{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T09:32:10Z","timestamp":1775554330741,"version":"3.50.1"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016308","name":"Wuxi Health Commission","doi-asserted-by":"publisher","award":["M202301"],"award-info":[{"award-number":["M202301"]}],"id":[{"id":"10.13039\/501100016308","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ibroneuroreports.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["IBRO Neuroscience Reports"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.ibneur.2025.11.012","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T05:34:48Z","timestamp":1763703288000},"page":"996-999","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["TMEM206 gene knockout improves balance performance in SCA1 transgenic mice"],"prefix":"10.1016","volume":"19","author":[{"given":"Jia-Hui","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun-Chang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ibneur.2025.11.012_bib1","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/mds.28355","article-title":"A chlorzoxazone-baclofen combination improves cerebellar impairment in spinocerebellar ataxia type 1","volume":"36","author":"Bushart","year":"2020","journal-title":"Mov. Disord."},{"key":"10.1016\/j.ibneur.2025.11.012_bib2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s40246-022-00404-0","article-title":"Identification of the ataxin-1 interaction network and its impact on spinocerebellar ataxia type 1","volume":"16","author":"Chen","year":"2022","journal-title":"Hum. Genom."},{"key":"10.1016\/j.ibneur.2025.11.012_bib3","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/s12276-024-01206-1","article-title":"Transmembrane proteins with unknown function (TMEMs) as ion channels: electrophysiological properties, structure, and pathophysiological roles","volume":"56","author":"Kang","year":"2024","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.ibneur.2025.11.012_bib4","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.70063","article-title":"The proton-activated chloride channel inhibits SARS-CoV-2 spike protein-mediated viral entry through the endosomal pathway","volume":"240","author":"Koylass","year":"2025","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.ibneur.2025.11.012_bib5","doi-asserted-by":"crossref","DOI":"10.1172\/JCI156616","article-title":"Cross-species genetic screens identify transglutaminase 5 as a regulator of polyglutamine-expanded ataxin-1","volume":"132","author":"Lee","year":"2022","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.ibneur.2025.11.012_bib6","doi-asserted-by":"crossref","DOI":"10.1177\/17474930251374471","article-title":"Multi-population genome-wide association study identifies multiple novel loci associated with asymptomatic intracranial large artery stenosis","author":"Liu","year":"2025","journal-title":"Int. J. Stroke"},{"key":"10.1016\/j.ibneur.2025.11.012_bib7","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s12311-025-01910-2","article-title":"Longitudinal study and characterization of gait impairment in a mouse model of SCA1","volume":"24","author":"Maharjan","year":"2025","journal-title":"Cerebellum"},{"key":"10.1016\/j.ibneur.2025.11.012_bib8","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.83935","article-title":"Inhibition of the proton-activated chloride channel PAC by PIP2","volume":"12","author":"Mihaljevi\u0107","year":"2023","journal-title":"Elife"},{"key":"10.1016\/j.ibneur.2025.11.012_bib9","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2200727119","article-title":"Molecular determinants of pH sensing in the proton-activated chloride channel","volume":"119","author":"Osei-Owusu","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ibneur.2025.11.012_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2023.106023","article-title":"BDNF is altered in a brain-region specific manner and rescues deficits in Spinocerebellar Ataxia Type 1","author":"Rosa","year":"2023","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ibneur.2025.11.012_bib11","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.3390\/ijms26062623","article-title":"Sex differences in a novel mouse model of spinocerebellar ataxia type 1 (SCA1)","volume":"26","author":"Selimovic","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ibneur.2025.11.012_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2024.106673","article-title":"Expanded ATXN1 alters transcription and calcium signaling in SCA1 human motor neurons differentiated from induced pluripotent stem cells","volume":"201","author":"Sheeler","year":"2024","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ibneur.2025.11.012_bib13","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1093\/brain\/awad329","article-title":"Widespread alternative splicing dysregulation occurs presymptomatically in CAG expansion spinocerebellar ataxias","volume":"147","author":"Shorrock","year":"2024","journal-title":"Brain"},{"key":"10.1016\/j.ibneur.2025.11.012_bib14","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/prot.26436","article-title":"Governing dynamics and preferential binding of the AXH domain influence the aggregation pathway of Ataxin-1","volume":"91","author":"Tammara","year":"2023","journal-title":"Proteins"},{"key":"10.1016\/j.ibneur.2025.11.012_bib15","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.neuron.2023.10.039","article-title":"Longitudinal single-cell transcriptional dynamics throughout neurodegeneration in SCA1","volume":"112","author":"Tejwani","year":"2024","journal-title":"Neuron"},{"key":"10.1016\/j.ibneur.2025.11.012_bib16","doi-asserted-by":"crossref","first-page":"e1836","DOI":"10.1212\/WNL.0000000000207088","article-title":"Baseline clinical and blood biomarkers in patients with preataxic and early-stage disease spinocerebellar ataxia 1 and 3","volume":"100","author":"Tezenas du Montcel","year":"2023","journal-title":"Neurology"},{"key":"10.1016\/j.ibneur.2025.11.012_bib17","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3389\/fnmol.2016.00067","article-title":"Gene, stem cell, and alternative therapies for SCA 1","volume":"9","author":"Wagner","year":"2016","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.ibneur.2025.11.012_bib18","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1126\/science.aav9739","article-title":"PAC, an evolutionarily conserved membrane protein, is a proton-activated chloride channel","volume":"364","author":"Yang","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.ibneur.2025.11.012_bib19","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.18240\/ijo.2024.11.01","article-title":"Knockout of TMEM206 in mice associated with a loss of corneal transparency","volume":"17","author":"Yang","year":"2024","journal-title":"Int. J. Ophthalmol."}],"container-title":["IBRO Neuroscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667242125001897?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667242125001897?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T10:43:30Z","timestamp":1773830610000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667242125001897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":19,"alternative-id":["S2667242125001897"],"URL":"https:\/\/doi.org\/10.1016\/j.ibneur.2025.11.012","relation":{},"ISSN":["2667-2421"],"issn-type":[{"value":"2667-2421","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TMEM206 gene knockout improves balance performance in SCA1 transgenic mice","name":"articletitle","label":"Article Title"},{"value":"IBRO Neuroscience Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ibneur.2025.11.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of International Brain Research Organization.","name":"copyright","label":"Copyright"}]}}