{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T21:37:07Z","timestamp":1793914627780,"version":"4.8.0"},"reference-count":18,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T00:00:00Z","timestamp":1750464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012899","name":"Lanzhou University","doi-asserted-by":"publisher","award":["lzuyxcx-2022-141"],"award-info":[{"award-number":["lzuyxcx-2022-141"]}],"id":[{"id":"10.13039\/100012899","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012899","name":"Lanzhou University","doi-asserted-by":"publisher","award":["lzuyxcx-2022-154"],"award-info":[{"award-number":["lzuyxcx-2022-154"]}],"id":[{"id":"10.13039\/100012899","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004775","name":"Natural Science Foundation of Gansu Province","doi-asserted-by":"publisher","award":["21JR1RA135"],"award-info":[{"award-number":["21JR1RA135"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004775","name":"Natural Science Foundation of Gansu Province","doi-asserted-by":"publisher","award":["23JRRA1001"],"award-info":[{"award-number":["23JRRA1001"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M751264"],"award-info":[{"award-number":["2024M751264"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["GZC20231010"],"award-info":[{"award-number":["GZC20231010"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81960673"],"award-info":[{"award-number":["81960673"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260612"],"award-info":[{"award-number":["82260612"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870329"],"award-info":[{"award-number":["81870329"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009590","name":"Gansu Education Department","doi-asserted-by":"publisher","award":["2021jyjbgs-02"],"award-info":[{"award-number":["2021jyjbgs-02"]}],"id":[{"id":"10.13039\/501100009590","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["lzujbky-2023-stlt01"],"award-info":[{"award-number":["lzujbky-2023-stlt01"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["20GSSY3-18"],"award-info":[{"award-number":["20GSSY3-18"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["lzujbky-2022-sp08"],"award-info":[{"award-number":["lzujbky-2022-sp08"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ibroneuroreports.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["IBRO Neuroscience Reports"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.ibneur.2025.06.014","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T19:10:42Z","timestamp":1750705842000},"page":"192-197","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Uptakes of boronophenylalanine in the in vitro and in situ glioblastoma and the potential efficacy of boron neutron capture therapy"],"prefix":"10.1016","volume":"19","author":[{"given":"Shining","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0039-3097","authenticated-orcid":false,"given":"Yujie","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjiao","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limei","family":"Shuai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yucai","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Futian","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiying","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ibneur.2025.06.014_bib1","first-page":"148","article-title":"Rodent brain tumor models for studies focusing on boron neutron capture therapy","volume":"38","author":"Barth","year":"2023","journal-title":"Cancer Biother. Radiopharm."},{"key":"10.1016\/j.ibneur.2025.06.014_bib2","first-page":"160","article-title":"New boron delivery agents","volume":"38","author":"Beck-Sickinger","year":"2023","journal-title":"Cancer Biother. Radiopharm."},{"key":"10.1016\/j.ibneur.2025.06.014_bib3","article-title":"Salvage boron neutron capture therapy for malignant brain tumor patients in compliance with emergency and compassionate use: evaluation of 34 cases in Taiwan","volume":"10","author":"Chen","year":"2021","journal-title":"Biology (Basel)"},{"key":"10.1016\/j.ibneur.2025.06.014_bib4","doi-asserted-by":"crossref","first-page":"71","DOI":"10.14338\/IJPT-22-00002.1","article-title":"A review of boron neutron capture therapy: its history and current challenges","volume":"9","author":"Jin","year":"2022","journal-title":"Int. J. Part Ther."},{"key":"10.1016\/j.ibneur.2025.06.014_bib5","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1016\/j.apradiso.2011.05.029","article-title":"Clinical results of boron neutron capture therapy (BNCT) for glioblastoma","volume":"69","author":"Kageji","year":"2011","journal-title":"Appl. Radiat. Isot."},{"key":"10.1016\/j.ibneur.2025.06.014_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107964","article-title":"Amino acid transporter LAT1 (SLC7A5) as a molecular target for cancer diagnosis and therapeutics","volume":"230","author":"Kanai","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ibneur.2025.06.014_bib7","article-title":"In vivo accelerator-based boron neutron capture therapy for spontaneous tumors in large animals: case series","volume":"11","author":"Kanygin","year":"2022","journal-title":"Biology (Basel)"},{"key":"10.1016\/j.ibneur.2025.06.014_bib8","article-title":"Accelerator-based BNCT for patients with recurrent glioblastoma: a multicenter phase II study","volume":"3","author":"Kawabata","year":"2021","journal-title":"Neurooncol. Adv."},{"key":"10.1016\/j.ibneur.2025.06.014_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.apradiso.2020.109105","article-title":"Using salvage Boron Neutron Capture Therapy (BNCT) for recurrent malignant brain tumors in Taiwan","volume":"160","author":"Lan","year":"2020","journal-title":"Appl. Radiat. Isot."},{"key":"10.1016\/j.ibneur.2025.06.014_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.apradiso.2024.111184","article-title":"A novel method for simultaneously measuring boronophenylalanine uptake in brain tumor cells and number of cells using inductively coupled plasma atomic emission spectroscopy","volume":"205","author":"Li","year":"2024","journal-title":"Appl. Radiat. Isot."},{"key":"10.1016\/j.ibneur.2025.06.014_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11060-020-03586-6","article-title":"Boron neutron capture therapy for malignant brain tumors","volume":"149","author":"Miyatake","year":"2020","journal-title":"J. Neurooncol."},{"key":"10.1016\/j.ibneur.2025.06.014_bib12","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1093\/jjco\/hys121","article-title":"Phase II study of single-agent bevacizumab in Japanese patients with recurrent malignant glioma","volume":"42","author":"Nagane","year":"2012","journal-title":"Jpn J. Clin. Oncol."},{"key":"10.1016\/j.ibneur.2025.06.014_bib13","first-page":"ZE01","article-title":"Boron neutron capture therapy - a literature review","volume":"10","author":"Nedunchezhian","year":"2016","journal-title":"J. Clin. Diagn. Res."},{"key":"10.1016\/j.ibneur.2025.06.014_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.925671","article-title":"Evaluation of pharmacokinetics of boronophenylalanine and its uptakes in gastric cancer","volume":"12","author":"Tang","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ibneur.2025.06.014_bib15","first-page":"21","article-title":"Advanced boron neutron capture therapy targeting cancer stem cells by selective induction of LAT1 overexpression","volume":"200","author":"Tani","year":"2023","journal-title":"Radiat. Res."},{"key":"10.1016\/j.ibneur.2025.06.014_bib16","first-page":"302","article-title":"Evaluation of 4-borono-2\u201318\u2009F-fluoro-L-phenylalanine-fructose as a probe for boron neutron capture therapy in a glioma-bearing rat model","volume":"45","author":"Wang","year":"2004","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.ibneur.2025.06.014_bib17","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/jrr\/rrac077","article-title":"Correlation between the expression of LAT1 in cancer cells and the potential efficacy of boron neutron capture therapy","volume":"64","author":"Watanabe","year":"2023","journal-title":"J. Radiat. Res."},{"key":"10.1016\/j.ibneur.2025.06.014_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.apradiso.2020.109234","article-title":"Difference in BPA uptake between glioma stem-like cells and their cancerous cells","volume":"164","author":"Yoshida","year":"2020","journal-title":"Appl. Radiat. Isot."}],"container-title":["IBRO Neuroscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667242125000971?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667242125000971?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T11:22:21Z","timestamp":1778930541000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667242125000971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":18,"alternative-id":["S2667242125000971"],"URL":"https:\/\/doi.org\/10.1016\/j.ibneur.2025.06.014","relation":{},"ISSN":["2667-2421"],"issn-type":[{"value":"2667-2421","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Uptakes of boronophenylalanine in the in vitro and in situ glioblastoma and the potential efficacy of boron neutron capture therapy","name":"articletitle","label":"Article Title"},{"value":"IBRO Neuroscience Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ibneur.2025.06.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of International Brain Research Organization.","name":"copyright","label":"Copyright"}]}}