{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T20:54:16Z","timestamp":1782161656514,"version":"3.54.5"},"reference-count":83,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ibroneuroreports.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["IBRO Neuroscience Reports"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.ibneur.2025.12.004","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T02:44:51Z","timestamp":1765593891000},"page":"14-24","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Medullary dorsal horn neurons activated during voluntary diving express neurotransmitter receptors for glutamate and substance P"],"prefix":"10.1016","volume":"20","author":[{"given":"P.F.","family":"McCulloch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9910-5061","authenticated-orcid":false,"given":"K.M.","family":"DiNovo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ibneur.2025.12.004_bib1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0006-8993(97)00637-9","article-title":"The N-methyl-D-aspartate (NMDA) receptor is postsynaptic to substance P-containing axon terminals in the rat superficial dorsal horn","volume":"772","author":"Aicher","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.ibneur.2025.12.004_bib2","first-page":"S142","article-title":"The concise guide to pharmacology 2019\/20: Ion channels","volume":"176","author":"Alexander","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ibneur.2025.12.004_bib3","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/cne.902770210","article-title":"Coexistence of glutamate and substance P in dorsal root ganglion neurons of the rat and monkey","volume":"277","author":"Battaglia","year":"1988","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.ibneur.2025.12.004_bib4","author":"Bettler","year":"2021","journal-title":"Ionotropic glutamate Recept. GtoPdb V. 2021. 3. IUPHAR\/BPS Guide Pharmacol. CITE 2021."},{"key":"10.1016\/j.ibneur.2025.12.004_bib5","doi-asserted-by":"crossref","first-page":"129","DOI":"10.2174\/187152708784083821","article-title":"Ionotropic glutamate receptors & CNS disorders","volume":"7","author":"Bowie","year":"2008","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.ibneur.2025.12.004_bib6","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1053\/j.gastro.2008.12.044","article-title":"Role of spinal microglia in visceral hyperalgesia and NK1R up-regulation in a rat model of chronic stress","volume":"136","author":"Bradesi","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ibneur.2025.12.004_bib7","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1152\/physrev.1997.77.3.837","article-title":"Physiology of diving birds and mammals","volume":"77","author":"Butler","year":"1997","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ibneur.2025.12.004_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/10454411920040010101","article-title":"Central connections of trigeminal primary afferent neurons: topographical and functional considerations","volume":"4","author":"Capra","year":"1992","journal-title":"Crit. Rev. Oral. Biol. Med."},{"key":"10.1016\/j.ibneur.2025.12.004_bib9","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.brainres.2005.10.054","article-title":"Differential expression of NMDA and AMPA\/KA receptor subunits in the inferior olive of postnatal rats","volume":"1067","author":"Chen","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.ibneur.2025.12.004_bib10","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0006-8993(00)02913-9","article-title":"Co-localization of NMDA receptors and AMPA receptors in neurons of the vestibular nuclei of rats","volume":"884","author":"Chen","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.ibneur.2025.12.004_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/phy2.141","article-title":"Bilateral sectioning of the anterior ethmoidal nerves does not eliminate the diving response in voluntarily diving rats","volume":"1","author":"Chotiyanonta","year":"2013","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.ibneur.2025.12.004_bib12","article-title":"Fos, nociception and the dorsal horn","volume":"77","author":"Coggeshall","year":"2005","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.ibneur.2025.12.004_bib13","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.neuropharm.2008.06.063","article-title":"A nomenclature for ligand-gated ion channels","volume":"56","author":"Collingridge","year":"2009","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ibneur.2025.12.004_bib14","series-title":"in Somatosensory System","first-page":"271","article-title":"The trigeminal system","author":"Darian-Smith","year":"1973"},{"key":"10.1016\/j.ibneur.2025.12.004_bib15","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2174\/1568026043451636","article-title":"Substance P: structure, function, and therapeutics","volume":"4","author":"Datar","year":"2004","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.ibneur.2025.12.004_bib16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0031-6997(24)01394-2","article-title":"The glutamate receptor ion channels","volume":"51","author":"Dingledine","year":"1999","journal-title":"Pharm. Rev."},{"key":"10.1016\/j.ibneur.2025.12.004_bib17","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0165-0270(89)90150-7","article-title":"The use of c-fos as a metabolic marker in neuronal pathway tracing","volume":"29","author":"Dragunow","year":"1989","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.ibneur.2025.12.004_bib18","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/j.2040-4603.2018.tb00014.x","article-title":"Breath-Hold Diving","volume":"8","author":"Fitz-Clarke","year":"2018","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.ibneur.2025.12.004_bib19","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/495704","article-title":"Biological and pharmacological aspects of the NK1-receptor","volume":"2015","author":"Garcia-Recio","year":"2015","journal-title":"BioMed. Res. Int."},{"key":"10.1016\/j.ibneur.2025.12.004_bib20","series-title":"in Oral-Facial Sensory and Motor Functions,","first-page":"211","article-title":"Anatomical similarities between medullary and spinal dorsal horns","author":"Gobel","year":"1988"},{"key":"10.1016\/j.ibneur.2025.12.004_bib21","doi-asserted-by":"crossref","first-page":"42","DOI":"10.32607\/20758251-2015-7-2-42-47","article-title":"NeuN as a neuronal nuclear antigen and neuron differentiation marker","volume":"7","author":"Gusel'nikova","year":"2015","journal-title":"Acta Nat."},{"key":"10.1016\/j.ibneur.2025.12.004_bib22","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jneumeth.2007.08.011","article-title":"Pharmacological analysis of excitatory and inhibitory synaptic transmission in horizontal brainstem slices preserving three subnuclei of spinal trigeminal nucleus","volume":"167","author":"Han","year":"2008","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.ibneur.2025.12.004_bib23","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/cne.902370205","article-title":"Morphology of central terminations of intra-axonally stained, large, myelinated primary afferent fibers from facial skin in the rat","volume":"237","author":"Hayashi","year":"1985","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.ibneur.2025.12.004_bib24","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.brainres.2007.09.070","article-title":"Kainate receptors are primarily postsynaptic to SP-containing axon terminals in the trigeminal dorsal horn","volume":"1184","author":"Hegarty","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.ibneur.2025.12.004_bib25","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/978-3-540-33823-9_7","article-title":"Neuropeptide and kinin antagonists","volume":"177","author":"Hill","year":"2007","journal-title":"Handb. Exp. Pharmacol. (Analg. )"},{"key":"10.1016\/j.ibneur.2025.12.004_bib26","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1046\/j.0954-6820.2000.00773.x","article-title":"Substance P: a pioneer amongst neuropeptides","volume":"249","author":"H\u00f6kfelt","year":"2001","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.ibneur.2025.12.004_bib27","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.brainres.2009.08.077","article-title":"Unmyelinated fibers of the anterior ethmoidal nerve in the rat co-localize with neurons in the medullary dorsal horn and ventrolateral medulla activated by nasal stimulation","volume":"1298","author":"Hollandsworth","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.ibneur.2025.12.004_bib28","doi-asserted-by":"crossref","first-page":"7670","DOI":"10.1523\/JNEUROSCI.19-17-07670.1999","article-title":"Spinal substance P receptor expression and internalization in acute, short-term, and long-term inflammatory pain states","volume":"19","author":"Honore","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ibneur.2025.12.004_bib29","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0304-3959(90)90010-B","article-title":"Response properties of nociceptive and non-nociceptive neurons in the rat's trigeminal subnucleus caudalis (medullary dorsal horn) related to cutaneous and deep craniofacial afferent stimulation and modulation by diffuse noxious inhibitory controls","volume":"41","author":"Hu","year":"1990","journal-title":"Pain"},{"key":"10.1016\/j.ibneur.2025.12.004_bib30","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/cne.902350202","article-title":"Fine structural survey of the rat's brainstem sensory trigeminal complex","volume":"235","author":"Ide","year":"1985","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.ibneur.2025.12.004_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/HMJ.HMJ_1_20","article-title":"Pain: physiologic background and therapeutic consequences","volume":"13","author":"Ilias","year":"2020","journal-title":"Hamdan Med. J."},{"key":"10.1016\/j.ibneur.2025.12.004_bib32","first-page":"1","article-title":"Neuronal types in the rat spinal trigeminal nucleus","volume":"31","author":"Ivanov","year":"2024","journal-title":"Acta Morphol. Et. Anthropol."},{"key":"10.1016\/j.ibneur.2025.12.004_bib33","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0014-4886(66)90104-X","article-title":"The ultrastructure of the spinal tract of the trigeminal nerve and the substantia gelatinosa","volume":"16","author":"Kerr","year":"1966","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ibneur.2025.12.004_bib34","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0006-8993(70)90035-1","article-title":"The fine structure of the subnucleus caudalis of the trigeminal nerve","volume":"23","author":"Kerr","year":"1970","journal-title":"Brain Res."},{"key":"10.1016\/j.ibneur.2025.12.004_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.job.2024.05.004","article-title":"Functional roles of descending projections from the cerebral cortex to the trigeminal spinal nucleus caudalis in orofacial nociceptive information processing","author":"Kobayashi","year":"2024","journal-title":"J. Oral. Biosci."},{"key":"10.1016\/j.ibneur.2025.12.004_bib36","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/j.1365-2826.2008.01734.x","article-title":"Measurement of immediate-early gene activation- c-fos and beyond","volume":"20","author":"Kovacs","year":"2008","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.ibneur.2025.12.004_bib37","doi-asserted-by":"crossref","first-page":"687","DOI":"10.3390\/neurosci3040050","article-title":"Current opinion on the use of c-Fos in neuroscience","volume":"3","author":"Lara Aparicio","year":"2022","journal-title":"NeuroSci"},{"key":"10.1016\/j.ibneur.2025.12.004_bib38","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1152\/jn.00912.2013","article-title":"Physiological temperatures drive glutamate release onto trigeminal superficial dorsal horn neurons","volume":"111","author":"Largent-Milnes","year":"2014","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ibneur.2025.12.004_bib39","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.coph.2005.08.004","article-title":"Kainate receptor physiology","volume":"6","author":"Lerma","year":"2006","journal-title":"Curr. Opin. Pharm."},{"key":"10.1016\/j.ibneur.2025.12.004_bib40","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/(SICI)1096-9861(19990830)411:3<399::AID-CNE4>3.0.CO;2-6","article-title":"Substantia gelatinosa neurons in the medullary dorsal horn: an intracellular labeling study in the rat","volume":"411","author":"Li","year":"1999","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.ibneur.2025.12.004_bib41","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/1096-9861(20001225)428:4<641::AID-CNE5>3.0.CO;2-Q","article-title":"Intracellular labeling study of neurons in the superficial part of the magnocellular layer of the medullary dorsal horn of the rat","volume":"428","author":"Li","year":"2000","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.ibneur.2025.12.004_bib42","first-page":"6","article-title":"Neurobiology of substance P and the NK1 receptor","author":"Mantyh","year":"2002","journal-title":"J. Clin. Psychiatry 63"},{"key":"10.1016\/j.ibneur.2025.12.004_bib43","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.brainres.2005.05.059","article-title":"Activation of the trigeminal medullary dorsal horn during voluntary diving in rats","volume":"1051","author":"Mcculloch","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.ibneur.2025.12.004_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphys.2012.00169","article-title":"Animal models for investigating the central control of the mammalian diving response","volume":"3","author":"Mcculloch","year":"2012","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ibneur.2025.12.004_bib45","doi-asserted-by":"crossref","DOI":"10.3791\/52093-v","article-title":"Training rats to voluntarily dive underwater: investigations of the mammalian diving response","author":"Mcculloch","year":"2014","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.ibneur.2025.12.004_bib46","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/152567","article-title":"Trigeminal medullary dorsal horn neurons activated by nasal stimulation coexpress AMPA, NMDA, and NK1 receptors","volume":"2013","author":"Mcculloch","year":"2013","journal-title":"ISRN Neurosci."},{"key":"10.1016\/j.ibneur.2025.12.004_bib47","doi-asserted-by":"crossref","DOI":"10.3389\/fnana.2018.00085","article-title":"Innervation of the nose and nasal region of the rat: implications for initiating the mammalian diving response","volume":"12","author":"Mcculloch","year":"2018","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.ibneur.2025.12.004_bib48","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0306-4522(96)00633-1","article-title":"FOS immunohistochemical determination of brainstem neuronal activation in the muskrat after nasal stimulation","volume":"78","author":"Mcculloch","year":"1997","journal-title":"Neuroscience"},{"key":"10.1016\/j.ibneur.2025.12.004_bib49","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2016.00148","article-title":"Repetitive diving in trained rats still increases fos production in brainstem neurons after bilateral sectioning of the anterior ethmoidal nerve","volume":"7","author":"Mcculloch","year":"2016","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ibneur.2025.12.004_bib50","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/cne.903470307","article-title":"Response properties of nociceptive and low-threshold neurons in rat trigeminal pars caudalis","volume":"347","author":"Mchaffie","year":"1994","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.ibneur.2025.12.004_bib51","doi-asserted-by":"crossref","first-page":"1007S","DOI":"10.1093\/jn\/130.4.1007S","article-title":"Glutamate as a neurotransmitter in the brain: review of physiology and pathology","volume":"130","author":"Meldrum","year":"2000","journal-title":"J. Nutr."},{"key":"10.1016\/j.ibneur.2025.12.004_bib52","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1146\/annurev.ne.14.030191.002225","article-title":"Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun","volume":"14","author":"Morgan","year":"1991","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.ibneur.2025.12.004_bib53","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/cne.900920305","article-title":"On the anatomical and functional organization of the spinal trigeminal nucleus","volume":"92","author":"Olszewski","year":"1950","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.ibneur.2025.12.004_bib54","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0301-0082(97)00085-3","article-title":"Glutamate receptors in the mammalian central nervous system","volume":"54","author":"Ozawa","year":"1998","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.ibneur.2025.12.004_bib55","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0165-1838(90)90257-J","article-title":"Controlled bradycardia induced by nasal stimulation in the muskrat, Ondatra zibethicus","volume":"30","author":"Panneton","year":"1990","journal-title":"J. Auton. Nerv. Syst."},{"key":"10.1016\/j.ibneur.2025.12.004_bib56","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1152\/physiol.00020.2013","article-title":"The mammalian diving response: an enigmatic reflex to preserve life?","volume":"28","author":"Panneton","year":"2013","journal-title":"Physiology"},{"key":"10.1016\/j.ibneur.2025.12.004_bib57","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1152\/japplphysiol.00110.2010","article-title":"Cardiorespiratory and neural consequences of rats brought past their aerobic dive limit","volume":"109","author":"Panneton","year":"2010","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ibneur.2025.12.004_bib58","doi-asserted-by":"crossref","first-page":"524","DOI":"10.3389\/fnins.2020.00524","article-title":"The mammalian diving response: inroads to its neural control","volume":"14","author":"Panneton","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.ibneur.2025.12.004_bib59","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.neuroscience.2006.04.055","article-title":"Brainstem projections from recipient zones of the anterior ethmoidal nerve in the medullary dorsal horn","volume":"141","author":"Panneton","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.ibneur.2025.12.004_bib60","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1152\/japplphysiol.00600.2009","article-title":"The rat: a laboratory model for studies of the diving response","volume":"108","author":"Panneton","year":"2010","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ibneur.2025.12.004_bib61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphys.2012.00111","article-title":"Activation of brainstem neurons by underwater diving in the rat","volume":"3","author":"Panneton","year":"2012","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ibneur.2025.12.004_bib62","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/S0006-8993(00)02549-X","article-title":"Trigemino-autonomic connections in the muskrat: the neural substrate for the diving response","volume":"874","author":"Panneton","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.ibneur.2025.12.004_bib63","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.autneu.2008.08.002","article-title":"Pressor responses to nasal stimulation are unaltered after disrupting the CPA","volume":"144","author":"Panneton","year":"2008","journal-title":"Autonomic Neurosci. Basic Clinic."},{"key":"10.1016\/j.ibneur.2025.12.004_bib64","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0006-8993(95)00597-J","article-title":"A medullary dorsal horn relay for the cardiorespiratory responses evoked by stimulation of the nasal mucosa in the muskrat Ondatra zibethicus: evidence for excitatory amino acid transmission","volume":"691","author":"Panneton","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.ibneur.2025.12.004_bib65","first-page":"249","article-title":"Excitatory amino acid neurotransmission","author":"Parsons","year":"2005","journal-title":"Handb. Exp. Pharm."},{"key":"10.1016\/j.ibneur.2025.12.004_bib66","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1998"},{"key":"10.1016\/j.ibneur.2025.12.004_bib67","doi-asserted-by":"crossref","DOI":"10.1096\/fasebj.2020.34.s1.04817","article-title":"Spinal trigeminal subnucleus pars muralis: an interface for apneic reflex","volume":"34","author":"P\u00e9rez","year":"2020","journal-title":"FASEB J."},{"key":"10.1016\/j.ibneur.2025.12.004_bib68","doi-asserted-by":"crossref","first-page":"4030","DOI":"10.1016\/j.cub.2023.08.041","article-title":"A brainstem circuit for the expression of defensive facial reactions in rat","volume":"33","author":"P\u00e9rez","year":"2023","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ibneur.2025.12.004_bib69","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0079-6123(08)61793-8","article-title":"Interaction of neuropeptides and excitatory amino acids in the rat superficial spinal dorsal horn","volume":"104","author":"Randic","year":"1995","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.ibneur.2025.12.004_bib70","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/B978-0-323-48110-6.00008-9","article-title":"Central nervous system physiology: neurophysiology","author":"Raz","year":"2019","journal-title":"Pharmacol. Physiol. Anesth."},{"key":"10.1016\/j.ibneur.2025.12.004_bib71","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3390\/receptors1010004","article-title":"The neurokinin-1 receptor: structure dynamics and signaling","volume":"1","author":"Rodr\u00edguez","year":"2022","journal-title":"Receptors"},{"key":"10.1016\/j.ibneur.2025.12.004_bib72","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.brainres.2005.12.112","article-title":"The anterior ethmoidal nerve is necessary for the initiation of the nasopharyngeal response in the rat","volume":"1075","author":"Rybka","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.ibneur.2025.12.004_bib73","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.neuroscience.2007.04.038","article-title":"Morphology and physiology of lamina I neurons of the caudal part of the trigeminal nucleus","volume":"147","author":"Sedlacek","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.ibneur.2025.12.004_bib74","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0304-3940(92)90339-9","article-title":"Excitatory amino acid binding sites in the trigeminal principal sensory and spinal trigeminal nuclei of the rat","volume":"141","author":"Tallaksen-Greene","year":"1992","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ibneur.2025.12.004_bib75","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1177\/00220345010800081101","article-title":"Qualitative light and electron microscope study of glutamate receptors in the caudal spinal trigeminal nucleus of the rat","volume":"80","author":"Tang","year":"2001","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.ibneur.2025.12.004_bib76","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/nrn2947","article-title":"Neuronal circuitry for pain processing in the dorsal horn","volume":"11","author":"Todd","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ibneur.2025.12.004_bib77","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1124\/pr.109.002451","article-title":"Glutamate receptor ion channels: structure, regulation, and function","volume":"62","author":"Traynelis","year":"2010","journal-title":"Pharm. Rev."},{"key":"10.1016\/j.ibneur.2025.12.004_bib78","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/cne.21688","article-title":"Developmental expression of NMDA and AMPA receptor subunits in vestibular nuclear neurons that encode gravity-related horizontal orientations","volume":"508","author":"Tse","year":"2008","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.ibneur.2025.12.004_bib79","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0306-4522(01)00456-0","article-title":"Ascending connections from the caudal part to the oral part of the spinal trigeminal nucleus in the rat","volume":"109","author":"Voisin","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.ibneur.2025.12.004_bib80","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.brainres.2003.11.034","article-title":"Differential expression of NMDA and AMPA receptor subunits in DARPP-32-containing neurons of the cerebral cortex, hippocampus and neostriatum of rats","volume":"998","author":"Wang","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.ibneur.2025.12.004_bib81","doi-asserted-by":"crossref","DOI":"10.1038\/sj.bjp.0706444","article-title":"The glutamate story","volume":"147","author":"Watkins","year":"2006","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.ibneur.2025.12.004_bib82","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.pneurobio.2010.01.005","article-title":"The synaptic connectivity that underlies the noxious transmission and modulation within the superficial dorsal horn of the spinal cord","volume":"91","author":"Wu","year":"2010","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.ibneur.2025.12.004_bib83","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00441-018-2922-y","article-title":"Substance P and pain chronicity","volume":"375","author":"Zieglg\u00e4nsberger","year":"2019","journal-title":"Cell Tissue Res."}],"container-title":["IBRO Neuroscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667242125001964?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667242125001964?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T20:22:41Z","timestamp":1782159761000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667242125001964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":83,"alternative-id":["S2667242125001964"],"URL":"https:\/\/doi.org\/10.1016\/j.ibneur.2025.12.004","relation":{},"ISSN":["2667-2421"],"issn-type":[{"value":"2667-2421","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Medullary dorsal horn neurons activated during voluntary diving express neurotransmitter receptors for glutamate and substance P","name":"articletitle","label":"Article Title"},{"value":"IBRO Neuroscience Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ibneur.2025.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of International Brain Research Organization.","name":"copyright","label":"Copyright"}]}}