{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T02:43:26Z","timestamp":1778899406441,"version":"3.51.4"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T00:00:00Z","timestamp":1711670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ibroneuroreports.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["IBRO Neuroscience Reports"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.ibneur.2024.03.010","type":"journal-article","created":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T02:22:21Z","timestamp":1711765341000},"page":"485-496","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Protective role of the ginsenoside Rg1 against methimazole-induced gestational hypothyroidism on reflexive behaviors, conditioned fear and cortical antioxidant levels in mice offspring"],"prefix":"10.1016","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2552-108X","authenticated-orcid":false,"given":"Ali","family":"Sanaiee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahin","family":"Hassanpour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bita","family":"Vazir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ibneur.2024.03.010_bib1","first-page":"6","article-title":"Maternal hypothyroidism and neonatal depression: current perspective","volume":"4","author":"Ahmed","year":"2018","journal-title":"Int. J. Res. Stud. Zool."},{"issue":"1","key":"10.1016\/j.ibneur.2024.03.010_bib2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13044-015-0013-7","article-title":"Hypothyroidism and brain developmental players","volume":"8","author":"Ahmed","year":"2015","journal-title":"Thyroid Res."},{"issue":"1-2","key":"10.1016\/j.ibneur.2024.03.010_bib3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0149-7634(03)00005-8","article-title":"Trajectories of brain development: point of vulnerability or window of opportunity?","volume":"27","author":"Andersen","year":"2003","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.ibneur.2024.03.010_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.alcohol.2022.04.004","article-title":"The influence of chromosome 4 on high ethanol consumption and blood pressure","volume":"102","author":"Anjos","year":"2022","journal-title":"Alcohol"},{"issue":"05","key":"10.1016\/j.ibneur.2024.03.010_bib5","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1142\/S0192415X16500543","article-title":"Effects of American ginseng on preimplantation development and pregnancy in mice","volume":"44","author":"Belanger","year":"2016","journal-title":"Am. J. Chin. Med."},{"issue":"12","key":"10.1016\/j.ibneur.2024.03.010_bib6","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1001\/jamapsychiatry.2021.2506","article-title":"Association of hypothyroidism and clinical depression: a systematic review and meta-analysis","volume":"78","author":"Bode","year":"2021","journal-title":"JAMA Psychiatry"},{"issue":"2","key":"10.1016\/j.ibneur.2024.03.010_bib7","first-page":"126","article-title":"Antidepressant-like activity of S 20098 (agomelatine) in the forced swimming test in rodents: involvement of melatonin and serotonin receptors","volume":"29","author":"Bourin","year":"2004","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.ibneur.2024.03.010_bib8","article-title":"The mouse forced swim test","volume":"59","author":"Can","year":"2012","journal-title":"J. Vis. Exp."},{"issue":"1","key":"10.1016\/j.ibneur.2024.03.010_bib9","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1139\/z98-198","article-title":"Effects of sex composition of the litter on anogenital distance in California mice (Peromyscus californicus)","volume":"77","author":"Cantoni","year":"1999","journal-title":"Can. J. Zool."},{"key":"10.1016\/j.ibneur.2024.03.010_bib10","article-title":"Comparative evaluation of forced swim test and tail suspension test as models of negative symptom of schizophrenia in rodents","volume":"2012","author":"Chatterjee","year":"2012","journal-title":"Int. Sch. Res. Not."},{"key":"10.1016\/j.ibneur.2024.03.010_bib11","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1007\/s11064-017-2438-y","article-title":"Ginsenoside Rg1 decreases oxidative stress and down-regulates Akt\/mTOR signalling to attenuate cognitive impairment in mice and senescence of neural stem cells induced by D-galactose","volume":"43","author":"Chen","year":"2018","journal-title":"Neurochem. Res."},{"issue":"1","key":"10.1016\/j.ibneur.2024.03.010_bib12","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1745-7254.2005.00019.x","article-title":"Ginsenoside Rg1 reduces MPTP-induced substantia nigra neuron loss by suppressing oxidative stress 1","volume":"26","author":"Chen","year":"2005","journal-title":"Acta Pharmacol. Sin."},{"issue":"3","key":"10.1016\/j.ibneur.2024.03.010_bib13","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0149-7634(01)00011-2","article-title":"A detailed ethological analysis of the mouse open field test: effects of diazepam, chlordiazepoxide and an extremely low frequency pulsed magnetic field","volume":"25","author":"Choleris","year":"2001","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"6","key":"10.1016\/j.ibneur.2024.03.010_bib14","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1111\/j.1365-2265.1995.tb00540.x","article-title":"Neuroendocrine evidence for an association between hypothyroidism, reduced central 5-HT activity and depression.","volume":"43","author":"Cleare","year":"1995","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.ibneur.2024.03.010_bib15","unstructured":"Corti, S., 2017. Grip strength. Experimental protocols for SMA animal models, TREAT-NMD."},{"issue":"10","key":"10.1016\/j.ibneur.2024.03.010_bib16","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1172\/JCI35432","article-title":"Neural stem cell transplantation can ameliorate the phenotype of a mouse model of spinal muscular atrophy","volume":"118","author":"Corti","year":"2008","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.ibneur.2024.03.010_bib17","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.rbmo.2015.11.016","article-title":"Investigation of possible teratogenic effects in the offspring of mice exposed to methylphenidate during pregnancy","volume":"32","author":"Costa","year":"2016","journal-title":"Reprod. Biomed. Online"},{"issue":"4","key":"10.1016\/j.ibneur.2024.03.010_bib18","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.pbb.2010.06.012","article-title":"Forced swim test behavior in postpartum rats","volume":"96","author":"Craft","year":"2010","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"4","key":"10.1016\/j.ibneur.2024.03.010_bib19","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.neubiorev.2005.03.009","article-title":"The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice","volume":"29","author":"Cryan","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"1","key":"10.1016\/j.ibneur.2024.03.010_bib20","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/jclp.20432","article-title":"Psychological treatment of postpartum depression: a meta-analysis","volume":"64","author":"Cuijpers","year":"2008","journal-title":"J. Clin. Psychol."},{"issue":"1","key":"10.1016\/j.ibneur.2024.03.010_bib21","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/BF02973143","article-title":"Effect of ginseng injection on congestive heart failure and thyroid hormones","volume":"6","author":"Dai","year":"2000","journal-title":"Chin. J. Integr. Tradit. West. Med."},{"issue":"5","key":"10.1016\/j.ibneur.2024.03.010_bib22","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.ijdevneu.2010.04.003","article-title":"Comparative study of the effects of experimentally induced hypothyroidism and hyperthyroidism in some brain regions in albino rats","volume":"28","author":"El-bakry","year":"2010","journal-title":"Int. J. Dev. Neurosci."},{"issue":"1","key":"10.1016\/j.ibneur.2024.03.010_bib23","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.expneurol.2008.02.025","article-title":"Identification of a battery of tests for drug candidate evaluation in the SMN\u03947 neonate model of spinal muscular atrophy","volume":"212","author":"El-Khodor","year":"2008","journal-title":"Exp. Neurol."},{"issue":"4","key":"10.1016\/j.ibneur.2024.03.010_bib24","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/BF03001163","article-title":"Conditional and unconditional components of post-shock freezing","volume":"15","author":"Fanselow","year":"1980","journal-title":"Pavlov. J. Biol. Sci.\u00a0Off. J. Pavlov."},{"issue":"117","key":"10.1016\/j.ibneur.2024.03.010_bib25","doi-asserted-by":"crossref","DOI":"10.3791\/53569-v","article-title":"A battery of motor tests in a neonatal mouse model of cerebral palsy","author":"Feather-Schussler","year":"2016","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.ibneur.2024.03.010_bib26","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.bbr.2014.06.041","article-title":"Postpartum depression in rats: differences in swim test immobility, sucrose preference and nurturing behaviors","volume":"272","author":"Fernandez","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ibneur.2024.03.010_bib27","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jep.2017.04.012","article-title":"Hepataprotective effects of ginsenoside Rg1 \u2013 a review","volume":"206","author":"Gao","year":"2017","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.ibneur.2024.03.010_bib28","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1006\/taap.1995.1209","article-title":"Effects of developmental hypothyroidism on auditory and motor function in the rat","volume":"135","author":"GoLDEY","year":"1995","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ibneur.2024.03.010_bib29","doi-asserted-by":"crossref","unstructured":"Gould, T.D., Dao, D.T., Kovacsics, C.E., 2009. The open field test. Mood and anxiety related phenotypes in mice: Characterization using behavioral tests, 1-20.","DOI":"10.1007\/978-1-60761-303-9_1"},{"issue":"2","key":"10.1016\/j.ibneur.2024.03.010_bib30","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0033-3182(98)71355-6","article-title":"Hormonal changes in the postpartum and implications for postpartum depression","volume":"39","author":"Hendrick","year":"1998","journal-title":"Psychosomatics"},{"issue":"11","key":"10.1016\/j.ibneur.2024.03.010_bib31","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1089\/105072503770867200","article-title":"Congenital hypothyroidism: developmental outcome in relation to levothyroxine treatment variables","volume":"13","author":"Heyerdahl","year":"2003","journal-title":"Thyroid"},{"issue":"1","key":"10.1016\/j.ibneur.2024.03.010_bib32","doi-asserted-by":"crossref","first-page":"8.18. 11","DOI":"10.1002\/0471142301.ns0818s25","article-title":"Assessment of developmental milestones in rodents","volume":"25","author":"Heyser","year":"2003","journal-title":"Curr. Protoc. Neurosci."},{"issue":"1","key":"10.1016\/j.ibneur.2024.03.010_bib33","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/jdn.10243","article-title":"Methimazole-induced gestational hypothyroidism affects the offspring development and differently impairs the conditioned fear in male and female adulthood rodents","volume":"83","author":"Hip\u00f3lito","year":"2023","journal-title":"Int. J. Dev. Neurosci."},{"issue":"4","key":"10.1016\/j.ibneur.2024.03.010_bib34","first-page":"46","article-title":"The anogenital distance index of mice (Mus musculus domesticus): an analysis","volume":"44","author":"Hotchkiss","year":"2005","journal-title":"J. Am. Assoc. Lab. Anim. Sci."},{"issue":"4","key":"10.1016\/j.ibneur.2024.03.010_bib35","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.jgr.2019.05.007","article-title":"Korean red ginseng alleviates neuroinflammation and promotes cell survival in the intermittent heat stress-induced rat brain by suppressing oxidative stress via estrogen receptor beta and brain-derived neurotrophic factor upregulation","volume":"44","author":"Iqbal","year":"2020","journal-title":"J. Ginseng Res."},{"issue":"8","key":"10.1016\/j.ibneur.2024.03.010_bib36","first-page":"1140","article-title":"Amelioration of metformin-induced hypothyroidism by Withania somnifera and Bauhinia purpurea extracts in type 2 diabetic mice.","volume":"23","author":"Jatwa","year":"2009","journal-title":"Phytother. Res.\u00a0Int. J. Devoted Pharmacol. Toxicol. Eval. Nat. Prod. Deriv."},{"issue":"2","key":"10.1016\/j.ibneur.2024.03.010_bib37","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0149-7634(81)90005-1","article-title":"Acute and chronic stress effects on open field activity in the rat: implications for a model of depression","volume":"5","author":"Katz","year":"1981","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"7","key":"10.1016\/j.ibneur.2024.03.010_bib38","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1002\/jdn.10060","article-title":"Prenatal exposure to hesperidin improves reflexive motor behaviors in mice offspring","volume":"80","author":"Khodadadeh","year":"2020","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.ibneur.2024.03.010_bib39","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.fct.2012.10.011","article-title":"Effects of Korean red ginseng extracts on neural tube defects and impairment of social interaction induced by prenatal exposure to valproic acid","volume":"51","author":"Kim","year":"2013","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.ibneur.2024.03.010_bib40","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3892\/ijmm.2014.2003","article-title":"Influence of Panax ginseng on the offspring of adult rats exposed to prenatal stress","volume":"35","author":"Kim","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.ibneur.2024.03.010_bib41","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/978-1-4939-8994-2_9","article-title":"The open field test for measuring locomotor activity and anxiety-like behavior","author":"Kraeuter","year":"2019","journal-title":"Pre-Clin. Model.\u00a0Tech. Protoc."},{"key":"10.1016\/j.ibneur.2024.03.010_bib42","first-page":"45","article-title":"Antioxidant effects of Korean red ginseng extracts on the glutathione and lipid peroxidation in the liver of mouse treated with paraquat","volume":"6","author":"Lee","year":"2000","journal-title":"Korean J. Biomed. Lab Sci."},{"issue":"4","key":"10.1016\/j.ibneur.2024.03.010_bib43","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.jgr.2018.07.005","article-title":"Ginsenoside Rg1 promotes browning by inducing UCP1 expression and mitochondrial activity in 3T3-L1 and subcutaneous white adipocytes","volume":"43","author":"Lee","year":"2019","journal-title":"J. Ginseng Res."},{"key":"10.1016\/j.ibneur.2024.03.010_bib44","article-title":"Ginsenoside-Rg1 rescues stress-induced depression-like behaviors via suppression of oxidative stress and neural inflammation in rats","volume":"2020","author":"Li","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ibneur.2024.03.010_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2010.03.096","article-title":"Ginsenoside Rg1 promotes glutamate release via a calcium\/calmodulin-dependent protein kinase II-dependent signaling pathway","volume":"1333","author":"Liu","year":"2010","journal-title":"Brain Res."},{"issue":"4","key":"10.1016\/j.ibneur.2024.03.010_bib46","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1172\/JCI38454","article-title":"Targeted electrode-based modulation of neural circuits for depression","volume":"119","author":"Mayberg","year":"2009","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.ibneur.2024.03.010_bib47","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1097\/SMJ.0b013e318200c221","article-title":"Postpartum depression: an essential overview for the practitioner","volume":"104","author":"McCoy","year":"2011","journal-title":"South. Med. J."},{"key":"10.1016\/j.ibneur.2024.03.010_bib48","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.bbr.2016.12.032","article-title":"Testing the correlation between experimentally-induced hypothyroidism during pregnancy and autistic-like symptoms in the rat offspring","volume":"321","author":"Melancia","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ibneur.2024.03.010_bib49","doi-asserted-by":"crossref","first-page":"703","DOI":"10.3389\/fendo.2018.00703","article-title":"A novel, synthetic, neuroactive steroid is effective at decreasing depression-like behaviors and improving maternal care in preclinical models of postpartum depression","volume":"9","author":"Mel\u00f3n","year":"2018","journal-title":"Front. Endocrinol."},{"issue":"9","key":"10.1016\/j.ibneur.2024.03.010_bib50","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1093\/cercor\/bhm232","article-title":"The expression of contextual fear conditioning involves activation of an NMDA receptor\u2013nitric oxide pathway in the medial prefrontal cortex","volume":"18","author":"Moraes Resstel","year":"2008","journal-title":"Cereb. Cortex"},{"issue":"6","key":"10.1016\/j.ibneur.2024.03.010_bib51","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1080\/1028415X.2019.1641294","article-title":"Prenatal dietary choline supplementation modulates long-term memory development in rat offspring","volume":"24","author":"Moreno","year":"2021","journal-title":"Nutr. Neurosci."},{"issue":"122","key":"10.1016\/j.ibneur.2024.03.010_bib52","doi-asserted-by":"crossref","DOI":"10.3791\/55261-v","article-title":"Neurodevelopmental reflex testing in neonatal rat pups","author":"Nguyen","year":"2017","journal-title":"J. Vis. Exp."},{"issue":"5","key":"10.1016\/j.ibneur.2024.03.010_bib53","first-page":"306","article-title":"Acute administration of Zn, Mg, and thiamine improves postpartum depression conditions in mice","volume":"15","author":"Nikseresht","year":"2012","journal-title":"Arch. Iran. Med."},{"issue":"3","key":"10.1016\/j.ibneur.2024.03.010_bib54","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.psyneuen.2006.12.010","article-title":"Antenatal thyroid correlates of postpartum depression","volume":"32","author":"Pedersen","year":"2007","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.ibneur.2024.03.010_bib55","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00213-004-2048-7","article-title":"Forced swimming test in mice: a review of antidepressant activity","volume":"177","author":"Petit-Demouliere","year":"2005","journal-title":"Psychopharmacology"},{"issue":"2","key":"10.1016\/j.ibneur.2024.03.010_bib56","first-page":"327","article-title":"Behavioral despair in mice: a primary screening test for antidepressants","volume":"229","author":"Porsolt","year":"1977","journal-title":"Arch. Int. De. Pharmacodyn. Et. De. Ther."},{"issue":"5604","key":"10.1016\/j.ibneur.2024.03.010_bib57","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/266730a0","article-title":"Depression: a new animal model sensitive to antidepressant treatments","volume":"266","author":"Porsolt","year":"1977","journal-title":"Nature"},{"key":"10.1016\/j.ibneur.2024.03.010_bib58","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1007\/s00011-021-01513-7","article-title":"Gisenoside Rg1 attenuates cadmium-induced neurotoxicity in vitro and in vivo by attenuating oxidative stress and inflammation","volume":"70","author":"Ren","year":"2021","journal-title":"Inflamm. Res."},{"issue":"1","key":"10.1016\/j.ibneur.2024.03.010_bib59","doi-asserted-by":"crossref","first-page":"25","DOI":"10.5214\/ans.0972.7531.260106","article-title":"Negative geotaxis: an early age behavioral hallmark to VPA rat model of autism","volume":"26","author":"Ruhela","year":"2019","journal-title":"Ann. Neurosci."},{"issue":"1-2","key":"10.1016\/j.ibneur.2024.03.010_bib60","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.autneu.2012.07.004","article-title":"Experimental gestational hypothyroidism evokes hypertension in adult offspring rats","volume":"170","author":"Santos","year":"2012","journal-title":"Auton. Neurosci."},{"issue":"2","key":"10.1016\/j.ibneur.2024.03.010_bib61","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/npp.2014.194","article-title":"Putative neuroprotective and neurotoxic kynurenine pathway metabolites are associated with hippocampal and amygdalar volumes in subjects with major depressive disorder","volume":"40","author":"Savitz","year":"2015","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.ibneur.2024.03.010_bib62","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1021\/tx700210j","article-title":"Oxidative stress and neurotoxicity","volume":"21","author":"Sayre","year":"2008","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.ibneur.2024.03.010_bib63","article-title":"Use of the open field maze to measure locomotor and anxiety-like behavior in mice","volume":"96","author":"Seibenhener","year":"2015","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.ibneur.2024.03.010_bib64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2013.04.001","article-title":"Brain development in rodents and humans: identifying benchmarks of maturation and vulnerability to injury across species","volume":"106","author":"Semple","year":"2013","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.ibneur.2024.03.010_bib65","doi-asserted-by":"crossref","first-page":"6477","DOI":"10.2147\/IJN.S139602","article-title":"Ginsenoside Rg1 nanoparticle penetrating the blood\u2013brain barrier to improve the cerebral function of diabetic rats complicated with cerebral infarction","author":"Shen","year":"2017","journal-title":"Int. J. Nanomed."},{"issue":"3","key":"10.1016\/j.ibneur.2024.03.010_bib66","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00428203","article-title":"The tail suspension test: a new method for screening antidepressants in mice","volume":"85","author":"Steru","year":"1985","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.ibneur.2024.03.010_bib67","doi-asserted-by":"crossref","DOI":"10.3389\/ftox.2021.705910","article-title":"Effects of prenatal exposure to titanium dioxide nanoparticles on DNA methylation and gene expression profile in the mouse brain","volume":"3","author":"Tachibana","year":"2021","journal-title":"Front. Toxicol."},{"key":"10.1016\/j.ibneur.2024.03.010_bib68","doi-asserted-by":"crossref","first-page":"434","DOI":"10.3389\/fpsyt.2018.00434","article-title":"Inhibition of autophagy in microglia alters depressive-like behavior via BDNF pathway in postpartum depression","volume":"9","author":"Tan","year":"2018","journal-title":"Front. Psychiatry"},{"issue":"4","key":"10.1016\/j.ibneur.2024.03.010_bib69","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1530\/acta.0.1260315","article-title":"Biogenic amines and thyrotoxicosis","volume":"126","author":"Upadhyaya","year":"1992","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.ibneur.2024.03.010_bib70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-069X-8-12","article-title":"Prenatal chlorpyrifos exposure alters motor behavior and ultrasonic vocalization in CD-1 mouse pups","volume":"8","author":"Venerosi","year":"2009","journal-title":"Environ. Health"},{"key":"10.1016\/j.ibneur.2024.03.010_bib71","unstructured":"Wahman, L.F., & Elgoly, A.H.M. Effect Of Panax ginseng on Monoamines and Amino Acids Levels in Brain Tissue, and DNA Damage in Experimentally Induced Hypothyroid Adult Female Rats."},{"issue":"3","key":"10.1016\/j.ibneur.2024.03.010_bib72","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1037\/0033-2909.83.3.482","article-title":"The open-field test: a critical review","volume":"83","author":"Walsh","year":"1976","journal-title":"Psychol. Bull."},{"key":"10.1016\/j.ibneur.2024.03.010_bib73","article-title":"Ginsenoside Rg1 ameliorates neuroinflammation via suppression of connexin43 ubiquitination to attenuate depression","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ibneur.2024.03.010_bib74","first-page":"35","article-title":"The development of social behavior patterns in the mouse, in relation to natural periods","author":"Williams","year":"1953","journal-title":"Behaviour"},{"issue":"3-4","key":"10.1016\/j.ibneur.2024.03.010_bib75","first-page":"169","article-title":"Effects of herbs and drugs during pregnancy and lactation","volume":"21","author":"Wong","year":"1979","journal-title":"J. Singap. Paediatr. Soc."},{"issue":"1","key":"10.1016\/j.ibneur.2024.03.010_bib76","doi-asserted-by":"crossref","first-page":"7790","DOI":"10.1038\/srep07790","article-title":"A systematic review and meta-analysis of Ginsenoside-Rg1 (G-Rg1) in experimental ischemic stroke","volume":"5","author":"Xie","year":"2015","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.ibneur.2024.03.010_bib77","doi-asserted-by":"crossref","first-page":"270","DOI":"10.3390\/cells7120270","article-title":"Protective effects and target network analysis of ginsenoside Rg1 in cerebral ischemia and reperfusion injury: a comprehensive overview of experimental studies","volume":"7","author":"Xie","year":"2018","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.ibneur.2024.03.010_bib78","first-page":"717","article-title":"Ginsenoside Rg1 protects against H2O2\u2011induced neuronal damage due to inhibition of the NLRP1 inflammasome signalling pathway in hippocampal neurons in vitro","volume":"43","author":"Xu","year":"2019","journal-title":"Int. J. Mol. Med."},{"issue":"6","key":"10.1016\/j.ibneur.2024.03.010_bib79","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1111\/cbdd.14041","article-title":"Ginsenoside Rg1 improves Alzheimer's disease by regulating oxidative stress, apoptosis, and neuroinflammation through Wnt\/GSK-3\u03b2\/\u03b2-catenin signaling pathway","volume":"99","author":"Yang","year":"2022","journal-title":"Chem. Biol. Drug Des."},{"issue":"3","key":"10.1016\/j.ibneur.2024.03.010_bib80","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0014-2999(88)90013-1","article-title":"Acute and chronic effects of ginseng saponins on maternal aggression in mice","volume":"150","author":"Yoshimura","year":"1988","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.ibneur.2024.03.010_bib81","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1139\/cjpp-2013-0274","article-title":"Comparative analysis of the neuroprotective effects of ginsenosides Rg1 and Rb1 extracted from Panax notoginseng against cerebral ischemia","volume":"92","author":"Zeng","year":"2014","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"11","key":"10.1016\/j.ibneur.2024.03.010_bib82","doi-asserted-by":"crossref","first-page":"3493","DOI":"10.1016\/j.apsb.2021.03.032","article-title":"Ginsenoside Rg1 ameliorates blood\u2013brain barrier disruption and traumatic brain injury via attenuating macrophages derived exosomes miR-21 release","volume":"11","author":"Zhai","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"issue":"4","key":"10.1016\/j.ibneur.2024.03.010_bib83","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1007\/s12035-020-02213-9","article-title":"Ginsenoside Rg1 prevents PTSD-like behaviors in mice through promoting synaptic proteins, reducing Kir4.1 and TNF-\u03b1 in the hippocampus","volume":"58","author":"Zhang","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ibneur.2024.03.010_bib84","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.neuroscience.2013.10.023","article-title":"Peripheral immunomodulation with ginsenoside Rg1 ameliorates neuroinflammation-induced behavioral deficits in rats","volume":"256","author":"Zheng","year":"2014","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.ibneur.2024.03.010_bib85","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/jcb.22233","article-title":"Ginsenoside Rg1 protects rat cardiomyocyte from hypoxia\/reoxygenation oxidative injury via antioxidant and intracellular calcium homeostasis","volume":"108","author":"Zhu","year":"2009","journal-title":"J. Cell. Biochem."}],"container-title":["IBRO Neuroscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667242124000344?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667242124000344?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T00:08:04Z","timestamp":1723853284000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667242124000344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":85,"alternative-id":["S2667242124000344"],"URL":"https:\/\/doi.org\/10.1016\/j.ibneur.2024.03.010","relation":{},"ISSN":["2667-2421"],"issn-type":[{"value":"2667-2421","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective role of the ginsenoside Rg1 against methimazole-induced gestational hypothyroidism on reflexive behaviors, conditioned fear and cortical antioxidant levels in mice offspring","name":"articletitle","label":"Article Title"},{"value":"IBRO Neuroscience Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ibneur.2024.03.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc. on behalf of International Brain Research Organization.","name":"copyright","label":"Copyright"}]}}