{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:29:21Z","timestamp":1793813361776,"version":"4.6.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ibroneuroreports.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["IBRO Neuroscience Reports"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.ibneur.2026.01.009","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T16:36:21Z","timestamp":1769099781000},"page":"647-656","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["The effects of nicotine on Parkinson's disease: A systematic review and meta-analysis of experimental evidence"],"prefix":"10.1016","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5982-9601","authenticated-orcid":false,"given":"Gudisa","family":"Bereda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javed","family":"Ahamad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ibneur.2026.01.009_bib1","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/ana.10277","article-title":"A meta-analysis of coffee drinking, cigarette smoking, and the risk of Parkinson\u2019s disease","volume":"52","author":"Hern\u00e1n","year":"2002","journal-title":"Ann. Neurol."},{"issue":"7","key":"10.1016\/j.ibneur.2026.01.009_bib2","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1001\/archneur.64.7.990","article-title":"Pooled analysis of tobacco use and risk of Parkinson disease","volume":"64","author":"Ritz","year":"2007","journal-title":"Arch. Neurol."},{"issue":"12","key":"10.1016\/j.ibneur.2026.01.009_bib3","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1002\/mds.21900","article-title":"Nicotine and Parkinson\u2019s disease: implications for therapy","volume":"23","author":"Quik","year":"2008","journal-title":"Mov. Disord."},{"issue":"7","key":"10.1016\/j.ibneur.2026.01.009_bib4","doi-asserted-by":"crossref","first-page":"613","DOI":"10.3109\/10408444.2012.680431","article-title":"Mitochondrial complex I inhibitor rotenone-induced toxicity and its potential mechanisms in Parkinson\u2019s disease models","volume":"42","author":"Xiong","year":"2012","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.ibneur.2026.01.009_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijsu.2021.105918","article-title":"PRISMA 2020 statement: what\u2019s new and the importance of reporting guidelines","volume":"88","author":"Sohrabi","year":"2021","journal-title":"Int J. Surg."},{"key":"10.1016\/j.ibneur.2026.01.009_bib6","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1471-2288-14-43","article-title":"SYRCLE\u2019s risk of bias tool for animal studies","volume":"14","author":"Hooijmans","year":"2014","journal-title":"BMC Med Res Method."},{"issue":"2","key":"10.1016\/j.ibneur.2026.01.009_bib7","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.toxlet.2009.05.013","article-title":"ToxRTool,\u201d a new tool to assess the reliability of toxicological data","volume":"189","author":"Schneider","year":"2009","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ibneur.2026.01.009_bib8","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s12874-015-0091-1","article-title":"Hartung-knapp-sidik-jonkman approach and its modification for random-effects meta-analysis with few studies","volume":"15","author":"R\u00f6ver","year":"2015","journal-title":"BMC Med Res Method."},{"issue":"4","key":"10.1016\/j.ibneur.2026.01.009_bib9","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1002\/jrsm.53","article-title":"Comparison of statistical inferences from the DerSimonian\u2013Laird and alternative random-effects model meta-analyses: an empirical assessment of 920 Cochrane primary outcome meta-analyses","volume":"2","author":"Thorlund","year":"2011","journal-title":"Res Synth. Methods"},{"key":"10.1016\/j.ibneur.2026.01.009_bib10","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/BF03033982","article-title":"Neuroprotective effects of nicotine against salsolinol-induced cytotoxicity: implications for Parkinson\u2019s disease","volume":"8","author":"Copeland","year":"2005","journal-title":"Neurotox. Res"},{"key":"10.1016\/j.ibneur.2026.01.009_bib11","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF03033901","article-title":"Antiapoptotic effects of nicotine in its protection against salsolinol-induced cytotoxicity","volume":"12","author":"Copeland","year":"2007","journal-title":"Neurotox. Res"},{"key":"10.1016\/j.ibneur.2026.01.009_bib12","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S0006-8993(03)03195-0","article-title":"Cigarette smoke and nicotine protect dopaminergic neurons against the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Parkinsonian toxin","volume":"984","author":"Parain","year":"2003","journal-title":"Brain Res"},{"key":"10.1016\/j.ibneur.2026.01.009_bib13","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/S0028-3908(03)00041-8","article-title":"Nicotine protects rat brain mitochondria against experimental injuries","volume":"44","author":"Cormier","year":"2003","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ibneur.2026.01.009_bib14","doi-asserted-by":"crossref","first-page":"4681","DOI":"10.1523\/JNEUROSCI.0215-06.2006","article-title":"Chronic oral nicotine normalizes dopaminergic function and synaptic plasticity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned primates","volume":"26","author":"Quik","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ibneur.2026.01.009_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1088957","article-title":"Nicotine alleviates MPTP-induced nigrostriatal damage through modulation of JNK and ERK signaling pathways in the mice model of Parkinson\u2019s disease","volume":"14","author":"Ruan","year":"2023","journal-title":"Front Pharm."},{"key":"10.1016\/j.ibneur.2026.01.009_bib16","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.neuro.2019.02.008","article-title":"Nicotine improved the olfactory impairment in MPTP-induced mouse model of Parkinson\u2019s disease","volume":"73","author":"Yang","year":"2019","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.ibneur.2026.01.009_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2024.1358141","article-title":"Nicotine-mediated therapy for Parkinson\u2019s disease in transgenic Caenorhabditis elegans model","volume":"16","author":"Ullah","year":"2024","journal-title":"Front Aging Neurosci."},{"key":"10.1016\/j.ibneur.2026.01.009_bib18","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1460-9568.2007.05636.x","article-title":"Neuroprotective effect of nicotine on dopaminergic neurons by anti-inflammatory action","volume":"26","author":"Park","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ibneur.2026.01.009_bib19","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1523\/JNEUROSCI.2126-15.2016","article-title":"Smoking-relevant nicotine concentration attenuates the unfolded protein response in dopaminergic neurons","volume":"36","author":"Srinivasan","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ibneur.2026.01.009_bib20","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.3933","article-title":"The neuroprotective effect of nicotine in Parkinson\u2019s disease models is associated with inhibiting PARP-1 and caspase-3 cleavage","volume":"5","author":"Lu","year":"2017","journal-title":"PeerJ"},{"key":"10.1016\/j.ibneur.2026.01.009_bib21","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s12640-018-9931-1","article-title":"Nicotine-induced neuroprotection in rotenone in vivo and in vitro models of Parkinson\u2019s disease: evidences for the involvement of the labile iron pool level as the underlying mechanism","volume":"35","author":"Mouhape","year":"2019","journal-title":"Neurotox. Res"},{"issue":"9","key":"10.1016\/j.ibneur.2026.01.009_bib22","article-title":"Transdermal nicotine treatment and progression of early Parkinson\u2019s disease","volume":"2","author":"Oertel","year":"2023","journal-title":"N. Engl. J. Med Evid."},{"issue":"1","key":"10.1016\/j.ibneur.2026.01.009_bib23","article-title":"Caffeine exposure and the risk of Parkinson's disease: a systematic review and meta-analysis of observational studies","volume":"20","author":"Costa","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.ibneur.2026.01.009_bib24","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1212\/01.wnl.0000256374.50227.4b","article-title":"Temporal relationship between cigarette smoking and risk of Parkinson disease","volume":"68","author":"Thacker","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.ibneur.2026.01.009_bib25","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s12031-014-0352-1","article-title":"Lynx1 supports neuronal health in the mouse dorsal striatum during aging: an ultrastructural investigation","volume":"53","author":"Kobayashi","year":"2014","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.ibneur.2026.01.009_bib26","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1002\/mds.25594","article-title":"Nicotine reduces established levodopa-induced dyskinesias in a monkey model of Parkinson\u2019s disease","volume":"28","author":"Quik","year":"2013","journal-title":"Mov. Disord."},{"key":"10.1016\/j.ibneur.2026.01.009_bib27","doi-asserted-by":"crossref","first-page":"3210","DOI":"10.3390\/ijms26073210","article-title":"The role of \u03b17-nicotinic acetylcholine receptors in the pathophysiology and treatment of Parkinson\u2019s disease","volume":"26","author":"ElNebrisi","year":"2025","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.ibneur.2026.01.009_bib28","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s10072-014-1652-5","article-title":"Effect of nicotine on L-dopa-induced dyskinesia in animal models of Parkinson\u2019s disease: a systematic review and meta-analysis","volume":"35","author":"Xie","year":"2014","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.ibneur.2026.01.009_bib29","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-93105-y","article-title":"Understanding the effect of smoking and drinking behavior on Parkinson's disease risk: a Mendelian randomization study","volume":"11","author":"Dom\u00ednguez-Bale\u00f3n","year":"2021","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.ibneur.2026.01.009_bib30","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1093\/ntr\/ntae180","article-title":"Integrating mendelian randomization with single-cell sequencing data reveals the causal effect and related mechanisms of smoking on Parkinson's disease","volume":"27","author":"Zhang","year":"2025","journal-title":"Nicotine Tob. Res"}],"container-title":["IBRO Neuroscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667242126000096?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667242126000096?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T16:40:43Z","timestamp":1793810443000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667242126000096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":30,"alternative-id":["S2667242126000096"],"URL":"https:\/\/doi.org\/10.1016\/j.ibneur.2026.01.009","relation":{},"ISSN":["2667-2421"],"issn-type":[{"value":"2667-2421","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effects of nicotine on Parkinson's disease: A systematic review and meta-analysis of experimental evidence","name":"articletitle","label":"Article Title"},{"value":"IBRO Neuroscience Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ibneur.2026.01.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of International Brain Research Organization.","name":"copyright","label":"Copyright"}]}}