{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:29:02Z","timestamp":1793813342300,"version":"4.6.1"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["ibroneuroreports.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["IBRO Neuroscience Reports"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.ibneur.2026.07.012","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:06:28Z","timestamp":1785283588000},"page":"413-420","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Protective effect of Glycyrrhizin on cuprizone-induced model of multiple sclerosis in male C57BL\/6 mice"],"prefix":"10.1016","volume":"21","author":[{"given":"Asal sadat","family":"Morakkabi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahin","family":"Hassanpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Razieh","family":"Hosseini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ibneur.2026.07.012_bib1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3390\/bs12030070","article-title":"Biochanin A improves memory decline and brain pathology in cuprizone-induced mouse model of multiple sclerosis","volume":"12","author":"Aldhahri","year":"2022","journal-title":"Behav. Sci."},{"key":"10.1016\/j.ibneur.2026.07.012_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.153999","article-title":"Recent advances in glycyrrhizin metabolism, health benefits, clinical effects and drug delivery systems for efficacy improvement; a comprehensive review","volume":"99","author":"Bakr","year":"2022","journal-title":"Phytomedicine"},{"issue":"10","key":"10.1016\/j.ibneur.2026.07.012_bib3","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/S1474-4422(20)30277-5","article-title":"Cognitive impairment in multiple sclerosis: clinical management, MRI, and therapeutic avenues","volume":"19","author":"Benedict","year":"2020","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ibneur.2026.07.012_bib4","series-title":"Grip strength. Experimental protocols for SMA animal models","author":"Corti","year":"2017"},{"key":"10.1016\/j.ibneur.2026.07.012_bib5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.brainresbull.2014.03.004","article-title":"CR. Hesperidin exerts antidepressant-like effects in acute and chronic treatments in mice: possible role of l-arginine-NO-cGMP pathway and BDNF levels","volume":"104","author":"Donato","year":"2014","journal-title":"Brain Res. Bull."},{"issue":"3","key":"10.1016\/j.ibneur.2026.07.012_bib6","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3390\/cosmetics10030069","article-title":"Silico Evaluation of the Antioxidant, Anti-Inflammatory, and Dermatocosmetic Activities of Phytoconstituents in Licorice (Glycyrrhiza glabra L.)","volume":"10","author":"Fatoki","year":"2023","journal-title":"Cosmetics"},{"key":"10.1016\/j.ibneur.2026.07.012_bib7","article-title":"A battery of motor tests in a neonatal mouse model of cerebral palsy","volume":"117","author":"Feather-Schussler","year":"2016","journal-title":"JoVE (J. Vis. Exp. )"},{"issue":"11","key":"10.1016\/j.ibneur.2026.07.012_bib8","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.3390\/jcm13113321","article-title":"Impact of cognitive impairment on quality of life in multiple sclerosis patients\u2014a comprehensive review","volume":"13","author":"G\u00f3mez-Melero","year":"2024","journal-title":"J. Clin. Med."},{"issue":"5","key":"10.1016\/j.ibneur.2026.07.012_bib9","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1177\/1352458519888178","article-title":"Biosensors to monitor MS activity","volume":"26","author":"Graves","year":"2020","journal-title":"Mult. Scler. J."},{"issue":"8","key":"10.1016\/j.ibneur.2026.07.012_bib10","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.2174\/1871527315666160527163526","article-title":"Glycyrrhizic acid ameliorates cognitive impairment in a rat model of vascular dementia associated with oxidative damage and inhibition of voltage-gated sodium channels","volume":"15","author":"Guo","year":"2016","journal-title":"CNS Neurol. Disord. Drug. Targets CNS Neurol. Disord."},{"issue":"4","key":"10.1016\/j.ibneur.2026.07.012_bib11","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1080\/08923973.2018.1490318","article-title":"The beneficial effects of 18\u03b2-glycyrrhetinic acid on the experimental autoimmune encephalomyelitis (EAE) in C57BL\/6 mouse model","volume":"40","author":"Kamisli","year":"2018","journal-title":"Immunopharmacol. Immunotoxicol."},{"issue":"3","key":"10.1016\/j.ibneur.2026.07.012_bib12","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s12031-017-0989-7","article-title":"The oral pretreatment of glycyrrhizin prevents surgery-induced cognitive impairment in aged mice by reducing neuroinflammation and Alzheimer\u2019s-related pathology via HMGB1 inhibition","volume":"63","author":"Kong","year":"2017","journal-title":"J. Mol. Neurosci."},{"issue":"10","key":"10.1016\/j.ibneur.2026.07.012_bib13","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1248\/bpb.30.1898","article-title":"Protective mechanism of glycyrrhizin on acute liver injury induced by carbon tetrachloride in mice","volume":"30","author":"Lee","year":"2007","journal-title":"Biol. Pharm. Bull."},{"issue":"12","key":"10.1016\/j.ibneur.2026.07.012_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2022.e12277","article-title":"Wuzi Yanzong Pill relieves CPZ-induced demyelination by improving the microenvironment in the brain","volume":"8","author":"Li","year":"2022","journal-title":"Heliyon"},{"issue":"1","key":"10.1016\/j.ibneur.2026.07.012_bib15","article-title":"Neurodegeneration in multiple sclerosis","volume":"15","author":"Mey","year":"2023","journal-title":"WIREs Mech. Dis."},{"issue":"3","key":"10.1016\/j.ibneur.2026.07.012_bib16","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3892\/etm.2022.11133","article-title":"Low-field magnetic stimulation improved cuprizone-induced depression-like symptoms and demyelination in female mice","volume":"23","author":"Mooshekhian","year":"2022","journal-title":"Exp. Ther. Med."},{"issue":"11","key":"10.1016\/j.ibneur.2026.07.012_bib17","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1002\/ptr.5893","article-title":"Toxicological effects of Glycyrrhiza glabra (licorice): a review","volume":"31","author":"Nazari","year":"2017","journal-title":"Phytother. Res."},{"issue":"122","key":"10.1016\/j.ibneur.2026.07.012_bib18","first-page":"55261","article-title":"Neurodevelopmental reflex testing in neonatal rat pups","author":"Nguyen","year":"2017","journal-title":"J. Vis. Exp. JoVE"},{"issue":"2","key":"10.1016\/j.ibneur.2026.07.012_bib19","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s12640-015-9579-z","article-title":"Glycyrrhizic acid attenuates neuroinflammation and oxidative stress in rotenone model of Parkinson\u2019s disease","volume":"29","author":"Ojha","year":"2016","journal-title":"Neurotox. Res."},{"issue":"4","key":"10.1016\/j.ibneur.2026.07.012_bib20","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1021\/acschemneuro.9b00640","article-title":"Potential neuroprotective effect of the HMGB1 inhibitor glycyrrhizin in neurological disorders","volume":"11","author":"Paudel","year":"2020","journal-title":"ACS Chem. Neurosci."},{"issue":"3","key":"10.1016\/j.ibneur.2026.07.012_bib21","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.nrl.2021.10.003","article-title":"Relationship between inflammation and oxidative stress and its effect on multiple sclerosis","volume":"39","author":"Ramos-Gonz\u00e1lez","year":"2024","journal-title":"Neurologia"},{"key":"10.1016\/j.ibneur.2026.07.012_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2013.04.001","article-title":"Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species","volume":"106","author":"Semple","year":"2013","journal-title":"Progress. Neurobiol."},{"issue":"12","key":"10.1016\/j.ibneur.2026.07.012_bib23","doi-asserted-by":"crossref","first-page":"15788","DOI":"10.3390\/molecules181215788","article-title":"Glycyrrhizin alleviates neuroinflammation and memory deficit induced by systemic lipopolysaccharide treatment in mice","volume":"18","author":"Song","year":"2013","journal-title":"Molecules"},{"key":"10.1016\/j.ibneur.2026.07.012_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2021.135871","article-title":"18\u03b2-Glycyrrhetinic acid alleviates demyelination by modulating the microglial M1\/M2 phenotype in a mouse model of cuprizone-induced demyelination","volume":"755","author":"Tian","year":"2021","journal-title":"Neurosci. Lett."},{"issue":"2","key":"10.1016\/j.ibneur.2026.07.012_bib25","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1037\/a0014477","article-title":"Behavioral and neurobiological changes in C57BL\/6 mice exposed to cuprizone","volume":"123","author":"Xu","year":"2009","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.ibneur.2026.07.012_bib26","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.phymed.2018.09.189","article-title":"Ethanol extract of Glycyrrhizae Radix modulates the responses of antigen-specific splenocytes in experimental autoimmune encephalomyelitis","volume":"54","author":"Yang","year":"2019","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.ibneur.2026.07.012_bib27","article-title":"18\u03b2-glycyrrhetinic acid suppresses experimental autoimmune encephalomyelitis through inhibition of microglia activation and promotion of remyelination","volume":"5","author":"Zhou","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ibneur.2026.07.012_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2021.105489","article-title":"Valproic acid suppresses cuprizone-induced hippocampal demyelination and anxiety-like behavior by promoting cholesterol biosynthesis","volume":"158","author":"Zhu","year":"2021","journal-title":"Neurobiol. Dis."},{"issue":"1","key":"10.1016\/j.ibneur.2026.07.012_bib29","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13024-022-00538-8","article-title":"Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination","volume":"17","author":"Zirngibl","year":"2022","journal-title":"Mol. Neurodegener."}],"container-title":["IBRO Neuroscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667242126001132?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667242126001132?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T16:36:10Z","timestamp":1793810170000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667242126001132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":29,"alternative-id":["S2667242126001132"],"URL":"https:\/\/doi.org\/10.1016\/j.ibneur.2026.07.012","relation":{},"ISSN":["2667-2421"],"issn-type":[{"value":"2667-2421","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effect of Glycyrrhizin on cuprizone-induced model of multiple sclerosis in male C57BL\/6 mice","name":"articletitle","label":"Article Title"},{"value":"IBRO Neuroscience Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ibneur.2026.07.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of International Brain Research Organization.","name":"copyright","label":"Copyright"}]}}