{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T20:54:08Z","timestamp":1782161648009,"version":"3.54.5"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T00:00:00Z","timestamp":1758326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 AG024904"],"award-info":[{"award-number":["U01 AG024904"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009804","name":"Northern California Institute for Research and Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014041","name":"Alzheimer's Disease Neuroimaging Initiative","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006034","name":"University of Southern California","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006034","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-12-2-0012"],"award-info":[{"award-number":["W81XWH-12-2-0012"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ibroneuroreports.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["IBRO Neuroscience Reports"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.ibneur.2025.09.007","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T20:16:01Z","timestamp":1758831361000},"page":"359-369","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Serum amino acid levels are associated with brain hypometabolism in patients across the Alzheimer\u2019s disease continuum"],"prefix":"10.1016","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2361-3308","authenticated-orcid":false,"given":"Hamide","family":"Nasiri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rezvan","family":"Nemati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiana","family":"Orangi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meysam","family":"Mansouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aileen","family":"Saranjam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Esmizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3109-5543","authenticated-orcid":false,"given":"Mahsa","family":"Sadeghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiana","family":"Sattari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasti","family":"Salem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masha","family":"Mayeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sima","family":"Sadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ibneur.2025.09.007_bib1","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.jalz.2018.02.001","article-title":"2018 alzheimer's disease facts and figures","volume":"14","author":"Association","year":"2018","journal-title":"Alzheimer's. Dement."},{"issue":"16","key":"10.1016\/j.ibneur.2025.09.007_bib2","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1001\/jama.2019.4782","article-title":"Diagnosis and management of dementia: review","volume":"322","author":"Arvanitakis","year":"2019","journal-title":"Jama"},{"issue":"11","key":"10.1016\/j.ibneur.2025.09.007_bib3","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.2174\/1570159X18666200528142429","article-title":"Recent advancements in pathogenesis, diagnostics and treatment of Alzheimer\u2019s disease","volume":"18","author":"Khan","year":"2020","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.ibneur.2025.09.007_bib4","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1007\/s11064-011-0438-x","article-title":"Biomarkers of Alzheimer\u2032 s disease in the cerebrospinal fluid of spanish patients with mild cognitive impairment","volume":"36","author":"Monge-Argiles","year":"2011","journal-title":"Neurochem. Res."},{"issue":"4","key":"10.1016\/j.ibneur.2025.09.007_bib5","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA research framework: toward a biological definition of alzheimer's disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimer's. Dement."},{"key":"10.1016\/j.ibneur.2025.09.007_bib6","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.arr.2016.01.002","article-title":"Brain atrophy in Alzheimer\u2019s disease and aging","volume":"30","author":"Pini","year":"2016","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.ibneur.2025.09.007_bib7","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.neuroimage.2014.10.050","article-title":"The mediational effects of FDG hypometabolism on the association between cerebrospinal fluid biomarkers and neurocognitive function","volume":"105","author":"Dowling","year":"2015","journal-title":"Neuroimage"},{"issue":"4","key":"10.1016\/j.ibneur.2025.09.007_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/hbm.70180","article-title":"Relationships between brain glucose metabolism patterns and impaired glycemic status: a systematic review of FDG-PET studies with a focus on alzheimer's disease","volume":"46","author":"Soltani","year":"2025","journal-title":"Hum. Brain Mapp."},{"issue":"1","key":"10.1016\/j.ibneur.2025.09.007_bib9","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s40035-023-00364-y","article-title":"Brain metabolism in Alzheimer\u2019s disease: biological mechanisms of exercise","volume":"12","author":"Xu","year":"2023","journal-title":"Transl. Neurodegener."},{"issue":"Pt 10","key":"10.1016\/j.ibneur.2025.09.007_bib10","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1093\/brain\/awm177","article-title":"FDG-PET improves accuracy in distinguishing frontotemporal dementia and alzheimer's disease","volume":"130","author":"Foster","year":"2007","journal-title":"Brain"},{"issue":"4","key":"10.1016\/j.ibneur.2025.09.007_bib11","doi-asserted-by":"crossref","first-page":"e396","DOI":"10.1212\/WNL.0000000000201439","article-title":"Brain metabolic profile in presymptomatic GRN carriers throughout a 5-Year Follow-up","volume":"100","author":"Saracino","year":"2023","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.ibneur.2025.09.007_bib12","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.neurobiolaging.2005.11.002","article-title":"Decline of cerebral glucose metabolism in frontotemporal dementia: a longitudinal 18F-FDG-PET-study","volume":"28","author":"Diehl-Schmid","year":"2007","journal-title":"Neurobiol. Aging"},{"issue":"8","key":"10.1016\/j.ibneur.2025.09.007_bib13","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1007\/s40520-022-02120-0","article-title":"The associations of serum valine with mild cognitive impairment and Alzheimer\u2019s disease","volume":"34","author":"Xiong","year":"2022","journal-title":"Aging Clin. Exp. Res."},{"issue":"2-3","key":"10.1016\/j.ibneur.2025.09.007_bib14","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s007020050058","article-title":"Abnormal amino acid metabolism in patients with early stage alzheimer dementia","volume":"105","author":"Fekkes","year":"1998","journal-title":"J. Neural Transm. (Vienna)"},{"issue":"7","key":"10.1016\/j.ibneur.2025.09.007_bib15","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S0197-4580(03)00007-1","article-title":"Increased concentrations of homocysteine and asymmetric dimethylarginine and decreased concentrations of nitric oxide in the plasma of patients with alzheimer's disease","volume":"24","author":"Selley","year":"2003","journal-title":"Neurobiol. Aging"},{"issue":"1","key":"10.1016\/j.ibneur.2025.09.007_bib16","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s10334-003-0004-x","article-title":"Reduced glutamate neurotransmission in patients with alzheimer's disease -- an in vivo (13)C magnetic resonance spectroscopy study","volume":"16","author":"Lin","year":"2003","journal-title":"Magma"},{"issue":"4","key":"10.1016\/j.ibneur.2025.09.007_bib17","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1176\/appi.ajp.157.4.638","article-title":"Cognitive deficit induced by acute tryptophan depletion in patients with alzheimer's disease","volume":"157","author":"Porter","year":"2000","journal-title":"Am. J. Psychiatry"},{"issue":"8","key":"10.1016\/j.ibneur.2025.09.007_bib18","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s00415-025-13268-w","article-title":"Interaction of metabolic and inflammatory dysregulation on central degeneration and cognitive function in behavioral variant frontotemporal dementia","volume":"272","author":"Hou","year":"2025","journal-title":"J. Neurol."},{"issue":"4","key":"10.1016\/j.ibneur.2025.09.007_bib19","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1159\/000287953","article-title":"Cerebrospinal fluid concentrations of functionally important amino acids and metabolic compounds in patients with mild cognitive impairment and alzheimer's disease","volume":"7","author":"Kaiser","year":"2010","journal-title":"Neurodegener. Dis."},{"issue":"1","key":"10.1016\/j.ibneur.2025.09.007_bib20","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1159\/000466688","article-title":"Serum amino acid profiles in normal subjects and in patients with or at risk of alzheimer dementia","volume":"7","author":"Corso","year":"2017","journal-title":"Dement Geriatr. Cogn. Dis. Extra"},{"issue":"4","key":"10.1016\/j.ibneur.2025.09.007_bib21","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.3233\/JAD-142925","article-title":"A blood-based, 7-metabolite signature for the early diagnosis of alzheimer's disease","volume":"45","author":"Olazar\u00e1n","year":"2015","journal-title":"J. Alzheimers Dis."},{"issue":"6","key":"10.1016\/j.ibneur.2025.09.007_bib22","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s11011-025-01647-1","article-title":"Amino acid patterns predict White matter integrity measures in the brain in patients across the alzheimer's disease continuum","volume":"40","author":"Goharmanesh","year":"2025","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.ibneur.2025.09.007_bib23","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.neuroscience.2025.05.013","article-title":"Elevated serum leucine levels are associated with cognitive impairment and reduced gray matter and cerebral volume across the Alzheimer\u2019s disease continuum","volume":"577","author":"Nasiri","year":"2025","journal-title":"Neuroscience"},{"issue":"5","key":"10.1016\/j.ibneur.2025.09.007_bib24","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1136\/jnnp.48.5.469","article-title":"Putative amino acid transmitters in lumbar cerebrospinal fluid of patients with histologically verified alzheimer's dementia","volume":"48","author":"Smith","year":"1985","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"2","key":"10.1016\/j.ibneur.2025.09.007_bib25","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s00726-006-0409-8","article-title":"Free amino acid and dipeptide changes in the body fluids from alzheimer's disease subjects","volume":"32","author":"Fonteh","year":"2007","journal-title":"Amino Acids"},{"issue":"6","key":"10.1016\/j.ibneur.2025.09.007_bib26","first-page":"670","article-title":"Plasma concentrations of glutamate and its metabolites in patients with alzheimer's disease","volume":"93","author":"Miulli","year":"1993","journal-title":"J. Am. Osteopath Assoc."},{"issue":"2-3","key":"10.1016\/j.ibneur.2025.09.007_bib27","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s007020050056","article-title":"Neurotransmitter amino acids in cerebrospinal fluid of patients with alzheimer's disease","volume":"105","author":"Jim\u00e9nez-Jim\u00e9nez","year":"1998","journal-title":"J. Neural Transm. (Vienna)"},{"issue":"1","key":"10.1016\/j.ibneur.2025.09.007_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02252617","article-title":"Amino acid concentrations in cerebrospinal fluid and serum in alzheimer's disease and vascular dementia","volume":"6","author":"Martinez","year":"1993","journal-title":"J. Neural Transm. Park Dis. Dement Sect."},{"issue":"2","key":"10.1016\/j.ibneur.2025.09.007_bib29","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.aninu.2020.11.007","article-title":"Serum biochemical parameters and amino acids metabolism are altered in piglets by early-weaning and proline and putrescine supplementations","volume":"7","author":"Wang","year":"2021","journal-title":"Anim. Nutr."},{"issue":"1","key":"10.1016\/j.ibneur.2025.09.007_bib30","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.aninu.2019.12.001","article-title":"Amino acids regulate energy utilization through mammalian target of rapamycin complex 1 and adenosine monophosphate activated protein kinase pathway in porcine enterocytes","volume":"6","author":"Xiao","year":"2020","journal-title":"Anim. Nutr."},{"issue":"1","key":"10.1016\/j.ibneur.2025.09.007_bib31","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s10571-021-01126-y","article-title":"Decreased glucose metabolism and glutamine synthesis in the retina of a transgenic mouse model of alzheimer's disease","volume":"42","author":"Tams","year":"2022","journal-title":"Cell Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.ibneur.2025.09.007_bib32","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s11064-024-04262-1","article-title":"l-Proline alters energy metabolism in brain cortical tissue slices","volume":"50","author":"Das","year":"2024","journal-title":"Neurochem. Res."},{"issue":"6","key":"10.1016\/j.ibneur.2025.09.007_bib33","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1007\/s11064-016-2070-2","article-title":"Alterations in cerebral cortical glucose and glutamine metabolism precedes amyloid plaques in the APPswe\/PSEN1dE9 mouse model of Alzheimer\u2019s disease","volume":"42","author":"Andersen","year":"2017","journal-title":"Neurochem. Res."},{"issue":"7","key":"10.1016\/j.ibneur.2025.09.007_bib34","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on alzheimer's disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.ibneur.2025.09.007_bib35","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1212\/WNL.0b013e3181cb3e25","article-title":"Alzheimer's disease neuroimaging initiative (ADNI): clinical characterization","volume":"74","author":"Petersen","year":"2010","journal-title":"Neurology"},{"issue":"9","key":"10.1016\/j.ibneur.2025.09.007_bib36","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1111\/j.1532-5415.1992.tb01992.x","article-title":"The mini-mental state examination: a comprehensive review","volume":"40","author":"Tombaugh","year":"1992","journal-title":"J. Am. Geriatr. Soc."},{"issue":"3","key":"10.1016\/j.ibneur.2025.09.007_bib37","first-page":"Cd010783","article-title":"Mini-Mental state examination (MMSE) for the detection of alzheimer's disease and other dementias in people with mild cognitive impairment (MCI)","volume":"2015","author":"Arevalo-Rodriguez","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.ibneur.2025.09.007_bib38","series-title":"Cognitive Screening Instruments: A Practical Approach","first-page":"37","article-title":"The Mini-Mental state examination (MMSE): update on its diagnostic accuracy and clinical utility for cognitive disorders","author":"Mitchell","year":"2017"},{"issue":"7","key":"10.1016\/j.ibneur.2025.09.007_bib39","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.neurobiolaging.2009.07.002","article-title":"Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI","volume":"32","author":"Landau","year":"2011","journal-title":"Neurobiol. Aging"},{"issue":"1","key":"10.1016\/j.ibneur.2025.09.007_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00726-024-03442-1","article-title":"Alterations of amino acids in older adults with Alzheimer\u2019s disease and vascular dementia","volume":"57","author":"Ma","year":"2025","journal-title":"Amino Acids"},{"issue":"1","key":"10.1016\/j.ibneur.2025.09.007_bib41","doi-asserted-by":"crossref","first-page":"15205","DOI":"10.1038\/s41598-022-19670-y","article-title":"Metabolomic alterations in the blood plasma of older adults with mild cognitive impairment and Alzheimer\u2019s disease (from the Nakayama Study)","volume":"12","author":"Ozaki","year":"2022","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.ibneur.2025.09.007_bib42","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1016\/j.neurobiolaging.2014.03.013","article-title":"Altered arginine metabolism in alzheimer's disease brains","volume":"35","author":"Liu","year":"2014","journal-title":"Neurobiol. Aging"},{"issue":"3","key":"10.1016\/j.ibneur.2025.09.007_bib43","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1134\/S1819712422030059","article-title":"The role of polyamines in the mechanisms of cognitive impairment","volume":"16","author":"Makletsova","year":"2022","journal-title":"Neurochem. J."},{"issue":"1","key":"10.1016\/j.ibneur.2025.09.007_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4062\/biomolther.2015.078","article-title":"Alpha-Ketoglutarate: physiological functions and applications","volume":"24","author":"Wu","year":"2016","journal-title":"Biomol. Ther. (Seoul.)"},{"issue":"4","key":"10.1016\/j.ibneur.2025.09.007_bib45","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.nurt.2010.05.015","article-title":"Astrocyte glutamine synthetase: importance in hyperammonemic syndromes and potential target for therapy","volume":"7","author":"Brusilow","year":"2010","journal-title":"Neurotherapeutics"},{"issue":"1","key":"10.1016\/j.ibneur.2025.09.007_bib46","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1186\/s12964-025-02328-3","article-title":"Urea cycle dysregulation: a new frontier in cancer metabolism and immune evasion","volume":"23","author":"Shou","year":"2025","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.ibneur.2025.09.007_bib47","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.578922","article-title":"Disturbance of the Glutamate-Glutamine cycle, secondary to hepatic damage, compromises memory function","volume":"15","author":"Lim\u00f3n","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.ibneur.2025.09.007_bib48","doi-asserted-by":"crossref","first-page":"5472792","DOI":"10.1155\/2017\/5472792","article-title":"Amino acid catabolism in alzheimer's disease brain: friend or foe?","volume":"2017","author":"Griffin","year":"2017","journal-title":"Oxid. Med. Cell Longev."},{"issue":"11","key":"10.1016\/j.ibneur.2025.09.007_bib49","doi-asserted-by":"crossref","first-page":"6039","DOI":"10.3390\/ijms23116039","article-title":"Altered brain arginine metabolism and polyamine system in a P301S tauopathy mouse model: a time-course study","volume":"23","author":"Mein","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.ibneur.2025.09.007_bib50","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0119452","article-title":"Untargeted metabolomic analysis of human plasma indicates differentially affected polyamine and L-Arginine metabolism in mild cognitive impairment subjects converting to Alzheimer\u2019s disease","volume":"10","author":"Graham","year":"2015","journal-title":"PLOS ONE"},{"key":"10.1016\/j.ibneur.2025.09.007_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176804","article-title":"A review on polyamines as promising next-generation neuroprotective and anti-aging therapy","volume":"978","author":"Arthur","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ibneur.2025.09.007_bib52","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.bbamem.2003.12.005","article-title":"Effects of polyamines on mitochondrial Ca2+ transport","volume":"1661","author":"Salvi","year":"2004","journal-title":"Biochim. Et. Biophys. Acta"},{"issue":"5","key":"10.1016\/j.ibneur.2025.09.007_bib53","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41419-024-06720-8","article-title":"Reduction of spermine synthase enhances autophagy to suppress tau accumulation","volume":"15","author":"Tao","year":"2024","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.ibneur.2025.09.007_bib54","doi-asserted-by":"crossref","first-page":"837","DOI":"10.3233\/JAD-231184","article-title":"Polyamine dysregulation and nucleolar disruption in alzheimer's disease","volume":"98","author":"Brooks","year":"2024","journal-title":"J. Alzheimers Dis."},{"issue":"5","key":"10.1016\/j.ibneur.2025.09.007_bib55","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1111\/jnc.16014","article-title":"Increased glucose metabolism and impaired glutamate transport in human astrocytes are potential early triggers of abnormal extracellular glutamate accumulation in hiPSC-derived models of alzheimer's disease","volume":"168","author":"Salcedo","year":"2024","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ibneur.2025.09.007_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2022.102331","article-title":"Astrocyte energy and neurotransmitter metabolism in Alzheimer\u2019s disease: integration of the glutamate\/GABA-glutamine cycle","volume":"217","author":"Andersen","year":"2022","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.ibneur.2025.09.007_bib57","doi-asserted-by":"crossref","unstructured":"Chen, J. and K. Herrup, Glutamine as a Potential Neuroprotectant in Alzheimer\u2019s Disease. 2015. p. 761-771.","DOI":"10.1016\/B978-0-12-407824-6.00070-7"},{"issue":"5","key":"10.1016\/j.ibneur.2025.09.007_bib58","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/labmed\/lmae016","article-title":"The Arg\/Arg genotype of leptin receptor gene Gln223Arg polymorphism May be an independent risk factor for nonalcoholic fatty liver disease","volume":"55","author":"Navari","year":"2024","journal-title":"Lab Med."},{"key":"10.1016\/j.ibneur.2025.09.007_bib59","doi-asserted-by":"crossref","first-page":"1275793","DOI":"10.3389\/fnagi.2023.1275793","article-title":"Development of a diagnostic and risk prediction model for alzheimer's disease through integration of single-cell and bulk transcriptomic analysis of glutamine metabolism","volume":"15","author":"Guo","year":"2023","journal-title":"Front. Aging Neurosci."},{"issue":"3","key":"10.1016\/j.ibneur.2025.09.007_bib60","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s10522-020-09860-4","article-title":"Alzheimer\u2019s disease: targeting the glutamatergic system","volume":"21","author":"Conway","year":"2020","journal-title":"Biogerontology"},{"issue":"1","key":"10.1016\/j.ibneur.2025.09.007_bib61","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1186\/s12974-024-03254-w","article-title":"Glutamine metabolism modulates microglial NLRP3 inflammasome activity through mitophagy in Alzheimer\u2019s disease","volume":"21","author":"Zhang","year":"2024","journal-title":"J. Neuroinflamm."},{"issue":"4","key":"10.1016\/j.ibneur.2025.09.007_bib62","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.3233\/JAD-215448","article-title":"Targeted metabolomic analysis in Alzheimer\u2019s disease plasma and brain tissue in non-hispanic whites","volume":"86","author":"Kaleck\u00fd","year":"2022","journal-title":"J. Alzheimer's. Dis."},{"issue":"1","key":"10.1016\/j.ibneur.2025.09.007_bib63","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13024-024-00704-0","article-title":"Collagen in the central nervous system: contributions to neurodegeneration and promise as a therapeutic target","volume":"19","author":"Wareham","year":"2024","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.ibneur.2025.09.007_bib64","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.707466","article-title":"Role of the extracellular matrix in alzheimer's disease","volume":"13","author":"Sun","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.ibneur.2025.09.007_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123504","article-title":"Extracellular matrix glycation epigenetically regulates brain aging and neurodegeneration in the in vitro aged neurovascular model","volume":"324","author":"Jang","year":"2026","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.ibneur.2025.09.007_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.clinre.2021.101792","article-title":"Targeting AGEs-RAGE pathway inhibits inflammation and presents neuroprotective effect against hepatic ischemia-reperfusion induced hippocampus damage","volume":"46","author":"Ren","year":"2022","journal-title":"Clin. Res. Hepatol. Gastroenterol."}],"container-title":["IBRO Neuroscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667242125001484?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667242125001484?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T20:20:18Z","timestamp":1782159618000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667242125001484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":66,"alternative-id":["S2667242125001484"],"URL":"https:\/\/doi.org\/10.1016\/j.ibneur.2025.09.007","relation":{},"ISSN":["2667-2421"],"issn-type":[{"value":"2667-2421","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum amino acid levels are associated with brain hypometabolism in patients across the Alzheimer\u2019s disease continuum","name":"articletitle","label":"Article Title"},{"value":"IBRO Neuroscience Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ibneur.2025.09.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of International Brain Research Organization.","name":"copyright","label":"Copyright"}]}}