{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T20:54:16Z","timestamp":1782161656526,"version":"3.54.5"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 AG024904"],"award-info":[{"award-number":["U01 AG024904"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-12\\u20132\\u20130012"],"award-info":[{"award-number":["W81XWH-12\\u20132\\u20130012"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014041","name":"Alzheimer's Disease Neuroimaging Initiative","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007333","name":"Alzheimer's Disease Neuroimaging Initiative","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007333","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ibroneuroreports.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["IBRO Neuroscience Reports"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.ibneur.2025.12.007","type":"journal-article","created":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T15:41:06Z","timestamp":1766331666000},"page":"76-83","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Cardiovascular risk factors, aging, and incidence of dementia (CAIDE) risk score and its association with cognitive performance and volumetric brain measures in mild cognitive impairment"],"prefix":"10.1016","volume":"20","author":[{"given":"Yasaman","family":"Abtahi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjan","family":"Falahati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheyda","family":"Sharabiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Gila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0249-5770","authenticated-orcid":false,"given":"Saeed","family":"Omidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1363-0154","authenticated-orcid":false,"given":"Farshad","family":"Goharmanesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousef","family":"Nourbakhsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marziye Jalalian","family":"Chaleshtari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hossein","family":"Nourbakhshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6506-0420","authenticated-orcid":false,"given":"Parham","family":"Mahmoudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7290-2721","authenticated-orcid":false,"given":"Raziyeh","family":"Zamiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0757-3958","authenticated-orcid":false,"given":"Laya","family":"Dalir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Gharehdaghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2361-3308","authenticated-orcid":false,"given":"Hamide","family":"Nasiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahsa","family":"Mayeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannaneh","family":"Azimizonuzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ibneur.2025.12.007_bib1","first-page":"107","article-title":"White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): knowledge gaps and opportunities","volume":"5","author":"Alber","year":"2019","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.ibneur.2025.12.007_bib2","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.3233\/JAD-180017","article-title":"A clinicopathological investigation of white matter hyperintensities and Alzheimer\u2019s disease neuropathology","volume":"63","author":"Alosco","year":"2018","journal-title":"J. Alzheimer\u2019S. Dis."},{"key":"10.1016\/j.ibneur.2025.12.007_bib3","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.3174\/ajnr.A1693","article-title":"Association of white matter hyperintensity measurements on brain MR imaging with cognitive status, medial temporal atrophy, and cardiovascular risk factors","volume":"30","author":"Appel","year":"2009","journal-title":"Am. J. Neuroradiol."},{"key":"10.1016\/j.ibneur.2025.12.007_bib4","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.media.2007.06.004","article-title":"Symmetric diffeomorphic image registration with cross-correlation: evaluating automated labeling of elderly and neurodegenerative brain","volume":"12","author":"Avants","year":"2008","journal-title":"Med Image Anal."},{"key":"10.1016\/j.ibneur.2025.12.007_bib5","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/WAD.0000000000000215","article-title":"Baseline white matter hyperintensities and hippocampal volume are associated with conversion from normal cognition to mild cognitive impairment in the Framingham Offspring Study","volume":"32","author":"Bangen","year":"2018","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.ibneur.2025.12.007_bib6","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1159\/000091536","article-title":"Age, hypertension, and lacunar stroke are the major determinants of the severity of age-related white matter changes: the LADIS (Leukoaraiosis and Disability in the Elderly) study","volume":"21","author":"Basile","year":"2006","journal-title":"Cerebrovasc. Dis."},{"key":"10.1016\/j.ibneur.2025.12.007_bib7","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.neuroimage.2018.03.025","article-title":"A comparison of publicly available linear MRI stereotaxic registration techniques","volume":"174","author":"Dadar","year":"2018","journal-title":"Neuroimage"},{"key":"10.1016\/j.ibneur.2025.12.007_bib8","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1002\/hbm.23894","article-title":"Validation of T1w-based segmentations of white matter hyperintensity volumes in large-scale datasets of aging","volume":"39","author":"Dadar","year":"2018","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.ibneur.2025.12.007_bib9","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.neuroimage.2017.06.009","article-title":"Performance comparison of 10 different classification techniques in segmenting white matter hyperintensities in aging","volume":"157","author":"Dadar","year":"2017","journal-title":"Neuroimage"},{"key":"10.1016\/j.ibneur.2025.12.007_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/alz.085994","article-title":"Can neuroimaging methods help us to disentangle WMH etiology in AD?","volume":"20","author":"Dadar","year":"2024","journal-title":"Alzheimer's. Dement."},{"key":"10.1016\/j.ibneur.2025.12.007_bib11","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1109\/TMI.2017.2693978","article-title":"Validation of a Regression Technique for Segmentation of White Matter Hyperintensities in Alzheimer's Disease","volume":"36","author":"Dadar","year":"2017","journal-title":"IEEE Trans. Med Imaging"},{"key":"10.1016\/j.ibneur.2025.12.007_bib12","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/jmri.1880060316","article-title":"Local histogram correction of MRI spatially dependent image pixel intensity nonuniformity","volume":"6","author":"Decarli","year":"1996","journal-title":"J. Magn. Reson Imaging"},{"key":"10.1016\/j.ibneur.2025.12.007_bib13","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.neurobiolaging.2016.03.007","article-title":"CAIDE Dementia Risk Score and biomarkers of neurodegeneration in memory clinic patients without dementia","volume":"42","author":"Enache","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ibneur.2025.12.007_bib14","article-title":"P4-053: atrophy specific MRI brain template for Alzheimer's disease and mild cognitive impairment","volume":"7","author":"Fonov","year":"2011","journal-title":"Alzheimer's. Dement."},{"key":"10.1016\/j.ibneur.2025.12.007_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/alz.092168","article-title":"All WMH are not of purely vascular origin: existence of AD-related WMH","volume":"20","author":"Garnier\u2010Crussard","year":"2024","journal-title":"Alzheimer's. Dement."},{"key":"10.1016\/j.ibneur.2025.12.007_bib16","doi-asserted-by":"crossref","first-page":"877","DOI":"10.3233\/JAD-201451","article-title":"Association of white matter hyperintensity progression with cognitive decline in patients with amnestic mild cognitive impairment","volume":"80","author":"Hirao","year":"2021","journal-title":"J. Alzheimer\u2019S. Dis."},{"key":"10.1016\/j.ibneur.2025.12.007_bib17","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1552-6569.2006.00047.x","article-title":"Prevalence of white matter hyperintensities in a young healthy population","volume":"16","author":"Hopkins","year":"2006","journal-title":"J. Neuroimaging"},{"key":"10.1016\/j.ibneur.2025.12.007_bib18","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1186\/s12967-023-04646-x","article-title":"Multipredictor risk models for predicting individual risk of Alzheimer\u2019s disease","volume":"21","author":"Hou","year":"2023","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.ibneur.2025.12.007_bib19","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neubiorev.2020.11.007","article-title":"White matter hyperintensities and risks of cognitive impairment and dementia: A systematic review and meta-analysis of 36 prospective studies","volume":"120","author":"Hu","year":"2021","journal-title":"Neurosci. Biobehav Rev."},{"key":"10.1016\/j.ibneur.2025.12.007_bib20","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1161\/01.STR.0000135226.53499.85","article-title":"Stroke risk profile predicts white matter hyperintensity volume: the Framingham Study","volume":"35","author":"Jeerakathil","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.ibneur.2025.12.007_bib21","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1136\/bmj.322.7300.1447","article-title":"Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study","volume":"322","author":"Kivipelto","year":"2001","journal-title":"Bmj"},{"key":"10.1016\/j.ibneur.2025.12.007_bib22","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S1474-4422(06)70537-3","article-title":"Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population-based study","volume":"5","author":"Kivipelto","year":"2006","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ibneur.2025.12.007_bib23","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S1474-4422(06)70537-3","article-title":"Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population-based study","volume":"5","author":"Kivipelto","year":"2006","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ibneur.2025.12.007_bib24","first-page":"149","article-title":"The prevalence and severity of white matter lesions, their relationship with age, ethnicity, gender, and cardiovascular disease risk factors: the ARIC Study","volume":"16","author":"Liao","year":"1997","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.ibneur.2025.12.007_bib25","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1007\/s00415-020-10383-8","article-title":"Higher midlife CAIDE score is associated with increased brain atrophy in a cohort of cognitively healthy middle-aged individuals","volume":"268","author":"Liu","year":"2021","journal-title":"J. Neurol."},{"key":"10.1016\/j.ibneur.2025.12.007_bib26","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1007\/s00415-020-10383-8","article-title":"Higher midlife CAIDE score is associated with increased brain atrophy in a cohort of cognitively healthy middle-aged individuals","volume":"268","author":"Liu","year":"2021","journal-title":"J. Neurol."},{"key":"10.1016\/j.ibneur.2025.12.007_bib27","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1016\/S0140-6736(17)31363-6","article-title":"Dementia prevention, intervention, and care","volume":"390","author":"Livingston","year":"2017","journal-title":"lancet"},{"key":"10.1016\/j.ibneur.2025.12.007_bib28","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1136\/jnnp-2021-327462","article-title":"CAIDE dementia risk score relates to severity and progression of cerebral small vessel disease in healthy midlife adults: the PREVENT-Dementia study","volume":"93","author":"Low","year":"2022","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.ibneur.2025.12.007_bib29","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/jmri.22003","article-title":"Adaptive non-local means denoising of MR images with spatially varying noise levels","volume":"31","author":"Manj\u00f3n","year":"2010","journal-title":"J. Magn. Reson Imaging"},{"key":"10.1016\/j.ibneur.2025.12.007_bib30","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease","volume":"34","author":"Mckhann","year":"1984","journal-title":"Neurology"},{"key":"10.1016\/j.ibneur.2025.12.007_bib31","doi-asserted-by":"crossref","unstructured":"Mitchell, A. 2017. The Mini-Mental State Examination (MMSE): Update on Its Diagnostic Accuracy and Clinical Utility for Cognitive Disorders.","DOI":"10.1007\/978-3-319-44775-9_3"},{"issue":"2","key":"10.1016\/j.ibneur.2025.12.007_bib32","article-title":"Development of cognitive instruments for use in clinical trials of antidementia drugs: additions to the Alzheimer's Disease Assessment Scale that broaden its scope. The Alzheimer's Disease Cooperative Study","volume":"11","author":"mohs","year":"1997","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.ibneur.2025.12.007_bib33","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ijcha.2018.04.006","article-title":"Cardiovascular disease and brain health: focus on white matter hyperintensities","volume":"19","author":"Moroni","year":"2018","journal-title":"IJC Heart Vasc."},{"key":"10.1016\/j.ibneur.2025.12.007_bib34","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1212\/WNL.43.11.2412-a","article-title":"The Clinical Dementia Rating (CDR): current version and scoring rules","volume":"43","author":"Morris","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.ibneur.2025.12.007_bib35","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000207854","article-title":"Association between hippocampal volumes and cognition in cerebral amyloid angiopathy","volume":"102","author":"Perosa","year":"2024","journal-title":"Neurology"},{"key":"10.1016\/j.ibneur.2025.12.007_bib36","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1176\/ajp.141.11.1356","article-title":"A new rating scale for Alzheimer's disease","volume":"141","author":"Rosen","year":"1984","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.ibneur.2025.12.007_bib37","doi-asserted-by":"crossref","first-page":"e1704","DOI":"10.1212\/WNL.0000000000200118","article-title":"Differential effects of APOE and modifiable risk factors on hippocampal volume loss and memory decline in A\u03b2\u2212 and A\u03b2+ older adults","volume":"98","author":"Rosenich","year":"2022","journal-title":"Neurology"},{"key":"10.1016\/j.ibneur.2025.12.007_bib38","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13195-018-0460-1","article-title":"Spatial patterns of white matter hyperintensities associated with Alzheimer\u2019s disease risk factors in a cognitively healthy middle-aged cohort","volume":"11","author":"Salvad\u00f3","year":"2019","journal-title":"Alzheimer's. Res. Ther."},{"key":"10.1016\/j.ibneur.2025.12.007_bib39","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1161\/STROKEAHA.118.023386","article-title":"Association of atrial fibrillation with white matter disease: the ARIC study","volume":"50","author":"Shao","year":"2019","journal-title":"Stroke"},{"key":"10.1016\/j.ibneur.2025.12.007_bib40","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1093\/gerona\/glab130","article-title":"Change in CAIDE dementia risk score and neuroimaging biomarkers during a 2-year multidomain lifestyle randomized controlled trial: results of a post-hoc subgroup analysis","volume":"76","author":"Stephen","year":"2021","journal-title":"J. Gerontol. Ser. A"},{"key":"10.1016\/j.ibneur.2025.12.007_bib41","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1136\/jnnp-2019-321652","article-title":"Association between midlife dementia risk factors and longitudinal brain atrophy: the PREVENT-Dementia study","volume":"91","author":"T O\u2032brien","year":"2020","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.ibneur.2025.12.007_bib42","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.3233\/JAD-210269","article-title":"A modified CAIDE risk score as a screening tool for cognitive impairment in older adults","volume":"82","author":"Tolea","year":"2021","journal-title":"J. Alzheimer\u2019S. Dis."},{"key":"10.1016\/j.ibneur.2025.12.007_bib43","doi-asserted-by":"crossref","first-page":"531","DOI":"10.3233\/JAD-2012-120802","article-title":"Midlife vascular risk factors and Alzheimer's disease: evidence from epidemiological studies","volume":"32","author":"Tolppanen","year":"2012","journal-title":"J. Alzheimer\u2019S. Dis."},{"key":"10.1016\/j.ibneur.2025.12.007_bib44","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1111\/j.1532-5415.1992.tb01992.x","article-title":"The mini-mental state examination: a comprehensive review","volume":"40","author":"Tombaugh","year":"1992","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.ibneur.2025.12.007_bib45","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3233\/JAD-180280","article-title":"Regional white matter hyperintensity influences grey matter atrophy in mild cognitive impairment","volume":"66","author":"Vipin","year":"2018","journal-title":"J. Alzheimer's. Dis."},{"key":"10.1016\/j.ibneur.2025.12.007_bib46","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1161\/STROKEAHA.124.047910","article-title":"Heterogeneity and penumbra of white matter hyperintensities in small vessel diseases determined by quantitative MRI","volume":"56","author":"Voorter","year":"2025","journal-title":"Stroke"},{"key":"10.1016\/j.ibneur.2025.12.007_bib47","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3233\/JAD-140924","article-title":"Midlife CAIDE dementia risk score and dementia-related brain changes up to 30 years later on magnetic resonance imaging","volume":"44","author":"Vuorinen","year":"2015","journal-title":"J. Alzheimer\u2019S. Dis."},{"key":"10.1016\/j.ibneur.2025.12.007_bib48","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3233\/JAD-140924","article-title":"Midlife CAIDE dementia risk score and dementia-related brain changes up to 30 years later on magnetic resonance imaging","volume":"44","author":"Vuorinen","year":"2015","journal-title":"J. Alzheimer's. Dis."},{"key":"10.1016\/j.ibneur.2025.12.007_bib49","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.neurobiolaging.2018.03.031","article-title":"The association of mid-to late-life systemic inflammation with white matter structure in older adults: the Atherosclerosis Risk in Communities Study","volume":"68","author":"Walker","year":"2018","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ibneur.2025.12.007_bib50","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.2205","article-title":"Association between homocysteine and white matter hyperintensities in rural-dwelling Chinese people with asymptomatic intracranial arterial stenosis: a population-based study","volume":"11","author":"Wang","year":"2021","journal-title":"Brain Behav."},{"key":"10.1016\/j.ibneur.2025.12.007_bib51","article-title":"Mediation effect of WMH on the associations of dementia risk with cognition and AD-related brain changes","volume":"19","author":"Wang","year":"2023","journal-title":"Alzheimer's. Dement."},{"key":"10.1016\/j.ibneur.2025.12.007_bib52","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/S1474-4422(13)70124-8","article-title":"Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration","volume":"12","author":"Wardlaw","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ibneur.2025.12.007_bib53","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2022.770184","article-title":"Association between white matter hyperintensities and chronic kidney disease: a systematic review and meta-analysis","volume":"9","author":"Wei","year":"2022","journal-title":"Front. Med."},{"key":"10.1016\/j.ibneur.2025.12.007_bib54","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.28225","article-title":"Association between obstructive sleep apnea and brain white matter hyperintensities in a population-based cohort in Germany","volume":"4","author":"Zacharias","year":"2021","journal-title":"JAMA Netw. Open"}],"container-title":["IBRO Neuroscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266724212500199X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266724212500199X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T20:22:29Z","timestamp":1782159749000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S266724212500199X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":54,"alternative-id":["S266724212500199X"],"URL":"https:\/\/doi.org\/10.1016\/j.ibneur.2025.12.007","relation":{},"ISSN":["2667-2421"],"issn-type":[{"value":"2667-2421","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiovascular risk factors, aging, and incidence of dementia (CAIDE) risk score and its association with cognitive performance and volumetric brain measures in mild cognitive impairment","name":"articletitle","label":"Article Title"},{"value":"IBRO Neuroscience Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ibneur.2025.12.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of International Brain Research Organization.","name":"copyright","label":"Copyright"}]}}