{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:35:05Z","timestamp":1790422505668,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T00:00:00Z","timestamp":1721433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006396","name":"Qazvin University of Medical Sciences","doi-asserted-by":"publisher","award":["14003255"],"award-info":[{"award-number":["14003255"]}],"id":[{"id":"10.13039\/501100006396","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ibroneuroreports.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["IBRO Neuroscience Reports"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.ibneur.2024.07.004","type":"journal-article","created":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T14:46:31Z","timestamp":1721573191000},"page":"131-137","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Reduced ischemia\u2010reperfusion oxidative stress injury by melatonin and N\u2010acetylcysteine in the male rat brain"],"prefix":"10.1016","volume":"17","author":[{"given":"Fatemeh","family":"Sabbaghziarani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pouria","family":"Soleimani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farideh Rajabian","family":"Eynshikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fariba","family":"Zafari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehsan","family":"Aali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ibneur.2024.07.004_bib1","doi-asserted-by":"crossref","first-page":"172","DOI":"10.15171\/PS.2017.26","article-title":"Prospects of N-acetylcysteine and melatonin as treatments for tramadol-induced renal toxicity in albino rats","volume":"23","author":"Adikwu","year":"2017","journal-title":"Pharm. Sci."},{"issue":"51","key":"10.1016\/j.ibneur.2024.07.004_bib2","doi-asserted-by":"crossref","DOI":"10.3791\/2879-v","article-title":"Intraluminal middle cerebral artery occlusion (MCAO) model for ischemic stroke with laser doppler flowmetry guidance in mice","author":"Ansari","year":"2011","journal-title":"JoVE"},{"issue":"11","key":"10.1016\/j.ibneur.2024.07.004_bib3","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.3390\/medicina59112026","article-title":"An evaluation of the effectiveness of melatonin and n-acetylcysteine in cerebral ischemia-reperfusion injury in adult rats","volume":"59","author":"Aydin","year":"2023","journal-title":"Medicina"},{"key":"10.1016\/j.ibneur.2024.07.004_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2019.146401","article-title":"Melatonin regulates neuroinflammation ischemic stroke damage through interactions with microglia in reperfusion phase","volume":"1723","author":"Azedi","year":"2019","journal-title":"Brain Res"},{"key":"10.1016\/j.ibneur.2024.07.004_bib5","doi-asserted-by":"crossref","first-page":"744","DOI":"10.3389\/fneur.2017.00744","article-title":"Systematic review of human and animal studies examining the efficacy and safety of N-acetylcysteine (NAC) and N-acetylcysteine amide (NACA) in traumatic brain injury: impact on neurofunctional outcome and biomarkers of oxidative stress and inflammation","volume":"8","author":"Bhatti","year":"2018","journal-title":"Front. Neurol."},{"issue":"1","key":"10.1016\/j.ibneur.2024.07.004_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12883-017-1007-y","article-title":"Reperfusion therapy in acute ischemic stroke: dawn of a new era?","volume":"18","author":"Bhaskar","year":"2018","journal-title":"BMC Neurol."},{"key":"10.1016\/j.ibneur.2024.07.004_bib7","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1600-079X.2006.00351.x","article-title":"Melatonin decreases neurovascular oxidative\/nitrosative damage and protects against early increases in the blood\u2013brain barrier permeability after transient focal cerebral ischemia in mice","volume":"41","author":"Chen","year":"2006","journal-title":"J. Pineal Res"},{"issue":"4","key":"10.1016\/j.ibneur.2024.07.004_bib8","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.bbi.2011.01.013","article-title":"Gonadal steroids prevent cell damage and stimulate behavioral recovery after transient middle cerebral artery occlusion in male and female rats","volume":"25","author":"Dang","year":"2011","journal-title":"Brain, Behav., Immun."},{"issue":"4","key":"10.1016\/j.ibneur.2024.07.004_bib9","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s11064-005-2690-4","article-title":"Changes of endogenous antioxidant enzymes during ischemic tolerance acquisition","volume":"30","author":"Danielisov\u00e1","year":"2005","journal-title":"Neurochem. Res"},{"issue":"4","key":"10.1016\/j.ibneur.2024.07.004_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0090617","article-title":"Efficacy of N-acetyl cysteine in traumatic brain injury","volume":"9","author":"Eakin","year":"2014","journal-title":"PloS one"},{"key":"10.1016\/j.ibneur.2024.07.004_bib11","first-page":"497","article-title":"The ischemic penumbra: from concept to reality (2021)","volume":"16","author":"Ermine","year":"2021"},{"issue":"2","key":"10.1016\/j.ibneur.2024.07.004_bib12","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3748\/wjg.v12.i2.259","article-title":"Antioxidative effect of melatonin, ascorbic acid and N-acetylcysteine on caerulein-induced pancreatitis and associated liver injury in rats","volume":"12","author":"E\u015frefo\u011flu","year":"2006","journal-title":"World J. Gastroenterol.: WJG"},{"issue":"171","key":"10.1016\/j.ibneur.2024.07.004_bib13","article-title":"Ginsenoside Rd: a promising target for ischemia-reperfusion injury therapy (A mini review)","volume":"4","author":"Feng","year":"2024","journal-title":"Biomed. Pharm."},{"issue":"4","key":"10.1016\/j.ibneur.2024.07.004_bib14","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.jointm.2023.02.002","article-title":"Oxidative stress as a bridge between age and stroke: a narrative review","volume":"3","author":"Feng","year":"2023","journal-title":"J. Intensive Med. 27"},{"issue":"2","key":"10.1016\/j.ibneur.2024.07.004_bib15","doi-asserted-by":"crossref","first-page":"e124","DOI":"10.1016\/j.jtcvs.2019.12.010","article-title":"Commentary: Ischemia reperfusion\u2014looking ahead","volume":"161","author":"Golts","year":"2021","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.ibneur.2024.07.004_bib16","doi-asserted-by":"crossref","unstructured":"Komsiiska D., 2019. Oxidative stress and stroke: a review of upstream and downstream antioxidant therapeutic options. Comp Clin Path 1-12. https:\/\/ doi.org\/10.1007\/s00580-019-02940-z.","DOI":"10.1007\/s00580-019-02940-z"},{"key":"10.1016\/j.ibneur.2024.07.004_bib17","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.neuroscience.2019.01.046","article-title":"Transcriptional regulation of antioxidant enzymes activity and modulation of oxidative stress by melatonin in rats under cerebral ischemia\/reperfusion conditions","volume":"406","author":"Kryl'skii","year":"2019","journal-title":"Neuroscience"},{"key":"10.1016\/j.ibneur.2024.07.004_bib18","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.brainresbull.2019.10.004","article-title":"Neuroprotective effects of N-acetylcysteine via inhibition of matrix metalloproteinase in a mouse model of transient global cerebral ischemia","volume":"154","author":"Lee","year":"2020","journal-title":"Brain Res. Bull."},{"issue":"2","key":"10.1016\/j.ibneur.2024.07.004_bib19","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1139\/cjpp-2015-0266","article-title":"Therapeutic value of melatonin post-treatment on CCl4-induced fibrotic rat liver","volume":"94","author":"Mortezaee","year":"2016","journal-title":"Can. J. Physiol. Pharm."},{"key":"10.1016\/j.ibneur.2024.07.004_bib20","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.freeradbiomed.2017.01.005","article-title":"Ischemic brain injury: new insights on the protective role of melatonin","volume":"104","author":"Ramos","year":"2017","journal-title":"Free Radic. Biol. Med"},{"issue":"1","key":"10.1016\/j.ibneur.2024.07.004_bib21","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s11011-016-9897-8","article-title":"Retinoic acid-pretreated Wharton\u2019s jelly mesenchymal stem cells in combination with triiodothyronine improve expression of neurotrophic factors in the subventricular zone of the rat ischemic brain injury","volume":"32","author":"Sabbaghziarani","year":"2017","journal-title":"Met Brain Di"},{"issue":"1","key":"10.1016\/j.ibneur.2024.07.004_bib22","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/cbf.3244","article-title":"Stimulation of neurotrophic factors and inhibition of proinflammatory cytokines by exogenous application of triiodothyronine in the rat model of ischemic stroke","volume":"35","author":"Sabbaghziarani","year":"2017","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/j.ibneur.2024.07.004_bib23","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.2147\/NDT.S241497","article-title":"Evidence for a beneficial effect of oral N-acetylcysteine on functional outcomes and inflammatory biomarkers in patients with acute ischemic stroke","volume":"16","author":"Sabetghadam","year":"2020","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.ibneur.2024.07.004_bib24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.exger.2017.03.009","article-title":"Protective roles of nanomelatonin in cerebral ischemia-reperfusion of aged brain: matrixmetalloproteinases as regulators","volume":"92","author":"Sarkar","year":"2017","journal-title":"Exp. Gerontol."},{"issue":"24","key":"10.1016\/j.ibneur.2024.07.004_bib25","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1016\/S0024-3205(03)00187-5","article-title":"Melatonin and N-acetylcysteine have beneficial effects during hepatic ischemia and reperfusion","volume":"72","author":"Sener","year":"2003","journal-title":"Life Sci."},{"key":"10.1016\/j.ibneur.2024.07.004_bib26","series-title":"The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine","first-page":"181","article-title":"Application of N-Acetylcysteine in Neurological Disorders","author":"Shahripour","year":"2019"},{"issue":"12","key":"10.1016\/j.ibneur.2024.07.004_bib27","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.3390\/molecules23123305","article-title":"Overview on the effects of N-acetylcysteine in neurodegenerative diseases","volume":"23","author":"Tardiolo","year":"2018","journal-title":"Molecules"},{"issue":"11","key":"10.1016\/j.ibneur.2024.07.004_bib28","doi-asserted-by":"crossref","first-page":"9303","DOI":"10.3390\/ijms24119303","article-title":"Expected and unexpected effects of pharmacological antioxidants","volume":"24","author":"Tyuryaeva","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.ibneur.2024.07.004_bib29","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/ana.21066","article-title":"N-acetylcysteine reduces lipopolysaccharide-sensitized hypoxic-ischemic brain injury","volume":"61","author":"Wang","year":"2007","journal-title":"Ann. Neurol.: Off. J. Am. Neurol. Assoc. Child Neurol. Soc."},{"issue":"5","key":"10.1016\/j.ibneur.2024.07.004_bib30","doi-asserted-by":"crossref","first-page":"883","DOI":"10.3727\/096368915X689749","article-title":"Melatonin as an antioxidant for stroke neuroprotection","volume":"25","author":"Watson","year":"2016","journal-title":"Cell Transpl."},{"issue":"7","key":"10.1016\/j.ibneur.2024.07.004_bib31","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1007\/s10571-017-0461-9","article-title":"Neuroprotective mechanisms of melatonin in hemorrhagic stroke","volume":"37","author":"Wu","year":"2017","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.ibneur.2024.07.004_bib32","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.mvr.2018.12.005","article-title":"The role of reactive oxygen species in angiogenesis and preventing tissue injury after brain ischemia","volume":"123","author":"Yang","year":"2019","journal-title":"Microvasc. Res"},{"key":"10.1016\/j.ibneur.2024.07.004_bib33","doi-asserted-by":"crossref","unstructured":"Yang Y., He B., Zhang X., Yang R., Xia X., Chen L., et al., 2022. Geraniin Protects against Cerebral Ischemia\/Reperfusion Injury by Suppressing Oxidative Stress and Neuronal Apoptosis via Regulation of the Nrf2\/HO-1 Pathway. Oxidative medicine and cellular longevity. Volume 2022, Article ID 2152746, 13 pages https:\/\/doi.org\/10.1155\/2022\/2152746.","DOI":"10.1155\/2022\/2152746"},{"key":"10.1016\/j.ibneur.2024.07.004_bib34","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.3390\/molecules28041747","article-title":"Pharmacological modulations of Nrf2 and therapeutic implications in aneurysmal subarachnoid hemorrhage","volume":"28","author":"Zhang","year":"2023","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.ibneur.2024.07.004_bib35","doi-asserted-by":"crossref","first-page":"396","DOI":"10.3109\/10799893.2014.908916","article-title":"Protective effect of N-acetylcysteine (NAC) on renal ischemia\/reperfusion injury through Nrf2 signaling pathway","volume":"34","author":"Zhang","year":"2014","journal-title":"J. Recept. Signal Transduct."},{"issue":"4","key":"10.1016\/j.ibneur.2024.07.004_bib36","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12521","article-title":"The protective effect of melatonin on brain ischemia and reperfusion in rats and humans: In vivo assessment and a randomized controlled trial","volume":"65","author":"Zhao","year":"2018","journal-title":"J. Pineal Res"},{"key":"10.1016\/j.ibneur.2024.07.004_bib37","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.brainresbull.2019.05.019","article-title":"Melatonin attenuates white matter damage after focal brain ischemia in rats by regulating the TLR4\/NF-\u03baB pathway","volume":"150","author":"Zhao","year":"2019","journal-title":"Brain Res. Bull."}],"container-title":["IBRO Neuroscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667242124000678?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667242124000678?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T08:44:47Z","timestamp":1734597887000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667242124000678"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":37,"alternative-id":["S2667242124000678"],"URL":"https:\/\/doi.org\/10.1016\/j.ibneur.2024.07.004","relation":{},"ISSN":["2667-2421"],"issn-type":[{"value":"2667-2421","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reduced ischemia\u2010reperfusion oxidative stress injury by melatonin and N\u2010acetylcysteine in the male rat brain","name":"articletitle","label":"Article Title"},{"value":"IBRO Neuroscience Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ibneur.2024.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Qazvin University of Medical Sciences. Published by Elsevier Inc. on behalf of International Brain Research Organization.","name":"copyright","label":"Copyright"}]}}