{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:29:41Z","timestamp":1793813381700,"version":"4.6.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011479","name":"Baotou Medical College","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ibroneuroreports.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["IBRO Neuroscience Reports"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.ibneur.2026.07.014","type":"journal-article","created":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T13:40:52Z","timestamp":1785073252000},"page":"401-412","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Mongolian warm acupuncture improves colonic barrier function and immune responses via the TLR4\/MyD88\/NF-\u03baB pathway in insomnia rats"],"prefix":"10.1016","volume":"21","author":[{"family":"Gaowa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8758-9133","authenticated-orcid":false,"given":"Zhiying","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengqiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ibneur.2026.07.014_bib1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1053\/smrv.2002.0186","article-title":"Epidemiology of insomnia: what we know and what we still need to learn","volume":"6","author":"Ohayon","year":"2002","journal-title":"Sleep. Med. Rev."},{"issue":"6","key":"10.1016\/j.ibneur.2026.07.014_bib2","doi-asserted-by":"crossref","DOI":"10.1111\/jsr.14035","article-title":"The European insomnia guideline: an update on the diagnosis and treatment of insomnia 2023","volume":"32","author":"Riemann","year":"2023","journal-title":"J. Sleep. Res."},{"issue":"2","key":"10.1016\/j.ibneur.2026.07.014_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0170772","article-title":"The prevalence of insomnia in the general population in China: A meta-analysis","volume":"12","author":"Cao","year":"2017","journal-title":"PLoS. One"},{"issue":"11","key":"10.1016\/j.ibneur.2026.07.014_bib4","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/s41577-019-0190-z","article-title":"Sleep and inflammation: partners in sickness and in health","volume":"19","author":"Irwin","year":"2019","journal-title":"Nat. Rev. Immunol."},{"issue":"12","key":"10.1016\/j.ibneur.2026.07.014_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26125654","article-title":"Dementia and sleep disorders: the effects of drug therapy in a systematic review","volume":"26","author":"Chavez-Mendoza","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.ibneur.2026.07.014_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12072493","article-title":"Alliance for sleep clinical practice guideline on switching or deprescribing hypnotic medications for insomnia","volume":"12","author":"Watson","year":"2023","journal-title":"J. Clin. Med."},{"issue":"19","key":"10.1016\/j.ibneur.2026.07.014_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph181910222","article-title":"Cognitive behavioral therapy and acceptance and commitment therapy for the discontinuation of long-term benzodiazepine use in insomnia and anxiety disorders","volume":"18","author":"Chapoutot","year":"2021","journal-title":"Int. J. Environ. Res. Public. Health"},{"issue":"1","key":"10.1016\/j.ibneur.2026.07.014_bib8","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1093\/sxmrev\/qead026","article-title":"Exploring the potential relationships among obstructive sleep apnea, erectile dysfunction, and gut microbiota: a narrative review","volume":"12","author":"Andersen","year":"2023","journal-title":"Sex. Med. Rev."},{"issue":"1","key":"10.1016\/j.ibneur.2026.07.014_bib9","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12574","article-title":"Role of melatonin in sleep deprivation-induced intestinal barrier dysfunction in mice","volume":"67","author":"Gao","year":"2019","journal-title":"J. Pineal Res."},{"issue":"2","key":"10.1016\/j.ibneur.2026.07.014_bib10","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s11325-020-02178-y","article-title":"Impaired intestinal barrier in patients with obstructive sleep apnea","volume":"25","author":"Li","year":"2021","journal-title":"Sleep. Breath."},{"issue":"3","key":"10.1016\/j.ibneur.2026.07.014_bib11","doi-asserted-by":"crossref","DOI":"10.3892\/ijmm.2025.5571","article-title":"Microbiota metabolites affect sleep as drivers of brain\u2011gut communication (Review)","volume":"56","author":"Cheng","year":"2025","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.ibneur.2026.07.014_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.106041","article-title":"Melatonin alleviates oxidative stress in sleep deprived mice: Involvement of small intestinal mucosa injury","volume":"78","author":"Gao","year":"2020","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.ibneur.2026.07.014_bib13","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jsmc.2023.02.003","article-title":"Sleep and Inflammation: bidirectional Relationship","volume":"18","author":"Veler","year":"2023","journal-title":"Sleep. Med. Clin."},{"issue":"1","key":"10.1016\/j.ibneur.2026.07.014_bib14","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41392-020-00312-6","article-title":"Targeting NF-\u03baB pathway for the therapy of diseases: mechanism and clinical study","volume":"5","author":"Yu","year":"2020","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"12","key":"10.1016\/j.ibneur.2026.07.014_bib15","doi-asserted-by":"crossref","first-page":"nwad309","DOI":"10.1093\/nsr\/nwad309","article-title":"Oral nano-antioxidants improve sleep by restoring intestinal barrier integrity and preventing systemic inflammation","volume":"10","author":"Wu","year":"2023","journal-title":"Natl. Sci. Rev."},{"key":"10.1016\/j.ibneur.2026.07.014_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2023.115528","article-title":"Relationship between sleep and serum inflammatory factors in patients with major depressive disorder","volume":"329","author":"Yang","year":"2023","journal-title":"Psychiatry Res."},{"issue":"12","key":"10.1016\/j.ibneur.2026.07.014_bib17","doi-asserted-by":"crossref","first-page":"3700","DOI":"10.1016\/j.jmb.2019.12.044","article-title":"Molecular Interactions Between Components of the Circadian Clock and the Immune System","volume":"432","author":"Hergenhan","year":"2020","journal-title":"J. Mol. Biol."},{"issue":"1","key":"10.1016\/j.ibneur.2026.07.014_bib18","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/s40168-021-01107-9","article-title":"Fecal microbiota transplantation protects rotenone-induced Parkinson's disease mice via suppressing inflammation mediated by the lipopolysaccharide-TLR4 signaling pathway through the microbiota-gut-brain axis","volume":"9","author":"Zhao","year":"2021","journal-title":"Microbiome"},{"key":"10.1016\/j.ibneur.2026.07.014_bib19","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1146\/annurev-psych-010213-115205","article-title":"Why sleep is important for health: a psychoneuroimmunology perspective","volume":"66","author":"Irwin","year":"2015","journal-title":"Annu. Rev. Psychol."},{"issue":"4","key":"10.1016\/j.ibneur.2026.07.014_bib20","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.14336\/AD.2022.0115","article-title":"Overview of traditional mongolian medical warm acupuncture","volume":"13","author":"Shao","year":"2022","journal-title":"Aging Dis."},{"issue":"6","key":"10.1016\/j.ibneur.2026.07.014_bib21","first-page":"2224","article-title":"Efficacy evaluation of Mongolian medical warm acupuncture for sciatica caused by lumbar disc herniation: a randomized, controlled, single-blind clinical trial","volume":"28","author":"Si","year":"2024","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.ibneur.2026.07.014_bib22","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/6190285","article-title":"Clinical Trial Research on Mongolian Medical Warm Acupuncture in Treating Insomnia","volume":"2016","author":"Bo","year":"2016","journal-title":"Evid. Based Complement. Altern. Med."},{"issue":"7","key":"10.1016\/j.ibneur.2026.07.014_bib23","first-page":"787","article-title":"Clinical effect of the warm acupuncture of Mongolian medicine on insomnia in the elderly and its brain-gut peptide mechanism: a randomized controlled trial","volume":"44","author":"Cao","year":"2024","journal-title":"Zhongguo Zhen Jiu"},{"issue":"1","key":"10.1016\/j.ibneur.2026.07.014_bib24","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3892\/etm.2017.4452","article-title":"Mechanism of Mongolian medical warm acupuncture in treating insomnia by regulating miR-101a in rats with insomnia","volume":"14","author":"Bo","year":"2017","journal-title":"Exp. Ther. Med."},{"issue":"5","key":"10.1016\/j.ibneur.2026.07.014_bib25","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1136\/acupmed-2016-011243","article-title":"Effect of Mongolian warm acupuncture on the gene expression profile of rats with insomnia","volume":"37","author":"A","year":"2019","journal-title":"Acupunct. Med."},{"issue":"4","key":"10.1016\/j.ibneur.2026.07.014_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0267843","article-title":"Influence of warm acupuncture on gut microbiota and metabolites in rats with insomnia induced by PCPA","volume":"17","author":"Yu","year":"2022","journal-title":"PLoS. One"},{"key":"10.1016\/j.ibneur.2026.07.014_bib27","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.2147\/NDT.S566386","article-title":"Antidepressant-like effects of mongolian medical warm acupuncture via remodeling the gut microbiota-metabolite-barrier Axis in CUMS rats","volume":"21","author":"Wu","year":"2025","journal-title":"Neuropsychiatr. Dis. Treat."},{"issue":"4","key":"10.1016\/j.ibneur.2026.07.014_bib28","first-page":"3228","article-title":"Establishment of a rat model with ageing insomnia induced by D-galactosef and para-chlorophenylalanine","volume":"20","author":"Ren","year":"2020","journal-title":"Exp. Ther. Med."},{"issue":"1","key":"10.1016\/j.ibneur.2026.07.014_bib29","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0006-8993(97)00286-2","article-title":"Effect of p-chlorophenylalanine (PCPA) on sleep and monoamines content in the brain of a lizard species","volume":"761","author":"Huitr\u00f3n-Res\u00e9ndiz","year":"1997","journal-title":"Brain Res."},{"issue":"11","key":"10.1016\/j.ibneur.2026.07.014_bib30","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/nri2653","article-title":"Intestinal mucosal barrier function in health and disease","volume":"9","author":"Turner","year":"2009","journal-title":"Nat. Rev. Immunol."},{"issue":"8","key":"10.1016\/j.ibneur.2026.07.014_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0126-x","article-title":"Mechanisms regulating intestinal barrier integrity and its pathological implications","volume":"50","author":"Chelakkot","year":"2018","journal-title":"Exp. Mol. Med."},{"issue":"3","key":"10.1016\/j.ibneur.2026.07.014_bib32","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nri3608","article-title":"Intestinal epithelial cells: regulators of barrier function and immune homeostasis","volume":"14","author":"Peterson","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ibneur.2026.07.014_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119195","article-title":"Mechanisms and regulation of IL-22-mediated intestinal epithelial homeostasis and repair","volume":"271","author":"Patnaude","year":"2021","journal-title":"Life Sci."}],"container-title":["IBRO Neuroscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667242126001144?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667242126001144?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T16:34:37Z","timestamp":1793810077000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667242126001144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":33,"alternative-id":["S2667242126001144"],"URL":"https:\/\/doi.org\/10.1016\/j.ibneur.2026.07.014","relation":{},"ISSN":["2667-2421"],"issn-type":[{"value":"2667-2421","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mongolian warm acupuncture improves colonic barrier function and immune responses via the TLR4\/MyD88\/NF-\u03baB pathway in insomnia rats","name":"articletitle","label":"Article Title"},{"value":"IBRO Neuroscience Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ibneur.2026.07.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of International Brain Research Organization.","name":"copyright","label":"Copyright"}]}}