{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T04:20:06Z","timestamp":1778732406335,"version":"3.51.4"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T00:00:00Z","timestamp":1517356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["106649"],"award-info":[{"award-number":["106649"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["134059"],"award-info":[{"award-number":["134059"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["IBRO Reports"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.ibror.2018.01.003","type":"journal-article","created":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T03:47:35Z","timestamp":1517543255000},"page":"18-21","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Preventing synaptic deficits in Alzheimer\u2019s disease by inhibiting tumor necrosis factor alpha signaling"],"prefix":"10.1016","volume":"4","author":[{"given":"Chelsea","family":"Cavanagh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tak Pan","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ibror.2018.01.003_bib0005","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S0165-5728(02)00050-4","article-title":"Up-regulation of the inflammatory cytokines IFN-gamma and IL-12 and down-regulation of IL-4 in cerebral cortex regions of APP(SWE) transgenic mice","volume":"126","author":"Abbas","year":"2002","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.ibror.2018.01.003_bib0010","series-title":"World Alzheimer Report 2015: The Global Impact of Dementia, An analysis of prevalence, incidence, cost and trends","author":"AD-International","year":"2015"},{"key":"10.1016\/j.ibror.2018.01.003_bib0015","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/S1474-4422(15)00153-2","article-title":"Prevention of sporadic Alzheimer's disease: lessons learned from clinical trials and future directions","volume":"14","author":"Andrieu","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ibror.2018.01.003_bib0020","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S1474-4422(11)70072-2","article-title":"The projected effect of risk factor reduction on Alzheimer's disease prevalence","volume":"10","author":"Barnes","year":"2011","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ibror.2018.01.003_bib0025","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1056\/NEJM200008173430701","article-title":"Patterns of brain activation in people at risk for Alzheimer's disease","volume":"343","author":"Bookheimer","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ibror.2018.01.003_bib0030","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.2105\/AJPH.88.9.1337","article-title":"Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset","volume":"88","author":"Brookmeyer","year":"1998","journal-title":"Am. J. Public Health"},{"key":"10.1016\/j.ibror.2018.01.003_bib0035","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1126\/science.1162844","article-title":"Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease","volume":"321","author":"Busche","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.ibror.2018.01.003_bib0040","doi-asserted-by":"crossref","first-page":"2966","DOI":"10.1093\/brain\/awl237","article-title":"Phenotype associated with APP duplication in five families","volume":"129","author":"Cabrejo","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.ibror.2018.01.003_bib0045","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3233\/JAD-122131","article-title":"betaCTF-correlated burst of hippocampal TNFalpha occurs at a very early, pre-plaque stage in the TgCRND8 mouse model of Alzheimer's disease","volume":"36","author":"Cavanagh","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.ibror.2018.01.003_bib0050","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.neurobiolaging.2016.07.009","article-title":"Inhibiting tumor necrosis factor-alpha before amyloidosis prevents synaptic deficits in an Alzheimer's disease model","volume":"47","author":"Cavanagh","year":"2016","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ibror.2018.01.003_bib0055","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1750-1326-6-16","article-title":"Hippocampal expression of murine TNFalpha results in attenuation of amyloid deposition in vivo","volume":"6","author":"Chakrabarty","year":"2011","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.ibror.2018.01.003_bib0060","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s12974-015-0349-x","article-title":"Tumor necrosis factor-alpha enhances voltage-gated Na(+) currents in primary culture of mouse cortical neurons","volume":"12","author":"Chen","year":"2015","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.ibror.2018.01.003_bib0065","doi-asserted-by":"crossref","first-page":"21562","DOI":"10.1074\/jbc.M100710200","article-title":"Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695","volume":"276","author":"Chishti","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ibror.2018.01.003_bib0070","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1523\/JNEUROSCI.21-06-02058.2001","article-title":"Reduction of potassium currents and phosphatidylinositol 3-kinase-dependent AKT phosphorylation by tumor necrosis factor-(alpha) rescues axotomized retinal ganglion cells from retrograde cell death in vivo","volume":"21","author":"Diem","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ibror.2018.01.003_bib0075","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.nbd.2003.09.004","article-title":"Neuronal localization of C1q in preclinical Alzheimer's disease","volume":"15","author":"Fonseca","year":"2004","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ibror.2018.01.003_bib0080","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/1742-2094-9-99","article-title":"Early intervention with a small molecule inhibitor for tumor necrosis factor-alpha prevents cognitive deficits in a triple transgenic mouse model of Alzheimer's disease","volume":"9","author":"Gabbita","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.ibror.2018.01.003_bib0085","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1111\/ejn.12233","article-title":"Alterations in hippocampal network oscillations and theta-gamma coupling arise before Abeta overproduction in a mouse model of Alzheimer's disease","volume":"37","author":"Goutagny","year":"2013","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ibror.2018.01.003_bib0090","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1016\/j.cell.2015.11.023","article-title":"Neuroinflammatory TNFalpha impairs memory via astrocyte signaling","volume":"163","author":"Habbas","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.ibror.2018.01.003_bib0095","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1016\/j.neurobiolaging.2014.03.026","article-title":"Neuronal driven pre-plaque inflammation in a transgenic rat model of Alzheimer's disease","volume":"35","author":"Hanzel","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ibror.2018.01.003_bib0100","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1212\/01.wnl.0000265223.25679.2a","article-title":"Does NSAID use modify cognitive trajectories in the elderly? The Cache County study","volume":"69","author":"Hayden","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.ibror.2018.01.003_bib0105","doi-asserted-by":"crossref","first-page":"e55091","DOI":"10.1371\/journal.pone.0055091","article-title":"Long-term treatment of thalidomide ameliorates amyloid-like pathology through inhibition of beta-secretase in a mouse model of Alzheimer's disease","volume":"8","author":"He","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ibror.2018.01.003_bib0110","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1083\/jcb.200705042","article-title":"Deletion of tumor necrosis factor death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer's mice","volume":"178","author":"He","year":"2007","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ibror.2018.01.003_bib0115","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer's disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ibror.2018.01.003_bib0120","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nature11729","article-title":"NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP\/PS1 mice","volume":"493","author":"Heneka","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.ibror.2018.01.003_bib0125","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1742-2094-2-22","article-title":"Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice","volume":"2","author":"Heneka","year":"2005","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.ibror.2018.01.003_bib0130","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1126\/science.aad8373","article-title":"Complement and microglia mediate early synapse loss in Alzheimer mouse models","volume":"352","author":"Hong","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.ibror.2018.01.003_bib0135","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1742-2094-2-23","article-title":"Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice","volume":"2","author":"Janelsins","year":"2005","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.ibror.2018.01.003_bib0140","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1111\/j.1471-4159.2006.04330.x","article-title":"Tumor necrosis factor alpha stimulates NMDA receptor activity in mouse cortical neurons resulting in ERK-dependent death","volume":"100","author":"Jara","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ibror.2018.01.003_bib0145","doi-asserted-by":"crossref","first-page":"17401","DOI":"10.1523\/JNEUROSCI.3028-12.2012","article-title":"Beta amyloid-induced depression of hippocampal long-term potentiation is mediated through the amylin receptor","volume":"32","author":"Kimura","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ibror.2018.01.003_bib0150","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3233\/JAD-2011-110830","article-title":"Hippocampal GABAergic neurons are susceptible to amyloid-beta toxicity in vitro and are decreased in number in the Alzheimer's disease TgCRND8 mouse model","volume":"29","author":"Krantic","year":"2012","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.ibror.2018.01.003_bib0155","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1523\/JNEUROSCI.5159-07.2008","article-title":"Rapid tumor necrosis factor alpha-induced exocytosis of glutamate receptor 2-lacking AMPA receptors to extrasynaptic plasma membrane potentiates excitotoxicity","volume":"28","author":"Leonoudakis","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ibror.2018.01.003_bib0160","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/0140-6736(90)91101-F","article-title":"Anti-inflammatory drugs and Alzheimer disease","volume":"335","author":"McGeer","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.ibror.2018.01.003_bib0165","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.expneurol.2012.10.007","article-title":"Astrocytes: conductors of the Alzheimer disease neuroinflammatory symphony","volume":"239","author":"Medeiros","year":"2013","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ibror.2018.01.003_bib0170","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/jcbfm.2013.183","article-title":"Elevated CNS inflammation in patients with preclinical Alzheimer's disease","volume":"34","author":"Monson","year":"2014","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.ibror.2018.01.003_bib0175","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3233\/JAD-2011-101815","article-title":"Expression profiles of cytokines in the brains of Alzheimer's disease (AD) patients compared to the brains of non-demented patients with and without increasing AD pathology","volume":"25","author":"Morimoto","year":"2011","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.ibror.2018.01.003_bib0180","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1001\/archgenpsychiatry.2011.1893","article-title":"Interactive effect of apolipoprotein e genotype and age on hippocampal activation during memory processing in healthy adults","volume":"69","author":"Nichols","year":"2012","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.ibror.2018.01.003_bib0185","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.neuron.2007.07.025","article-title":"Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease","volume":"55","author":"Palop","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.ibror.2018.01.003_bib0190","doi-asserted-by":"crossref","first-page":"184","DOI":"10.5698\/1535-7511-12.5.184","article-title":"Seizures in Alzheimer disease: clinical and epidemiological data","volume":"12","author":"Pandis","year":"2012","journal-title":"Epilepsy Curr."},{"key":"10.1016\/j.ibror.2018.01.003_bib0195","doi-asserted-by":"crossref","first-page":"15879","DOI":"10.1523\/JNEUROSCI.0530-13.2013","article-title":"TNF-alpha downregulates inhibitory neurotransmission through protein phosphatase 1-dependent trafficking of GABA(A) receptors","volume":"33","author":"Pribiag","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ibror.2018.01.003_bib0200","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/S1474-4422(12)70228-4","article-title":"Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study","volume":"11","author":"Reiman","year":"2012","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ibror.2018.01.003_bib0205","doi-asserted-by":"crossref","first-page":"e38170","DOI":"10.1371\/journal.pone.0038170","article-title":"Inhibition of soluble tumor necrosis factor ameliorates synaptic alterations and Ca2+ dysregulation in aged rats","volume":"7","author":"Sama","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ibror.2018.01.003_bib0210","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1096\/fj.03-1378fje","article-title":"Gene structure and organization of the human beta-secretase (BACE) promoter","volume":"18","author":"Sambamurti","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.ibror.2018.01.003_bib0215","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.neuron.2011.02.003","article-title":"TNFalpha controls glutamatergic gliotransmission in the hippocampal dentate gyrus","volume":"69","author":"Santello","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.ibror.2018.01.003_bib0220","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1001\/archneurol.2009.130","article-title":"Seizures in Alzheimer disease: who, when, and how common?","volume":"66","author":"Scarmeas","year":"2009","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.ibror.2018.01.003_bib0225","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.brainres.2010.10.053","article-title":"Anti-TNF-alpha reduces amyloid plaques and tau phosphorylation and induces CD11c-positive dendritic-like cell in the APP\/PS1 transgenic mouse brains","volume":"1368","author":"Shi","year":"2011","journal-title":"Brain Res."},{"key":"10.1016\/j.ibror.2018.01.003_bib0230","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jalz.2011.03.003","article-title":"Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"Sperling","year":"2011","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.ibror.2018.01.003_bib0235","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1126\/science.1081297","article-title":"Inactivation of TNF signaling by rationally designed dominant-negative TNF variants","volume":"301","author":"Steed","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.ibror.2018.01.003_bib0240","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1038\/nature04671","article-title":"Synaptic scaling mediated by glial TNF-alpha","volume":"440","author":"Stellwagen","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.ibror.2018.01.003_bib0245","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/ana.410300410","article-title":"Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment","volume":"30","author":"Terry","year":"1991","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ibror.2018.01.003_bib0250","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/1742-2094-9-106","article-title":"Tumor necrosis factor-alpha synthesis inhibitor 3,6'-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease","volume":"9","author":"Tweedie","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.ibror.2018.01.003_bib0255","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.cytogfr.2011.09.004","article-title":"Treatment of TNF mediated diseases by selective inhibition of soluble TNF or TNFR1","volume":"22","author":"Van Hauwermeiren","year":"2011","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.ibror.2018.01.003_bib0260","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.cell.2012.02.046","article-title":"Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model","volume":"149","author":"Verret","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.ibror.2018.01.003_bib0265","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1111\/j.1471-4159.2009.06038.x","article-title":"Tumor necrosis factor-alpha-induced neutral sphingomyelinase-2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors","volume":"109","author":"Wheeler","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ibror.2018.01.003_bib0270","doi-asserted-by":"crossref","first-page":"e59586","DOI":"10.1371\/journal.pone.0059586","article-title":"Neuroinflammation and neuronal loss precede Abeta plaque deposition in the hAPP-J20 mouse model of Alzheimer's disease","volume":"8","author":"Wright","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ibror.2018.01.003_bib0275","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.celrep.2015.04.017","article-title":"Chronic optogenetic activation augments abeta pathology in a mouse model of Alzheimer disease","volume":"11","author":"Yamamoto","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.ibror.2018.01.003_bib0280","doi-asserted-by":"crossref","first-page":"680","DOI":"10.2353\/ajpath.2007.060378","article-title":"Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice","volume":"170","author":"Yamamoto","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ibror.2018.01.003_bib0285","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1523\/JNEUROSCI.2531-15.2016","article-title":"Attenuation of beta-amyloid deposition and neurotoxicity by chemogenetic modulation of neural activity","volume":"36","author":"Yuan","year":"2016","journal-title":"J. Neurosci."}],"container-title":["IBRO Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451830117300468?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2451830117300468?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T12:55:16Z","timestamp":1762520116000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2451830117300468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":57,"alternative-id":["S2451830117300468"],"URL":"https:\/\/doi.org\/10.1016\/j.ibror.2018.01.003","relation":{},"ISSN":["2451-8301"],"issn-type":[{"value":"2451-8301","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preventing synaptic deficits in Alzheimer\u2019s disease by inhibiting tumor necrosis factor alpha signaling","name":"articletitle","label":"Article Title"},{"value":"IBRO Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ibror.2018.01.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Ltd on behalf of International Brain Research Organization.","name":"copyright","label":"Copyright"}]}}