{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T20:53:57Z","timestamp":1782161637000,"version":"3.54.5"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ibroneuroreports.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["IBRO Neuroscience Reports"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.ibneur.2026.05.002","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T23:44:26Z","timestamp":1778283866000},"page":"720-728","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Default modetwork connectivity and its clinical relevance for depression in multiple sclerosis: A scoping review"],"prefix":"10.1016","volume":"20","author":[{"given":"Laura","family":"Culicetto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5971-1400","authenticated-orcid":false,"given":"Giulia","family":"Marafioti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana Lo","family":"Buono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giangaetano","family":"D\u2019Aleo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmela","family":"Rifici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Sessa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Quartarone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Marino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ibneur.2026.05.002_bib1","first-page":"98","article-title":"Clinical presentation of the \u201cdepression\u2013executive dysfunction syndrome\u201d of late life","volume":"10","author":"Alexopoulos","year":"2002","journal-title":"Am. J. Geriatr. Psychiatry"},{"issue":"5","key":"10.1016\/j.ibneur.2026.05.002_bib2","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1017\/S1092852900022744","article-title":"Longitudinal consistency of the relationship between depression symptoms and cognitive functioning in multiple sclerosis","volume":"10","author":"Arnett","year":"2005","journal-title":"CNS Spectr."},{"issue":"6","key":"10.1016\/j.ibneur.2026.05.002_bib3","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.biopsych.2018.09.031","article-title":"The impact of stress and major depressive disorder on hippocampal and medial prefrontal cortex morphology","volume":"85","author":"Belleau","year":"2019","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ibneur.2026.05.002_bib4","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.conb.2014.08.013","article-title":"Depression: from psychopathology to pathophysiology","volume":"30","author":"Belzung","year":"2015","journal-title":"Curr. Opin. Neurobiol."},{"issue":"13","key":"10.1016\/j.ibneur.2026.05.002_bib5","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1177\/1352458517730932","article-title":"Fatigue in multiple sclerosis: the contribution of resting-state functional connectivity reorganization","volume":"24","author":"Bisecco","year":"2018","journal-title":"Mult. Scler."},{"issue":"4","key":"10.1016\/j.ibneur.2026.05.002_bib6","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/mrm.1910340409","article-title":"Functional connectivity in the motor cortex of resting human brain using echo-planar mri","volume":"34","author":"Biswal","year":"1995","journal-title":"Magn. Reson. Med."},{"issue":"6","key":"10.1016\/j.ibneur.2026.05.002_bib7","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1111\/j.1440-1819.2009.02030.x","article-title":"Resting state default-mode network connectivity in early depression using a seed region-of-interest analysis: decreased connectivity with caudate nucleus","volume":"63","author":"Bluhm","year":"2009","journal-title":"Psychiatry Clin. Neurosci."},{"issue":"4","key":"10.1016\/j.ibneur.2026.05.002_bib8","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1177\/1352458510394609","article-title":"Distributed changes in default-mode resting-state connectivity in multiple sclerosis","volume":"17","author":"Bonavita","year":"2011","journal-title":"Mult. Scler. J."},{"issue":"1","key":"10.1016\/j.ibneur.2026.05.002_bib9","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/ene.13112","article-title":"Default mode network changes in multiple sclerosis: a link between depression and cognitive impairment?","volume":"24","author":"Bonavita","year":"2017","journal-title":"Eur. J. Neurol."},{"issue":"3","key":"10.1016\/j.ibneur.2026.05.002_bib10","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.neubiorev.2008.09.002","article-title":"Default-mode brain dysfunction in mental disorders: a systematic review","volume":"33","author":"Broyd","year":"2009","journal-title":"Neurosci. & Biobehav. Rev."},{"issue":"2\u20133","key":"10.1016\/j.ibneur.2026.05.002_bib11","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.jad.2012.03.002","article-title":"Disrupted resting-state functional connectivity of the hippocampus in medication-na\u00efve patients with major depressive disorder","volume":"141","author":"Cao","year":"2012","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.ibneur.2026.05.002_bib12","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jad.2015.04.052","article-title":"Aberrant connectivity within the default mode network in first-episode, treatment-na\u00efve major depressive disorder","volume":"183","author":"Chen","year":"2015","journal-title":"J. Affect. Disord."},{"issue":"1","key":"10.1016\/j.ibneur.2026.05.002_bib13","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1017\/S135561770809005X","article-title":"Negative affect predicts subsequent cognitive change in multiple sclerosis","volume":"15","author":"Christodoulou","year":"2009","journal-title":"J. Int. Neuropsychol. Soc."},{"issue":"4","key":"10.1016\/j.ibneur.2026.05.002_bib14","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.psc.2007.07.003","article-title":"Psychiatric issues in multiple sclerosis","volume":"30","author":"Chwastiak","year":"2007","journal-title":"Psychiatr. Clin. North Am."},{"issue":"9648","key":"10.1016\/j.ibneur.2026.05.002_bib15","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/S0140-6736(08)61620-7","article-title":"Multiple sclerosis","volume":"372","author":"Compston","year":"2008","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.ibneur.2026.05.002_bib16","first-page":"1636","article-title":"Mapping functionally related regions of brain with functional connectivity MR imaging","volume":"21","author":"Cordes","year":"2000","journal-title":"Ajnr. Am. J. Neuroradiol."},{"issue":"4","key":"10.1016\/j.ibneur.2026.05.002_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurobiolaging.2011.06.024","article-title":"Functional connectivity tracks clinical deterioration in Alzheimer\u2019s disease","volume":"33","author":"Damoiseaux","year":"2012","journal-title":"Neurobiol. Aging"},{"issue":"1","key":"10.1016\/j.ibneur.2026.05.002_bib18","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1146\/annurev.psych.53.100901.135148","article-title":"Depression: perspectives from affective neuroscience","volume":"53","author":"Davidson","year":"2002","journal-title":"Annu. Rev. Psychol."},{"issue":"1","key":"10.1016\/j.ibneur.2026.05.002_bib19","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1177\/2167702619863427","article-title":"Changes in positive and negative affect during pharmacological treatment and cognitive therapy for major depressive disorder: a secondary analysis of two randomized controlled trials","volume":"8","author":"Dunn","year":"2020","journal-title":"Clin. Psychol. Sci."},{"issue":"9","key":"10.1016\/j.ibneur.2026.05.002_bib20","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1177\/1352458511435930","article-title":"Assessing brain connectivity at rest is clinically relevant in early multiple sclerosis","volume":"18","author":"Faivre","year":"2012","journal-title":"Mult. Scler. J."},{"issue":"4","key":"10.1016\/j.ibneur.2026.05.002_bib21","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1212\/01.WNL.0000110316.12086.0C","article-title":"Structural brain abnormalities in multiple sclerosis patients with major depression","volume":"62","author":"Feinstein","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.ibneur.2026.05.002_bib22","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.neuroimage.2017.09.021","article-title":"Brain mapping in multiple sclerosis: lessons learned about the human brain","volume":"190","author":"Filippi","year":"2019","journal-title":"NeuroImage"},{"key":"10.1016\/j.ibneur.2026.05.002_bib23","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.neuroimage.2017.09.021","article-title":"Brain mapping in multiple sclerosis: lessons learned about the human brain","volume":"190","author":"Filippi","year":"2019","journal-title":"NeuroImage"},{"issue":"6","key":"10.1016\/j.ibneur.2026.05.002_bib24","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.biopsych.2010.04.025","article-title":"Smaller Cornu ammonis 2\u20133\/dentate gyrus volumes and elevated cortisol in multiple sclerosis patients with depressive symptoms","volume":"68","author":"Gold","year":"2010","journal-title":"Biol. Psychiatry"},{"issue":"4","key":"10.1016\/j.ibneur.2026.05.002_bib25","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1097\/WCO.0b013e328306f2c5","article-title":"Resting-state functional connectivity in neuropsychiatric disorders","volume":"21","author":"Greicius","year":"2008","journal-title":"Curr. Opin. Neurol."},{"issue":"5","key":"10.1016\/j.ibneur.2026.05.002_bib26","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.biopsych.2006.09.020","article-title":"Resting-state functional connectivity in major depression: abnormally increased contributions from subgenual cingulate cortex and thalamus","volume":"62","author":"Greicius","year":"2007","journal-title":"Biol. Psychiatry"},{"issue":"5","key":"10.1016\/j.ibneur.2026.05.002_bib27","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.biopsych.2006.09.020","article-title":"Resting-state functional connectivity in major depression: abnormally increased contributions from subgenual cingulate cortex and thalamus","volume":"62","author":"Greicius","year":"2007","journal-title":"Biol. Psychiatry"},{"issue":"5","key":"10.1016\/j.ibneur.2026.05.002_bib28","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.biopsych.2006.09.020","article-title":"Resting-state functional connectivity in major depression: abnormally increased contributions from subgenual cingulate cortex and thalamus","volume":"62","author":"Greicius","year":"2007","journal-title":"Biol. Psychiatry"},{"issue":"3","key":"10.1016\/j.ibneur.2026.05.002_bib29","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.jad.2013.09.003","article-title":"Dissociation of regional activity in the default mode network in first-episode, drug-naive major depressive disorder at rest","volume":"151","author":"Guo","year":"2013","journal-title":"J. Affect. Disord."},{"issue":"4","key":"10.1016\/j.ibneur.2026.05.002_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0210375","article-title":"Symptoms of fatigue and depression is reflected in altered default mode network connectivity in multiple sclerosis","volume":"14","author":"H\u00f8gest\u00f8l","year":"2019","journal-title":"PLOS One"},{"issue":"Q1","key":"10.1016\/j.ibneur.2026.05.002_bib31","doi-asserted-by":"crossref","first-page":"34","DOI":"10.7224\/1537-2073.2024-003","article-title":"Aerobic exercise training and depressive symptoms in people with multiple sclerosis: brief report on default-mode network resting-state functional connectivity","volume":"27","author":"Iosipchuk","year":"2025","journal-title":"Int. J. MS Care"},{"issue":"6","key":"10.1016\/j.ibneur.2026.05.002_bib32","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1001\/jamapsychiatry.2015.0071","article-title":"Large-scale network dysfunction in major depressive disorder: a meta-analysis of resting-state functional connectivity","volume":"72","author":"Kaiser","year":"2015","journal-title":"JAMA Psychiatry"},{"issue":"10","key":"10.1016\/j.ibneur.2026.05.002_bib33","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s11910-019-0992-1","article-title":"Depression and suicidality in multiple sclerosis: red flags, management strategies, and ethical considerations","volume":"19","author":"Kalb","year":"2019","journal-title":"Curr. Neurol. Neurosci. Rep."},{"issue":"4","key":"10.1016\/j.ibneur.2026.05.002_bib34","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.2475","article-title":"Default mode network connectivity and treatment response in geriatric depression","volume":"12","author":"Kilpatrick","year":"2022","journal-title":"Brain Behav."},{"issue":". 1","key":"10.1016\/j.ibneur.2026.05.002_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000367614","article-title":"New multiple sclerosis phenotypic classification","volume":"72","author":"Lublin","year":"2014","journal-title":"Eur. Neurol."},{"issue":"15","key":"10.1016\/j.ibneur.2026.05.002_bib36","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1097\/WNR.0000000000000013","article-title":"Effects of exercise on resting-state default mode and salience network activity in overweight\/obese adults","volume":"24","author":"McFadden","year":"2013","journal-title":"NeuroReport"},{"issue":"15","key":"10.1016\/j.ibneur.2026.05.002_bib37","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1097\/WNR.0000000000000013","article-title":"Effects of exercise on resting-state default mode and salience network activity in overweight\/obese adults","volume":"24","author":"McFadden","year":"2013","journal-title":"NeuroReport"},{"issue":"15","key":"10.1016\/j.ibneur.2026.05.002_bib38","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1097\/WNR.0000000000000013","article-title":"Effects of exercise on resting-state default mode and salience network activity in overweight\/obese adults","volume":"24","author":"McFadden","year":"2013","journal-title":"NeuroReport"},{"issue":"9","key":"10.1016\/j.ibneur.2026.05.002_bib39","doi-asserted-by":"crossref","DOI":"10.1001\/archneur.65.9.1223","article-title":"A magnetic resonance imaging voxel-based morphometry study of regional gray matter atrophy in patients with benign multiple sclerosis","volume":"65","author":"Mesaros","year":"2008","journal-title":"Arch. Neurol."},{"issue":"11","key":"10.1016\/j.ibneur.2026.05.002_bib40","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1212\/01.WNL.0000095964.34294.B4","article-title":"Major depression in multiple sclerosis","volume":"61","author":"Patten","year":"2003","journal-title":"Neurology"},{"issue":"11","key":"10.1016\/j.ibneur.2026.05.002_bib41","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/nrneurol.2017.117","article-title":"Fatigue as a symptom or comorbidity of neurological diseases","volume":"13","author":"Penner","year":"2017","journal-title":"Nat. Rev. Neurol."},{"issue":"3","key":"10.1016\/j.ibneur.2026.05.002_bib42","doi-asserted-by":"crossref","first-page":"520","DOI":"10.11124\/JBIES-22-00123","article-title":"Recommendations for the extraction, analysis, and presentation of results in scoping reviews","volume":"21","author":"Pollock","year":"2023","journal-title":"JBI Evid. Synth."},{"issue":"3","key":"10.1016\/j.ibneur.2026.05.002_bib43","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.neuroimage.2005.08.034","article-title":"Grey matter loss in relapsing\u2013remitting multiple sclerosis: a voxel-based morphometry study","volume":"29","author":"Prinster","year":"2006","journal-title":"NeuroImage"},{"issue":"4","key":"10.1016\/j.ibneur.2026.05.002_bib44","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1212\/WNL.49.4.1105","article-title":"Lesions in the left arcuate fasciculus region and depressive symptoms in multiple sclerosis","volume":"49","author":"Pujol","year":"1997","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.ibneur.2026.05.002_bib45","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1073\/pnas.98.2.676","article-title":"A default mode of brain function","volume":"98","author":"Raichle","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"12","key":"10.1016\/j.ibneur.2026.05.002_bib46","doi-asserted-by":"crossref","first-page":"5051","DOI":"10.1002\/hbm.22992","article-title":"Hippocampal- <scp>DMN<\/scp> disconnectivity in <scp>MS<\/scp> is related to <scp>WM<\/scp> lesions and depression","volume":"36","author":"Rocca","year":"2015","journal-title":"Hum. Brain Mapp."},{"issue":"16","key":"10.1016\/j.ibneur.2026.05.002_bib47","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1212\/WNL.0b013e3181d9ed91","article-title":"Default-mode network dysfunction and cognitive impairment in progressive MS","volume":"74","author":"Rocca","year":"2010","journal-title":"Neurology"},{"issue":"14","key":"10.1016\/j.ibneur.2026.05.002_bib48","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1212\/WNL.0b013e31826d5f10","article-title":"Large-scale neuronal network dysfunction in relapsing-remitting multiple sclerosis","volume":"79","author":"Rocca","year":"2012","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.ibneur.2026.05.002_bib49","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1093\/brain\/awq058","article-title":"Resting state networks change in clinically isolated syndrome","volume":"133","author":"Roosendaal","year":"2010","journal-title":"Brain"},{"issue":"10","key":"10.1016\/j.ibneur.2026.05.002_bib50","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1177\/1545968318798938","article-title":"Integrative CNS plasticity with exercise in MS: the PRIMERS (PRocessing, Integration of Multisensory Exercise-Related Stimuli) conceptual framework","volume":"32","author":"Sandroff","year":"2018","journal-title":"Neurorehabil. Neural Repair"},{"key":"10.1016\/j.ibneur.2026.05.002_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.cct.2021.106563","article-title":"Effects of walking exercise training on learning and memory and hippocampal neuroimaging outcomes in MS: a targeted, pilot randomized controlled trial","volume":"110","author":"Sandroff","year":"2021","journal-title":"Contemp. Clin. Trials"},{"key":"10.1016\/j.ibneur.2026.05.002_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.cct.2021.106563","article-title":"Effects of walking exercise training on learning and memory and hippocampal neuroimaging outcomes in MS: a targeted, pilot randomized controlled trial","volume":"110","author":"Sandroff","year":"2021","journal-title":"Contemp. Clin. Trials"},{"key":"10.1016\/j.ibneur.2026.05.002_bib53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/212693","article-title":"Resting-state fMRI in MS: general concepts and brief overview of its application","volume":"2015","author":"Sbardella","year":"2015","journal-title":"BioMed. Res. Int."},{"key":"10.1016\/j.ibneur.2026.05.002_bib54","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.jad.2014.03.048","article-title":"Imbalanced hippocampal functional networks associated with remitted geriatric depression and apolipoprotein E \u03b54 allele in nondemented elderly: a preliminary study","volume":"164","author":"Shu","year":"2014","journal-title":"J. Affect. Disord."},{"issue":"4","key":"10.1016\/j.ibneur.2026.05.002_bib55","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1136\/jnnp.2004.054635","article-title":"Depression in multiple sclerosis: a review","volume":"76","author":"Siegert","year":"2005","journal-title":"J. Neurol. Neurosurg. & Psychiatry"},{"issue":"9","key":"10.1016\/j.ibneur.2026.05.002_bib56","doi-asserted-by":"crossref","DOI":"10.1001\/archneurol.2009.190","article-title":"Multiple sclerosis with predominant, severe cognitive impairment","volume":"66","author":"Staff","year":"2009","journal-title":"Arch. Neurol."},{"issue":"2","key":"10.1016\/j.ibneur.2026.05.002_bib57","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1093\/arclin\/acs113","article-title":"Cognitive impairment has a strong relation to nonsomatic symptoms of depression in relapsing-remitting multiple sclerosis","volume":"28","author":"Sundgren","year":"2013","journal-title":"Arch. Clin. Neuropsychol."},{"issue":"3","key":"10.1016\/j.ibneur.2026.05.002_bib58","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0278-5846(02)00358-5","article-title":"Localization of age-associated white matter hyperintensities in late-life depression","volume":"27","author":"Taylor","year":"2003","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.ibneur.2026.05.002_bib59","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1146\/annurev.neuro.30.051606.094313","article-title":"Multiple sclerosis: an immune or neurodegenerative disorder?","volume":"31","author":"Trapp","year":"2008","journal-title":"Annu. Rev. Neurosci."},{"issue":"7","key":"10.1016\/j.ibneur.2026.05.002_bib60","doi-asserted-by":"crossref","first-page":"467","DOI":"10.7326\/M18-0850","article-title":"PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation","volume":"169","author":"Tricco","year":"2018","journal-title":"Ann. Intern. Med."},{"issue":"14","key":"10.1016\/j.ibneur.2026.05.002_bib61","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1177\/1352458520970841","article-title":"Rising prevalence of multiple sclerosis worldwide: Insights from the Atlas of MS, third edition","volume":"26","author":"Walton","year":"2020","journal-title":"Mult. Scler. J."},{"issue":"4","key":"10.1016\/j.ibneur.2026.05.002_bib62","doi-asserted-by":"crossref","first-page":"e1105","DOI":"10.1038\/tp.2017.40","article-title":"Instability of default mode network connectivity in major depression: a two-sample confirmation study","volume":"7","author":"Wise","year":"2017","journal-title":"Transl. Psychiatry"},{"issue":"3","key":"10.1016\/j.ibneur.2026.05.002_bib63","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.genhosppsych.2013.12.009","article-title":"Prevalence of depressive symptoms and predictors of treatment among U.S. adults from 2005 to 2010","volume":"36","author":"Wittayanukorn","year":"2014","journal-title":"Gen. Hosp. Psychiatry"},{"issue":"5","key":"10.1016\/j.ibneur.2026.05.002_bib64","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1093\/brain\/aws059","article-title":"Identifying major depression using whole-brain functional connectivity: a multivariate pattern analysis","volume":"135","author":"Zeng","year":"2012","journal-title":"Brain"},{"issue":"5","key":"10.1016\/j.ibneur.2026.05.002_bib65","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1093\/brain\/aws059","article-title":"Identifying major depression using whole-brain functional connectivity: a multivariate pattern analysis","volume":"135","author":"Zeng","year":"2012","journal-title":"Brain"},{"issue":"5","key":"10.1016\/j.ibneur.2026.05.002_bib66","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1093\/brain\/aws059","article-title":"Identifying major depression using whole-brain functional connectivity: a multivariate pattern analysis","volume":"135","author":"Zeng","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.ibneur.2026.05.002_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2019.116287","article-title":"Rumination and the default mode network: Meta-analysis of brain imaging studies and implications for depression","volume":"206","author":"Zhou","year":"2020","journal-title":"NeuroImage"},{"issue":"7","key":"10.1016\/j.ibneur.2026.05.002_bib68","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.biopsych.2011.10.035","article-title":"Evidence of a dissociation pattern in resting-state default mode network connectivity in first-episode, treatment-naive major depression patients","volume":"71","author":"Zhu","year":"2012","journal-title":"Biol. Psychiatry"}],"container-title":["IBRO Neuroscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667242126000679?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667242126000679?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T20:18:15Z","timestamp":1782159495000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667242126000679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":68,"alternative-id":["S2667242126000679"],"URL":"https:\/\/doi.org\/10.1016\/j.ibneur.2026.05.002","relation":{},"ISSN":["2667-2421"],"issn-type":[{"value":"2667-2421","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Default modetwork connectivity and its clinical relevance for depression in multiple sclerosis: A scoping review","name":"articletitle","label":"Article Title"},{"value":"IBRO Neuroscience Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ibneur.2026.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of International Brain Research Organization.","name":"copyright","label":"Copyright"}]}}