{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:53:59Z","timestamp":1792072439740,"version":"4.4.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006518","name":"University of Nebraska Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006518","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["EY10542"],"award-info":[{"award-number":["EY10542"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["EY32396"],"award-info":[{"award-number":["EY32396"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"NIH National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ibroneuroreports.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["IBRO Neuroscience Reports"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.ibneur.2025.03.009","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T22:38:45Z","timestamp":1743806325000},"page":"592-603","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Distribution of mRNA for the exocytotic calcium sensor, synaptotagmin 9, in mouse brain"],"prefix":"10.1016","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5617-4566","authenticated-orcid":false,"given":"Kwadwo O.","family":"Boateng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8899-2805","authenticated-orcid":false,"given":"Lucian D.","family":"Hadford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly L.","family":"Stauch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony E.","family":"Kincaid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7104-042X","authenticated-orcid":false,"given":"Wallace B.","family":"Thoreson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ibneur.2025.03.009_bib1","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nsmb1076","article-title":"Ca(2+)-synaptotagmin directly regulates t-SNARE function during reconstituted membrane fusion","volume":"13","author":"Bhalla","year":"2006","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.ibneur.2025.03.009_bib2","doi-asserted-by":"crossref","first-page":"4755","DOI":"10.1091\/mbc.e05-04-0277","article-title":"Synaptotagmin isoforms couple distinct ranges of Ca2+\u2009, Ba2+\u2009, and Sr2+\u2009concentration to SNARE-mediated membrane fusion","volume":"16","author":"Bhalla","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.ibneur.2025.03.009_bib3","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1126\/science.1589771","article-title":"Synaptotagmin: a calcium sensor on the synaptic vesicle surface","volume":"256","author":"Brose","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.ibneur.2025.03.009_bib4","doi-asserted-by":"crossref","first-page":"R7","DOI":"10.1016\/j.cub.2023.11.048","article-title":"The cerebellum","volume":"34","author":"Carey","year":"2024","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ibneur.2025.03.009_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.113956","article-title":"Relapse to cocaine seeking is regulated by medial habenula NR4A2\/NURR1 in mice","volume":"43","author":"Childs","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.ibneur.2025.03.009_bib6","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1471-2164-11-37","article-title":"A manual collection of Syt, Esyt, Rph3a, Rph3al, Doc2, and Dblc2 genes from 46 metazoan genomes--an open access resource for neuroscience and evolutionary biology","volume":"11","author":"Craxton","year":"2010","journal-title":"BMC Genom."},{"key":"10.1016\/j.ibneur.2025.03.009_bib7","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/35065004","article-title":"Synaptotagmin I functions as a calcium regulator of release probability","volume":"410","author":"Fernandez-Chacon","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.ibneur.2025.03.009_bib8","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/0092-8674(94)90556-8","article-title":"Synaptotagmin I: a major Ca2+\u2009sensor for transmitter release at a central synapse","volume":"79","author":"Geppert","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.ibneur.2025.03.009_bib9","doi-asserted-by":"crossref","first-page":"5210","DOI":"10.1073\/pnas.0500941102","article-title":"Three distinct kinetic groupings of the synaptotagmin family: candidate sensors for rapid and delayed exocytosis","volume":"102","author":"Hui","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ibneur.2025.03.009_bib10","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3389\/fpsyt.2019.00100","article-title":"The role of the medial habenula cholinergic system in addiction and emotion-associated behaviors","volume":"10","author":"Lee","year":"2019","journal-title":"Front Psychiatry"},{"key":"10.1016\/j.ibneur.2025.03.009_bib11","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/375594a0","article-title":"Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins","volume":"375","author":"Li","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.ibneur.2025.03.009_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceca.2023.102797","article-title":"Dual function of the choroid plexus: cerebrospinal fluid production and control of brain ion homeostasis","volume":"116","author":"Macaulay","year":"2023","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ibneur.2025.03.009_bib13","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/nature00846","article-title":"The C(2)B Ca(2+)-binding motif of synaptotagmin is required for synaptic transmission in vivo","volume":"418","author":"Mackler","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.ibneur.2025.03.009_bib14","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.neubiorev.2018.06.018","article-title":"From controlled to compulsive drug-taking: the role of the habenula in addiction","volume":"106","author":"Mathis","year":"2019","journal-title":"Neurosci. Biobehav Rev."},{"issue":"2","key":"10.1016\/j.ibneur.2025.03.009_bib15","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/jnc.14008","article-title":"The medial habenula and interpeduncular nucleus circuitry is critical in addiction, anxiety, and mood regulation","volume":"142","author":"Mclaughlin","year":"2017","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ibneur.2025.03.009_bib16","doi-asserted-by":"crossref","DOI":"10.1017\/S0952523824000026","article-title":"Synaptotagmin-9 in mouse retina","volume":"41","author":"Mesnard","year":"2024","journal-title":"Vis. Neurosci."},{"key":"10.1016\/j.ibneur.2025.03.009_bib17","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/cne.21908","article-title":"Differential mRNA expression patterns of the synaptotagmin gene family in the rodent brain","volume":"512","author":"Mittelsteadt","year":"2009","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.ibneur.2025.03.009_bib18","doi-asserted-by":"crossref","first-page":"1006773","DOI":"10.3389\/fnsyn.2022.1006773","article-title":"Neocortical layer 5 subclasses: from cellular properties to roles in behavior","volume":"14","author":"Moberg","year":"2022","journal-title":"Front Synaptic Neurosci."},{"key":"10.1016\/j.ibneur.2025.03.009_bib19","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s00439-017-1821-8","article-title":"The landscape of genetic diseases in saudi arabia based on the first 1000 diagnostic panels and exomes","volume":"136","author":"Monies","year":"2017","journal-title":"Hum. Genet"},{"key":"10.1016\/j.ibneur.2025.03.009_bib20","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3389\/fncir.2014.00098","article-title":"Neuronal organization of olfactory bulb circuits","volume":"8","author":"Nagayama","year":"2014","journal-title":"Front Neural Circuits"},{"key":"10.1016\/j.ibneur.2025.03.009_bib21","doi-asserted-by":"crossref","first-page":"13493","DOI":"10.1523\/JNEUROSCI.3519-06.2006","article-title":"Synaptotagmin-2 is essential for survival and contributes to Ca2+\u2009triggering of neurotransmitter release in central and neuromuscular synapses","volume":"26","author":"Pang","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ibneur.2025.03.009_bib22","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/jnc.13865","article-title":"C2-domain containing calcium sensors in neuroendocrine secretion","volume":"139","author":"Pinheiro","year":"2016","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ibneur.2025.03.009_bib23","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s13059-017-1220-4","article-title":"Easi-CRISPR: a robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins","volume":"18","author":"Quadros","year":"2017","journal-title":"Genome Biol."},{"key":"10.1016\/j.ibneur.2025.03.009_bib24","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1523\/JNEUROSCI.1857-22.2023","article-title":"Synaptotagmin 9 modulates spontaneous neurotransmitter release in striatal neurons by regulating substance P secretion","volume":"43","author":"Seibert","year":"2023","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ibneur.2025.03.009_bib25","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1093\/emboj\/21.3.270","article-title":"Synaptotagmins form a hierarchy of exocytotic Ca(2+) sensors with distinct Ca(2+) affinities","volume":"21","author":"Sugita","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.ibneur.2025.03.009_bib26","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.neuron.2020.05.036","article-title":"SNAREopathies: diversity in Mechanisms and Symptoms","volume":"107","author":"Verhage","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.ibneur.2025.03.009_bib27","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.conb.2020.04.006","article-title":"The diversity of synaptotagmin isoforms","volume":"63","author":"Wolfes","year":"2020","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.ibneur.2025.03.009_bib28","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.neuron.2007.05.004","article-title":"Synaptotagmin-1, -2, and -9: Ca(2+) sensors for fast release that specify distinct presynaptic properties in subsets of neurons","volume":"54","author":"Xu","year":"2007","journal-title":"Neuron"}],"container-title":["IBRO Neuroscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667242125000430?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667242125000430?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T07:42:07Z","timestamp":1784360527000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667242125000430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":28,"alternative-id":["S2667242125000430"],"URL":"https:\/\/doi.org\/10.1016\/j.ibneur.2025.03.009","relation":{},"ISSN":["2667-2421"],"issn-type":[{"value":"2667-2421","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Distribution of mRNA for the exocytotic calcium sensor, synaptotagmin 9, in mouse brain","name":"articletitle","label":"Article Title"},{"value":"IBRO Neuroscience Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ibneur.2025.03.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of International Brain Research Organization.","name":"copyright","label":"Copyright"}]}}