motor subtype and gender","volume":"310","author":"van der Hoek","year":"2011","journal-title":"J. Neurol. Sci."},{"issue":"Suppl 14","key":"10.1016\/j.ibneur.2024.03.004_bib10","doi-asserted-by":"crossref","first-page":"S219","DOI":"10.1002\/mds.20957","article-title":"Deep brain stimulation: postoperative issues","volume":"21","author":"Deuschl","year":"2006","journal-title":"Mov. Disord.\u00a0Off. J. Mov. Disord. Soc."},{"key":"10.1016\/j.ibneur.2024.03.004_bib11","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.neubiorev.2018.10.004","article-title":"The hidden side of Parkinson's disease: studying pain, anxiety and depression in animal models","volume":"96","author":"Faivre","year":"2019","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.ibneur.2024.03.004_bib12","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/jnr.20162","article-title":"Exercise-induced behavioral recovery and neuroplasticity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse basal ganglia","volume":"77","author":"Fisher","year":"2004","journal-title":"J. Neurosci. Res"},{"key":"10.1016\/j.ibneur.2024.03.004_bib13","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.apmr.2008.01.013","article-title":"The effect of exercise training in improving motor performance and corticomotor excitability in people with early Parkinson's disease","volume":"89","author":"Fisher","year":"2008","journal-title":"Arch. Phys. Med Rehabil."},{"key":"10.1016\/j.ibneur.2024.03.004_bib14","doi-asserted-by":"crossref","first-page":"8106","DOI":"10.1073\/pnas.1414728112","article-title":"Optogenetic stimulation of infralimbic PFC reproduces ketamine's rapid and sustained antidepressant actions","volume":"112","author":"Fuchikami","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ibneur.2024.03.004_bib15","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.bbr.2011.12.007","article-title":"Sensorimotor assessment of the unilateral 6-hydroxydopamine mouse model of Parkinson's disease","volume":"230","author":"Glajch","year":"2012","journal-title":"Behav. Brain Res"},{"key":"10.1016\/j.ibneur.2024.03.004_bib16","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/ejn.12044","article-title":"Exercise-induced stress resistance is independent of exercise controllability and the medial prefrontal cortex","volume":"37","author":"Greenwood","year":"2013","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ibneur.2024.03.004_bib17","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.genhosppsych.2017.04.012","article-title":"Exercise effects on depression: possible neural mechanisms","volume":"49","author":"Gujral","year":"2017","journal-title":"Gen. Hosp. Psychiat"},{"key":"10.1016\/j.ibneur.2024.03.004_bib18","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.genhosppsych.2017.04.012","article-title":"Exercise effects on depression: possible neural mechanisms","volume":"49","author":"Gujral","year":"2017","journal-title":"Gen. Hosp. Psychiatry"},{"key":"10.1016\/j.ibneur.2024.03.004_bib19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1749-6632.2003.tb07459.x","article-title":"Physiology and pathophysiology of Parkinson's disease","volume":"991","author":"Hamani","year":"2003","journal-title":"Ann. Ny. Acad. Sci."},{"key":"10.1016\/j.ibneur.2024.03.004_bib20","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.biopsych.2009.08.025","article-title":"Antidepressant-like effects of medial prefrontal cortex deep brain stimulation in rats","volume":"67","author":"Hamani","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ibneur.2024.03.004_bib21","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.nbd.2014.08.007","article-title":"Deep brain stimulation in rats: different targets induce similar antidepressant-like effects but influence different circuits","volume":"71","author":"Hamani","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ibneur.2024.03.004_bib22","first-page":"10","article-title":"Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant","author":"Hare","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ibneur.2024.03.004_bib23","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1111\/ejn.13193","article-title":"Neurochemical and behavioural indices of exercise reward are independent of exercise controllability","volume":"43","author":"Herrera","year":"2016","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ibneur.2024.03.004_bib24","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1016\/j.neubiorev.2013.04.005","article-title":"Beneficial effects of physical exercise on neuroplasticity and cognition","volume":"37","author":"Hotting","year":"2013","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.ibneur.2024.03.004_bib25","first-page":"11","article-title":"Aerobic exercise prevents depression via alleviating hippocampus injury in chronic stressed depression rats","author":"Kang","year":"2020","journal-title":"Brain Sci."},{"key":"10.1016\/j.ibneur.2024.03.004_bib26","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.yebeh.2012.01.007","article-title":"Depression and epilepsy: epidemiologic and neurobiologic perspectives that may explain their high comorbid occurrence","volume":"24","author":"Kanner","year":"2012","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.ibneur.2024.03.004_bib27","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.expneurol.2014.09.004","article-title":"Sucrose consumption test reveals pharmacoresistant depression-associated behavior in two mouse models of temporal lobe epilepsy","volume":"263","author":"Klein","year":"2015","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ibneur.2024.03.004_bib28","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jad.2016.03.063","article-title":"Exercise as a treatment for depression: a meta-analysis","volume":"202","author":"Kvam","year":"2016","journal-title":"J. Affect Disord."},{"key":"10.1016\/j.ibneur.2024.03.004_bib29","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.expneurol.2012.05.022","article-title":"Do alpha-synuclein vector injections provide a better model of Parkinson's disease than the classic 6-hydroxydopamine model?","volume":"237","author":"Lindgren","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ibneur.2024.03.004_bib30","article-title":"Physical activity and risk of Parkinson's disease and parkinsonism in a prospective population-based study (NEDICES)","volume":"23","author":"Llamas-Velasco","year":"2021","journal-title":"Prev. Med Rep."},{"key":"10.1016\/j.ibneur.2024.03.004_bib31","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0893-133X(97)00113-9","article-title":"Neurobiological similarities in depression and drug dependence: a self-medication hypothesis","volume":"18","author":"Markou","year":"1998","journal-title":"Neuropsychopharmacol"},{"key":"10.1016\/j.ibneur.2024.03.004_bib32","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s11910-013-0409-5","article-title":"Depression and Parkinson's disease: current knowledge","volume":"13","author":"Marsh","year":"2013","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.ibneur.2024.03.004_bib33","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1037\/0882-7974.6.3.487","article-title":"The effect of exercise on depressive symptoms in the moderately depressed elderly","volume":"6","author":"McNeil","year":"1991","journal-title":"Psychol. Aging"},{"key":"10.1016\/j.ibneur.2024.03.004_bib34","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jneumeth.2006.06.001","article-title":"Comparison of incremental and accelerating protocols of the rotarod test for the assessment of motor deficits in the 6-OHDA model","volume":"158","author":"Monville","year":"2006","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.ibneur.2024.03.004_bib35","doi-asserted-by":"crossref","first-page":"R77","DOI":"10.1530\/JME-17-0165","article-title":"Voluntary exercise and depression-like behavior in rodents: are we running in the right direction","volume":"60","author":"Mul","year":"2018","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.ibneur.2024.03.004_bib36","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.neuroscience.2006.10.042","article-title":"Running wheel exercise enhances recovery from nigrostriatal dopamine injury without inducing neuroprotection","volume":"144","author":"O'Dell","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.ibneur.2024.03.004_bib37","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.1523\/JNEUROSCI.15-05-03863.1995","article-title":"Forelimb akinesia in the rat Parkinson model: differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test","volume":"15","author":"Olsson","year":"1995","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.ibneur.2024.03.004_bib38","doi-asserted-by":"crossref","first-page":"5291","DOI":"10.1523\/JNEUROSCI.1069-07.2007","article-title":"Effects of treadmill exercise on dopaminergic transmission in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injury","volume":"27","author":"Petzinger","year":"2007","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.ibneur.2024.03.004_bib39","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/S1474-4422(13)70123-6","article-title":"Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease","volume":"12","author":"Petzinger","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ibneur.2024.03.004_bib40","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2202-10-6","article-title":"Restorative effect of endurance exercise on behavioral deficits in the chronic mouse model of Parkinson's disease with severe neurodegeneration","volume":"10","author":"Pothakos","year":"2009","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.ibneur.2024.03.004_bib41","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1212\/01.wnl.0000268695.63392.10","article-title":"The impact of depressive symptoms in early Parkinson disease","volume":"69","author":"Ravina","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.ibneur.2024.03.004_bib42","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.lfs.2019.03.057","article-title":"Parkinson's disease: mechanisms, translational models and management strategies","volume":"226","author":"Raza","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.ibneur.2024.03.004_bib43","unstructured":"Ross G.W., Abbott R.D., Petrovitch H., Tanner C.M., Popper J., McMurtray A., Masaki K., Launer L., White L.R. (2007), Association of mid-life physical activity with risk of future Parkinson's disease. Movement Disord 22:Xi-Xii."},{"key":"10.1016\/j.ibneur.2024.03.004_bib44","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0165-0270(98)00078-8","article-title":"The overall rod performance test in the MPTP-treated-mouse model of Parkinsonism","volume":"83","author":"Rozas","year":"1998","journal-title":"J. Neurosci. Meth"},{"key":"10.1016\/j.ibneur.2024.03.004_bib45","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0166-4328(00)00364-8","article-title":"Physical activity-antidepressant treatment combination: impact on brain-derived neurotrophic factor and behavior in an animal model","volume":"120","author":"Russo-Neustadt","year":"2001","journal-title":"Behav. Brain Res"},{"key":"10.1016\/j.ibneur.2024.03.004_bib46","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.1083328","article-title":"Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants","volume":"301","author":"Santarelli","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.ibneur.2024.03.004_bib47","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1126\/science.564552","article-title":"Compulsive, abnormal walking caused by anticholinergics in akinetic, 6-hydroxydopamine-treated rats","volume":"199","author":"Schallert","year":"1978","journal-title":"Science"},{"key":"10.1016\/j.ibneur.2024.03.004_bib48","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0028-3908(00)00005-8","article-title":"CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury","volume":"39","author":"Schallert","year":"2000","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ibneur.2024.03.004_bib49","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1111\/j.1468-1331.2009.02793.x","article-title":"Perspectives on recent advances in the understanding and treatment of Parkinson's disease","volume":"16","author":"Schapira","year":"2009","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.ibneur.2024.03.004_bib50","first-page":"322","article-title":"Physical exercise ameliorates psychiatric disorders and cognitive dysfunctions by hippocampal mitochondrial function and neuroplasticity in post-traumatic stress disorder","author":"Seo","year":"2019","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ibneur.2024.03.004_bib51","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s00213-006-0630-x","article-title":"Evaluation of reward processes in an animal model of depression","volume":"190","author":"Slattery","year":"2007","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.ibneur.2024.03.004_bib52","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.brainres.2011.02.003","article-title":"Effects of treadmill exercise on behavioral recovery and neural changes in the substantia nigra and striatum of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse","volume":"1386","author":"Smith","year":"2011","journal-title":"Brain Res."},{"key":"10.1016\/j.ibneur.2024.03.004_bib53","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.biopsych.2008.02.022","article-title":"Drug-dependent requirement of hippocampal neurogenesis in a model of depression and of antidepressant reversal","volume":"64","author":"Surget","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ibneur.2024.03.004_bib54","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0306-4522(03)00096-4","article-title":"Exercise induces behavioral recovery and attenuates neurochemical deficits in rodent models of Parkinson's disease","volume":"119","author":"Tillerson","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.ibneur.2024.03.004_bib55","doi-asserted-by":"crossref","first-page":"e859","DOI":"10.1212\/WNL.0000000000013218","article-title":"Long-term effect of regular physical activity and exercise habits in patients with early Parkinson disease","volume":"98","author":"Tsukita","year":"2022","journal-title":"Neurology"},{"key":"10.1016\/j.ibneur.2024.03.004_bib56","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s00702-017-1686-y","article-title":"Epidemiology of Parkinson's disease","volume":"124","author":"Tysnes","year":"2017","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.ibneur.2024.03.004_bib57","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.tics.2013.08.001","article-title":"Bridging animal and human models of exercise-induced brain plasticity","volume":"17","author":"Voss","year":"2013","journal-title":"Trends Cogn. Sci."},{"key":"10.1016\/j.ibneur.2024.03.004_bib58","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1212\/WNL.0b013e3181ea1597","article-title":"Physical activities and future risk of Parkinson disease","volume":"75","author":"Xu","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.ibneur.2024.03.004_bib59","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1212\/WNL.0b013e3181ea1597","article-title":"Physical activities and future risk of Parkinson disease","volume":"75","author":"Xu","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.ibneur.2024.03.004_bib60","doi-asserted-by":"crossref","first-page":"4323","DOI":"10.1523\/JNEUROSCI.3071-19.2020","article-title":"Frequency-specific optogenetic deep brain stimulation of subthalamic nucleus improves Parkinsonian motor behaviors","volume":"40","author":"Yu","year":"2020","journal-title":"J. Neurosci.\u00a0Off. J. Soc. Neurosci."}],"container-title":["IBRO Neuroscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667242124000289?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667242124000289?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T11:22:24Z","timestamp":1778930544000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667242124000289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":60,"alternative-id":["S2667242124000289"],"URL":"https:\/\/doi.org\/10.1016\/j.ibneur.2024.03.004","relation":{},"ISSN":["2667-2421"],"issn-type":[{"value":"2667-2421","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aerobic exercise improves depressive symptoms in the unilateral 6-OHDA-lesioned rat model of Parkinson\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"IBRO Neuroscience Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ibneur.2024.03.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc. on behalf of International Brain Research Organization.","name":"copyright","label":"Copyright"}]}}